The Rate of the Acquisition of L2 Speech

( Eun Kyung Yoon ) 한국외국어대학교 언어연구소 2008 언어와 언어학 Vol.0 No.41

The purpose of this paper is to investigate the role of similarity and markedness and the effect of L2 experiences in second language speech learning. This is a revisited paper of Yoon``s (2007) study. In her study the theoretical framework was mainly grounded in Flege``s (1995) Speech Learning Model (SLM), claiming that L2 phonological categories for new sounds become established as L2 experience increases. To extend her study, this paper employed the idea of Major and Kim``s (1999) Similarity Differential Rate Hypothesis (SDRH), which claims that L2 sounds which is dissimilar to L1 sounds are acquired at a faster rate than similar sounds. The results from the combined production accuracy rating test and the GFA confirmed Major and Kim``s (1999) SDRH. The order of acquisition between similarity and markedness was also determined: similarity has a priority over markedness in interlanguage phonology.

Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats

Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*

腦卒中患者에 倂發된 肺炎에 대한 東西醫學 協力治療의 臨床的 硏究 : 抗生劑 使用實態와 死亡率을 中心으로

尹相協,柳在煥,景銀培,羅嶺雪,閔炳一,金裕國,金鍾烈,柳基遠 경희대학교 1992 慶熙醫學 Vol.8 No.4

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

허브식물과 아로마테라피

윤경은,장매희 韓國植物ㆍ人間ㆍ環境學會 2002 인간식물환경학회지 Vol.5 No.4

허브는 초기에는 향기가 나는 목초나 푸른 작물과 같이 초본성 식물로 정의되었으나 요즘에는 허브를 식물체의 뿌리, 줄기, 잎, 꽃 또는 열매를 음식이나 약재로 사용하거나 향기를 내는 데에 이용하는 식물이라고 정의하고 있으며, 초본성 식물 외에 관목을 비롯한 목본성 다년생 식물들도 포함된다. 허브는 예로부터 식용이나 약용 뿐 아니라 음식의 향신료로 사용되어 왔으며, 목욕이나 미용용품 제조에도 쓰였고, 염료, 세척제, 방충제와 같은 생활 용품들에도 이용되었다. 현대의학과 과학기술의 발달에도 불구하고 허브에 대한 관심은 날로 증가하여 이제 대체요법이나 아로마테라피와 같은 허브를 이용한 치료법들이 일반화되고 있다. 이는 요즈음 자연과 가까워지려는 환경친화적인 경향과도 일치하며, 최근에는 새로운 과학적 연구를 통하여 허브의 항박테리아, 항균, 항우울제 등의 작용과 체내 호르몬 작용 변화에 의한 치료효과가 인정되고 있다. 이러한 추세를 고려하여 가정에서 허브식물을 손쉽게 이용하기 위한 재배요령을 아로마테라피와 함께 소개하였다.

개의 아토피 피부염에 대한 Leflunomide의 임상적 적용 1례

홍은지,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A Shih-tzu(8-year-old, castrated male) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of relapsing pruritus, recurrent dermatitis. On the physical examination, generalized erythema, otitis externa, alopecia and lichenification were observed. Using Favrot's criteria for diagnishing atopic dermatitis, 7 criteria were satisfied out of 8 criteria. After treatment for infection, intradermal skin test was performed(positive allergen : Df, Dp). And then immunotherapy was performed, but clinical signs were not getting better. Next treatment of glucocorticoid shown little improvement of clinical signs, and adverse effect(diarrhea) was shown after cyclosporine application. So application of leflunomide which is used for human atopic dermatitis treatment in some case was planned. After 6 months of application of leflunomide, clinical signs were decreased gradually.

전기영동에 의한 동양란(Cymbidium spp.)의 단백질 유형비교

윤경은,홍성숙,이남희 서울여자대학교 자연과학연구소 1991 자연과학연구논문집 Vol.2 No.-

본실험은 전기영동을 이용하여 단백질과 동위효소의 유형을 비교 분석함으로 종과 품종을 구분할 수 있는가의 가능성을 조사하고 전기영동에 적합한 난의 부위와 효소의 종류를 선정코자 실시하였다. 1. 한국춘란은 부위별로 꽃봉오리, 뿌리끝, 어린잎, 성엽을 6% polyacrylamide slab gel로 단백질을 비교한 결과 부위별로 유형을 달리하였으나 band의 분리가 명확하지 않았다. 2. 10% SDS polyacrylamide slab gel에서는 band의 분리가 명확하였고 영동재료로는 어느 때나 쉽게 채취가 가능한 잎이나 뿌리를 사용하는 것이 편리하나 뿌리는 phenol 함량은 적으나 단백질 함량이 극히 낮으므로 잎을 시료로 쓰는 것이 양호한 편이었다. 3. 잎을 시료로 쓰는 경우는 엽록소, phenol의 제거가 필요하나 배양중인 rhizome을 사용하면 이러한 난점이 없이 단백질 유형이 뚜렷이 나타나, 춘란(Cymbidium goeingii), 한란(C, kanran), 죽백란(C, lancifolium)을 구분할 수 있었다. 4. Rhyzome의 esterase, peroxidase, acid phosphatase, glucose phosphate isomerase의 동위효소를 비교한 결과 단백질 유형으로는 분류가 어려웠던 춘란(Cymbidium goeringii)과 춘란복륜(Cymbidium goeringii:variated leaves)도 구분할 수 있었다. Peroxidase는 band는 여러가지로 나타났으나 esterase와 같이 band pattern이 명확지 못하였고 acid phosphatase와 glucose phosphate isomerase는 한개씩의 band만이 나타나 분류에는 적합하지 않은 효소로 생각되어졌다. The buffer soluble proteins were extracted from flower, root, young leaves, old leaves, and cultured rhizome. Different patterns of general protein were observed among the tested organs. Among the samples rhizome were the most suitable for electrophoresis to differentiate cultivars. Band patterns of general protein, esterase, peroxidase showed typical band patterns among Cymbidium goeringii, Cymbidium kanran, and Cymbidium lancifolium which have similar appearance of vegetative leaves. The isozymes of esterase, peroxidase, acid phosphatase, and glucose phosphate isomerase in cultured rhizome were analized. The well-resolved zones of esterase activity were detected. The differentiation of Cymbidium goeringii and Cymbidium goeringii : variated leaves which was hard to differentiated by general protein patterns, could be done by esterase isozyme band pattern.

Capsaicin이 동통억제효과를 나타내는 기전에 관한 연구

이종은,김봉옥,이원택,윤호,박경아 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.5