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근치적 위절제술을 시행한 위암 환자에서 보조요법으로서 5-Fluorouracil, Epirubicin과 5-Epirubicil,Cisplatin의 복합화학요법의 효과 비교
최정혜,안명주,한동수,손주현,전용철,박훤겸,백홍규,이홍기,남영수 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.2
To compare 5-fluorouracil plus epirubicin (FE) to 5-fluorouracil plus cisplatin (FP) chemotherapy as adjuvant therapy for patients with resected gastric cancer. Between August 1995 and March 2000, 46 patients with completely resected gastric cancer received six courses of FE (5-fluorouracil 1000mg/m2/day, D2-D5, epirubicin 70mg/m2, D1) or FP (5-fluorouracil 1000mg/m2/day, D2-D5, cisplatin 70mg/m2, D1) chemotherapy. The 23 patients were assigned to each treatment group. A total of 127 courses of treatment were given both FE and FP group. The FP group tended to show more risk of overall death rate. But there were no differences between FE and FP groups in terms of overall survival or disease-free survival. Both treatment arms were generally well tolerated to chemotherapy. We concluded to be no significant differences between FE and FP groups in terms of overall survival or disease-free survival. To define the efficacy of adjuvant chemotherapy for gastric adenocarcinoma, further prospective randomized trials with large number of patients should be warranted.
잉어류 바이러스성전신괴사증바이러스 (VSNCV) 백신 투여에 대한 잉어의 면역반응
조미영,손상규,김이청,김진우,오명주,정성주,박수일 한국어병학회 2003 한국어병학회지 Vol.16 No.3
양식 잉어류에서 심각한 피해를 야기하고 있는 VSNCV에 대한 백신을 제작하며 잉어에 투여한 후 특이적 및 비특이적 면역반응을 조사하였다. 백신은 포르마린처리백신 (FKV)과 가온처리백신 (HKV)를 제작하여 건강한 잉어에 0.2㎖씩 복강주사 하였으며, 2주 후 동일한 방법으로 boost처리하였다. 백신 투여 후 비특이적 면역반응 중 혈청 라이소자인 활성과 대식세포의 chemiluminescent (CL) reponses은 1차 주사 후 및 boost 처리 후 2일째부터 7일째까지 유의적인 증가를 나타내었으며, 이후 대조구 수준으로 감소하였다. ELISA법으로 항체가를 조사한 결과 대조구를 제외한 FKV와 HKV 투여구에서 주사 후 2주 째부터 boost처리 후 6주 째까지 유의적으로 증가하였으며, 그 중에서도 boost 처리 후 2주 째에 VSNCV로 공격 실험한 결과 FKV 투여구에서는 20%의 누적폐사율을 나타내어 방어력이 인정 되었으나, HKV투여구에서는 70%의 누적폐사율이 나타나 방어효과가 거의 없는 것으로 나타났다. VSNC is a viral disease causing significant economic losses in cultured carp Ciprinus carpio L. in Korea. Carps were immunized with prepared vaccines against VSNCV and examined specific and nonspecific immune responses. Carps were injected by 0.2㎖ of formalin-killed vaccine(FKV), heat-killed vaccine(HKV) or E-MEM, respectively and dealt with boost with same way two weeks later. The lysozyme activity of serum and chemiluminescent reponses of head-kidney leucocytes showed increased responses during 2-7 days post-first injection(pfi) and post-boost(pb) in the vaccinated fish, and then decreased to the level of control. As measured by ELISA, vaccinated groups showed a significant increase in VSNCV-specific serum antibodies between 2 weeks pfi and 6 weeks pb with a peak at 2 weeks pb. Results of the virus challenge showed that the fish vaccinated with FKV have induced protective immunity, white HKV injection hardly provided protection.
비호지킨 림프종환자에서 proMACE-cytaBOM 복합항암화학요법의 유효성에 대한 제 2상 임상시험
김성우,안명주,박석규,이영렬,정태준,최일영,김인순 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1
Aggressive non-Hodgkin's lymphoma by REAL classification is a heterogenous group of disease. With recent advances in combination chemotherapy, the long-term survival is improved to 40-65%. We investigated twenty-one aggressive non-Hodgkin's lymphoma patients treated with pro-MACE-cytaBOM (prednisone, adriamycin, cyclophosphamide, etoposide, cytosine arabinoside, bleomycin, vincristine and methotrexated) to determine the efficacy and toxicites. There were seven patients older than 60 years. Histologic types by REAL classification were as follows : diffuse large B cell (12/21), peripheral T cell (6/21), anaplastic large cell (2/21) and angiocentric T cell (1/21). Most of patients were classified in Stage Ⅱ-Ⅳ (20/21). According to IPI (international prognostic index) score, seven patients were included in low risk, five were low-intermediate risk, three were high-intermediated risk and six were high risk group. seventeen complete responses (85%) and two partial responses (10%) were achieved. The overall response rate was 95%. The mena disease free survival was 30 months, the mean overall survival was 29 months (range:21-36), and the median overall survival was not reached. WHO grade Ⅲ/Ⅳ neutropenia or thrombocytopenia was observed in 16.7% and 2.8%, respectively. There was no treatment-related death. These results suggest that proMACE-cytaBOM combination chemotherapy is very effective and has low toxicity in the treatment of aggressive non-Hodgkin's lymphoma even treated in elderly patients.
합성 Goethite에 의한 인산이온, 황산이온 및 구리이온의 흡착 특성
김정두,유수용,문명준,감상규,주창식,이민규 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9
Adsorption of phosphate, sulfate, and copper ion to goethite was investigated. Goethite was prepared in the alkaline solution. In the single adsorbate systems, the final equilibrium plateau reached within 20 min. The adsorption isotherms of the individual ions could be well described by the Langmuir equation. The maximum adsorption capacities (q_(max)) were calculated as 0.483 mmol/g and 0.239 mmol/g at pH 3 for phosphate and sulfate ion, and 0.117 mmol/g at pH 6 for copper ion, respectively. In competitive adsorption system with phosphate and sulfate, phosphate ion was a stronger competitor for adsorption on goethite than sulfate ion, which was consistent with higher affinity of phosphate ion for the surface compared to sulfate ion. The existence of sulfate ion enhanced the adsorption of copper ion but the adsorption of sulfate was inhibited when copper ion was present.
Ju, Sung-Kyu,Park, Jung-Hyun,Na, Shin-Young,You, Kwan-Hee,Kim, Kil-Lyong,Lee, Myung-Kyu Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.2
Leptin is a circulating non-glycosylated protein that is mainly produced in adipocytes. Leptin acts in the brain to regulate food intake and energy expenditure. Previously we reported our success in the isolation of a partial cDNA of the long form of the leptin receptor, OB-Rb, from rat spleen, and showed that leptin might also play a role in peripheral immune organs. In the present study, for the first time, the complete coding region of OB-Rb cDNA was cloned from rat splenocytes, and its nucleotide sequence was determined. The cDNA was then further expressed in E. coli and mammalian cells, thereby confirming the functional integrity of this receptor. Prokaryotically overexpressed OB-R protein was then used as an immunizing antigen in BALE/c mice to produce leptin receptor-specific antibodies. By using them, we confirmed the cell surface expression of OB-Rb in transfected CHO cells. It is our belief that the reagents, as produced in this study, will be of great use in further studies of the biological role of rat leptin.