Log-Polar 변화에 기반한 눈동자 검출

최 일,오주환,류명춘 경운대학교 산업기술연구소 1999 産業技術硏究論文誌 Vol.1 No.1(B)

We present a scale and rotation invariant approach to detect the eyeballs of upright-frontal face images. The proposed method uses the Log-Polar transform which can obtain the scale and rotation invariant features from an object and an intensity-based template matching with a single template that made from a Log-Polar image of a face. Experimental results showed that the proposed method achieves 98.3% detection rate on a data set of 795 images.

안구길이, 수정체전낭-망막길이, 굴절상태 및 각막굴절력간의 상호관계

최시환,박주희,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Axial length is major determinant of ocular refractive power. The purpose of this study was to establish the interrelationship among axial length, anterior lens capsule to retina length(ACRL), refractive states, and corneal refractive power. We measured above four variables of 364 normal adult eyes. The results were as follows: 1. The mean axial length and ACRL of all 364 eyes were 24.93(±1.25mm) and 21.59(±1.20mm) respectively. 2. The mean axial length and ACRL of 63 eyes within ±1 diopter were 23.64(±0.82mm) and 20.34(±0.79mm) respectively. 3. Refractive states, axial length, and ACRL were closely associated. The coefficient of correlation between refractive states and axial length is r=-0.7542(p<0.001), the one between refractive states and ACRL is r=-0.7526(p<0.001). 4. The coefficient of correlation between corneal refractive power and axial length is r=-0.3589(p<0.001), the one between corneal refractive power and ACRL is r=-0.3727(p<0.001). 5. Axial length/ACRL ratio of 63 eyes within ±1 diopter is 1.16(±0.02).

신생검증례에 의한 사구체신질환의 분석

최두환,구시선,배승훈,박병현,안선호,송주흥 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

To elucidate the incidences and the clinical characteristics of glomerular diseases in our hospital, we reviewed the clinical records and histological findings of the 117 cases, which were diagnosed as one of the glomerular disease in renal biospy for about 6 years since 1991. In these 117 cases, 74 cases (63.2 %) fell into primary glomerulonephritis(GN), 18 cases (15.4%) into secondary GN, 2 cases (1.7 %) into end stage kidney, 4 cases (3.4%) into tubulointerstitial disease and the biopsy samples were inadequate for diagnosis in 19 cases. In primary glomerular diseases, most common pathologic diagnosis was IgA nephropathy (36.5 %}, followed by minimal change nephrotic syndrome (29.7%). The incidence of IgA nephropathy would be increased if we had biopsied every asymptomatic urinary abnormality (AUA) patients. Systemic lupus erythematosus (SLE) . hepatitis B accounted for most of secondary GN in our cases. One case of progressive scleroderma was included in this secondary GN. Minimal change nephrotic syndrome (22 cases) was the most common cause of nephrotic syndrome, followed by membranous GN (9 cases) and IgA nephropathy (8 cases). 2 cases of primary amyloidosis were presented with nephrotic syndrome. Nephrotic syndrome as presenting symptom in our IgA nephropathy patients was higher than in other studies, which may be due to indication bias for renal biopsy. We suggest that renal biopsy should be done in adult nephrotic syndrome and in SLE, because various kind of glomerular diseases can develop nephrotic syndrome in adult, renal biopsy can affect the treatment and prognosis in each patients and renal biopsy also determines the extent of renal involvement in SLE on which the treatment depends. In AUA urinary patients, renal biopsy could be reserved for the patients who show declining of GFR or rising of proteinuria. Because IgA nephropathy account for most of AUA. and there is no specific treatment for IgA nephropathy, and renal biopsy in those cases is helpful in ruling out the patients who need no treatment.

이진 배열 기법을 이용한 내포된 곡선 성분 검출에 관한 연구

최종주,위승정,양환석 서강정보대학 1997 論文集 Vol.16 No.-

The general Hough transform was not influenced to detect the external circle and ellipse for when the circle and ellipse was detected by the external noises, it was filtered in various way, and the rest image had inclused trouble in detecting, for it was regarded as the intinernal noises. So, this paper suggests the new algoritsm to detect another circle existing inside and to remove not from the general method but from the original image when the external circle detected is excluded.

대동맥-장골동맥 폐색증에 대한 경피경관 혈관성형술 및 스텐트삽입술의 누적개존율

최동현,이상목,고석환,홍성화,오수명,윤충,박호철,오주형 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

지역·지구 경계부 대지의 건축기준 적용에 관한 연구 : 개발용량에 의한 총합개념을 중심으로

최찬환,황용연,김주석 대한건축학회 2003 대한건축학회논문집 Vol.19 No.6

The purpose of this study is to analyze a problem of the application of 'Korean building code' occurred by discord a zoning line and a lot line, and to find a way out of this problem. The application of 'Korean building code' is based on the development capacity which is decided by urban planning, and it is grounded that 'the total development capacity' should not be over-estimated for the public profit. In a lot, that is including several zones, we suppose to estimate the 'floor area ratio'&'building coverate ratio', which determine the lot's development capacity, by respective zone's area ratio.

Serratia marcescens에서 cAMP receptor protein(CRP)유전자의 클로닝 및 해석

유주순,문종환,정수열,김혜선,최용락 東亞大學校附設遺傳工學硏究所 1999 遺傳工學硏究 Vol.- No.6

전사조절인자로서 잘 알려져 있는 cAMP receptor protein(CRP)은 cAMP와 DNA에 결합하는 특별한 활성을 가지고 있으며, cAMP-CRP complex를 형성하여 수많은 유전자의 발현조절에 관여한다. 이러한 측면에서 cAMP-CRP의 조절은 어떤 면에서 총체적 조절체계라고까지 한다. 본 연구는 Serratia 균주에서 crp유전자의 분자적 특성 및 cAMP에 의한 발현조절을 받는 분자기구를 해석하고자 유전자를 클로닝하고 발현을 확인하였다. MacConkey배지에서 maltose를 탄소원으로 충분히 이용하지 못하는 대장균 TP2139(△crp,△lac)를 숙주로 이용하고, 염색체DNA를 library로 작성하여 얻은 형질전환체 약 일만개의 콜로니에서 red colony를 나타내는 5종류 의 양성 클론을 얻었다. 이들 클론을 Southern방법으로 확인한 결과 3kb의 단편을 가진 pCKB12클론이 crp유전자를 coding하고 있음을 확인하였다. glpD-lacZ 융합 plasmid인 pLDC6 의 BamHI부위에 pCKB12의 3kb 단편을 삽입시킨 재조합 plasmid pLDC 6-Scrp를 작성하여, 클로닝된 Serratia 의 crp 유전자가 대장균에서 유전자 전사조절에 미치는 영향을 확인한 결과 cAMP-CRP 복합체 형성에 의한 전사조절 기능이 확인되어졌다. One of the better-characterized transcription factor of E. coli is the cAMP receptor protein(CRP) and the CRP binds cAMP and DNA. The cAMP-CRP complex is involved in regulation of many genes at bacteria. The cAMP-CRP regulatory element represents, in some respects, a global regulatory network. The aim of this work was to study the structure and the mechanisms controlling the expression of CRP in Serratia marcescens. We have been get 5 different clones from Serratia which stimulated the cells to use maltose as a sole carbon source in E. coli TP2139. The crp gene clone, pCKB12, was confirmed by Southern hybridization with E. coli crp gene. The location of the crp gene was determined by constructing subclones carrying various portions of pCKB12. To investigate the potential role of CRP in E. cloi, lacZ fused plasmids were constructed and investigated the β-galactosidase activity of the fused plasmid. The Serratia marcescens cAMP receptor protein can substitute the E. coli CRP in transcriptional activation at the lacZ gene. These results suggest that Serratia marcescens cAMP receptor protein complex functions to regulate several promoters in E. coli.

흰쥐에 있어서 Sparganum의 移行과 發育에 관한 硏究

金昌煥,徐淑才,崔朱卿 慶尙大學校 1985 論文集 Vol.24 No.1

This study was carried out to investigate the migration and development of the Sparganum in rats and the changes of haematological values in the hosts infected with Sparganum. The results obtained were summarized as follows: 1. The recovery rate of the Sparganum in the infected rats was 57 per cent on the autopical findings of the infected individual rats during observations from 2 hours to 32 days after infection with Sparganum. 2. The larval Sparganum was found in the digestive tract within two hours after administration with oral route and then, the worms began to penetrate and migrate via the abdominal cavity within 4 to 6 hours and the worms were found in the muscular tissues 2 days onwards after infections. 3. The infected Sparganum began to deveolp the size of the body from 4 day after infection and then, the size of the Sparganum was measured by 52.9mm long and 3.2mm broad on 32 days after infection . 4. In the haematological observation of the host the red blood cell values changed little, while the white blood cells were increased significantly during 2 days after infection and thereafter they were recovered to the normal values.

Streptobacillus sp.가 생산하는 pullulanase에 관한 연구

오두환,지희숙,최형택,신원철,유주현 연세대학교 산업기술연구소 1986 논문집 Vol.18 No.2

A bacterium with the highest pullulanase activity was isolated from the soil and identified as Streptobacillus sp. Y-716. The optimum culture condition of Streptobacillus sp. for the production of pullulanase was as follows; 1.2%(w/v)soluble starch, 0.7%(w/v) CH₃COONH₄, 0.05%(w/v) MgSO₄7 H₂O, 0.01%(w/v)FeSO₄7H₂O, at 30℃, for 48 hrs. The pullulanase from the culture broth of Streptobacillus sp. Y-716 was purified about 46 fold by ammonium sulfate precipitation, dialysis. DEAE-cellulose and Sephadex G-200 column chromatography. The purified enzyme was stable between pH 5.0 and pH 7.5. It was inactivated rapidly above 35℃. The Km value and Vmax of the purified enzyme were 0.0137mg/m/ and 0.666μm/min. on pullulan, respectively.

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.