허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

스마트폰 기반 마이크로블로그 학습활동이 사회적 실재감에 미치는 영향

김경연,고유정,정수정,임걸,심현애 안암교육학회 2010 한국교육학연구 Vol.16 No.3

This study aimed to understand the enhancement of social presence through microblogging learning activities with smartphones. With the research contract and help of an IT company, the study conducted with 16 participants at a "Distance Learning" class in K University. The class lasted 12 weeks in a blended learning format. Triangulation methods were adopted for the analysis of the study: Paired T-tests, semi-structured interviews, and content analysis. As a result, all of the approaches showed that the participants' social presence enhanced in a significant way. Based on the results, it was suggested that (1) other variables such as academic performances, satisfaction should be dealt with to understand other effect of microblogging with smartphoens (2) discrepancies of social presence between online and offline classes should be addressed for other blended learning environments, and (3) more diverse mobile learning strategies should be developed for preparing for the ubiquitous learning society. 본 연구는 스마트폰 기반의 블렌디드 학습환경 속에서 마이크로블로그 활동이 사회적 실재감에 미치는 영향을 다양한 자료를 통해 파악하고자 하는데 목적이 있다. 이를 위하여 K대학교의 2010년 1학기 ‘원격교육활용론’ 강좌를 등록한 대학생 16명을 대상으로 12주 동안 수업과 직ㆍ간접적으로 관련된 다양한 형태의 의사소통이 마이크로블로그상에서 진행되었다. 연구문제에 대한 검증을 위해 사회적 실재감 측정치에 대한 사전-사후 양적결과 분석, 마이크로블로그 메시지에 대한 내용분석, 그리고 인터뷰 결과에 대한 분석을 실시하였다. 분석 결과 공통적으로 사회적 실재감이 향상된 것으로 나타났다. 이런 연구결과를 바탕으로 사회적 실재감에서 더 나아가 마이크로블로그의 학습 효과 등에 대한 연구, 온-오프라인 간의 사회적 실재감 격차를 줄이는 방안에 대한 연구, 나아가 향후 유비쿼터스 학습환경을 대비한 다양한 각도에서의 폭넓은 교육효과를 위한 지속적인 모바일 기반의 학습전략 접근 등이 요구됨을 제안하였다.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

A Study on Health Risk Behavior Factors and Chronic Disease Risk Factors

Su Jeong SHIM,Ji Hee LEE,백진경 한국식품보건융합학회 2022 식품보건융합연구 (KJFHC) Vol.8 No.1

This study classified subjects aged 30 to 64 into normal group, impaired fasting glucose group, and diabetes mellitus patient group based on data from the 6th period of the National Health and Nutrition Examination Survey (2013-2015). Skipping breakfast, lack of physical activity, inadequate sleep time, inadequate weight, excessive drinking, and current smoking are classified as a low health risk group when three or less items are present, and a high health risk group when three or more items are included. By classification, each item included in the physical measurement and biochemical analysis factors and health risk behavior factors was comparatively analyzed. As a result, in the normal group, impaired fasting glucose group, and diabetes group, the average age was higher in the group with high health risk factors than the group with low risk factors, and the male ratio was higher. Body mass index, waist circumference, blood pressure, triglyceride showed a significantly higher result. In the normal group, the fasting blood glucose level and total cholesterol level were also higher in group 2. Therefore, it is thought that it is necessary to control health risk behaviors through lifestyle changes in the normal group, fasting glucose disorder group, and diabetes group.

Signaling pathways underlying nitrogen transport and metabolism in plants

Su Jeong Choi,Zion Lee,Eui-Jeong Han,Sohyun Kim,Jun Sung Seo,Taeyoung Um,Jae Sung Shim 생화학분자생물학회 2023 BMB Reports Vol.56 No.2

Nitrogen (N) is an essential macronutrient required for plantgrowth and crop production. However, N in soil is usuallyinsufficient for plant growth. Thus, chemical N fertilizer hasbeen extensively used to increase crop production. Due tonegative effects of N rich fertilizer on the environment, improvingN usage has been a major issue in the field of plantscience to achieve sustainable production of crops. For thatreason, many efforts have been made to elucidate how plantsregulate N uptake and utilization according to their surroundinghabitat over the last 30 years. Here, we provide recent advancesfocusing on regulation of N uptake, allocation of N byN transporting system, and signaling pathway controlling Nresponses in plants.

해수 중 이산화탄소의 증가가 감성돔(Acanthopagrus schlegelii)의 초기성장에 미치는 영향

심정희 ( Jeong Hee Shim ),김경수 ( Kyung Su Kim ),김수암 ( Su Am Kim ) 한국수산과학회 2013 한국수산과학회지 Vol.46 No.6

Since the industrial revolution, seawater has increased in temperature and acidity due to the increase in anthropogenic carbon dioxide in the atmosphere. To understand the effect of elevated CO2 on the early life stages of fish, we reared fertilized eggs of black sea bream Acanthopagrus schlegelii under three CO2 concentrations (400, 850 and 1550 ppm) for 3 weeks. The standard length and wet weight of black sea bream larvae declined with enhanced CO2 concentration in the rearing water (P<0.05). However, chemical analysis using ICP-OES on internal tissues of black sea bream larvae indicated that the whole-body calcium concentration increased with CO2 concentration in the rearing water. These conflicting results suggest that future experiments should examine the acid-base balance to investigate the formation of bone and otolith during larval growth.

세치제내 SLS함유에 따른 타액과 세균변화

심연수(Shim, Youn-Su),정미애(Jeong, Mi-Ae),정상희(Jeong, Sang-Hee) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.9

이 연구는 세치제 내 함유되어 있는 SLS의 함유여부에 따라 구강 내 타액과 세균수의 변화정도를 비교분석 하여 향후 보다 양질의 세치제 개발을 위한 기초자료를 제공하고자 하였다. SLS의 함유량을 2.2%와 0.0%의 세치제 를 제조하여 각각 30명으로 구성된 두 집단의 실험대상자에게 4주간 사용하게 하고 실험 전 후의 타액과 구강 내 세 균 수의 변화 차이를 보았다. 연구결과 SLS의 배합여부는 타액, 세균수의 변화에 현저한 차이를 보이지 않았다. 또한 SLS 배합여부는 타액량과 구강 내 세균수의 관련성이 없는 결과를 보였다. 하지만 실험대상자들이 사용한 세치제에 대한 만족도 조사에서는 SLS가 함유되지 않은 그룹 보다 SLS가 함유된 그룹에서 만족도가 현저하게 높은 것으로 나 타났다. 만일 SLS가 선호감 때문에 이용되고 있다면 SLS의 적정 함유량에 대한 구체적 개선방안을 모색하여 할 것 이다. Dentifrices comtaining SLS of 2.2% and 0.0% were applied to 60 subjects for 4 weeks in this study. Dentifrice is used for salivary and oral bacteria amount change according to its SLS contents in toothpaste. The results were as follows. Anaysis of LSL contents befor and after the after experiment in salivary and bacterial count oral cavity didn't show significant difference in time interval. There was no correlation between salivary flow rate and bacterial count in the oral cavity according to content of SLS. Dentifrice of 2.2% content satisfied the subjects much more than that of 0.0% content(p<0.001).

동해안의 Cochlodinium polykrikoides 적조 발생에 미치는 해황의 특성

심정민 ( Jeong Min Shim ),황재동 ( Jae Dong Hwang ),정창수 ( Chang Su Jeong ),이용화 ( Yong Hwa Lee ),전경암 ( Kyeong Am Jeon ),권기영 ( Kee Young Kwon ) 한국환경과학회 2010 한국환경과학회지 Vol.19 No.12

Harmful dinoflagellate Cochlodinium polykrikoides blooms have been frequently occurred in coastal areas of the East Sea since 1995. We compared the oceanic conditions in years 1995, 2001 and 2003 when the C. polykrikoides bloom was strong, and in years 1998 and 2004 when the C. polykrikoides bloom was not appeared. We studied temporal and spatial variation of upwelling and geostrophic currents on the western channel of Korean Strait, an entrance of the East Sea. The period and occurrence area of C. polykrikoides bloom was depended on variation of upwelling in summer. In the distributions of geostrophic current, southward current was dominant near the coast in August, 1998 and 2000. Whereas northward current was dominant near and off the coast in August, 1995 and 2003 which the C. polykrikoides bloom was strong. When compared dominant phytoplankton of the coastal areas in each year, Kuroshio indicator species Proboscia alata and Chaetoceros affine were dominant, respectively, in 2001 and 2003 at every stations. However, the dominant species was variable at each coastal area in 1998 and 2000. In 2003, the abundance of Sagitta elegans which is known as the cold water indicator was low, but the abundance of S. enflata, warm water indicator, was very high in Gangneung compared to Sokcho. It seemed that the distribution of S. elegans is restricted by strong warm water current. In conclusion, it was estimated that the distribution of C. polykrikoides bloom in the coastal area of the East Sea was closely related with the strength of East Korea Warm Current and upwelling.

Clinical significance of HPV 16 and 18 DNA in serum of patients with cervical cancer

정대훈 ( Dae Hoon Jeong ),( Joo Ran Kim ),( Dae Shim Lee ),( Young Mi Park ),( Su Jeon Jeong ),( Young Nam Kim ),( Chul Hoi Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Ki Tae Kim ) 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-