구강관리 프로토콜 적용이 항암화학요법을 받는 고형암 환자의 구강상태 및 자가간호수행에 미치는 효과

정미숙(Mi Sook Jeong),송지은(Chi Eun Song),이애리(Ae Ri Lee),정은숙(Eun-Suk Jung),김광숙(Gwang Sug Kim) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.8

본 연구의 목적은 항암화학요법을 받는 고형암 환자를 대상으로 구강관리 개별교육과 냉동요법 및 벤지다민 구강함수를 포함한 구강관리 프로토콜 적용이 대상자의 구강상태와 수행에 미치는 효과를 파악하기 위함이다. 총 연구 대상자는 31명이었으며, 실험군에 13명, 대조군에 18명이 배정되었다. 실험군에게는 구강관리교육, 냉동요법 및 벤지다민 구강함수를 적용하였으며 대조군은 기존의 구강간호를 제공하였고, 대상자의 구강상태와 자가간호 수행정도를 측정하였다. 수집된 자료는 Mann-Whitney test, Friedman test, 및 Chi-square test로 분석하였다. 연구결과, 매 측정 시기 별 두 그룹 간 구강상태의 차이는 없는 것으로 나타났다. 그러나 두 그룹 모두 측정시기에 따른 구강상태의 변화는 유의하였는데 항암치료 후 14일경에 구강상태점수가 가장 낮게 측정되었다. 자가간호 수행정도는 실험군이 대조군보다 유의하게 높았으며 연구 완료 후 4개월까지 유지되는 것으로 나타났다. 이러한 결과는 종양간호사에 의한 환자개별교육의 효과로 여겨지며 고형암 환자의 구강상태 개선을 위하여 냉동요법과 벤지다민 구강함수에 대한 효과를 파악하기 위한 추가적인 연구가 요구된다. The purpose of this study was to identify the effectiveness of oral care protocol including individual oral care education, cryotherapy and benzydamine gargling on oral cavity status and self-care performance in solid cancer patients receiving chemotherapy. Thirty-one patients were enrolled by convenience sampling in this study and allocated to control (n=18) and experimental group (n=13). In the intervention group, individual oral care education, oral cryotherapy and benzydamine gargling were applied, while the control group received pre-existed oral care. Oral cavity status and self-oral care behavior were measured in five periods. The data were analyzed using the Mann-Whitney test, Friedman test, and Chi-square test. There was no significant difference in oral cavity status between the groups. But the two groups showed the poorest oral cavity status on 14th day. Self-care behavior was significantly higher in the intervention group than the control group. This effect had maintained for 4months after completion of study. The results showed that individual oral care education by oncology nurse is effective to encourage patients to do self-care behavior and a further study is needed to explore the effect of cryotherapy and benzydamine gargling on oral cavity status of patient with solid tumor.

한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰

우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.

리튬이온전지용 양극활물질 폐기물로부터 침출 및 용매추출에 의한 코발트의 분리

정진기,이재천,김민석,김치권 한국공업화학회 2005 응용화학 Vol.9 No.1

LiCoO₂ that is used as an cathode active material of lithium ion batteries has been generated as a waste for manufacturing the batteries. As a method for recycling the waste, solvent extraction was carried out to separate cobalt from the leaching solution of the waste. Many researchs were conducted for recovering Li and Co from waste lithium ion batteries. However, little were reported for recovering Li and Co from wastes generated for manufacturing the lithium ion batteries. In the study, the experiments of leaching and solvent extraction were conducted to recover Li and Co from the waste. The effects of operational variables on the concentration of sulfuric acid, temperature, agitation rate, the addition amount of H₂O₂, and pulp density were investigated. The leaching rate of Li was larger than that of Co under the experimental conditions, and the leaching rate of Li and Co was increased with increasing the concentration of sulfuric acid, temperature, agitation rate, and the addition amount of H₂O₂. There are also differences between the leaching results of wastes generated for manufacturing the lithium ion batteries and that of waste lithium ion batteries. Solvent extraction was carried out using Na-CYANEX 272, and cobalt was separated from the leaching solution of the waste.

제주도 청소년소비자의 과시소비성향에 관한 연구

이지혜,김정숙 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.2

The purpose of this study is to investigate the effects of self-concept, reference group, consumer education, and materialism on the propensity for conspicuous consumption of adolescents. The data used in this study were collected through questonnaires on 604 adolescents living in Cheju City. The data were analyzed by using SPSS PC?? program. The propensity for conspicuous consumption of adolescents differed significantly acording to their age and allowance, and sex. The propensity for conspicuous consumption of the middle school studynts was higher than that of the high school students. The propensity for conspicuous consumption of byys was higher than of girl's. The propensity for conspicuous consumptionof the adolscents was influenced by materialism and the reference group. According to the results of the multiple regression analysis, the most influential factor was materialism and reference group. in clothing materialism was the most influential factor and the reference group was the second influential factor. But in shoes, bag, and school supplies the reference group was the most influential factor and materialism was the second influential factor.

1%Cr-Mo-V 강 회전자축의 크리이프 특성과 수명예측에 관한 연구

이치우,장윤석,정순호,조판근 慶南大學校 附設 工業技術硏究所 1986 硏究論文集 Vol.4 No.-

본 연구는 1%Cr-Mo-V강 회전자축의 보다 개선된 크리이프특성을 위한 최적열 처리 조건의 선정과 크리이프 수명을 예측하기 위하여 행해졌다. 실험결과 970℃∼980℃ 퀜칭/660℃∼680℃ 템퍼링의 조합에서 최적크리이프 특성치가 나타났다. 또한 Larson-Miller법 및 Curvelinear Regression법에 의해 1%Cr-Mo-V강 회전자축의 주파단곡선을 구하였다. 회전자축이 530℃에서 연속 작동되며 순수크리이프 변형만을 고려할 때 회전자축의 최고응력 집중부에서의 예상크리프수명은 21.9×105hrs이었다. This study was carried out to find out optimum heat treatment conditions for improved creep properties and to estimate creep life of 1% Cr-Mo-V-steel rotor shaft. The effect of heat treatment on the creep properties of 1% Cr-Mo-V-steel rotor shaft was investigated under the conditions of various heat treatment temperatures. Experimental result shows that the best combination of quenching and tempering temperatures for good creep properties is 970℃-980℃ quenching 660℃-680℃ tempering sequence. A master curve for 1% Cr-Mo-V-steel rotor shaft was obtained by Larson-Miller parameter and curvelinear regression method. Life prediction at the maximum stress concentration points in the rotor was computed about 21.9×10??hours, if the rotor shaft would be continuously operated at 530℃ and be influenced by the effect of creep strain only.

항혈청 투여에 따른 돼지 유행성 설사병 예방효과 : Ⅱ.임상증상, 병리조직학적 검사, 면역조직학적 검사 Ⅱ.Clinical sign, Histopathological Lesion and Immunohistochemical Finding

지영철,한정희,권혁무,정현규,이함희 한국수의병리학회 2002 한국수의병리학회지 Vol.6 No.1

The purpose of this study was to investigate to potective effects against porcine epidemic diarrhea virus (PEDV) infection in piglets by administration of the PEDV antiserum orally at 2 hrs, 24 hrs and 36 hrs after birth. six piglets adiminstered the antiserum were experimentally infected with PEDV at five-day-old. Control group were four piglets infected with PEDV only. Clinical signs and gross, histopathological lesion and immunohistochemical findings were examined. The results obtained were as follows; 1. In clinical signs, piglets of the control group appeared the typical signs of severe watery diarrhea, depression and anorexia but piglets of the PEDV antiserum treated group recovered progressively. In mortality, control group showd 75%, but PEDV antiserum treated group showed 16.7%, respectively. 2. In gross findings, piglets of the control group appeared the typical findings of congestion, distension of lumen, contaning curdes of undigested milk in stomach. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 3. In histopathological findings, piglets of the control group appeared the typical findings of villous atrophy and fusion, congesion, exfoliation, vacuolation, squamation, loss of cilia and proliferation of crypt. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 4. In immunohistochemical findings, piglets of the PEDV antiserum treated group showed more intensive in reaction for IgG and IgG than those of control group. The recation for IgA was stronger than that of IgG. It was concluded that oral administration of PEDV antiserum to piglets was effective in preventing PEDV infection and reduced their mortality.

CVD 다이아몬드 박막의 열전도 특성

이광만,고정대,최치규 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1

Diamond has outstanding thermal properties that make it the material of choice for heat spreading applications in microelectronic devices. In order to asses thermal properties of diamond films grown by microwave plasma CVD method. we have applied an ac thermal conductivity measurement technique where films are thermally excited at frequency ω while the thermal response is measured at the third harmonic via a lock-in amplifier. This method is insensitive to errors due thermal noise. Before the application to diamond. the measurement technique was tested on fused silica and sapphire. The results were in good agreement with published values. The thermal conductivity of CVD diamond films were measured to be around 3 W/cm·K.

CVD 다이아몬드 박막의 열전도 특성

이광만,고정대,최치규 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1

Diamond has outstanding thermal properties that make it the material of choice for heat spreading applications in microelectronic devices. In order to asses thermal properties of diamond films grown by microwave plasma CVD method, we have applied an ac thermal conductivity measurement technique where films are thermally excited at frequency w while the thermal response is measured at the third harmonic via a lock-in amplifier. This method is insensitive to errors due thermal noise. Before the application to diamond, the measurement technique was tested on fused silica and sapphire. The results were in good agreement with published values. The thermal conductivity of CVD diamond films were measured to be around 3 W/cm·K.

콘크리트 構造物의 混合모드 龜裂傳播모델 (第 4 報)

진치섭,오정민,이홍주 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

2 차원 선형탄성 균열문제에 적합한 파괴기준을 알아보기 위해, 응력확대계수 K과 K 균열파단각과 파괴하중을 최소 변형에너지밀도 기준에 의해 구하는 유한요소 프로그램, SED를 개발하였다. 이 프로그램에서는, 6절점 삼각형 특이요소를 사용한 균열선단을 제외한 다른 부분에서는 고전적인 8절점 사변형 등매개변수 요소를 사용하였다. SED의 결과를 최대 원주방향 인장응력 기준과 최대 에너지 해방률 기준에 의한 프로그램의 결과차, 그리고 Jenq & Shah의 실험결과와 동일한 조건에서 비교하였다. 본 연구는 혼합모드 균열전파 모델의 계속적인 연구로서 이전의 최대 원주방향 인장응력 기준과 최대 에너지 해방률 기준에 의한 해석치와는 다소 차이가 있으나 전반적으로 Jenq 와 Shah의 실험치와 비슷한 양상을 보였다. To find out an adequate failure criterion in two-dimensional linear elastic crack problems, finite element program, SED, which determines stress intensity factors K, K, crack angle and peak load by the minimum strain energy density failure criterion were developed. In this program, the conventional quadratic isoparametric elements were used in all regions except the crack tip zone where triangular singular elements with 6 nodes were used. The results of SED were compared with the results of those which followed by the maximum circumferential tensile stress criterial and those by the maximum energy release rate criteria and those by Jenq and Shah's experiments of the same geometry and material properties. This study which has kept continuously as mixed mode crack propagation models is somewhat different from previous results, maximum circumferential tensile stress criterial and the maximum energy release rate criteria, but SED's result is generally similar to Jenq & Shah's experiments.

디클로페낙 프로드럭들의 흰쥐 피부 투과

도희정,조원제,용철순,이치호,김대덕 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Various alkyl ester prodrugs of diclofenac were synthesized in order to investigate the relationship between their skin permeation characteristics and physicohemical properties. Solubility in various vehicles was meastured at room temperature. 1-Octanol/water partition coefficients (Log P) and capacity factors (k") were measured to detemine the lipophilicity of the prodrugs. Stability of prodrugs in the skin extract and homogenate was also investigated before conduction the skin permeation studies. Increases in the Log P and capacity factor values were observed when alkyl esters of diclofenac were perpared. Since the aqueous solubility of the prodrugs was not high enough, they were saturated in propylene glycol (PG) for skin permeation studies. Prodrugs were rapidly metabolized to diclofenac, both in skin homogenate and in dernal extract of skin. The skin permeation rate of alkyl ester prodrugs was significantly higher than diclofenac with shorter lag time. Morecover, a parabolic relationship was observed between the pemeation rate and the log P values of prodrugs, and the maximum flux was achieved at a log P value of around 4.0.