고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

DAP 신념에 근거한 유아과학 교수·학습모형의 현장적용 효과

이정화,이미은 미래유아교육학회 2003 미래유아교육학회지 Vol.10 No.4

DAP(Developmentally Appropriate Practice)는 유아교육실제의 질을 진단ㆍ평가하는 타당한 기준으로 인정받고 있을 뿐 아니라 유아교육과정의 설계나 프로그램 개발에 고려해야 할 준거로 널리 활용되고 있다. 본 연구는 DAP 신법에 근거하여 만들어진 절차화된 유아과학 교수ㆍ학습모형(이정화, 2002)을 유아교육 현장에 적용하여 그 효과를 검증해 보고자 하였다. 이를 위해 연구자들은 두 가지 교수학습방법(DAP 신념에 근거한 유아과학 수업모형과 전통적 수업모형)을 적용한 과학활동 프로그램을 구성, 처치한 후 유아들의 과학적 호기심 및 과학적 과정 기능의 향상 정도를 살펴보았다. 연구결과 DAP 신념에 근거한 절차화된 유아과학 교수ㆍ학습모형에 의한 과학활동 프로그램에 참여한 유아들이 전통적 교수법에 의한 과학활동 프로그램에 참여한 유아들보다 유의하게 높은 향상을 보였음이 확인되었다. The purpose of this study was to examine the effects of a developmently appropriate model of teaching science(DAP model) which is developed by Lee Jeong-Hwa(2002) on children’s curiosity and scientific process skills. Two research questions were made from the review of the literature, as follows ; 1. Are there any differences in science curiosity between children in an experimental and a control group? 2. Are there any differences in science process skills between children in an experimental and a control group? To answer the questions, forty five-year-old children attending a preschool in Busan participated in this study. They were randomly assigned to either an experimental or a control group. Children in the experimental group, took part in eight 40~45 minute sessions of science program based on the DAP model; whereas, their counterparts in the same sessions of a traditional science program. After the sessions of each program, all children were tested on the science processing skill test and the science curiosity test. The children who took the DAP model received higher achievement than their counterparts on curiosity and scientific process skills. From the results, the researchers suggest to apply the DAP model of teaching science for young children in the education field.

1995-96년 한반도 남동부 지역의 미소지진 자료를 이용한 지각구조 모델의 비교 연구

이기화,정태웅,Lee, Gi Hwa,Jeong, Tae Ung 한국지구물리물리탐사학회 1999 지구물리 Vol.2 No.1

한국자원연구소 지진관측망의 1995-96년 미소지진 자료를 바탕으로 한반도 남동지역의 지각구조에 대하여, Lee (1979), 김상조·김소구(1983), 김성균·정부흥(1985)의 세 지각 모델 중 어느 것이 잔차의 최소자승을 만족하는지 검증하였다. 세 모델 잔차의 뚜렷한 차이가 관찰되지 않았으나, Lee 의 지각 모델이 약간 깊은 진원을 산출하는 경향이 있다. 한반도 지각의 층상구조는 아직 명백하지 않으므로 앞으로 더 많은 자연지진 자료 또는 인공지진 자료를 통해서 규명되어져야 한다. Using the microearthquake data acquired from 1995 to 1996 through the seismic network operated by the Korea Institute of Geology, Mining & Materials (KIGAM), the three P-wave velocity models proposed by Lee (1979), Kim·Kim (1983) and Kim·Jung (1985) concerning the structure of the southeastern part of the Korean peninsula were examined in terms of the least square errors of the P-wave arrival times. The three models do not differ significantly in arrival time residuals except that the Lee's model gives slightly deeper focuses than the others. The layering of the crust of the peninsula is not clear as yet and to be studied by more earthquake and explosion data in the future.

Plant regeneration from callus of Iris odaesanensis Y. N. Lee native to Korea via organogenesis

Bae, Kee-Hwa,Yoo, Kyoung-Hwa,Lee, Mi-Hyun,Jeong, Jae-Hun,Choi, Yong-Eui,Yoon, Eui-Soo The Korean Society of Plant Biotechnology 2013 식물생명공학회지 Vol.40 No.3

Iris odaesanensis Y. N. Lee. is an important endangered and native plant belonging to the family Iridaceae in Korea. This study describes a method for rapid micropropagation of this species via from leaf, rhizome and root explants derived calli. Leaf, rhizome and root explants were cultured on Murashige and Skoog (MS) medium supplemented with 2,4-dichlorophenoxy acetic acid (2,4-D) for callus induction. Rhizome explants yielded calli at a frequency of 72% when cultured at 1.0 mg/l 2,4-D. Calli were maintained at 1.0 mg/l 2,4-D. These calli were transferred to MS medium supplemented with 0, 0.5, 1.0, and 2.0 mg/l 2,4-D in combination with 0, 0.5, 1.0, and 3.0 mg/l BA for adventitious shoot induction. The highest number of adventitious shoot (228.9 per petri-dish) were formed at 1.0 mg/l 2,4-D and 1.0 mg/l BA. WPM medium was the best to convert calli into plantlets, where up to 98.2% of calli were regenerated into plantlets. This in vitro propagation protocol should be useful for conservation of this endangered plant.

화병(火病)을 동반한 갱년기 환자 치험 5례

송유림 ( Yu-rim Song ),박경미 ( Kyung-mi Park ),양승정 ( Seung-jeong Yang ),이은규 ( Eun-kyu Lee ),김혜화 ( Hye-hwa Kim ),조성희 ( Seong-hee Cho ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.4

Objectives: The purpose of this study is to evaluate the effects of Korean traditional treatments for Climacteric Syndrome Patients with Hwa-Byung. Methods: From February 2015 to May 2015, We treated 5 Cases Patients with Korean traditional treatments for a month. We measured treatment effects by Menopause Rating Scale (MRS), Beck`s Depression Inventory (BDI), Visual Analogue Scale (VAS) and Digital Infrared Thermal Imaging (DITI). Results: After treatment, First, the scores of MRS, BDI were decreased. Second, the symptoms such as hot flush, pantalgia, palpitation, insomnia, fatigue were significantly improved. Also, the difference of ?中 (CV17, Danjung) and 關元 (CV4, Guanyuan) temperatures were significantly decreased after treatment. Conclusions: This study suggests that Korean traditional treatments such as Gamicheonglijagam-hwan, acupuncture, moxibustion are effective on Climacteric Syndrome Patients with Hwa-Byung.

청간소요산으로 호전된 설통 환자 3례

김연진,양승보,김정화,이상화,조승연,박성욱,박정미,고창남,Kim, Yeon-jin,Yang, Seung-bo,Kim, Jeong-hwa,Lee, Sang-hwa,Cho, Seung-yeon,Park, Seong-uk,Park, Jung-mi,Ko, Chang-nam 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4

Objectives: This clinical study reports the effects of Cheonggansoyo-san (CSS) on three patients with glossodynia. Methods: Three patients with glossodynia were treated with CSS (i.e., an herbal medicine) and acupuncture. Numeric rating scales (NRSs) for glossodynia and dry mouth and hwa-byung questionnaire scores were evaluated, and the results from heart rate variability (HRV) evaluations were analyzed. Results: After treatment with CSS, three patients' glossodynia symptoms, such as burning sensations, tingling, and numbness of the tongue, were improved. NRS ratings for glossodynia and dry mouth and the hwa-byung questionnaire scores also improved, and HRV parameters were closer to the normal range. Conclusion: Cheonggansoyo-san could be used to treat glossodynia.

Indomethacin-Ethylcellulose Microcapsules의 용출 특성에 관한 연구

이화정,구영순 梨花女子大學校 藥學硏究所 1993 藥學硏究論文集 Vol.- No.3

Indomethacin-ethylcellulose microcapsules(IDM-MC) were prepared by solvent evaporation method using sod. lauryl sulfate(SLS) as a surfactant. In case of IDM-MC prepared with various rations of ethylcellulose(EC) and polyethylene glycon 4000(PEG 4000) in 0.25% SLS solution, drug content of IDM-MC were 17.80% to 21.25%, while those of IDM-MC prepared using EC in various concentrations of SLS solution were 11.25% to 16.06%. Scanning Electron Microgram showed that the IDM-MC were almost spherical and had pores on the surface. Particle size distributions of IDM-MC were relatively regular. The dissolution rates of IDM from the IDM-MC retarded considerable compared with that of IDM powder; the dissolution of IDM was more than 90% within 1 hour, but those of IDM from IDM-MC were about 20 to 70% within 24 hours. And, the dissolution of IDM from IDM-MC prepared with EC: PEG 4000=1:1 and stirred in 30(w/w)% glycerin solution was more twice than those of IDM from IDM-MC prepared without PEG 4000.

제강 전로 및 고로 슬래그를 이용한 인제거 기법에 관한 기초연구

이승환,장정화 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

In this study, several series of experiments were conducted to investigate the phosphorus (P) removal process in slag-containing solution using fumace and converter slags. High amount of OH-, Ca^(2+) and alkalinity were discharged from the slags and hydroxyapatites [Ca_(5)(PO₄)₃(OH)] were kept accumulated on the surface of slag. P removal capacity of the slag decreased with the increase of slag dosage. The maximum capacity was found to be 11.25 mug at the converter slag. Converter slag adsorbed P more than fumace slag(about four times in average). An experimental study on the effect of pH shows that the percentage removal of P increased upto 30% at the pH range of 56 than that of abave pH 8. Langmuir isotherm constants gave a better correlation than Freundlich ones. P removal amount in the presence of NH₄^(+) was less compared to the one in the absence of NH₄^(+). Maximum percentage reduction was 23%.

한국인에서 도파민 D4 수용체 다형성과 Novelty Seeking 성격 특성의 연관성

이헌정,이홍석,강화연,김린,이민수,서광윤,변영찬 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.4

연구목적 : 저자들은 한국인에서 도파민 D4 수용체(DRD4) 유전자의 다형성과 성격의 관련성을 알아보고자 본 연구를 시행하였다. 방 법 : 173명의 건강한 한국인 여자 청소년(13.88±0.29세)을 대상으로 하여 성격 기질 설문지(Temperament and Character Inventory : TCI)를 작성하도록 하였으며, 이들에서 DRD4 exon Ⅲ 48-bp VNTR(variable numbers of tandem repeats) 다형성을 분석하였다. 결 과 : DRD4 exon Ⅲ Vntr에서 긴 대립유전자(≥5 repeats)를 가진 군이 긴 대립유전자를 가지지 않은군에 비하여 Novelty Seeking 척도 점수가 유의하게 높았다(t=2.11,p=0.037). 결 론 : 본 연구 결과는 DRD4-exon Ⅲ의 긴 대립유전자가 Novelty Seeking 성격과 관련이 있다는 기존의 외국에서의 연구결과를 다시금 확인해주는 것이다. Objectives : We investigated the relationship of personality traits with dopamine D4 receptor(DRD4) exon Ⅲ polymorphism in a Korean population. Methods : We analysed DRD4 exon Ⅲ 48-bp repeats polymorphism in 173 Korean heakthy female adolescents(age=13.88±0.29years) who also completed Temperament and Charater Inventory(TCI). Results : Novelty seeking score of the TCI was significantly higher in the subjects with DRD4 long alleles(≥5 repeats) compares with the subjects without these (t=2.11, p=0.037). Conclusion : The present study supports the previous reports that long repeats of the DRD4-exon Ⅲ polymorphism are relatedwith Novelty Seeking personality.

中空 坐劑의 약물방출(Ⅰ) : Witepsol H-15 기제로부터의 인도메타신의 방출속도 Release Rate of Indomethacin from Witepsol H-15 Suppository

이화정,구영순 梨花女子大學校 藥學硏究所 1991 藥學硏究論文集 Vol.- No.1

In order to study drug release from the suppository, three types of hollow suppositories and one conventional suppository were prepared using indomethacin (IDM) as a model drug and Witepsol H-15 as a base. The 4 types of suppository prepared are as follows : typeⅠ, conventional suppository containing 50mg of IDM powder, typeⅡ, hollow suppository containing 50mg of IDM powder in the cavity, typeⅢ, hollow suppository containing 25mg of IDM powder in the base and IDM microcapsules (25mg as IDM powder) in the cavity, and type Ⅳ, hollow suppository containing IDM microcapsules (25mg as IDM powder) in the base ans 0.5ml of 5%(w/v) IDM-PEG 300 solution in the cavity. The drug amount released(%) from typeⅡ and Ⅰ within 24hrs was 46.7% and 66.9%, respectively. Comparing with the drug amount released from four types of suppository within initial 2hrs and 24hrs, that of type Ⅳ was high as 32.7% and 76.6%, respectively. IDM-ethycellulose microcapsules passed through 270 mesh sieve and the IDM content was 20.95%.