위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy

Kyoung Sik Park,Kyu Eun Lee,Do Hoon Ku,Su-Jin Kim,Won Seo Park2,Hoon Yub Kim3,,Mi Ra Kwon1,Yeo-Kyu Youn1 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.6

Purpose: To evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy. Methods: Seventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period. Results: Total adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups. Conclusion: Interceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.

지역냉방 시스템용 초고효율 판형 열교환기 개발에 관한 연구

박재홍(Jae-Hong Park),임혁(Hyug-Lim),조성열(Sung-Youl Cho),강인성(In-Sung Kang),김정규(Jung-Kyu Kim),허인은(In-Eun Hur),고성규(Seong-Kyu Ko),곽승식(Sung-Sik Kwak),김종재(Jong-Jae Kim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.10

Plate heat exchanger consists of thin, rectangular, pressed sheet metal plates that are sandwiched between full peripheral gaskets and clamped together in a frame. The frame has a fixed end-cover plate, fitted with the connecting ports, which is bolted together with a movable cover plate to hold the embossed plates in between; the top and bottom carrying bars allow proper alignment of the plate stacks. When compared with the well-established shell and tube heat exchangers, the plate heat exchanger shows a lot of advantages like high NTU values, compactness, low cost, multi duties and reduced fouling etc. Plate heat exchangers are often used to transfer heating or cooling water which is produced in the energy production( district heating or district cooling) facilities to residential areas and industrial parks. The district cooling systems of Middle East are the biggest market of plate heat exchanger, but the technical specifications for cooling system are different from the domestic one. To achieve its specifications, the new plate heat exchanger was developed, and its thermal performance results are introduced in this paper.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

Interleukin-2가 Mouse 골수에 미치는 영향

박준영,이군자,정호삼,이규식 대한해부학회 1990 Anatomy & Cell Biology Vol.23 No.3

골수에서 혈구형성과정은 interleukin-3, interleukin-4 및 임파구 분비물질 등의 액소성 인자와 대식세포 및 임파구에 의하여 조절되며, 흉선 및 비장에서 형성되는 임파구의 조절은 interleukin-2가 관여한다. Interleukin-2 는 T 임파구에서 분비되는 T 임파구 성장인자로서 세포독성임파구의 증식을 유도하고 임파구의 활성을 증가시켜 여러 육종 및 암종에 탁월한 효과를 나타내는 종양치료제이나 interleukin-2를 암환자에 투여하면 가역적 호산구증가증, 말초혈액임파구의 변동 등 혈액학적 독성이 야기된다. 이에 저자는 mouse에 interleukin-2를 투여하면 흉골 골수에서 임파구 발생이 변동될 것으로 사료되어 mouse에 interleukin-2를 투여한 후 나타나는 흉골임파구의 변동을 관찰하였다. 실험동물로는 체중 15gm 내외의 웅성 mouse를 사용하였으며 체중 ㎏당 200만 단위의 interleukin-2, 0.2ml를 복강내에 주사하고 3시간, 6시간, 12시간, 24시간 및 48시간 경과 후에 각각 희생시켜 흉골을 적출하고 Zenker 용액에 고정한 후 Hematoxylin-eosin-azure II 염색을 시행하여 다음과 같은 결과를 얻었다. 1. Interleukin-2 투여 3시간 경과군의 mouse 흉골골수에서는 소형임파구가 약간 증가하였으며 6시간 경과군 및 12시간 경과군에서는 소형임파구가 현저히 증가하였다. 2. Interleukin-2 투여 24시간 경과군 및 48시간 경과군의 mouse 흉골골수에서는 미분화 혈구세포들이 다수 관찰되었다. 이상의 결과를 종합하면 interleukin-2는 흉골의 임파구 형성에 관여하는 것으로 사료된다. It is known that hemopoiesis is regulated by lymphocytes, macrophages and T lymphocyte-derived lymphokines, and lymphopoiesis in thymus is controlled by the interleukin-2. Interleukin-2 is a T-cell growth factor produced by antigen or mitogen activated T lymphocyte, and mediates antitumor effect by stimulating the differentiation of precurssor T cells into lymphokine activated killer cells. Although, interleukin-2 shows therapeutic effects on various sarcoma and carcinoma, it induces many hematologic toxicities, reversible eosinophilia and marked changes in peripheral lymphoid cells. Therefore the author undertook the present study to pursue the effect of interleukin-2 on the lymphocytes in the sternal marrow. Albino mice, DDY strain, weighing 15 gm were used as experimental animals. Experimental animals were killed at 3, 6, 12, 24 and 48 hours after administration of 2,000,000 unit/㎏ inter leukin-2. The specimens obtained from the sternum were stained with Hematoxylin-eosin-Azure II for histological observation. The results were as follows. 1. The number of small lymphocytes were increased slightly in the sternal marrow at 3 hours after interleukin-2 injection and considerably increased in the 6 hours and 12 hours group. 2. Undifferentiated hemopoietic cells were observed numerously at the 24 and 48 hours after interleukin-2 injection. Consequently, it is suggested that interleukin-2 would influence the lymphopoiesis in the mouse sternal marrow.

우리대학의 주문식교육 방향에 관한 연구

박정민,김태곤,이규식,신승우 慶北專門大學 2003 慶北專門大學 論文集 Vol.22 No.-

This study was conducted to establish an operational direction for customized training in our college. The demands for customized training were analyzed on paper and in person 37 junior colleges, 100 companies and 468 students. The interview results were formulated into educational policies on customized training in our college. From the these results, the reasonable direction to be taken by customized training would be to develop various training program that meet the demands of the industry and students. In order to do this, our college must analyze its own regional and social environment and develop a variety of programs.

Cementless 인공고관절 수술중에 발생된 대퇴골 골절

박명식,김규형 대한고관절학회 1990 Hip and Pelvis Vol.2 No.2

外傷性 神經腫에 關한 電子顯微鏡的 硏究

朴明植,曺圭赫 全南大醫大 1984 전남의대학술지 Vol.21 No.3

분만시 지속적 또는 간헐적 투여에 의한 경막외 제통의 비교

박욱,이은찬,배상철,강규식,곽수달 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Background : Continuous epidural infusion of the mixed solution of local anesthetic (bupivacaine) and lipid-soluble opioid (fentanyl) has known as a more useful method than intermittent epidural injection for relief of pain during labor. The purpose of this study was to compare a clinical usefulness between continuous infusion and intermittent injection with epidural analgesia during labor. Methods: One hundred healthy parturients were divided into two groups as follows: Continuous epidural group (C-group); 50 parturients received epidural analgesia continuously with 0.167% bupivacaine and 0.000167% fentanyl in the speed of 10 ml h-1 at cervical dilatation (3-5 cm) and then injected 0.25% bupivacaine 5 ml additionally at complaints of severe labor pain. Intermittent epidural group (I-group); 50 parturients received inermittently 0.167% bupivacaine and 0.00083% fentanyl in the initial dose of 12 ml at cervical dilatation (3-5 cm) and then additionally used the same dose at severe labor pain. Result: There were no statistically significant differences in the clinical states of maternoneonate, pain free score, degree of motor block, mode of delivery, cause of Cesarean section, neonatal Apgar score and incidence of side effects between groups(Table 1.2.3.7.8). The total dose of bupivacaine and fentanyl, the duration of lst and 2nd delivery stages and the frequency of top up injection for incomplete relief of pain during labor appeared significant differences in statistics between groups (Table 4.5.6). Conclusion: It was similar to the effectiveness of maternal epidural analgesia during labor between groups by means of continuous or intermittent injection.