Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

하악에 발생한 과잉치의 치험례 : A CASE REPORT

박정아,양규호,,최남기,김선미,장희숙 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

과잉치는 정상치판(dental lamina)의 과도한 증식이 결과로 발생되어, 가족적 성향을 보이며, 쇄골두개이형성(Cleidocranial dysplasia), Gardner 증후군 등의 여러 질환과 관련되어 나타나기도 한다. 그 빈도는 유치열에서 0.3~0.8%, 영구치열에서 1.0~3.5% 이고, 남성에서 호발되며(2:1), 상악에서 더 많이 발생한다(9:1). 상악에서는 mesiodens라고 불리는 중절치 사이의 위치가 가장 흔한 부위이고, 그 다음은 fourth molar와 측절치 부위이다. 하악에서는 소구치 부위가 가장 흔한 부위이고 전치부위에서는 약 2%로 매우 드물게 발생한다. 과잉치의 만기 잔존은 치간 이개, 인접한 치아의 맹출 장애, 치근 흡수 등을 야기하고 과잉치와 관련되어 함치성 낭종이 발생될 수 있으므로 조기진단과 적절한 치료가 중요하다. 본 두 증례는 비교적 드물게 나타나는 하악에 발생한 과잉치로, 하악 전치부와 소구치부에 발생한 과잉치를 발거하고 교정치료를 시행하여 양호한 결과를 얻었기에 보고하는 바이다. Supernumerary tooth was resulted from excessive proliferation of dental lamina and associated with familial tendency and a congenital syndrome such as Cleidocranial dysostosis or Gardner's syndrome. Incidence reports identify a range of 0.3~0.8% in primary dentition. 1.0~3.5% in permanent dentistion with males being affected twice as frequently as females. maxilla nine times as frequently as mandible. The most common supernumeraty tooth is the mesiodens, which located between the maxillary central incisors, and the next common site is the fourth molar and lateral incisors. Supernumerary teeth are uncommon in the mendible, but premolars are the most common supernumerary teeth and occurrence is very rare in the incisor region of the mandible of possibility of diastema and cruption failure displacement. rotation of the associated permanent teeth, root resorption and dentigerous cyst with presence of the supernumerary teeth. In this two case, one supernumerary tooth located in the mandibular incisor region, the other supernumerary tooth located in premolar region. We could get normal alignment of mandibular dentition by extraction and orthodontic treatment.

성인 인터넷 중독자의 기질 특성

임선진,김진훈,장동원,정은기,윤해주,김의정 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : Since mid-90s there have been numerous studies to understand and establish the concept of internet addiction as one of diagnostic classifications in psychiatry. Among them, many studies on the personality characteristics of internet addiction have been conducted. Recently, interests are expanding to temperament characteristics of internet addictors but the subjects have been limited to adolescents, In this study, the temperament characteristics of internet addiction in adults were investigated using Tridimensional Personality Questionnaire (TPQ). Methods : 430 participants (189 males, 241 females) answered the on-line and off-line questionnaires from January to December in 2005. Participants completed questionnaires on demography and the onset of internet use, Young's Internet Addiction Scale and Korean Contracted Version of Cloninger's Tridimensional Personality Questionnaire (TPQ). Rcsults : There were statistically significant differences in age, marital status, occupation, psychiatric history, smoking history, alcohol history and onset age of internet use among non-addiction, overuse and addiction groups by Young's scale. Of the TPQ items harm avoidance (HA) scores were significantly higher in addiction and overuse groups than non-addiction group. Reward dependence (RD) scores were significantly lower in addiction group than non-addiction group. Novelty seeking (NS) scores were significantly higher in addiction group than non-addiction group. Conclusion : This study suggests a significant difference of novelty seeking in temperament characteristics between adults and adolescents with internet addiction. Further studies are expected for profound understanding of internet addiction.

Identifying pregnancy episodes and estimating the last menstrual period using an administrative database in Korea: an application to patients with systemic lupus erythematosus

Yu-Seon Jung(Yu-Seon Jung),Yeo-Jin Song(Yeo-Jin Song),Jihyun Keum(Jihyun Keum),Ju Won Lee(Ju Won Lee),Eun Jin Jang(Eun Jin Jang),Soo-Kyung Cho(Soo-Kyung Cho),Yoon-Kyoung Sung(Yoon-Kyoung Sung),Sun-You 한국역학회 2024 Epidemiology and Health Vol.46 No.-

Photodegradation of Reactive Black-5 in Photoreactors using TiO₂ Immobilized on a Glass Tube

Jang, Seon-Jung,Kim, Moon-Sun,Kim, Byung-Woo 한국공업화학회 2004 Journal of Industrial and Engineering Chemistry Vol.10 No.4

The photodegradation experiments of a dye, reactive black 5 (C.I. 20505), were performed in batch-and continuous-flow-type reactors using TiO₂-immobilized glass tubes to investigate the effects of the TiO₂ film thickness, pH, feed rate, and aeration on the removal efficiency in the presence of both ferric ion and H₂O₂. The photocatalytic reaction with respect to the initial concentration can be explained by a reaction rate having an apparent first-order equation. The rate constant (K) increased with increasing TiO₂film thickness up to 5.29 ㎛, which we obtained by dip coating three times. The rate constants at pH 3.5 were 0.19, 0.27, 0.50, and 0.32 /h, for films that had seen coated once, twice, three times, and four times, respectively. The photodegradation rate of reactive black 5 dye was 0.33 /h higher at pH 3 (0.33/h) than at pH 9 (0.20 /h). The rate constants were 0.27, 032, 0.28, and 0.28 at feed rates of 60, 120, 180. and 240 mL/min, respectively. The rate at 120 mL/min was higher than those at the other feed rates, because the photodegradation capability decreased as a result of a wash-out effect overriding an optimal feed rate. Rate constants increased from 0.26 to 0.27. 0.29, and 0.31 /h as the air flow rate increased from 1, to 3, 5, and10 mL/min, respectively.

Jageum-Jung, the herbal pharmaceuticals, inhibits the hepatic fibrogenesis as mediated with TGF-β1/smad signaling

송유림,Jang Mi Hee,Jang Boyun,Bae Su Jin,Bak Seon Been,Lee Sung Min,Yun Un-Jung,Lee Ju Hee,Park Sang Mi,Jung Dae Hwa,Sa Bok Suk,Song Jong Kuk,이은혜,김광연,Park Kwang-Il,김영우,김상찬 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2

Background Herbal prescriptions have various effects and their efficacy is potentiated by the use of combinations of medicinal herbs. Objective Jageum-Jung (JGJ) is a traditional oriental medical prescription composed of five herbs. It has been used for detoxifi cation, and as an anti-inflammatory and antitumor agent. However, the effect of JGJ on hepatic fibrogenesis is unclear. Results We investigated the role of JGJ in TGF-β1/smad signaling, which is implicated in fibrogenesis, and its hepatoprotective effect in CCl 4 -treated mice with liver fi brosis. Treatment of LX-2 cells with TGF-β induced expression of mediators (α-SMA, PAI-1, and MMP-2) of fibrogenesis and activation of proinflammatory cytokines (TNF-α, IL-1β, and IL-6). However, these were downregulated by pretreatment with JGJ. In mice, oral administration of JGJ prevented liver injury induced by CCl 4 , as indicated by decreases in the ALT and AST levels. Conclusions JGJ inhibits hepatic fibrogenesis and TGF-β1/Smad signaling.

커넥트엑스 테라피가 허벅지 셀룰라이트 감소에 미치는 영향

Seon Jung Jang,Joo Hyun Ham,Hye Eun Kim 한서대학교 보완대체의학연구소 2016 Research Journal of Complementary and Alternative Vol.- No.7

This study was conducted to find out the effect of the ConnecTX therapy, observing the change of the amount of cellulite in thighs between experimental group and control group. The experiment was conducted with 41 women aged 20∼30 in Hanseo University. They were randomly grouped in to two. Their thigh circumference and body fat percentage were measured on a weekly basis during three weeks. Follows are the result. 1. In the result of applying ConnecTX therapy, on both circumference of the thighs and body fat percentage were decreased in meaningful difference (p<0.05). 2. In the result of both thighs exercise, on both circumference of the thighs were decreased in no meaningful difference (p>0.05). 3. In the result of both thighs exercise, body fat percentage in thighs was decreased only for the second week (p<0.05). There was no meaningful difference in the first and third week (p>0.05). Overall, ConnecTX therapy seems to affect decreasing of the thigh circumference and body fat percentage.

동해안 침식 원인분석 및 침식 영향도 평가

박선중(Seon Jung Park),서희정(Heui Jung Seo),박승민(Seung Min Park),박설화(Seol Hwa Park),안익장(Ike Jang Ahn),서경식(Gyeong Sik Seo) 한국해안해양공학회 2021 한국해안해양공학회 논문집 Vol.33 No.6

연안을 중심으로 시행되는 각종 개발사업은 표사수지 불균형, 연안표사 이동상 및 횡단표사 이동상 변화를 야기하며, 이로 인한 해빈의 완충구간 축소로 연안재해 위험성을 크게 증대시킬 뿐 아니라 회복 불가능한 장기적 해안침식 문제를 초래하게 된다. 연안개발을 위해 건설된 각종 구조물의 영향으로 발생되는 장기적·지속적인 해안침식 현상은 표사수지 및 연안표사와 횡단표사 변화량 평가를 통해 직접적인 원인 규명이 가능하다. 즉, 표사수지 변화, 연안표사 이동, 횡단표사 이동 구분되는 이들 개별적인 원인에 기인한 침식지역과 복합적인 작용에 의한 침식지역의 분류를 통해 연안개발과 해안침식 현상의 인과성 평가가 가능할 것이다. 본 연구에서는 연안개발에 따른 침식 문제가 지속적으로 제기되고 있는 동해안(강원도, 경상북도) 일대 해안을 대상으로 연안 구조물 건설 및 육역 개발 등 주요 개발현황과 연안침식 실태조사 결과를 기반으로 장기적·지속적 침식원인을 분석하였다. 아울러 인공구조물 건설에 따른 침식의 정도를 평가하고자 침식 영향도 개념을 정립하고, 침식 영향도 평가를 위한 세 가지 방법론을 제안하였다. 연안침식 실태조사에서 검토된 해빈 영상분석 자료를 활용하여 하저항을 대상으로 침식 영향도를 평가하였으며, 평가결과 하저항 개발은 93.4%, 호안도로 건설은 6.6%로 침식에 영향을 미친것으로 평가되었다. Various development projects occurring on the coast cause an imbalance of surface sediments, causing coastal disasters or irreversible coastal erosion. Coastal erosion caused by the influence of various port structures built through coastal development can be directly identified by evaluating changes in the sediment budget, longshore sediment, and cross-shore sediment. In other words, it will be possible to evaluate the causality between coastal development and coastal erosion by classifying regions due to single cause and regions due to multiple causes according to the changes in the sediment classified into the three types mentioned above. In this study, the cause of long-term and continuous erosion was analyzed based on the analysis results of the coastal development history and the Coastal Erosion Monitoring targeting the coast of Gangwon-do and Gyeongsangbuk-do on the east coast. In addition, in order to evaluate the degree of erosion caused by the construction of artificial coastal structures, the concept of erosion impact assessment was established, three methods were proposed for the impact assessment. The erosion impact of Hajeo port was assessed using the results of satellite image analysis presented in the Coastal Erosion Monitoring Report, it was assessed that the development of Hajeo port had an impact of 93.4% on erosion, and that of the coastal road construction had an impact of 6.6%.