주요우울증이 근로자의 생산성에 미치는 영향 : WHO-HPQ(Health and Work Performance Questionnaire)를 이용한 예비연구

김원,황태연,함병주,이준석,최병휘,김세주,서용진,강은호,우종민 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Major depressive disorder (MDD) causes patients' distress and makes socioeconomic burden, both directly and indirectly. We used the concept of lost productive time (LPT) to estimate the indirect costs and calculated both absenteeism and presenteeism among workers with MDD. Mcthods : Depression group was recruited from workers visiting psychiatric outpatient clinic who had MDD without major physical or mental disorders (N= 106). Age and sex matched healthy control group was also recruited through advertisement (M=100). All participants completed a interview using WHO Health and Work Performance Questionnaire (HPQ), Job Stress Measurement Scale for Korean Employees, and Hamilton Rating Scale for Depression. Statistical analysis was performed with independent t-test or χ² test as characteristics of values (p=0.05). Results : The number of absence (0.94-day/month vs. 0.10-day/month, P=0.015) andthe numberofearly leaving (2.56-day/month vs. 0.24-day/month, P<0.001) were significantly higher in the depression group. Depression group evaluated their Perfor-mance level much lower than controls with significant value (5.16 vs. 7.62, P<0.001). In addition, depression group estimated their performance level during the last 4 weeks lower compared to the level of past 1-year (5.16 vs 6.63, P<0.001). The estimated costs of absenteeism in depression group were higher than controls by 2,520,000 Korean Won per year, and those of presenteeism were also higher by 4,880,000 Korean Won per year. The total costs of LPT in depression group were higher than controls by 7,400,000 Korean Won, which corresponds to 26% ofmean annual salary. In addition, the level of occupational stress, such as high demand and interpersonal conflict, was higher in the depression group. Conclusion : Major depressive disorder costs substantial productivity loss to workers and their company. Presenteeism imposes more time cost than absenteeism. Effectiveness trials are needed to devise cost-effective programs for the early detection and treatment of depression at the workplace.

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

필리핀 여행 후 발생한 쯔쯔가무시병 1예

김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.

압축력과 휨을 받는 Hollow Core Slab의 구조적 거동에 관한 연구

강원석,김승훈,이리형,김용남,김종수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Recently, Many engineers have used Hollow Core Slab(HCS) system on buildings. However, they couldn't apply this system to under three underground buildings, because the axial force effect hasn't yet been clearly investigated. This paper presents the test results for structural behaviors of HCS under axial and bending load. Variables are the thickness of Topping concrete and the maginitude of axial forces. The thicknesses are 100mm and l50mm. The axial forces are 0kN, 911.4kN, 1313.2kN, 1640.5kN. The results showed that HCS system has more strength capacity as the axial forces are increaser.

신경 교차연결 후 흰쥐 골격근섬유의 마이오신 동질형의 변화

이종은,이원택,강유선,박경아 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

Resin Casting Mold Process를 이용한 복합재료 펌프 제작에 관한 연구

강길호,최원종,김명식 한국항공대학교 항공우주산업기술연구소 2002 航空宇宙産業技術硏究所 硏究誌 Vol.12 No.-

본 연구에서는 vinyl ester를 복합재료의 기지로, milled fiber와 mineral filler를 강화재료로 사용하여, resin casting mold process 성형제조 방법으로 펌프 부품들을 제조하였다. 본 연구에서 제시된 제작 방법을 이용하여 부품을 제작할 경우 기존의 방법에 비해 균일한 품질보장과 함께 생산단가를 절감시킬 수 있으며 복잡한 형상제작이 가능하다. DSC 열분석과 경도시험을 수행하여 수지, 경화제, 촉진제의 비율을 결정하였고, 내식성 실험을 통해 vinyl ester의 각종 화학약품에 대한 내식 특성을 평가한 결과 다른 수지에 비해 내식성이 우수함을 알 수 있었다. 또한, 경도시험 data의 제조된 시편의 단면을 SEM으로 관찰한 결과, 수지 : milled fiber : mineral filler의 최적혼합비를 100 : 30 : 10 으로 결정할 수 있었다. 이와 같은 실험결과들을 이용하여 mold를 제작한 후 vacuum 상태에서 경화시킴으로써, 우수한 물성을 갖는 균질한 펌프 시제품 part들을 제작할 수 있었다. In this study, composite pump parts were manufactured by resin casting mold process using vinyl ester matrix, reinforcements of milled fiber and mineral filler. Comparing the fabrication method adopted in this study with other process, it is shown that composite parts manufactured by present method have higher quality, lower cost than those manufactured by conventional hand lay up process. To determine the optimum ratio of resin, hardner and accelerator, carried out a series of DSC thermal analysis, hardness test and corrosion test. The optimum mixing ratio of resin, milled fiber, and mineral filler has been determined as 100 : 30 : 10 by means of hardness test data and SEM observation.

養液栽培商品의 生産과 流通實態 및 改善方向

姜宗求,梁承烈,梁元模 順天大學校 農業科學硏究所 1993 農業科學硏究 Vol.7 No.-

To illuminate the state and countermeasure of soilless cultural production and marketing in Korea, the survey of soilless cultural production through Agricultural Agent Center, questionnaire, field investigation, and literature analysis were performed. Soilless cultural farm-houses were 82 and area was 11.1 ㏊ on September, 1992. But its area of chief producing district and kind of crops are rapidly being changed. To solve the problems of soilless culture in Korea; old age and low education of farmers, small cultural area, financial difficulty, none standardization of facilities material and none specialization of varieties for soilless culture, it must be actively put in practice for soilless cultural improvement of Korea that the technical education strengthenning, financial support by government, standardization of facilities material and variety specialization. Poor sales network and policy, poor marketing intelligence network and activities, negligent selection and packing of products become the major cause of soilless culture's failure. Therefore, spontaneous sales network organization, marketing support of Horticultural Cooperative Association and Agricultural Cooperative Association, elevation of marketing intelligence power, and continuous effort of farmer for successful selection and packing of products are essential factors for soilless cultural development of Korea. Soilless culture is a royal road to change from primary agriculture to secondary agriculture for agricultural innovation, but there are many problems in this system and it is difficult to solve that problems by only farmer's effort. Therefore, not only farmer but also researcher, scholar, related groups and government concentrate their effort on solution of soilless cultural problems.

개에서 디스템퍼 바이러스와 톡소플라즈마의 혼합 감염

강홍원,강상철,양형석,배종희,김재훈 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A 3 month-old male dog with clinical signs of anorexia, soft stool, ocular and nasal discharge, cough and respiratory distress was submitted to the Cheju National University for diagnosis. At necropsy, tan to purple-red sublobar to lobar consolidations were presented in apical and cardiac lobe of lung. Histopathologically, severe diffuse bronchointerstitial pneumonia with necrotic bronchiolitis was noted in the lung. The demyelinating encephalitis and astrocytosis were presented in cerebellum and cerebrum. Numerous round, ovoid or cluster of tachyzoites were also identified in alveolar lumen, alveolar wall and cytoplasm of macrophages in the lung. The orgasnisms were demonstrated as Toxoplasma (T) gondii by immunohistochemistry. Intranuclear or intracytoplasmic eosinophilic inclusion bodies were seen in the glial cells of the cerebellum. Canine distemper virus (CDV) specific antigens were demonstrated in the cerebellum by the immunohistochemistry. In our knowledge, this is believed to be the first confirmed report of co-infection of CDV and T gondii in dog in Korea.

판막 질환에서의 심근 섬유화 : 심근 조직을 이용한 형태학적 연구 및 혈청 생화학적 지표의 분석

강수진,박덕우,송재관,박경민,송종민,강덕현,한기훈,송현,이재원,주석중,송명근,김정선 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

사범대학 영어 강의에 대한 학생들의 인식 및 만족도 조사

강순희,서혁,신상근,이종원,이현주,최진영 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.2

이 연구는 교사교육의 국제화를 지향하는 사범대학 특성화 프로그램 개발을 위한 기초 조사 차원에서 2007학년도 1학기에 146명의 사범대학 학생들을 대상으로 전공 영어 강의에 대한 인식과 만족도 등에 대해 설문조사의 방법으로 이루어졌다. 학생들의 영어 능력에 대한 자기 평가 결과, 대부분의 학생들이 자신의 영어 능력이 영어 강의 수강에 부족하고, 영어 강의에 대한 심리적 부담이 크다는 반응을 나타냈다. 또 영어 강의가 한국어 강의에 비해 전공 지식을 쌓는 데 도움이 되었다는 반응은 이공계를 중심으로 한 기존의 연구 결과보다 상대적으로 낮게 나타나는데, 이는 사범대학 영어 강의의 운영과 관련하여 좀 더 다양하고도 효과적인 방안이 고려되어야 함을 시사한다. 영어 강의 수강 시 어려움을 묻는 질문에서 과제 발표하기, 질문하기, 보고서 작성하기의 순으로 어려움을 호소하고 있는데, 이 역시 영어 강의를 위해서는 전반적인 영어 표현 및 이해 능력 향상 이 전제되어야 하며 무엇보다도 말하기, 듣기의 구어 능력 신장이 우선되어야 함을 재확인해 준다. 영어 강의 개선안에 대한 의견으로는 평가 방법의 다양성 및 융통성 확대, 영어 강의 수강을 돕는 전공 교재의 개발, 영어 강의 내에서의 교수-학생 상호 작용 증대, 국제교류의 기회 확대 등의 순으로 높은 반응을 보였다. 이는 향후 사범대학 영어 강의와 관련한 프로그램 개발에 시사하는 바가 크다. 즉, 영어 강의 평가를 결과 중심의 평가뿐만 아니라 과정평가와 수행평가에 초점을 두고, 영어 표현이 어려운 복잡한 사고 과정이 요구되는 경우 제한적으로 국문 반응을 허용하는 방안도 고려할 만하다. 또한 학습자들에게 좀 더 상세화된 강의 교재를 제공하고, 온·오프라인을 모두 활용하여 교수와 학생의 상호작용을 활성화할 수 있는 방안을 적극적으로 탐색할 필요가 있다. 아울러 학생들이 실질적인 국제교류가 가능하도록 다양한 교류 방안 함께 구체적인 강좌 개설도 요구된다.