한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

여성요도구협착의 수술적 교정

오범석,김도완,오철규,노안식,박석산 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Objective: We describe various clinical presentations of female urethral meatal stricture, which may mimic other pelvic floor disorders and result in diagnostic delay. Diagnosis, management, and outcome results are reported Materials and Methods: We reviewed retrospectively 26 consecutive cases of female urethral meatal stricture. Patient characteristics, history, clinical presentation, symptom score, maximal flow rate, residual urine, diagnosis, management and short-term follow up are reported. Results: Mean patient age plus or minus standard deviation was 54 years. Most 21 (81%) cases were referred as diagnostic dilemmas with symptoms present for 1 month to 30 years. Mean interval between onset of symptoms to diagnosis was 5.8 years. The most common symptoms were residual urine sensation (77% of cases), frequency (54%), pelvic pain (46%), dysuria (46%), weak stream urine (27%), urgency (15%) and 17 patients (65%) have combined symptoms. 16 patients (62%) had been treated with oral and/or vaginal medication and/or psychotherapy. The female urethral meatal stricture was visible on physical examination in 21 patients (81%) and cystoscopy in 5 patients (19%). Of these visible urethral meatal stricture, 11 patients (45%) contained recurrent urinary tract infection, 9 patients (35%) contained urethral mucosal prolapse, 7 patients (27%) contained urethral diverticulum, and 3 patients (12%) contained stress urinary incontinence. 18 patients (69%) who has been treated with oral and/or vaginal medication or psychotherapy was not successfully improved. Treatment consist of urethral meatal excision and/or everted urethral mucosal excision and/or urethral diverticulum excision and/or anti-incontinence surgery when indicated. Subsequently 24 patients (92%) had improved symptom score, but 2 patient was not changed. In 9 patients new symptom developed. Conclusions: Female urethral meatal stricture have several urinary symptoms and may mimic other pelvic floor disorders. This condition should be considered in women with frequency, residual urine sensation, pelvic pain, dysuria and etc. Medical treatment is not sufficient but surgical treatment is usually simple, safe and effective in alleviation associated symptoms.

근위 대퇴정을 이용한 대퇴 전자부 골절의 치료

김범수,류석우,고상훈,조성도,양정훈,박문수 대한골절학회 2004 대한골절학회지 Vol.17 No.1

이황화탄소 중독자들의 노출중단 이후의 심박동수 변이

이상윤,조성일,백도명,변창범,김미정,박경근,임상혁,양길승,황창국,전형준 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 2000년도에 이황화탄소 중독증 환자들과 대조군의 심박동수 변이를 비교하여 이황화탄소 중독증 환자들의 심박동수 변이가 대조군에 비해 유의하게 낮다는 연구보고가 있었다. 당시의 연구가 이황화탄소 노출이 중단된 상태에서 이황화탄소 중독자들의 건강 문제를 연구했다는 점에 의의가 있으나 연구 결과를 해석하는데 있어 제한점들이 있었다. 이 연구는 2000년도에 수행하였던 연구의 제한점을 극복하고 이황화탄소 노출이 중단된 이후의 이황화탄소 중독자들의 심혈관계 상태를 심박동수 변이를 이용하여 평가해보고자 하였다. 방법: 이황화탄소 중독증으로 진단받은 환자 122명과 환자군의 연령대와 성별 빈도에 따라 무작위 추출한 112명을 대조군으로 선정하였다. 자기 기입식 설문지와 건강검진을 통해 연령, 성별, 신장, 체중, 흡연, 음주, 규칙적 운동, 질병력, 직업력, 흉부 방사선 촬영, 심전도 측정을 실시하였다. 연구 대상자들은 의자에 앉힌 상태에서 5분 동안 심박동수 변이를 측정하였다. 이 연구에서 측정한 심박동수 변이 지표들은 정상 RR간격의 표준편차(standard deviation of all norma-to-normal intervals, SDNN), 인접한 RR간격들의 차이를 제곱의 합의 평균의 제곱근(square root of the mean of the sum of squares of differences between adjacent normal-to-normal intervals, RMSSD). 저주파영역(low frequency power, LF: 0.04~0.15Hz), 고주파 영역 (high frequency power, HF:0.15~0.4Hz), 전체 주파수 강도(total power, TP), 저주파/고주파 비 (LF/HF ratio)이다. 결과: 단변량 분석에서 이황화탄소 중독자들의 모든 심박동수 변이 지표들이 대조군에 비하여 낮았다. 다중선형회귀분석에서 이황화탄소 중독은 RMSSD를 유의하게 감소시키는 것으로 나타났다.(P<0.05). 결론: 이 연구는 이황화탄소 노출이 중단된 상태에서도 이황화탄소 중독자들에게 심혈관계와 관련된 건강문제가 있을 수 있음을 시사한다. Objectives: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS_(2))-poisoned subjected suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS_(2)-poisoned subjects participated, (2) no females participated, and (3) the CS_(2)-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. Methods: The study subjects comprised 122 retired workers with CS_(2) poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, wight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. Results: Univariate analysis revealed that all HRV indices of CS_(2)-poisoned subjected were lower than those of the controls. Multiple linear regression analysis showed that CS_(2) poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant(P<0.05). Conclusions: This study suggests that CS_(2)-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.

Effect of MoO3 surface coating on electrochemical performances of LiNi0.8Co0.1Mn0.1O2 cathode

Park Sung-Bum,Kang Chea-Yun,Hwang Do-Young,Yoo Ye-wan,Park Hye-Jin,Park Jun-Ho,Kim Hyun-Soo,Lee Seung-Hwan 한국물리학회 2022 Current Applied Physics Vol.44 No.-

In this paper, we synthesize the MoO 3 modified LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode (denoted as M-NCM81) and compare with pristine LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode (denoted as P-NCM81). The M-NCM81 cathode delivers good cation ordering and typical spherical form. The M-NCM81 cathode shows initial discharge capacity of 203.8 mAh g - 1 at 0.1 C, capacity retention of 79.8% under the 5.0 C. In addition, the M-NCM81 cathode still retain a discharge capacity of 172.2 mAh g -1after 100 cycles. Such electrochemical performances are significantly improved compared to those of P-NCM81. It can be elucidated that MoO 3 coating layer acts as a HF inhibitor/scavenger. The MoO 3 modification plays an important role in inhibiting severe structural degradation, derived from a harmful side reaction with electrolyte. It effectively suppresses the increase in charge-transfer resistance, leading to superior electrochemical performances.

Establishment of three-dimensional (3D) pathological evaluation for nervous system using tissue clearing method

Do-Yong Park,Woojin Kim,Wan-Jung Im,Mi-Jin Yang,Byoung-Seok Lee,Ji-Seok Han,Jae-Woo Cho,HeeJin Park,Yong-Bum Kim 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.1

복막 투석 환자에서 복막염 시 한외여과에 미치는 인자에 대한 분석

박종원,김영진,박준범,정항재,조규향,도준영,윤경우 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.4

Ultrafiltration failure is frequently observed during peritonitis in PD patients but the mechanism of UF failure is uncertain. To determine how important the aquaporin mediated water transport on ultrafiltration failure at the time of peritonitis is, we designed this study. PETs(peritoneal equilibration tests) were performed during peritonitis in 14 CAPD patients and dialysate-to-plasma ratios of sodium at 60 minutes with 3.86% glucose dialysate(D1/Pl Na) were measured. We compared the results of D4/P4 Cr, D4/DO glucose and UF volumes at the time of stable peritoneal function with the values of at the time of recovery from peritonitis. During the peritonitis, the value of D4/P4 Cr and Dl/Pl Na were significantly higher than before (mean 0.867 vs 0.65, p$lt;0.001 and 0.897 vs 0.849, p= 0.002) but D4/DO glucose and ultrafiltration were significantly lower during peritonitis(mean 0.284 vs 0.381, p=0.008 and 150cc vs 310cc, p$lt;0.001). After recovery from the peritonitis, the values of D4/P4 Cr were close to those of preperitonitis values(mean 0.740 vs 0.641, p=0.073). According to the linear regression analysis, UF volume change during peritonitis was significantly correlated with a change of Dl/Pl Na(coefficients=-0.630, p$lt;0.05), but was not correlated with changes of D4/P4 Cr or D4/DO glucose. The levels of cytokines were significantly higher during peritonitis than preperitonitis period(TNF: mean 467 vs 10.34, p$lt;0.05, IL-6: 236.8 vs 61.6, p$lt;0.001, N=10). In conclusion, ultrafiltration failure during peritonitis seems to be associated with the impaired aqua-porin-mediated water transport mechanism rather than loss of osmotic gradients due to increased solute transport and glucose absorption. Peritoneal equalibrium test.

Higher incidence of sperm granuloma in the epididymis of C57BL/6N mice

Do-Yong Park,Byoung-Seok Lee,Woo-Jin Kim,Wan-Jung Im,Ji-Seok Han,Heejin Park,Mi-Jin Yang,Jae-Woo Cho,Da Hee Kim,Su-Cheol Han,Yong-Bum Kim,Hwa-Young Son 한국실험동물학회 2018 Laboratory Animal Research Vol.34 No.1

C57BL/6N mice are inbred strains widely used in biomedical research. Hence, a large amount of basic data has been accumulated. However, in the field of histopathology, spontaneous data for relatively younger mice that are used more frequently are not yet abundant, in contrast to data for older mice and their neoplastic lesions. To acquire the essential background data required by various research and toxicological assessments, 120 mice of the C57BL/6N strain (10 and 13 weeks of age) were collected from two institutions (From Korea and Japan) and subjected to histopathological analyses of the major organs (liver, spleen, kidney, thymus, heart, testis, epididymis). The results showed significantly higher incidence of sperm granulomas in the epididymides (10-56%) of these mice, compared with that in other strains or species of lab animals. Upon closer inspection, oligospermia/clear cell hyperplasia, cellular debris, and tubular vacuolation were also observed in the epididymides with sperm granulomas. Moreover, diseased organs were significantly heavier than healthy ones. Immunohistochemical staining showed a significant increase in the chromatic figures of cysteine-dependent aspartate-directed proteases-3 (caspase-3) and cleaved-poly(ADP-ribose) polymerase (c-PARP), and damages to the tubule due to spontaneous apoptosis, which may have led to the sperms leaking out of the tubule, causing the granuloma. To conclude, spontaneous sperm granuloma can occur in 10- and 13-week-old C57BL/6N mice and may thus affect the results of various studies using these mice. Therefore, sperm granuloma in epididymis needs to be carefully considered as an important factor when design the study using C57BL/6N.

Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

Park, Young Suk,Park, Do Joong,Lee, Yoontaek,Park, Ki Bum,Min, Sa-Hong,Ahn, Sang-Hoon,Kim, Hyung-Ho American Association for Cancer Research 2018 Cancer Epidemiology, Biomarkers & Prevention Vol.27 No.8

<P><B>Background:</B> Most patients with gastric cancer rapidly lose weight after gastrectomy. Therefore, analysis of the effect of body mass index (BMI) on patients with gastric cancer survival should include postoperative BMI and BMI loss and preoperative BMI. This retrospective cohort study analyzed the effect of three BMI variables and their interaction on long-term outcomes.</P><P><B>Methods:</B> Preoperative BMI analysis included 2,063 patients with gastric cancer who underwent curative gastrectomy between January 2009 and December 2013 at Seoul National University Bundang Hospital. BMI at postoperative 6 to 12 months was available in 1,845 of these cases.</P><P><B>Results:</B> Patients with preoperative BMI 23.0 to <27.5 [HR, 0.63; 95% confidence interval (CI), 0.48–0.82 for BMI 23.0 to <25.0 and HR, 0.57; 95% CI, 0.42–0.78 for BMI 25.0 to <27.5] and postoperative BMI 23.0 to <25.0 (HR, 0.67; 95% CI, 0.46–0.98) showed significantly better overall survival (OS) than pre- and postoperative patients with BMI 18.5 to <23.0, respectively. Postoperative underweight (BMI <18.5; HR, 1.74; 95% CI, 1.27–2.37) and postoperative severe BMI loss (>4.5; HR, 1.79; 95% CI, 1.29–2.50) were associated with higher mortality. Severe BMI loss and preoperative BMI <23.0 had an adverse synergistic effect; patients with BMI <23.0 were more vulnerable to severe BMI loss than those with BMI ≥23.0. Associations with cancer-specific survival were similar.</P><P><B>Conclusions:</B> All three BMI variables were prognostic factors for survival of patients with gastric cancer. Preoperative BMI and severe BMI loss had an interaction.</P><P><B>Impact:</B> Perioperative BMI and weight loss should be analyzed collectively in patients with gastric cancer undergoing gastrectomy. <I>Cancer Epidemiol Biomarkers Prev; 27(8); 955–62. ©2018 AACR</I>.</P>

회화문화재 객체검출을 위한 학습용 이미지 데이터셋 구축 방안 연구

권도형 ( Do-hyung Kwon ),유정민 ( Jeong-min Yu ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2

본 연구는 회화문화재 속에 표현된 다양한 종류의 객체를 검출할 수 있는 딥러닝 모델생성을 위해 필요한 학습용 이미지 데이터셋 구축방안을 제안한다. 먼저 기존 동양화 기반의 회화문화재 이미지 데이터 및 객체 특징 분석을 진행하였고, 이를 바탕으로 Natural image에 Pose transfer 및 Style transfer를 적용한 새로운 방식의 회화문화재 이미지 데이터 생성 방법을 제안한다. 제안한 프레임워크를 통해 기존 문화재 분야에서 가지고 있던 제한된 데이터 구축문제를 극복하고, 검출모델 생성을 위한 대용량의 학습데이터 구축 가능성을 제시하였다.