양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

국내 5개 3차 병원의 β-lactam계 항생제 사용 실태 및 Klebsiella pneumoniae의 항생제 내성과의 상관 관계

정숙인,박경화,권기태,고관수,오원섭,정두련,백경란,염준섭,장현하,김신우,손준성,송재훈 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Background : This study was performed to evaluate the prescribing pattern of β-lactam antibiotics and the relationship between antimicrobial resistance and antimicrobial use in 5 tertiary care hospitals in Korea. Materials and Methods : Data on annual patient-days and annual consumption (defined daily dose (DDD) per 100 patient-days) of β-lactam antibiotics from 2003 to 2005 in 5 tertiary hospitals were analyzed. To determine the antimicrobial resistance in K. pneumoniae, broth microdilution test and double disk synergy were performed according to the CLSI performance standards. Spearman's correlation coeffient was used to determine the relationship between antibiotic consumption and resistance. Results : The prescription of β-lactam antibiotics in 5 tertiary hospitals markedly varied. In two hospitals, increase in consumption of β-lactam antibiotics was more than 30% during recent 3 years. The higher consumption of β-lactam antibiotics significantly correlated with the higher rate of antibiotic-resistant K. pneumoniae in 5 tertiary care hospitals. Conclusion : Continuous surveillance of antibiotic use is needed to encourage appropriate prescribing of antibiotics and to reduce antibiotic resistance. 목적 : 항생제의 오남용으로 인한 내성균의 발현 및 급속한 확산이 전세계적으로 문제시 되고 있다. 특히 병원은 항생제 내성의 중심점에 있는 것으로 여겨진다. 본 연구에서는 최근 3년간 국내 5개 3차 병원의 β-lactam계 항생제의 사용량을 조사하고, 각 병원별 항생제 사용량과 K. pneumoniae의 항생제 내성률과의 상관관계를 알아보고자 하였다. 재료 및 방법 : 국내 5개 3차 병원에서 2003년 1월부터 2005년 12월까지 병원 입원 환자를 대상으로 연도별 재원연인원수와 각 β-lactam계 항생제의 총사용량을 수집하여 DDD (defined daily dose) per 100 patient-days로 환산하여 비교하였다. 2005년 6월부터 8월까지 각 병원의 임상검체에서 동정된 K. pneumoniae를 수집하여 액체배지미량희석법으로 항생제 감수성 검사를 시행하였고 ESBL(extended-spectrum β-lactamase) 생성 여부는 double disk synergy test를 시행하였다. 항생제 사용량과 내성의 상관관계는 Spearman 상관관계 분석을 시행하였다. 결과 : 5개 병원 중 3개 병원에서는 연도별 β-lactam계 항생제 사용량이 비슷하게 유지되었으나, 2개 병원에서는 2003년에 비해 2005년에 항생제 사용량이 30% 이상 증가하였다. β-lactam계 항생제 중 제제별 비율은 각 병원마다 차이가 있었으나, 3세대 cephaosporin의 사용이 가장 많았고 2세대 ceaphlosporin, β-lactam/β-lactamase inhibitor, 1세대 cephalosporin 순이었다. 경구용 β-1actam계 항생제의 사용량(r=0.900, P<0.037)과 2세대 cephalosporin의 사용량(r=0.900, P<0.037)은 각각 K. pneumoniae의 ESBL 생성과 양의 상관관계가 있었다. Ceftazidime의 사용량은 K. pneumoniae의 ceftazidime 내성률과 양의 상관관계가 있었다(r=0.900, P<0.037). 반면 imipenem의 사용량은 piperacillin/tazobactam 내성과 음의 상관관계가 있었다(r=-0.900, P<0.037). 결론 : 최근 3개년간 항생제 사용량은 병원별로 차이가 있으나 일부 병원에서는 증가하였다. β-lactam계 항생제의 사용량은 K. pneumoniae의 항생제 내성과 상관관계가 있었다. 항생제 사용을 줄임으로써 항생제 내성을 감소시킬 수 있을 것으로 기대되며, 병원별로 항생제 사용에 대한 지속적인 감시가 필요할 것이다.

A Digital Watermark

신정화,김인택,한승수 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

In this paper, watermark technique has been proposed as a method to hide secret information into the signals so as to discourage unauthorized copying or attest the origin of the media. We present an approach for still image watermarking in which the watermark is embedded in the middle frequence area. It is confirmed from numerical experiments that the proposed method yields the watermarked image which is robust to several attacks.

수술적으로 치료한 통증을 동반한 흉추부의 후외상성 Schmorl씨 결절 : 2례 보고 Report of Two Cases

신병준,이재철,송화용,정석봉,권계원,조영일,김연일 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Study Design : Two patients who had painful Schmorl's node at thoracic level from acute trauma were adopted and taken operation for its treatment Objectives : To document the effect of operation for the treatment of painful Schmorl's node at thoracic level summary of background data : Schrmorl's nodes are common spinal lesion generally believed to be asymptomatic, but in some cases there were painful symptom by Schmorl's node. This case report is to explain the effect of operative treatment for the painful Schmorl's node. Methods : Two patients were adopted who had traumatic painful Schmorl's node at thoracic level for our case report. They were treated conservative methods at first but it's effect were poor, so they were taken anterior decompression and fusion, and checked back pain symptom. Result : In all two patients, the symptom of back pain by Schmorl's nodes at thoracic level was almost subsided. conclusion : For the treatment of traumatic painful Schmorl's node, most of surgeon says that conservative treatments were treatment of choice, but operative treatments are also benefit to subsidence of back pain by Schmorl's node.

동시성 공유정신병 : 일란성 쌍생아 자매의 역할반전 Case Formulation of Role Reversal

신화식,유희정,김헌수,김현실,민병근 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.1

The twin sisters case of folie simultanee is reported here in this paper. A case of folie simultanee is described as two or more people becoming psychotic simultaneously and sharing the same delusion. The results of psychodynamic approach for this case are as follows. 1. There are a variety of conflicting hypotheses on the orgin of the disorder, ranging from the etiological explanation of organic factor to various psychodynamic approach. In this case, there is no evidence of hereditary factor on the laboratory findings and family history. Therefore the authors stressed that the psychodynamic formulation of the disorder is on the importance .of the etiological rol. It seem significant to describe that the etiology is multidimensional and includes factors such as character structure formation in processing of object relations, the emotional relationship between the partners, socio-environmental conditions and hereditary predisposition. 2. There are two issues in folie simultanee. The one is related to diagnosis. It is consider to distinguish the inductor from the recipient. The other is subject to treatment. It is important to determine whether separate the inductor and recipient by admitting the inductor for a psychiatric center or not. Furthermore, the inductor and recipient's weak ego state should be recognized in planning various psychiatric treatments. 3. It could be found in the role reversal phenomenon between the inductor and recipient during long-term course.

도시고형폐기물의 성분분석에 관한 연구

선정화,김희택,배성렬,강신춘 한양대학교 에너지·환경기술연구소 1994 에너지·環境技術論文集 Vol.1 No.-

도시지역에서 배출되는 일반폐기물에 대한 성분분석결과 밀도는 250∼300㎏/㎥, 수분함량은 중량비로 평균 51.83%, 가연성분 42.09%, 회분 6.08%로 각각 측정되었다. 한편, 저위발열량은 주거지역이 700∼1,700㎉/㎏, 상업지역이 2,000㎉/㎏이상으로 측정되어 상업지역이 주거 지역보다 발열량이 높은 폐기물이 배출됨을 알 수 있었는데 이는 수분함량이 높은 주개류의 배출이 상업지역이 주거지역보다 적으며 소비자 포장지로서 종이, 비닐, 플라스틱류 등의 사용이 많은데 기인하는 것으로 생각되어 진다. 한편, 분리수거, 유가품에 대한 자원 재활용, 연탄재 배출의 감소추세 등의 효과로 폐기물 중 불연성 함량은 줄어들고 반면 종이, 비닐, 플라스틱류 등의 가연성 폐기물의 함량은 크게 늘어 전체적으로 폐기물의 질이 향상되고 있음을 알 수 있다. The analysis results of components of municipal solid wastes are as follows : ① Density ranged from 250㎏/㎥ to 300㎏/㎥. ② Water content, combustible content and ash content measured 51.83%, 42.09%, 6.08% respectively. ③ Low calorific value was ranged from 700 to 1,700㎉/㎏ in residential area and measured 2,000㎉/㎏ in commercial one. Therefore, it was known that calorific value of wastes in residential area is smaller than that in commercial area. Also, the quality of wastes was improved by increase of combustible content which results from vitality of valuable recycling, reduction trend of briquette ash generation rate and increase of paper, plastic consumption as wrapping materials.

체육공원의 환경 색채에 관한 연구 : 수원시 체육공원을 중심으로

여화선,김신원,김민정 경희대학교 부설 디자인연구원 2008 예술· 디자인학연구 Vol.11 No.1

This paper studied general ideas of the color theory that affects the psychological response of the sports park users based on the color and then suggested an appropriate environmental color plan of the sports park in Suwon. Also, our purpose is to raise the efficiency of exercise and form vibrant and harmonious sports park with healthful surroundings. The place of investigation were Yeogisan sorts park(2004), Hwasan sports park(2005), youngheung sports park(2006) in Suwon, and the range of investigation was limited the three requisites for construction of a space in the sports park. This study was performed by analysis of the present condition of the place and suggested the color palette and color plan. There weren't used colors stand for symbolism and emphasis. Moreover, the place of investigation used the dark color and the turbid color that didn't match with nature and lessen the efficiency of exercise. The result of this study can be summarized as follows: Seven colors which stand for Suwon apply to environmental colors of the sports park. Green and Blue represent desire, wealth of Suwon city and planned the place which was in harmony with nature. We used Orange, Gold fitted 4 season for energetic and dynamic atmosphere. Also, we offer people with calmness and comfort by making use of Gray, Light gray and Silver. Environmental color of sports park improves the quality of cultural and social life for revitalizing of physical exercise. Furthermore, it leads a foothold in reinforcement of global competitiveness and revitalization of local economy through better image of city.

초등학교 아동을 위한 리더십 프로그램 개발

김정효,정인숙,김신래,엄화정 이화여자대학교 교육과학연구소 2007 교육과학연구 Vol.38 No.3

학교교육과정에서는 자율성의 확대에 밀려 타인배려와 공동체에 대한 책임의식 교육은 상대적으로 열세의 위치에 처해있다. 그러나 21세기 정보화 산업구조에서는 한개인에게 리더이자 동시에 멤버로서의 역할을 요구하고 있다. 특별히 학령기 아동에있어서는 또래 집단 형성이라는 사회성 발달 과업의 특성이 초등학교아동기에 ‘자신이가진 독특한 자질을 발휘하여 공동체의 유익을 위해 영향을 발휘할 수 있는 능력’ 으로서의 리더십 교육을 필요로 한다. 본 연구에서는 자신자질에 대한 이해를 기반으로 자신감을 가지도록 하는 심리적요소, 자신 뿐 아니라 공동체의 유익을 중요한 삶의 목적이 되어야 한다는 가치적 요소, 그리고 의사소통능력, 대인관계기술 등의 기술적 요소를 기반으로 하는 초등학교고학년 아동을 위한 5일간의 단기 리더십 프로그램을 개발하였다. 서울 시내 한 사립초등학교 5학년을 대상으로 형성평가를 위한 예비실행연구를 하였고, 아동의 자기평가와 교사와의 면담을 통해 개발된 리더십프로그램은 대체로 심리적, 가치적, 기술적요소에 효과를 가지고 온 것으로 보였다. 특히 리더십이란 특정 개인에게만 있는 것이아니라 모두에게 잠재되어 있다는 인식의 전환을 가져옴으로써 자신감과 리더십 개념획득에 두드러진 효과를 가지고 오는 것으로 보였다. This study is to develop a leadership program for elementary school children. Due to extension of freedom, education of responsibility such as taking care ofothers and consideration of community is inferior in the school education. However, in information-oriented society asks for an individual to become aleader and a member at the same time. In addition, specific character of creatingpeer group in children of school age makes it more necessary educate "ability todisplay individual's specific quality for benefit of community". In this study, based on including psychological factor to understand themselvesto bring their confidence, value factor that benefit for the community has to bethe reason for their life and technological factors such as communicating skillsand interpersonal relationship, 5day short-trial for senior students of elementaryschool was developed. A preliminary inspection was held to 5th graders in anelementary school in Seoul. In result, our leadership program gave positive effecton psychological factor, value factor and technological factors. Especially, thisprogram was effective to give confidence and rearranged the definition ofleadership by the idea that leadership is not for the certain individuals buteveryone has their potentials.

산후에 발병한 특발성 부갑상선 기능저하증 I 예

김정인,김상용,신병철,김경남,서영욱,이범주,김진화,배학연 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Hypoparathyroidism is usually the result of an inadvertent surgical removal of all the parathyroid glands, In some instances, not all the tissues are removed, but the remainder undergoes vascular supply compromise secondary to the fibrotic changes in the neck after surgery, Previously, the surgery for hyperthyroidism was the most frequent cause of acquired hypoparathyroidism. Idiopathic hypoparathyroidism is a relatively rare disease that is characterized by hypocalcemia and hyperphosphatemia due to a parathyroid hormone deficiency of an unknown cause, It usually develops at a young age, and shows various clinical symptoms and signs accompanied with hypocalcemia. In addition, it is rarely associated with polyglandular autoimmune syndrome during the follow-up. Hypocalcemia and idiopathic hypoparathyroidism associated with labor and lactation are rarely reported condition previously. We here describe a case of a woman in whom the symptomatic severe hypocalcemia appeared after her delivery. We reviewed all the previously reported cases and suggest a possible physiological explanation for the association between pregnancy, lactation, and the appearance of symptomatic hypocalcemia.