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Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression
Yoo, Jung-Yoon,Choi, Kyung-Chul,Kang, HeeBum,Kim, Young Jun,Lee, Jeongmin,Jun, Woo Jin,Kim, Mi-Jeong,Lee, Yoo-Hyun,Lee, Ok-Hee,Yoon, Ho-Geun Elsevier 2010 FEBS letters Vol.584 No.11
<P><B>Abstract</B></P><P>This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.</P><P><B>Structured summary</B></P><P>MINT-7719975: <I>L3MBTL2</I> (uniprotkb:Q969R5) and <I>HDAC3</I> (uniprotkb:O15379) <I>colocalize</I> (MI:0403) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7719941, MINT-7719921: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>binds</I> (MI:0407) to <I>HDAC3</I> (uniprotkb:O15379) by <I>pull down</I> (MI:0096)</P><P>MINT-7719991: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-7719958: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>physically interacts</I> (MI:0915) with <I>HDAC3</I> (uniprotkb:O15379) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7719897: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>two hybrid</I> (MI:0018)</P>
Factors influencing choosing teaching as a career: South Korean preservice teachers
Jeong‑Ae Lee,Mi Ok Kang,Bitnara Jasmine Park 서울대학교 교육연구소 2019 Asia Pacific Education Review Vol.20 No.3
This study validated the underlying factor structure of the Factors Influencing Teaching (FIT)-Choice survey in the South Korea context and examined motivations and perceptions of 903 Korean preservice teachers by major demographic characteristics. Secondary preservice teachers reported significantly higher values than elementary preservice teachers for Qualification fit and desire to teach and Task return. Male preservice teachers believed more strongly than female preservice teachers that they chose the teaching profession because of Qualification fit, Influencing others, and Task return. Compared to freshmen/sophomores, juniors/seniors reported significantly higher values for Task demand. Participants with low- to medium-level self-reported income ($12K–$46K) weighted Benefits significantly higher than those with medium-level income ($46K–$88K). STEM majors reported higher values for the Qualification fit and Influencing others than non-STEM majors. As South Korea is one of the few countries which has an oversupply of highly qualified teacher candidates, findings were compared with other countries to provide useful insights to improve recruitment of highly qualified individuals to teaching workforce in many countries where teacher shortage is a chronic problem. Based on these data analyses, we argue that policy makers, politicians, education researchers, and others who care about quality education and student academic achievements need to make efforts to increase task returns and benefits.
Text Network Analysis of Research Topics on Virtual Simulation in Nursing
Mi Ok Song,Aeri Jang,Jeong Eun Moon 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): The purpose of this study is to examine the relationship between keywords on virtual simulation in nursing studies and to develop schematic diagrams of the relationship between these keywords from a macro perspective. It is to identify the trend of the literature on virtual simulation in nursing. Method(s): This was a text-mining study that collected, processes, analyzed text data. For this study, we searched several databases such as PubMed, CINAHL, EMBASE, Web of Science, SCOPUS from 1st~15th, July, 2021. The Inclusion criteria included the following: (a) peer-reviewed, (b) journal article, (c) written in English, (d) including a text ‘virtual’ or ‘virtual reality’, ‘simulation’, ‘education’, ‘learning’, ‘training’ in its each title, abstract and keywords. (e) with nursing students and nurses, (f) to 31, May, 2021. Exclusion criteria included following: (a) not journal articles (dissertations, conference proceedings, Book section et al. b) language besides English, c) not involved virtual simulation, d) participants that did not include nurses and nursing students. Thus, 570 studies were selected in the library databases. Among these data, duplicate (222), no abstract (8), unrelated studies (72) and not articles (63) were excluded. As a result, a total of 213 papers were extracted. The keywords from 213 articles were preprocessed and keyword analysis and topic modeling were performed using NetMiner 4.3 software. For topic modeling, Latent Dirichlet Allocation was applied. Result(s): As for virtual simulation in nursing, keywords with the most frequent appearance and the highest networking degree in centrality were ‘nurse’, ’skill’, ‘care’, ‘knowledge’, ‘performance’, ‘communication’, ‘disaster’, ‘experience’, ‘health’. A total of 2347 keywords were categorized into 10 topics: ‘dementia care competency’, ‘pain assessment’, ‘airway placement management’, ‘operating procedure’, ‘presence & satisfaction’, ‘communication & attitude improvement’, ‘platform world’, ‘disaster response’, ‘game usability’, ‘system for confidence’ Conclusion(s): The identified trends in this study will help nursing educators and researchers to grasp the trends and insight for virtual simulation in nursing and to guide future research directions on virtual simulation in nursing.
Enhanced Production of Phenolic Compounds from Pumpkin Leaves by Subcritical Water Hydrolysis
Jeong-Yeon Ko,Mi-Ok Ko,Dong-Shin Kim,Sang-Bin Lim 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.2
Enhanced production of individual phenolic compounds by subcritical water hydrolysis (SWH) of pumpkin leaves was investigated at various temperatures ranging from 100 to 220℃ at 20 min and at various reaction times ranging from 10 to 50 min at 160℃. Caffeic acid, p-coumaric acid, ferulic acid, and gentisic acid were the major phenolic compounds in the hydrolysate of pumpkin leaves. All phenolic compounds except gentisic acid showed the highest yield at 160℃, but gentisic acid showed the highest yield at 180℃. The cumulative amount of individual phenolic compounds gradually increased by 48.1, 52.2, and 78.4 ㎍/g dry matter at 100℃, 120℃, and 140℃, respectively, and then greatly increased by 1,477.1 ㎍/g dry matter at 160℃. The yields of caffeic acid and ferulic acid showed peaks at 20 min, while those of cinnamic acid, p-coumaric acid, p-hydroxybenzoic acid, and procatechuic acid showed peaks at 30 min. Antioxidant activities such as 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power values gradually increased with hydrolysis temperature and ranged from 6.77 to 12.42 ㎎ ascorbic acid equivalents/g dry matter and from 4.25 to 8.92 m㏖ Fe<SUP>2+</SUP>/100 g dry matter, respectively. Color L<SUP>*</SUP> and b<SUP>*</SUP> values gradually decreased as hydrolysis temperature increased from 100℃ to 140℃. At high temperatures (160℃ to 220℃), L<SUP>*</SUP> and b<SUP>*</SUP> values decreased suddenly. The a<SUP>*</SUP> value peaked at 160℃ and then decreased as temperature increased from 160℃ to 220℃. These results suggest that SWH of pumpkin leaves was strongly influenced by hydrolysis temperature and may enhanced the production of phenolic compounds and antioxidant activities.
Ok-Mi Jeong,Min-Chul Kim,Min-Jeong Kim,Hyun-Mi Kang,Hye-Ryoung Kim,Yong-Joo Kim,Seong-Joon Joh,권준헌,Youn-Jeong Lee 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.1
Highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype have spread since 2003 in poultry and wild birds in Asia, Europe and Africa. In Korea, the highly pathogenic H5N1 avian influenza outbreaks took place in 2003/2004, 2006/2007 and 2008. As the 2006/2007 isolates differ phylogenetically from the 2003/2004 isolates, we assessed the clinical responses of chickens, ducks and quails to intranasal inoculation of the 2006/2007 index case virus, A/chicken/Korea/IS/06. All the chickens and quails died on 3 days and 3-6 days post-inoculation (DPI), respectively, whilst the ducks only showed signs of mild depression. The uninoculated chickens and quails placed soon after with the inoculated flock died on 5.3 and 7.5 DPI, respectively. Both oropharyngeal and cloacal swabs were taken for all three species during various time intervals after inoculation. It was found that oropharyngeal swabs showed higher viral titers than in cloacal swabs applicable to all three avian species. The chickens and quails shed the virus until they died (up to 3 to 6 days after inoculation, respectively) whilst the ducks shed the virus on 2-4 DPI. The postmortem tissues collected from the chickens and quails on day 3 and days 4-5 and from clinically normal ducks that were euthanized on day 4 contained the virus. However, the ducks had significantly lower viral titers than the chickens or quails. Thus, the three avian species varied significantly in their clinical signs, mortality, tissue virus titers, and duration of virus shedding. Our observations suggest that duck and quail farms should be monitored particularly closely for the presence of HPAIV so that further virus transmission to other avian or mammalian hosts can be prevented.
Efficacy of a Hierarchical Treatment of Aphasic Perseveration (TAP) Program : A Case Study
Jeong, Ok Ran,Lee, Sang Heun,Cho,Tae Hwan,Sohn, Jin Ho,Yeh, Mi Kyung 한국음성과학회 2001 음성과학 Vol.8 No.1
This paper explored the effectiveness of a hierarchical Treatment of Aphasic Pcr-Teveratiorx (TAP) program on an aphasic in two regards: decrease in the frequency of perseveration and improvement in naming ability. The subject was a 54-year-old female with Transcortical Sensory (TC) aphasia following a left ischemic crcbrovascular Accident (CVA). It was concluded that the hierarchical TAIL program was more effective and efficient in terms of decreasing perseveration and increasing correct naming performance. Within the data of the hierarchical TAP program, however, a substantial decrease in the frequency of occurrence of perseverative behaviors did not necessarily result in proportionate improvement of naming ability. The probable causes and reasons were discussed,