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Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
이지범,박형순,박세정,이효진,권경아,최영진,김유정,남정모,조남훈,강보들,정현철,라선영 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment of naïve Asian patients with metastatic/recurrent nccRCC. Materials and Methods From January 2008 to July 2017, data of treatment-naïve, metastatic/recurrent nccRCC patients, who were treated with temsirolimus according to the standard protocol, were collected. The primary end-point was progression-free survival (PFS). Secondary end points were overall survival (OS), objective response rate (ORR), and tolerability of temsirolimus. Results Forty-four metastatic/recurrent nccRCC patients, 10 from prospective and 34 from retrospective groups, were enrolled; 24 patients (54%) were papillary type, and other histology subtypes included 11 chromophobes (25%), two collecting ducts (5%), one Xp11.2 translocation (2%), and six others (14%). The median PFS and OS were 7.6 months and 17.6 months, respectively. ORR was 11% and disease control rate was 83%. Patients with prior nephrectomy had longer PFS (hazard ratio [HR], 0.16; 95% confidence interval [CI], 0.06 to 0.42; p < 0.001) and OS (HR, 0.15; 95% CI, 0.05 to 0.45; p < 0.001). Compared to favorable/ intermediate prognosis group, poor prognosis group had shorter median PFS (4.7 months vs. 7.6 months [HR, 2.91; 95% CI, 1.39 to 6.12; p=0.005]) and median OS (9.2 months vs. 17.6 months [HR, 2.84; 95% CI, 1.23 to 6.56; p=0.015]). Conclusion Temsirolimus not only benefits poor-risk nccRCC patients, but it is also effective in favorable or intermediate-risk group in Asians. Temsirolimus was well-tolerated with manageable adverse events.
인터리빙과 랜덤 셔플링을 이용한 디지털 영상의 암호화 방법
이지범,고형화,Lee Ji-Bum,Ko Hyung-Hwa 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.5C
본 논문에서는 디지털 컨텐츠의 저작권 보호를 위해 기존의 고정된 셔플링 테이블을 이용한 암호화의 가장 큰 단점인 평문 공격에 대한 취약성을 보완할 수 있는 암호화 기법을 제안하였다. 이를 위해 우선, 영상의 특징 값에 따라 적응적으로 변하는 인터리빙 방법을 제안하고 제안된 인터리빙 방법만을 사용하여 DPCM 처리된 $8^*8$블록을 셔플링하는 암호화 방법과 인터리빙과 기존의 랜덤 셔플링 방법을 결합한 다중 셔플링 방법을 이용하여 영상을 암호화하는 두 가지 방법을 제안하였다. 모의 실험 결과 제안한 두 가지 셔플링 방법을 이용한 암호화 방법은 영상의 국소적인 특징 값에 따라 적응적으로 변하기 때문에 기존의 고정된 형태의 랜덤 셔플링 테이블만을 사용하는 방법에 비해 평문 공격에 강인한 특징을 가졌고 또한 추가적인 비트량 증가도 발생하지 않는 장점을 보였다. In this paper, we propose a digital image encryption method using adaptive interleaving and multiple random shuffling table to improve the existing encryption methods which use a fixed random shuffling table. In order to withstand the plaintext attack, at first, we propose a interleaving method that is adaptive to the local feature of image. Secondly, using the proposed interleaving only shuffling method and multiple shuffling method that is combined interleaving with existing random shuffling method, we encrypted image by shuffled the DPCM processed $8^*8$ blocks. Experimental results show that, the proposed algorithm is very robust to plaintext attack and there is no overhead bit.