심경병성 근이영양증에 동반된 심근병증의 단기 성장호르몬 치료효과 1례

변기현,김동수,나준식,오수환,김인재,홍범기,권혁문,남수연,강성웅,김현승 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

졸-겔공정을 이용한 초고용량 캐패시터용 Nickel oxide 나노입자의 합성

김두현,송기창,변태강,송연호 조선대학교 생산기술연구소 2003 生産技術硏究 Vol.25 No.2

The Ni (OH)₂ nanoparticles with average diameter of 50 nm were synthesized by hydrolyzing nickel acetate with water, and were dispersed in the distilled water to prepare the coating solution. The electrodes for supercapacitor were prepared by dip-coating the coating solution on the Ni-foam. The electrodes heat-treated at several temperatures showed the highest specific capacitance, 160 F/g, at 250℃. It can be explained that the Ni(OH)₂ particles heat-treated at 100 and 200℃ on the electrodes contained the impurities such as acetate groups in the pores, and resulted in low specific surface areas. However, as the calcination temperature increases. the impurities incorporated in the pores are removed at 250℃, and thus, the particles on the electrodes show the highest specific surface area (177 ㎡/g).

초경 드릴의 절삭 성능에 관한 실험적 평가 연구

장성규,변상기,이승수,김현수,전언찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

Among the cutting process, recently hole processing in one of extensive using. This study, we made use of the 3 point edge drill. Regarding the cutting efficiency, we investigated the shape of cutting hole and studied cutting hole, a slope of center shaft, roundness and surface roughness. By using carbide 3 point cutting edge, compare with 2 cutting edge, it is possible that high precision drill processing and near the hole, at extremely limited area, quantity of magnification is a little big. After 15m cutting distance, a gradient of center shaft values was fixed 22㎛. It is necessary that a sufficient consideration concerned with jig intensity of workpiece, cutting conditions etc.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

정신분열병 환자 자녀에서의 주의력 장애

김철권,조현기,장정희,강동호,조진석,김명정,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

본 연구의 목적은 정신분열병 환자의 자녀들과 알코올 의존증 환자의 자녀, 그리고 정신과학적으로 건강한 부모의 자녀들을 대상으로 연속 작업수행력 검사를 이용한 정보처리 과정에서의 지속적 주의력에 관한 사항과 정보 감지능력 검사를 이용한 정보 처리과정에서의 감각등록에 관한 사항을 측정하고 세 군간에 그 결과를 서로 비교하여 차이 유무를 검증하기 위함이다. 연구 대상은 정신분열병 환자의 자녀 28명을 대상군으로 그리고 알코올 의존증 환자의 자녀 18명과 정신과학적으로 건강한 부모를 둔 중고등학생 41명을 대조군으로 하였다. 연구 방법은 대상군 및 두 대조군 모두에게 연속 작업수행력 검사와 정보 감지능력 검사를 순차적으로 시행한 후 그 결과를 서로 비교하였다. 그 결과는 다음과 같다. 1) 연속 작업수행력 검사에서는 대상군이 두 대조군에 비해 맞춘 횟수와 비율이 유의하게 낮았고 놓친 횟수는 반대로 유의하게 높았다. 가장 중요한 변인인 민감도는 대상군이 두 대조군에 비해 유의하게 낮았다. 2) 연속 작업수행력 검사에서 시간 경과에 따른 각 변인의 변화를 보면 맞춘 횟수와 비율에서 대상군이 두 대조군에 비해 시간이 경과할수록 유의하게 감소하였다. 민감도 역시 시간이 경과할수록 대상군이 두 대조군에 비해 유의하게 감소하였다. 3) 연속 작업수행력 검사의 민감도, 정보 감지능력 검사에서의 정답반응 횟수에서 정상 대조군의 분포 곡선중 하위 10% 수치를 절단점으로 잡아 그 수치 이하를 보이는 대상 숫자를 비교해 보면 연속 작업수행력 검사에서만 정신분열병 환자의 자녀군과 정상 대조군 사이에 유의한 차이를 보였다. 4) 대상군, 정상 대조군, 대상군중 연속 작업수행력 검사의 민감도가 하위 10% 이하에 속하는 군의 MMPI를 서로 비교한 결과 세 군간에 MMPI의 모든 변인에서 유의한 차이를 발견할 수 없었다. 5) 정보 감지능력 검사에서는 대상군이 두 대조군에 비해 정답반응과 오답반응을 보이기까지 걸린 평균 시간이 유의하게 길었다. 이상의 연구결과를 통해 저자들은 정신분열병의 발병 위험성이 높은 정신분열병 환자의 자녀군이 알코올 의존증 환자의 자녀군이나 정신과학적으로 건강한 부모를 둔 대조군보다 지속적 주의력에서 결손이 있음을 발견하였고 나아가 이와 같은 지속적 주의력에서의 결손이 정신분열병의 한 가능한 취약지표가 될 수 있을 것으로 사료된다. In order to study the possible vulnerability in the markers of schizophrenia, offsprings of the schizophrenic parents(n=28), offsprings of the alcohol dependent parents(n=18), and offsprings of the psychiatrically normal persons(n=41) were examined for their sustained attention and sensory register by means of Continuous performance test(CPT) and Span apprehension task(SPAN) respectively. The results were as follows : 1) The offsprings of the schizophrenic parents showed a significant deficit in the sustained attention as manifested in the data of CPT by significantly lower hit rate and sensitivity, compared with the offsprings of the alcohol dependent parents and those of the psychiatrically normal persons. No difference was evident in the false alarm rate and response bias among three groups. There was no difference in all variables of the CPT between the offsprings of the alcohol dependent parents and those of the psychiatrically normal persons. 2) The deficit in the sustained attention as revealed by lower hit rate and sensitivity was not apparent in the first part of the CPT. However it emerged and aggravated itself as the test continued in the offsprings of the schizophrenic parents only. 3) Proportion of subjects falling in the extreme low sensitivity of lower 10% of the normal controls was significantly higher in the offsprings of the schizophrenic parent group as compared with the offsprings of the alcohol dependent parents and those of the psychiatrically normal persons with a rate of 29%, 17%, and 10% respectively. 4) No significant difference was noted in all variables of MMPI among normal controls, index group, and the extreme low CPT sensitivity subgroup of index group. 5) The offsprings of the schizophrenic parents showed a significantly delayed response in the time to correct and incorrect response in SPAN compared to the offsprings of the alcohol dependent parents and those of the psychiatrically normal persons. No difference was evident in the number of correct response, number of incorrect response, and number of no response among three groups. There was no difference in all variables of the SPAN between the offsprings of the alcohol dependent parents and those of the psychiatrically normal persons. These results suggest that a subgroup of the offsprings of schizophrenic parents may suffer from the deficit in the sustained attention which may be a vulnerability marker of schizophrenia.

난원공 개존을 통한 우심방에서 좌심방으로의 단락 진단에 있어 경흉부 심초음파 하모닉 영상의 유용성

신미승,강석민,장길진,변기현,하종원,정남식,허지회,이병인 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

AN EFFICIENT AND SECURE STEGANOGRAPHY SCHEME SUITABLE FOR M-COMMERCE

Hyun-Jin Park,Se-Min Kim,Eun-Jun Yoon,Ki-Jong Kim,Ki-Hyun Jung,Jin-Yong Byun,Kee-Young Yoo 대한전자공학회 2006 ITC-CSCC :International Technical Conference on Ci Vol.2006 No.2

Functional Improvement Following Revision Surgery in a Patient with the Dual Disability of a Complicated Residual Limb and Contralateral Hemiplegia: A Case Report

Byun, Ki Hyun,Yang, Dong Seok,Jang, Baek Hee The Korean Society of Physical Therapy 2018 대한물리치료학회지 Vol.30 No.5

The number of reported cases with dual disability is increasing for the past few decades. Currently, dual disability of lower limb amputation and motor weakness after stroke became a strong issue in public concern. The functional levels of patients have shown in the wide range from independent community ambulation to non-ambulation. Thus, it indicates that favorable outcomes for dual disability may depend upon adopted rehabilitative strategies. We present the case of a man with left below-knee amputation and severe right-sided weakness following a huge putaminal hemorrhage. He had suffered from extreme pain and misfit of the prosthetic socket and the complicated residual limb for three years prior to the stroke. Forty days post-stroke, we performed a revision surgery to resolve the complications of bony overgrowth, verrucous hyperplasia, and neuroma and applied an ankle foot orthosis (AFO). Two years post-stroke, he was able to ambulate outside his home and negotiate stairs using a cane. This is the first case with the dual disability of lower limb amputation and contralateral hemiplegia to undergo revision surgery. The results suggest that an early revision surgery and use of an AFO are crucial for achieving a higher level of mobility in such cases.

Gh Mediates α1-Adrenoreceptor-Induced Transactivation of Integrin Signaling and Hypertrophy in Cardiac Myocytes

( Ki Hyun Byun ),( Woo Chul Chang ),( So Yeon Lim ),( Sun Ju Lee ),( Byeong Wook Song ),( Hye Jung Kim ),( Min Ji Cha ),( Ki Chul Hwang ),( Nam Sik Chung ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4

In cardiac myocytes, stimulation of the alpha(1)-adrenoreceptor(AR) leads to a hypertrophic phenotype. The Gh protein(transglutaminase II, TGII) is tissue type transglutaminase that transmits the alpha(1B)-AR signal with GTPase activity. Recent evidence suggests that integrin activation, in concert with G protein activation, might be essential for cardiomyocyte growth.In this study, our objectives were to evaluate how Gh and integrin interact to promote cardiomyocyte hypertrophy and to identify Gh molecular determinants and downstream signals involved. First, we observed the selectivity of alpha-adrenoceptors in norepinephrine(NE)-induced cardiac hypertrophy by protein synthesis and estimation of the constitutive genes MLC-2 and ß-MHC. NE-mediated hypertrophic responses activated ERK1,2 and their upstream regulators MEK1,2, which were inhibited by siRNA for Gh.We also identified significant activation of ß1-integrin in NE-induced cardiomyocyte hypertrophy. In addition, FAK and Shc, a regulator of FAK, were directly related with integrin and Gh protein in NE-induced cardiomyocyte hypertrophy. The activation of FAK and Shc were suppressed by siRNA for Gh. In conclusion, the hypertrophic response induced by norepinephrine in cardiomyocytes occurs through ß1-Integrin/Shc/FAK/MEK1,2/ERKs signal pathways via α1-AR/Gh.

640절편 MDCT를 이용한 좌심실 박출률과 좌심실 용적 측정: 2차원 심장초음파 비교

박기현 ( Ki Hyun Park ),변세진 ( Se Jin Byun ),강은규 ( Eun Gyu Kang ),박서화 ( Seo Hwa Park ),김현수 ( Hyun Soo Kim ),김민욱 ( Min Wook Kim ),이병호 ( Byung Ho Lee ),정현숙 ( Hyun Sook Jung ),윤성보 ( Seong Bo Yoon ),김영우 ( You 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2

Objectives: The assessment of global left ventricular function and volumes is important in patients with coronary artery disease (CAD) and serves as a valuable diagnostic and prognostic marker. The purpose of this study was to compare left ventricular ejection fraction (LVEF) and volume parameters as measured by 640-slice multidetector CT (MDCT) and two-dimensional transthoracic echocardiography (2D-TTE). Methods: We retrospectively analyzed 125 consecutive patients (Men=56%, mean age, 62.0±12.9 years) who underwent 640-slice MDCT to evaluate known or suspected CAD between October 2011 and March 2012. Agreement for the LVEF and volume parameters by 640-slice MDCT and 2D-TTE was assessed by Pearson’s correlation coefficient for linear regression and Bland-Altman analysis. Results: On 640-slice MDCT, average LVEF was 61.6 ± 12.6 %. On 2D-TTE, average LVEF was 62.8 ± 14.9%. Correlations between 640-slice MDCT and 2D-TTE were that LVEDV (r: 0.801, p<0.001); LVESV (r: 0.929, p<0.001) and LVEF (r: 0.862, p<0.001). Conclusions: There was a good correlation between 640-slice MDCT and 2D-TTE in the evaluation of left ventricular function and volume parameters in practical and clinical situation.