관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

α-디아조 케톤과 올레핀의 광반응

李學沂,曺燦湜,金宇鍾,禹海允 慶北大學校 1990 論文集 Vol.50 No.-

The majority of carbenes add to olefins to give cyclopropanes. In this study, 2-diazo-1,3-indandione, 2-diazo-1-indanone, and 3-diazooxindole were used as carbene precursors. Irradiation of these diazo compounds with trichloroethylene, acrylonitrile, cyclohexene, and cyclooctene was investigated. The addition of carbenes to benzene generally affords norcaradiene or cycloheptatriene or both. Irradiation of 2-diazo-1,3-indandione with benzene gave only cycloheptatriene derivative in 24% yield. But irradiation of 2-diazo-1-indanone with benzene gave norcardiene in equiribrium with cycloheptatriene derivative in 24% yield.

Comparison of the Pharmacological Effects of Roasted and Non-roasted Zizyphi Spinosi Semen: Differences in Chemical Constituents

홍학기, 이기남, 마유안, 김윤배, 남상윤, 송인섭, 문동철, 오기완 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

低溫光反應 裝置의 製作과 이를 利用한 테트라페닐디아조시클로펜타디엔의 低溫光反應

李學沂,金鴻洛,李忠熙 慶北大學校 1987 論文集 Vol.44 No.-

The apparatus for low temperature photoreaction is very useful one for detecting reactive intermediates such as carbene, benzyne etc. So, the major portion of this work dealt with the construction of apparatus for low temperature photoreaction. And tetraphenyldianzocyclopentadiene was synthesized as a precursor by reaction of benzil with 1, 3-diphenylacetone and p-toluenesulfonylhydrazide. Using this apparatus constructed for low temperature photoreaction, tetraphenyldiazocyclopentadiene was irrdiated by UV (λ>280nm) at 10K, 7 exp (-6)mbar. Irradiation of tetraphenyldiazocyclopentadiene through quartz window at 10K gave three new strong IR peaks; 2,110 cm^-1, 1,675cm^-1, and 765cm^-1. Comparison with the results of matrix isolated study of diazocyclopentadiene, it was believed photoproducts to be tetraphenylcyclopentadienylidene (765cm^-1) as carbene and tetraphenylcyclopropenylallene (2,110cm^-1, 1,675cm^-1) formed by intramolecular rearrangement of the carbene.

Imidazole-Azo유도체의 Spectra

李學沂,林龍進 慶北大學校 1976 論文集 Vol.21 No.-

In order to investigate the possibility as a dyestuff, the spectra of imidazole azo derivatives were studied in comparison with phenyl azo ones. The λmax of imidazole azo derivatives was 17-23 nm longer wave region than that of phenyl derivatives and it means that imidazole azo dyes have more bathochromic effect than phenly azo dyes. The spectra of substituted 2'-oxyphenyl azo imidazole showed isosbestic points in accordance with the variation of pH range in the methanol-water solution. It will be due to the protonation and deprotonation of dyes in acid-alkali solution. The authors discussed these imidazole azo dervatives on the possibility as a disperse azo dye.

상악동 후비공 용종에서 줄기의 경로에 따른 상악동구 전산화단층촬영 소견

이승훈,박동우,이승로,함창곡,이학수,김용수,박충기 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.2

Purpose: We evaluate the pathway of the stalk of antrochoanal polyp on the coronal and axial computed tomography scans (CT), comparing with operative findings. Materials and Methods: Fourteen patients (7∼40 years old, median= 12.5 years old, ratio of male to female: 8/6) with antrochoanal polyp were examined, who took the orbitomeatal unit (OMU) CT including both coronal and axial scans as well as the operation. The CT findings and clinical findings were analyzed for the pathway of the stalk of antrochoanal polyp, comparing with the operative findings. Results: The antrochoanal polyps were mostly located on the left side (12/14, 85.7%) and equally passed through the natural and accessory ostia (7/14, 7/14) in our cases. Those that were passing through the accessory ostium were located more inferiorly and posteriorly, with preserving the natural ostium on CT scans, comparing to those via the natural ostium. However, those passing through the natural ostium had a larger stalk that eroded the uncinate process widely. So each ostium was hardly discriminated on CT scans. Conclusions: The pathway of the stalk of the antrochoanal polyp could be more specifically evaluated on both coronal and axial OMU CT scans. So, it could be more hilpful in the presurgical planning.

신장조직 손상의 진행에 있어서 Renin-Angiotensin System 의 역할에 관한 연구

이강욱,송정헌,강민규,황평주,김종학,나기량,서광선,박정규,신영태 대한신장학회 2001 대한신장학회잡지 Vol.20 No.3

폴리프로필렌 纖維用 Carbene染料의 開發에 關한 硏究

李學沂,林龍進,민경은 慶北大學校 1982 論文集 Vol.33 No.-

Reactive dyes, which reaction center is carbene, were prepared and the dyeability of polypropylene fiber by those dyestuffs was investigated. Furthermore, a new say of dyeing and an applied technique for pretreating polypropylene with carbenic precursor were studied to improve dyeability. In this experiment, ketones were used as starting materials because these are mostly common functional group in dyes and dyestuff intermediates. Ketones could be changed to tosylhydrazone derivatives by tosylhydrazine in methanol at 0℃ in the presence of aqueous hydrochloric acid. Reactive carbenic dyes were prepared by the reaction of n-butyllithium and these hydrazone derivatives in ethly ether solvent. Dyed polypropylene showed excellent endurance to the light and preserverance to laundry, which were confirmed by means of blue and gray scales. The fact that polypropylene was bonded covalently to dyestuff molecules was confirmed by extraction and reprecipitation. Using the aldehyde as the starting material, carbenic precursor was also prepared analogous route to the dyestuff. After pretreating polypropylene fiber with this precursor, dyeing pattern of fiber in acidic media with butyl orange showed similar adsorption curve which is the typical results of acidic dyeing process. It means that polypropylene could be dyed easily in acidic media if it had pretreated by carbenic precursor.

불포화 에스테르기를 함유하는 중합체의 합성

李學沂,金鴻洛 慶北大學校 1986 論文集 Vol.42 No.-

Functionalized resins have found numerous applications recently as supports in organic synthesis. Active functional groups may be incorporated into polymer chains by direct polymerization and copolymerization of monomers containing the desired functional groups. Furan derivatives undergo ring opening with nitric-acetic acid oxidation. Polymer bound furan as studied as a successful and convenient reagent for the synthesis of unsaturated ester.

2-Vinylpyridine과 Methylmethacrylate의 Anion共重合

李學沂,金祐埴,鄭明秀 慶北大學校 1975 論文集 Vol.20 No.-

2-Vinylpyridine and methylmethacrylate were copolymerized with n-butyllithium as an initiator in n-hexane at o˚ to determine the reactivity ratio of this monomer system. r_1=0.041(2-vinylpyridine) r_2=1.14 (methylmethacrylate) From the reactivity ratio and Q-e value, it was known that the copolymerization of this monomer system is anionic and controlled by the polar effect of the monomer.