일반연제 : 구연 ; 하부 : 연제 10 ; 과민성 장증후군 환자에서 베타 아드레날린 수용체 활성도

강은호,이풍렬,이준행,이종철,유범희 대한소화관운동학회 2003 대한소화관운동학회 춘계학술대회 Vol.15 No.-

사업장내 폭력

강은호,Gang, Eun-Ho 대한산업보건협회 2007 산업보건 Vol.226 No.-

심인성 어지럼증에 대한 치료

강은호 대한평형의학회 2011 Research in Vestibular Science Vol.10 No.-

Serotonin Transporter and COMT Polymorphisms as Independent Predictors of Health-Related Quality of Life in Patients with Panic Disorder

강은호,최아영,김보라,이준엽,최태규,나해란,이상혁 대한의학회 2016 Journal of Korean medical science Vol.31 No.5

There is growing evidence of poor health-related quality of life (HRQOL) in patients with panic disorder (PD). However, little is known about the factors affecting HRQOL in patients with PD. The authors examined whether 5-HTTLPR tri-allelic approach and Cathechol-Omethyltransferase (COMT) Val158Met polymorphism can predict HRQOL in patients with PD controlling for sociodemographic factors and disorder-related symptom levels. The sample consisted of 179 patients with PD consecutively recruited from an outpatient clinic and age- and gender ratio-matched 110 healthy controls. The SF-36 was used to assess multiple domains of HRQOL. Hierarchical multiple regression analysis was performed to determine the independent effect of the 5-HTTLPR and COMT Val158Met on the SF-36 in panic patients. Patients with PD showed lowered HRQOL in all sub-domains of the SF-36 compared to healthy controls. The 5-HTTLPR independently and additively accounted for 2.2% of variation (6.7% of inherited variance) of perceived general health and the COMT Val158Met independently and additively accounted for 1.5% of variation (5.0% of inherited variance) of role limitation due to emotional problems in patient group. The present study suggests that specific genetic polymorphisms are associated with certain domains of HRQOL and provides a new insight on exploring the factors that predict HRQOL in patients with PD.

Platelet Serotonin Transporter Function and Heart Rate Variability in Patients with Panic Disorder

강은호,이인수,박주언,김경정,유범희 대한의학회 2010 Journal of Korean medical science Vol.25 No.4

Many studies showed abnormal serotonin transporter (5-HTT) function and heart rate variability (HRV) in panic disorder patients. The present study investigated the relationship between HRV power spectral analysis findings and platelet serotonin uptake in panic disorder patients. Short-term HRV over 5 min and platelet serotonin transporter uptake parameters (Vmax and Km) were measured both in 45 patients with panic disorder and in 30 age-matched normal healthy control subjects. Low frequency power (LF) normalized unit (nu) and LF/high frequency power (HF) were significantly higher, whereas HF and HF nu were lower in the patient group than in the control group. Vmax and Km were all significantly lower (i.e., reflects decreased 5-HTT function) in patients with panic disorder than in normal controls. In the patient group,Km was negatively correlated with LF/HF and LF nu whereas no such correlations between them were found in the control group. By multivariate analysis based on multiple hierarchical linear regression, a low Km independently predicted an increased LF nu even after controlling for age, sex, and body mass index in the patient group. These results suggest that impaired 5-HTT function is closely related to dysregulation of autonomic nervous system in panic disorder.

실시간 모바일 GIS 응용 구축을 위한 주기억장치 데이터베이스 시스템 설계 및 구현

강은호,윤석우,김경창,Kang, Eun-Ho,Yun, Suk-Woo,Kim, Kyung-Chang 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.1

최근 들어 계속되는 램 가격 하락으로 인해 대용량의 램을 사용하는 주기억장치 데이터베이스 시스템의 구축이 실현 가능하게 되었다. 주기억장치 데이터베이스는 여러 다양한 실시간 응용 분야를 위해 사용되며, 매년 CPU 속도가 60% 정도 증가되고, 메모리 속도가 10% 증가되는 현실에서, 케쉬 미스(Cache miss)를 얼마나 줄이느냐 하는 문제가 주기억장치 데이터베이스의 검색 성능 측면에서 가장 중요한 문제로 대두되고 있다. 본 논문에서는 이러한 환경을 고려한 실시간 모바일 GIS응용을 위한 주기억장치 데이터베이스 시스템을 설계 및 구현한다. 본 시스템은 크게 PDA를 사용하는 모바일 사용자를 위한 인터페이스 관리기와 가상 메모리 기법을 사용해 전체 데이터를 주기억장치에 상주시키며 관리하는 주기억 데이터 관리기, 공간 및 비 공간 질의를 처리하는 질의처리기, 새롭게 제시하는 공간 데이터를 위한 MR-트리 인덱스와 비 공간 데이터를 위한 T-트리 인덱스 구조를 관리하는 인덱스 관리기, 데이터를 디스크에 저장하기 위한 GIS 서버 인터페이스로 구성된다. 새롭게 제시하는 공간 인덱싱을 위한 MR-트리는 노트 분할이 발생될 경우, 입력 경로 상에 하나 이상의 빈 엔트리를 지니는 노드가 존재할 경우에만, 노드 분할을 상위로 전송한다. 그러므로 중간 노드들은 항상 100%에 가깝게 채워져 있게 된다. 본 논문의 실험 결과, 2차원의 MR-트리는 기존의 R-트리에 비해 2.4배 이상의 빠른 검색 속도를 나타냈다. 한편, 주 기억 데이터 관리기는 가상 메모리 제공을 위해 전체 벡터 데이터 및 MR-트리, T-트리, 데이터 객체 텍스트 정보를 페이지 단위로 분할하여 관리하고, 간접 주소 기법을 사용하여 디스크로부터의 재 로딩시 발생할 수 있는 문제점을 제거하였다. As random access memory chip gets cheaper, it becomes affordable to realize main memory-based database systems. Consequently, reducing cache misses emerges as the most important issue in current main memory databases, in which CPU speeds have been increasing at 60% per year, compared to the memory speeds at 10% per you. In this paper, we design and implement a main-memory database system for real-time mobile GIS. Our system is composed of 5 modules: the interface manager provides the interface for PDA users; the memory data manager controls spatial and non-spatial data in main-memory using virtual memory techniques; the query manager processes spatial and non-spatial query : the index manager manages the MR-tree index for spatial data and the T-tree index for non-spatial index : the GIS server interface provides the interface with disk-based GIS. The MR-tree proposed propagates node splits upward only if one of the internal nodes on the insertion path has empty space. Thus, the internal nodes of the MR-tree are almost 100% full. Our experimental study shows that the two-dimensional MR-tree performs search up to 2.4 times faster than the ordinary R-tree. To use virtual memory techniques, the memory data manager uses page tables for spatial data, non- spatial data, T-tree and MR-tree. And, it uses indirect addressing techniques for fast reloading from disk.

Effect of Biofeedback-assisted Autogenic Training on Headache Activity and Mood States in Korean Female Migraine Patients

강은호,박주언,정진상,유범희 대한의학회 2009 Journal of Korean medical science Vol.24 No.5

Biofeedback with or without combined autogenic training is known to be effective for the treatment of migraine. This study aimed to examine the effect of biofeedback treatment on headache activity, anxiety, and depression in Korean female patients with migraine headache. Patients were randomized into the treatment group (n=17) and monitoring group (n=15). Mood states including anxiety and depression, and psychophysiological variables such as mean skin temperature of the patients were compared with those of the normal controls (n=21). We found greater treatment response rate (defined as ≥50% reduction in headache index) in patients with biofeedback- assisted autogenic training than in monitoring group. The scores on the anxiety and depression scales in the patients receiving biofeedback-assisted autogenic training decreased after the biofeedback treatment. Moreover, the decrease in their anxiety levels was significantly related to the treatment outcome. This result suggests that the biofeedback-assisted autogenic training is effective for the treatment of migraine and its therapeutic effect is closely related to the improvement of the anxiety level.

공황장애의 신경생물학

강은호,유범희 대한신경정신의학회 2009 신경정신의학 Vol.48 No.4

Panic disorder is a common mental disorder that causes considerable disability. However, the etiology of panic disorder remains unclear. Preclinical neuroanatomical and neurophysiological studies have provided clues to the neurobiological basis of panic disorder, and recent developments in neurobiological techniques in neurochemical research, brain imaging, and genetic research provide a further understanding of anxiety, fear, and panic disorder. In this article, we introduce a functional neuroanatomic model of fear and anxiety, and consider the implications of recent developments and debates in neurobiological findings with respect to panic disorder. 공황장애가 단일 질환으로 분류되고 연구되기 시작한 지 는 불과 30년이 채 안 되었지만, 각종 신경생물학적 연구 기 법의 발전으로 공황장애의 병태생리 기전에 대한 구체적인 모 델들이 제시되었다. 신경해부학적 측면에서는 편도를 중심으 로 한 공포회로의 이상 가설이 제기되었으며, NE와 5-HT 를 비롯한 여러 신경전달 물질의 역할도 많이 밝혀진 상태 이다. 그러나 그럼에도 불구하고 아직 공황장애에서 신경전 달 물질의 역할에 대한 서로 상반된 의견이 팽팽한 상태이며, 신경내분비 계통이나 뇌영상 연구, 특히 유전학 분야에 대한 연구는 아직 많이 미흡한 실정이다. 따라서, 향후 이러한 부 분에 대한 추가적인 연구가 필요한 실정이며, 유전적 요인과 스트레스 같은 환경적 요인이 내부표현형(endophenotype) 으로 고려할 수 있는 신경생물학적 소견, 뇌영상 소견들과 어 떤 관련성을 보이는지에 대한 연구는 아직 초보적인 단계여 서 앞으로 이 분야에 대한 활발한 연구가 필요할 것으로 생 각된다.

한국정신분석학회 창립 31주년 기념 국제학술대회 및 마스터클래스 참여기

강은호 한국정신분석학회 2011 精神分析 (Psychoanalysis) Vol.22 No.2

정서가 및 각성수준에 대한 자가 평가 마네킹 척도개발 및 표준화

강은호,최정은,함병주,석정호,이경욱,김원,이승환,임현국,박영민,양종철,안미경,이재선,채정호,Kang, Eun-Ho,Choi, Jeong-Eun,Ham, Byung-Joo,Seok, Jeong-Ho,Lee, Kyoung-Uk,Kim, Won,Lee, Seung-Hwan,Lim, Hyun-Kook,Park, Young-Min,Yang, Jong-Chul,Ahn 대한불안의학회 2011 대한불안의학회지 Vol.7 No.2

Objectives : The Self-Assessment Manikin (SAM) developed by Bradley and Lang is a non-verbal pictorial assessment tool that measures human emotion and has been widely used. However, the pictures in SAM have not been easy for Korean subjects to understand or relate to. The authors developed a new manikin (Emotional Valence and Arousal Manikin, EVAS) modeling it after Korean faces while modifying and standardizing the SAM. Methods : Forty-one healthy subjects participated in this study. They were asked to rate the emotional valence and level of arousal using both the SAM and EVAS after being exposed to pictures of facial expressions for affective neurosciences-Korean version. The internal consistency of the EVAS and the correlation between EVAS and SAM were examined. Resuts : Internal consistencies of the valence using the EVAS were from 0.63 (surprise) to 0.82 (happiness) and those of the arousal were from 0.90 to 0.95. Correlation coefficients of the valence and arousal between the SAM and EVAS were from 0.61 (both surprise and disgust) to 0.84 (neutral) and from 0.82 (sadness) to 0.94 (fear), respectively. Conclusions : We developed a new manikin (the EVAS) for the Korean population modifying and standardizing the SAM. The EVAS demonstrated a good internal consistency and validity. As such, it can be used in the field of human emotion research.