Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

급성신우신염의 임상적 고찰

신영태,신승훈,이순구,이정호,이강욱 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989. The results were as follows : 1. Total number of patients studied was 81(M/F ratio, 1 : 4.4). The M/F ratio of 22 complicated patients (27.2%) was 1 : 2.7 2. The predisposing factors associated with complicated patients were as follows : 7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease. 3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61% and 95% of patients respectively. And 50.6% of patients revealed right CVA tenderness and 28.4% in left, 16% in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups 4. In 50 patients(61.7%) microorganisms were isolated on the urine culture specimens. The most common organism was E. coli(80%), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93%), tobramycin(83.3%) and gentamycin(79.4%) and 88.9 percent of E coli were ressistant to ampicillin 5. In urinary examination on admission, pyuria was noted in 81% of patients, and proteinuria and microscopic hematuria were noted in 68% and 44% of patients respectively. 6. Within 3 days after antibiotics treatment deference was occured in 73.5% of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.

Newton-Raphson 방법에 기반한 공개키의 암호화 전달

신승호,노희영 강원대학교 정보통신연구소 2009 정보통신논문지 Vol.13 No.-

It is necessary to cipher for secrete of public key in processing of the certification for secrete key. Hence, this paper offers a method based on Newton-Raphson for encryption transmission of public keys that are generated by Diffi-Hellman cipher algorithm.

어린 나이에 피부암을 동반한 색소성 건피증 1예

신삼식,이지범,이승철,원영호 全南大醫大 2000 전남의대학술지 Vol.36 No.1

GT rotary file을 이용한 만곡 근관형성시 작업 효율 및 file 변형 발생에 관한 연구

신주희,백승호,배광식,임성삼,윤수한,김병현 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

Root canal preparation process is of utmost importance in successful treatment of root canal. Also, one of the most important purpose of the root canal preparation is to enlarge the root canal three dimensionally without changing the curvature of the root canal. However, as the curvature of the root canal increases, there are many difficulties involved in formation of optimum root canal. Therefore, in order to solve the above mentioned problems, new developments in methods of root canal preparation and equipments for such purposes were made. Recently, vigorous studies about newly introduced engine-driven nitckel-ti-tanium rotary file are conducted. As shown in research results to dates, it is well established that the use of nickel-titanium file is better suited for curved root canal than stainless steel file in maintaining the curvature of root canal and reducing the deformation of root canal. However, it is also acknowledged that there are a few discrepancies in research results according to protocol, due to failure to remove variables in experiments. In addition, although it is recommended by the manufacturer that the GT rotary file should maintain a low rotational speed of 150∼350rpm and 'light pressure' as light as not to break the lead of a pencil, academic studies about the vertical force which is not yet standardized are not sufficiently explored. Therefore, this research devised and utilized a special research equipment to standardize the appropriate range of vertical force for GT rotary file through experiments by breaking of the lead of a pencil as expressed by the manufacturer and to accurately measure factors involved through repeating and recreating the environment of root canal preparation. Forming nine experimental groups by varying the vertical forces (150g, 220g, 300g) and rpm (150rpm, 250rpm, 350rpm), the effects of changing vertical forces and rpm on working efficiency were measured in terms of time expended in root canal preparation by crown-down method using a transparent resin block with 35 degree curvature and GT rotary file (z-test). The following research using this special research equipment that involved nine experimental groups and varying the vertical force for root canal preparation from 300g which is within the normal vertical force range to 700g and 1000g which fall outside the normal rpm range. The results were as follows : 1.Analysis of the experiment results revealed that the tome spent in root canal preparation decreased as the vertical forces and rpm increased (p<0.05). Also, the effects of rpm were greater than those of the vertical forces within the normal vertical force range (β-weight test) . 2.Observation of the deformation of GT rotary file revealed that deformation increases in a direct correlation with the vertical force increase and in a reverse correlation with the rpm decrease, In the case of the vertical forces close to the normal range, the probability of GT rotary file deformation were quite different depending on the rpm changes. In the case of◎eater tier◎cal forces, the occurrences of deformation of the file were more frequent regardless of the rpm changes. 3.Deformation and breakage of file were also commonly observed in the expended time measurement experiments and GT rotary file deformation experiments in which low speed rpm (150rpm) was used and at the curved portion of the resin block. Key words : GT rotary file, Crown-down method, Working efficiency, Vertical force, Rpm, Deformation and breakage of file

강재 슬릿형 댐퍼를 부착한 철근콘크리트조 골조의 거동

신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.

지속적 운동습관과 행동수정요법이 비만 아동의 생리적 변인에 미치는 영향

신호주,정승환 명지대학교 예체능연구소 2003 藝體能論集 Vol.14 No.-

This research is aimed at implanting confidence in solving obesity to growing obese children, haying them maintain dietary habit, and providing a method to early control factors of losing weight and developing adult diseases by understanding the status of their weight control, and applying behavioral correction therapy and constant exercise habit for managing the obese child's weight. For this, 80 students with over 20% obesity (male'40, female . 40) using 50 percentile value of weight by Korean children measured by Korea Podiatric Association in 1985 were sampled among the students attending a primary school located at K City, and 10 male and female students were randomly participated at the 4 groups of aerobic exorcise therapy, behavioral correction therapy, combined behavioral correction and aerobic exercise therapy, and comparison group for 12 weeks, and its difference between groups analyzed, then following conclusion was obtained. The group whose weight and physical fat were reduced most at the 12 week program was at both male and female students who carried out the combined behavioral correction and aerobic exercise therapy. At both male and female groups, the biggest weight loss was indicated between 8 weeks and 12 weeks. As for the physical fat of male and female students in terms of the program application term, the group whose physical fat was most reduced was that carried out combined aerobic exercise therapy and behavioral correction therapy, which was statistically significant. In the measurement time, physical fat was most reduced between 8 weeks and 12 weeks. The measurement of physical fact during the program's application was generally more in male students than female students. As for the maximum and minimum blood pressure of male and female students, the group carrying out the combined aerobic exercise therapy and behavioral correction therapy was reduced most, and the descending highest rate was the exercise therapy group, behavioral correction therapy group, comparison group, which was statistically significant.. As for total cholesterol (TC) of blood fat, the group at both male and female students that reduced it most was that who carried out the combined aerobic exercise therapy and behavioral correction therapy, which was statisticalIy significant. As for high density fat (HDL) of male and female students, the group carrying out the combined aerobic exercise therapy and behavioral correction therapy increased most and the descending highest rate was the aerobic exercise therapy group, behavioral correction therapy group, comparison group, which was statistically significant. As for neutral fat (TG) of male and female students, the group reducing it most was that who carried out the combined aerobic exercise therapy and behavioral correction therapy, which was statistically significant. In measurement time, TG volume was reduced most between 4 weeks and 8 weeks. As for low density fat (LDL) of male and female, the group reducing it most was that who carried out the aerobic exercise therapy and behavioral correction therapy. It was statistically significant in terms of program application period. The groups reducing calorie intake amount most was those who carried out the aerobic exercise therapy and the behavioral correction therapy, and the descending highest rates were the behavioral correction therapy, the exercise therapy group, the comparison group. Both male and female students reduced calorie intake amount most between previous term and 4 weeks.

날씨와 주가지수 수익률간의 상관관계 : 행태재무학적 접근 Behavioral Finance Approach

신진영,박승호 한국금융연구원 2003 금융연구 Vol.17 No.2

본 논문은 형태재무학적인 분석 방법을 통해 우리나라 주식시장에서 날씨가 주가에 영향을 미치는지를 검증한다. 전운량으로 측정된 날씨와 종합주가지수 일일 수익률간의 상관관계 분석을 통해, 외국인 거래가 확대되기 전인 IMF 금융위기 이전 기간은 날씨와 종합주가지수의 일일 수익률간에 통계적으로 유의한 관계가 존재하나 외국인 투자가 확대되고 투자한도제한이 철폐된 IMF 금융위기 이후기간에는 날씨와 주가의 유의적인 상관관계가 사라졌음을 확인할 수 있다. 이러한 결과는 Hirshleifer and Shumway(2003)의 연구 결과와 일치하는 것으로서, 1990년대 중반 이후 전세계적으로 진행된 자본시장의 세계화로 인해 주가에 대한 날씨효과가 사라지고 있다는 추론을 가능하게 한다. This paper seeks to determine if weather has affected stock returns in the Korean financial market. Analysis is conducted to find any statistically significant relationship between weather as measured by sky cover(SKC) and the daily stock index returns of the Korean Stock Exchange. In the years before foreign investors were allowed to trade on the Korean stock market, there had been a statistically significant relationship between weather and stock returns in that stocks tended to perform better on days when the sky was clearer. The weather effect on stock returns has since weakened and almost disappeared after the IMF crisis, when foreign investors started to establish a significant presence in the Korean financial market. These findings are consistent with those of Saunders(1993) and Hirshleifer and Shumway(2003). It can be inferred that globalization of the world financial markets since the mid 1990s has done much to remove the weather effect on stock returns.

스포츠마케팅의 정체성을 위한 철학적 기초

신승호 남서울대학교 2001 남서울대학교 논문집 Vol.7 No.-

This study was to offer a philosophical basic and concept to enhance the role and value of sport marketing in the area of sport industry, which has been dramatically expanded and developed in our society. First of all, the sport marketing manager should recognize the various essence of sport which positively functions to the public. Even though the nature of sport has been changed in our society, it is essential to recognize that the nature of sport is one of the most important assets in implementing sport marketing. The true meaning of sport marketing is to have the public to experience, to feel, and to enjoy the value of sport through exact deliverying of the nature of sport. Second, it is important to have a valence between two levels of sport marketing, which one is 'marketing of sport' that means the activation of sport to the public and the other one is 'marketing through sport' that mainly means corporation's sponsorship. That is, 'the marketing of sport' should be first emphasized, and then 'the marketing through sport' needs to be developed on the foundation of 'marketing of sport'. Finally, scholars and managers in sport marketing should have a commitment in developing basic theories and principles of sport marketing to be an unique learning aera in our society.