당뇨병 환자에서 발생한 대장 가성폐색증 1예

이재형,강준구,박준성,이창범,박용수,김동선,함준수,김태화,안유헌,박충기 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.2

가성 장폐색은 기계적인 폐색부위가 없이 복부팽만과 구토 등 장폐색의 증상과 징후가 나타나는 질환을 말하며, 선행원인을 찾을 수 없는 원발성 가성 장폐색과 다른 질환에 이차적으로 발생하는 속발성 가성 장폐색으로 나눌 수 있다. 당뇨병은 잘 알려진 속발성 가성 장폐색의 원인이지만 실제로 당뇨병에 의한 가상 장폐색의 발생 빈도는 매우 드문 것으로 보이며, 가성 장폐색의 적절한 치료에 대해서는 아직 논란이 있다. 저자들은 2형 당뇨병 환자에게 대장에 국한된 급성 가성 장폐색을 진단하고 보존적 치료를 시행하여 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Colonic pseudo-obstruction is a disorder characterized by gross dilatation of the colon in the absence of any anatomic lesions, which obstructs the flow of the intestinal contents. Diabetes is a well known cause of secondary pseudo-obstruction but its prevalence in rare and not well understood. A 59-year-old woman patient was admitted due to abdominal distension and nausea of a day's duration. She was diagnosed with diabetes 15 years ago, but the condition had been poorly controoled. On the abdominal radiographs, there were marked small and large bowel dilatation with the, exception of the descending colon. Our initial diagnosis was mechanical obstruction, but the possible causes were not found. Also, we could not find another cause of the secondary pseudo-obstruction, with the exception of diabetes mellitus. Thus, she was diagnosed with a diabetes induced intestinal pseudo-obstruction. The colonic dilatation was resolved by conservative management and she became comfortable in 10 hospital days, and was subsequently discharged.

지문인식의 특이점 추출 알고리즘 구현

박종민,조범준 조선대학교 전자정보통신연구소 2003 電子情報通信硏究所論文誌 Vol.6 No.1

본 논문에서는 특이점 추출에서의 과다한 추출 단계로 인하여 발생되는 문제점들을 줄이기 위하여 기존의 6단계인 특이점 추출 과정을 개선하여 3단계로 줄이면서도 정확성을 높이는 특이점 추출 알고리즘을 설계/구현하고자 한다.

대절토 암반사면의 안정화 검토 및 현장계측 분석

박범준,류권일,고영헌,김팔규 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2

We investigated the stability of rock slope caused by large-scale cutting on construction of rapid-transit railway. Applying anchor method in order to build the up, we analyzed the stability using long-term measurement. Slope stability analysis is established by STABL 5M and DIPS as basic programs. Field measurement is required to prove the stability of rock slope which results from the reinforcement corresponding to slope stability analysis. Thus, we used one ground inclinometer and 8 load-cells for the measurement system.

토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학

박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.

최근 7년간 충남 북서지역의 소아에서 발생한 쯔쯔가무시열의 임상적 고찰

권기범,박준수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : Tsutsugamushi fever has been reported in Korean children. However there are not any reports regarding children of the Northwestern Choongnam province. Hence we are reporting clinical features of the Tsutsugamushi disease in chidren of these area. Methods : We reviewed clinically or serologically confirmed 11 Children of Tsutsugamushi fever from Cheonan and Choongchung Nam Province, who were admitted to Soonchunhyang University Cheonan Hospital from October 1997 through October 2003. We investigated the age, sex ratio, clinical manifestations, laboratory findings and response to therapy. Results : The mean age of patients was 6.5 years, ranging from 2 to 14 years. 7 cases(63.6%) were bovs and 4 cases(36.4%) were girls. The mean duration of the treatment was 6.8 days. The most common symptoms were fever in all cases and cough in 2 cases (18.1%). Frequent signs were skin rash in all cases, eschar in 9 cases (81.8), regional lymphadenopathy in 3 cases (27.2%). The main locations of the eschars were neck in 3 cases(33.3%), and chest, thigh, penis, occipital, back, ear in each 1. Laboratory findings included leukopenia in 4 cases(36.3%), lejkocytosis in 3 cases(27.2%), anemia in 2, ESR elevation in 5, and positive CRP in all cases, SGOT elevation in 9 cases, SGPT elevation in 8 cases, positive passive hem agglutination test in 7 cases (63.6%). Clinical improvement was noticed in all cases after treatment with chloramphenicol, tetracycline, doxycycline, or roxythromycin. The mean duration for defervescence after treatment was 1.4 days. There were not complications or recurrence in any case. Conclusions : Tsutsugamushi fever have appeared in children of Cheonan and Choongnam Province. We should be aware of clinical manifestation such as fever, skin rash, eschar, and lymphadenopathy during the period of October and November in order to diagnose the Tsutsugamushi fever properly.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

fmGA를 이용한 하수관거정비 최적화 모델

류재나,기범준,박규홍,이차돈 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

A long-term sewer rehabilitation project consuming an enormous budget needs to be conducted systematically using an optimization skill. The optimal budgeting and ordering of priority for sewer rehabilitation projects are very important with respect to the effectiveness of investment. In this study, the sewer rehabilitation optimization model using fast-messy genetic algorithm is developed to suggest a schedule for optimal sewer rehabilitation in a subcatchment area by modifying the existing GOOSER model having been developed using simple genetic algorithm. The sewer rehabilitation optimization model using fast-messy genetic algorithm can improve the speed converging to the optimal solution relative to GOOSE , suggesting that it is more advantageous to the sewer rehabilitation in a larger-scale subcatchment area than GOOSER .

돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학

윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.

우리대학교 연구소통폐합 및 특성화추진전략에 관한 연구

이강옥,김규영,조범준,박노경 조선대학교 경영경제연구소 1999 經營經濟硏究 = Management and economics research Vol.22 No.2

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.