건초 섬유종 1예

문경원,김소연,최유원,명기범,김성현 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

양이온교환수지에 대한 Co(Ⅱ), Ni(Ⅱ), Cr(Ⅲ) 및 Fe(Ⅲ) 이온의 흡착 특성 : 원자로 일차 냉각재 계통내 탈염공정에의 적용 Application to the Demineralizing Process in a Primary Coolant System of PWR

강소영,이병태,이종운,문승현,김경웅 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.1

가압경수로 일차냉각수내 탈염공정의 효과적 운용을 위하여 Amberlite IRN-77 양이온 교환수지의 특성 및 Co(II), Ni(II), Cr(III), Fe(III) 이온의 흡착거동을 연구하였다. 용존 금속이온 농도가 약 200 mgL^-1 인 용액 100 mL에 대하여 이온교환수지 투입량은 약 0.6g이 가장 적절하였으며, 이온교환 반응 속도 측정 결과 대부분의 흡착은 반응 1 시간 이내에 신속히 발생하였다. 수지에서의 양이온 교환은 Langmuir 흡착등온선을 잘 따르는 것으로 나타났으나, Fe(III)의 경우, 다른 금속과는 달리 쉽게 평형에 이르지 못하였으며 이는 공기와 오래 접촉한 결과 철산화물 또는 수산화물을 형성하며 용액 중으로부터 침전되기 때문인 것으로 관찰되었다. 전자가가 동일한 Co(II)와 Ni(II)가 동시에 포함된 모의 조제용액에 대하여 흡착실험을 한 결과, 각 이온은 거의 동일한 흡착 거동을 보였다. 그러나 전자가가 큰 Cr(III)이 첨가된 경우, 이들은 기존에 수지에 흡착되어 있던 전자가가 낮은 금속들을 탈착시키고 대신 흡착하는 경향을 보였다. 따라서 이온교환수지를 이용한 효과적인 탈염 공정을 위해서는 용존 금속 상호간의 경쟁적 흡착관계의 규명이 필요한 것으로 여겨진다. Characteristics of Amberlite IRN-77, a cation exchange resin, and the mechanisms of its adsorption equilibria with Co(II), Ni(II), Cr(III) and Fe(III) and Fe(III) ions were investigated for the application of the demineralizing process in the primary coolant system of a pressurized water reactor (PWR). The optimum dosage of the resin for removal of the dissolved metal ions at 200 mgL^-1 was 0.6 g for 100 mL solution. Most of each metal ion was absorbed onto the resin in an hour from the start of the reaction. Each metal adsorption onto the resin could be well represented by Langmuir isotherms. However, in the case of Fe(III) adsorption, continuous formation of Fe-oxide or -hydroxide and its subsequent precipitation inhibited the completion of the equilibrium between the metal and the adsorbent. Cobalt(II) and Ni(II), which have an equivalent electrovalence, were adsorbed to the resin with a similar adsorption amount when they coexisted in the solution. However, Cr(III) added to the solution competitively replaced Co(II) and Ni(II) which were already adsorbed onto the resin, resulting in desorption of these metals into the solution. The result was likely due to a higher adsorption affinity of Cr(III) than Co(II) and Ni(II). This implies that the interactively competitive adsorption of multi-cations onto the resin should be fully considered for an efficient operation of the demineralizing ion exchange process in the primary coolant system.

추적조사를 중심으로 한 腰椎間板脫出症에 대한 蜈蚣藥鍼의 臨床的 硏究

최회강,소기숙,고강훈,박소영,김성남,이종덕,원경숙,문형철,김성철 大韓鍼灸學會 2003 대한침구의학회지 Vol.20 No.3

Objective : This study is performed for the purpose of examining the efficacy of the scolopendrid(Scolopendra morsitans L) which has been to low back pain as a folk remedy. Methods & Results : Seventy patints with H.I.V.D. treated with the scolopendrid aquacupuncture and examined 4 tests; D.I.T.I., physical test, Oswestry disability index, and self-conscious pain rate were studied. And we follow up after discharge, we evaluated the present state and recovery period. Or we evaluated by herniated type and duration of onset. There was 58~97% of efficacy rate in each tests. Moreover, statistically valuable change in all 7D.I.T.I. points and in disability index and in self-conscious pain rate was showed. Conclusion : The scolopendrid aquacupuncture is possible to be effective terating the H.I.V.D patients. so we suggest the possibility using this new remedy to the H.I.V.D. patients.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

Mixed Tumor of the Skin : Clinicopathological Study of Seven Cases

Choi, Jee Ho,Sung, Kyung Jeh,Moon, Kee Chan,Koh, Jai Kyoung,Jang, Kyoung Ae,Kim, So Hyung,Koh, Gwang Jin 대한피부과학회 2000 Annals of Dermatology Vol.12 No.3

Background : Mixed tumor of the skin or chondroid syringoma is a benign neoplasm characterized by histological features of a mixture of epithelial and mesenchymal components. It is a rare and benign appendageal tumor, found mostly on the head and neck, and present as an asymptomatic, firm, subcutaneous nodule. There have only been a few reported cases in Korea. Objectives : This study was aimed to characterize the clinical and histopathlological features of mixed tumor of the skin. Methods: We reviewed the clinical data and histologic slides of seven patients who have been diagnosed with mixed tumor of the skin by histopathological examination. Results : There were six male patients and only one female. Age of onset of mixed tumor of the skin varied from 26 to 65 years. All patients had the lesion on the head: perioral area (3 cases), nose (2 cases), cheek (1 case), and temple area (1 case). Each tumor was a solitary, asymptomatic, and firm, about 0.5-1.5 cm sized, subcutaneous nodule. Histopathologically, all 7 cases presented apocrine differentiation. Two cases showed follicular differentiation, and 2 cases showed sebaceous differentiation. Every tumor showed myxoid stroma except two with typical chondroid matrix. Adipose metaplasia of the matrix was present in 2 cases. In 3 cases, the so-called hyaline cells were rich in the stroma.

갈색세포종의 임상 표현을 보인 부신 피질 선종 1예

정문경 ( Mun Kyung Chung ),김용철 ( Yong Cheol Kim ),전은경 ( Eun Kyoung Jeon ),이근호 ( Keun Ho Lee ),맹이소 ( Lee So Maeng ),한제호 ( Je Ho Han ),문성대 ( Sung Dae Moon ) 대한내과학회 2008 대한내과학회지 Vol.75 No.4

하나의 부신 세포에서 피질과 수질의 특징이 함께 공존하는 피질-수질세포에 관한 예들이 1960년대 이후로 보고되어 왔다. 저자들은 갈색세포종의 임상적 특징을 보이지만, 수술 후 갈색세포종의 임상증상과 생화학적 특징이 정상으로 회복되었으며 광학현미경상 부신 피질 선종의 특징을 보이지만, 면역조직화학 검사와 전자현미경 검사에서 피질-수질세포를 보인 1예를 경험하였기에 문헌고찰과 함께 국내 처음으로 보고하는 바이다. The coexpression of cortical and medullary features in a single adrenal cortical cell has been recognized, leading to terms such as cortico-medullary cells. Here, we reported a case of adrenocortical adenoma consisting of cortico-medullary cells that clinically mimicked pheochromocytoma. A 52-year-old woman was admitted to our hospital complaining of an 8-month history of paroxysmal palpitation with refractory hypertension. A 24-hour urine study revealed increased norepinephrine and metanephrine levels. Computed tomography of the abdomen revealed a 1.0×0.9-cm mass in the left adrenal gland. The patient subsequently underwent unilateral laparoscopic adrenalectomy for a presumptive pheochromocytoma. Light microscopic findings of the left adrenal mass indicated an adrenocortical adenoma, but electron microscopy identified lipid vacuoles and smooth endoplasmic reticulum, along with dense core neurosecretory granules, so-called cortico-medullary cells. This is the first report of the detection of cortico-medullary cells in adrenocortical adenoma presenting as pheochromocytoma in Korea. (Korean J Med 75:479-483, 2008)

CASE REPORTS : Agranulocytosis Induced by Ethambutol in a Patient with Pulmonary Tuberculosis

( Kyoung Min Moon ),( Min Soo Han ),( So Hee Chung ),( Ju Ri Kim ),( Jin Young Kim ),( Sun Young Jung ),( Yong Seon Cho ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.2

We report a case of agranulocytosis caused by ethambutol in a 79-year-old man with pulmonary tuberculosis. He was referred for fever and skin rash developed on 21th day after antituberculosis drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide) intake. Complete blood count at the time of diagnosis of pulmonary tuberculosis was normal. On the seventh admission day, agranulocytosis was developed with absolute neutrophil count of 70/μL. We discontinued all antituberculosis drugs, and then treated with granulocyte colony-stimulating factor. Three days later, the number of white blood cell returned to normal. We administered isoniazid, pyrazinamide, and ethambutol in order with an interval. However, fever and skin rash developed again when adding ethambutol, so we discontinued ethambutol. After these symptoms disappeared, we added rifampicin and ethambutol in order with an interval. However after administering ethambutol, neutropenia developed, so we discontinued ethambutol again. He was cured with isoniazid, rifampicin, and pyrazinamide for 9 months.

An Optimization of AAV-82Q-Delivered Rat Model of Huntington's Disease

So, Kyoung-Ha,Choi, Jai Ho,Islam, Jaisan,KC, Elina,Moon, Hyeong Cheol,Won, So Yoon,Kim, Hyong Kyu,Kim, Soochong,Hyun, Sang-Hwan,Park, Young Seok The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.5

Objective : No optimum genetic rat Huntington model both neuropathological using an adeno-associated virus (AAV-2) vector vector has been reported to date. We investigated whether direct infection of an AAV2 encoding a fragment of mutant huntingtin (AV2-82Q) into the rat striatum was useful for optimizing the Huntington rat model. Methods : We prepared ten unilateral models by injecting AAV2-82Q into the right striatum, as well as ten bilateral models. In each group, five rats were assigned to either the 2×10¹² genome copies (GC)/mL of AAV2-82Q (×1, low dose) or 2×10¹³ GC/mL of AAV2-82Q (×10, high dose) injection model. Ten unilateral and ten bilateral models injected with AAV-empty were also prepared as control groups. We performed cylinder and stepping tests 2, 4, 6, and 8 weeks after injection, tested EM48 positive mutant huntingtin aggregates. Results : The high dose of unilateral and bilateral AAV2-82Q model showed a greater decrease in performance on the stepping and cylinder tests. We also observed more prominent EM48-positive mutant huntingtin aggregates in the medium spiny neurons of the high dose of AAV2-82Q injected group. Conclusion : Based on the results from the present study, high dose of AAV2-82Q is the optimum titer for establishing a Huntington rat model. Delivery of high dose of human AAV2-82Q resulted in the manifestation of Huntington behaviors and optimum expression of the huntingtin protein in vivo.

Agranulocytosis Induced by Ethambutol in a Patient with Pulmonary Tuberculosis

Moon, Kyoung Min,Han, Min Soo,Chung, So Hee,Kim, Ju Ri,Kim, Jin Young,Jung, Sun Young,Cho, Yongseon The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.2

We report a case of agranulocytosis caused by ethambutol in a 79-year-old man with pulmonary tuberculosis. He was referred for fever and skin rash developed on 21th day after antituberculosis drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide) intake. Complete blood count at the time of diagnosis of pulmonary tuberculosis was normal. On the seventh admission day, agranulocytosis was developed with absolute neutrophil count of $70/{\mu}L$. We discontinued all antituberculosis drugs, and then treated with granulocyte colony-stimulating factor. Three days later, the number of white blood cell returned to normal. We administered isoniazid, pyrazinamide, and ethambutol in order with an interval. However, fever and skin rash developed again when adding ethambutol, so we discontinued ethambutol. After these symptoms disappeared, we added rifampicin and ethambutol in order with an interval. However after administering ethambutol, neutropenia developed, so we discontinued ethambutol again. He was cured with isoniazid, rifampicin, and pyrazinamide for 9 months.

What we need to know when performing and interpreting US elastography

( So Hyun Park ),( So Yeon Kim ),( Chong Hyun Suh ),( Seung Soo Lee ),( Kyoung Won Kim ),( So Jung Lee ),( Moon-gyu Lee ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.3

According to the increasing need for accurate staging of hepatic fibrosis, the ultrasound (US) elastography techniques have evolved significantly over the past two decades. Currently, US elastography is increasingly used in clinical practice. Previously published studies have demonstrated the excellent diagnostic performance of US elastography for the detection and staging of liver fibrosis. Although US elastography may seem easy to perform and interpret, there are many technical and clinical factors which can affect the results of US elastography. Therefore, clinicians who are involved with US elastography should be aware of these factors. The purpose of this article is to present a brief overview of US techniques with the relevant technology, the clinical indications, diagnostic performance, and technical and biological factors which should be considered in order to avoid misinterpretation of US elastography results. (Clin Mol Hepatol 2016;22:406-414)