원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

멕시코와 네팔도입 고추 유전자원의 두 가지 점무늬병에 대한 저항성

조은형,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

Pepper genetic resources consisting of introductions from Mexico and Nepal and susceptible and resistant controls were tested for resistance to gray leaf spot and to bacterial spot by serially inoculating the two disease pathogens, Stemphylium spp. first and Xanthomonas campestris pv. vesicatoria next, with application of fungicide after evaluation of resistance to gray leaf spot first. KC866, KC872, KC902, KC905 were resistant to gray leaf spot in addition to known resistance sources, KC43, KC47, KC220, KC319, KC320, KC380. KC897 was on the top of the resistance sources list, even better than KC177(163192), and was followed by KC889, KC896, KC898, all of which were introductions from Nepal.

알코올이 흰쥐 소뇌피질의 복합당질에 미치는 영향에 관한 조직화학적 연구

조지은,정길남,조운복 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-

This study was performed to investigate the effects of 10% alcohol on the changes of histological structure and glycoconjugates in rats cerebellar cortex. Sprague-Dawley rats weighing about 200~250 g were divided into control and 10% alcohol treated groups. The treated group with 10% alcohol was divided into 4 subgroups; 1, 2, 4 and 6 weeks alcohol treatment. To investigate the distribution and change of glycoconjugates, nine biotinylated lectins (DBA, SBA, PNA, BSL-1, RCA-1, sWGA, UEA-1, LCA and Con A) were applied according to the avidin-biotin-peroxidase complex methods. The morphological changes in the cerebellar cortex of the 10% alcohol groups were significant compared with the control group. In 10% alcohol groups for 2 and 4 weeks, molecular layer of cerebellar cortex was separated, and number of cells in molecular layer and Purkinje layer decreased. Purkinje cell layer and granular layer were separated. There were extended separation between molecular layer and granular layer matrix, abnormal multiplication and extention of layers. Especially, nerve cells showed histopathological lesions, such as lysis, depression and crush. Because of cerebellar Purkinje cell degeneration, Purkinje cell was fallen apart or got buried in granular layer. In 10% alcohol groups for 6 weeks, size of cerebellar cortex decreased and number and size of cells were also decreased. The change in RCA-1 binding was similar to both drinking and control groups. sWGA binding compared with the control group was decreased 2 and 4 weeks alcohol drinking groups, but showed tendency to increase in 6 weeks group. All lectins binding except sWGA and RCA-1 appeared tendency to increase in drinking groups, especially, LCA binding was notably increased in 6 weeks alcohol drinking group. In conclusion, the present study suggests that alcohol induce significant changes in the morphological structures and glycoconjugates in the rat cerebellar cortex. 흰쥐 소뇌피질의 형태적 구조와 복합당질에 알코올이 미치는 영향을 규명하기 위해 체중 200~250g의 Sprague-Dawley계 흰쥐를 대조군과 알코올음용군으로 나누고 알코올음용군은 10% 알코올을 계속 음용시켜 1주군, 2주군, 4주군, 6주군으로 나누어 연구하였다. 소뇌 피질의 복합당질의 양상을 9종의 biotinylated lectin(DBA, SBA, PNA, RCA-1, sWGA, UEA-1, LCA, Con A, BSL-1)으로 관찰하였다. 알코올음용군에서 소뇌피질의 형태적인 변화를 관찰한 결과 음용기간에 따라 현저한 변화가 나타났다. 알코올음용 1주군에서 대조군과 유의미한 변화가 나타나지 않았으나, 알코올음용 2주 및 4주군의 소뇌피질의 분자층 세포들과 조롱박세포의 수가 크게 줄어들었으며 조롱박층이 과립층과 분리되는 경향이 나타났고 분자층과 과립층 기질이 나누어지며 비정상적인 증식 및 층의 확장 경향이 나타났다. 특히 신경세포들이 용해되거나 신경세포의 모양이 찌그러지고 함몰되는 현상이 나타났으며, 소뇌 조롱박세포의 변성으로 조롱박 세포가 탈락되어지거나, 과립층에 묻혀 구분되지 않는 현상도 나타났다. 알코올음용 6주군에서는 전체적인 소뇌피질의 크기 감소와 더불어 신경세포의 수와 크기가 크게 감소하며 조롱박세포의 함몰, 찌그러짐, 용해현상이 심하게 나타나며 신경세포 이상증식에 의한 다층화가 나타났다. 알코올음용군 흰쥐 소뇌피질의 세포들의 복합당질에 대한 렉틴결합양상은 RCA-1의 경우 대조군에 비해 변화가 없었으나, sWGA는 알코올음용 2주군, 4주군에서 대조군에 비해 감소되었다가 알코올음용 6주군에서 회복되는 경향을 보였다. 그 외 렉틴반응은 증가하는 경향을 나타내었으며 특히 LCA는 알코올음용 6주군에서 많이 증가하였다. 이상의 결과로 보아 알코올섭취는 소뇌피질의 신경세포의 형태적 변화 그리고 복합당질 대사에 심한 영향을 미치는 것으로 사료된다.

청소년의 스마트폰 중독과 우울 및 불안과의 관계

김경은,김필송,민주연,박수경,신서인,이지은,정해인,조호정,최정원,최정인 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to investigate the relationships between the degree of smart phone addiction among adolescents and their depression and anxiety levels. Method: In this study, 379 high school students were selected using the convenient sampling method. The instruments used for this study were smart phone addiction measure, the CES-D (Center for Epidemiological Studies-Depression Scale), and the STAI (State-Trait Anxiety Inventory). Data were analyzed using the SPSS 20.0 program with descriptive statistics, t-test, ANOVA with Scheffe test, and Pearson’s correlation coefficient. Result: The mean score for smart phone addiction was 40.45±17.27, depression was 36.56±9.58, state anxiety was 44.00±9.61, and trait anxiety was 45.70±9.75. There were significant differences between the degree of smart phone addiction and the following variables: gender (t=-4.953, p<.001), hours of smart phone use per day (F=12.259, p<.001), types of frequently used features (F=3.485, p=.008), and satisfaction level for smart phone (F=5.18, p<.001). There were statistically significant relationships (p<.001) among degree of smart phone addiction, depression level, and state and trait anxiety levels. Conclusion: The results of this study suggested that there was a significant relationship between smart phone addiction and mental health, specifically, depression and anxiety among adolescents. Further research is needed to develop nursing strategies to provide care for adolescents who frequently utilize smart phones.

장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

악성종양환자와 정상인이 발성한 모음의 좁은대역 스펙트럼값의 상관계수와 절대차이합 비교

양병곤,왕수건,조철우,김형순,김은지,권순복 한국음성과학회 2003 음성과학 Vol.10 No.4

The objective of this study was to examine two new parameters by which we could screen people with malignant vocal folds. The new parameters were the difference sums and Pearson correlation coefficients between adjacent pairs of intensity level matrices of narrow-band spectra. Audio files from the Korean Disordered Speech Database were analyzed by Praat, a speech analysis softWare, to obtain matrices of 400 intensity levels at 16 time points of each sustained vowel spectra. We limited our study to 12 normal subjects and 20 patients with malignant vocal folds who recorded at least three Korean vowels at a sound-proofed booth in Busan National University Hospital. Results indicated that the average coefficients of the abnormal subjects were much lower than those of the normal subjects while the average difference sums of the patients were much higher than those of the normal ones. Also, we found that the degree of the malignancy of the vocal folds was related to the coefficients and sums. However, some subjects at the initial stages of cancerous vocal folds yielded almost comparable coefficients and difference sums to those of the normal speakers. Further studies on larger databases will be desirable to set certain criteria or threshold levels for screening people with vocal fold diseases.

음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

Pulmonary Embolism in First trimester

( Eun Ji Jo ),( Yeon Ji Joo ),( Ga Hyun Son ),( Keun Young Lee ),( Ji Eun Song ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Pulmonary embolism is the leading cause of maternal mortality in the developed world. A-32-year-old nulliparous woman at 10+4 weeks of gestation was referred to our hospital via 119 for the loss of consciousness(LOC). When arrived at ER, she recovered her consciousness but, her vital sign was unstable: hypotension(65/54mmHg); tachycardia(175bpm); dyspnea. Fetal sonography showed fetus with normal heart beat(153bpm/min). Laboratory tests revealed D-dimer 30.4 ug/mL, troponin I 613.9 pg/mL, and metabolic acidosis (pH 7.34). The echocardiogram showed 4x2cm sized thrombus in right atrium. Chest CT revealed multiple thrombus in Rt. atrium, both pulmonary artery, and Inferior vena cava(IVC). Emergent thromobo-embolectomy was performed under extracorporeal membrane oxygenation(ECMO). Postoperatively, she went to ICU with ECMO under sedation, keeping intubation state. Postoperative fetal sonography showed missed abortion. On the postoperative day(POD)#3, she was still hemodynamically unstable with 14% of ejection fraction(EF), and almost akinetic Lt ventricle on echocardiogram. And fever up to 37.9℃, and elevated CRP(35.1mg/L) were developed under ECMO state: Inflammatory crisis resulting from missed abortion was suspected. We planned to perform emergent D&C on the day, but we postponed due to her abrupt unstable hypotension. On the POD#4 of thrombo-embolectomy, she was still unconscious with ECMO, but EF was improved up to 55%. Emergent D&C was performed successfully on the day. Next day, her condition was dramatically improved, and showed hemodynamically stable condition. Echocardiogram showed favorable EF, and she got alert mentality. ECMO weaning was successfully performed on the POD#2 of D&C. She transferred to general ward on the POD#3 of D&C without any complication. Although the risk of VTE events is similar in all three trimesters, it is rare to develop PE due to VTE in the first trimester. Herein, we report a successful treatment of PE in the first trimester.

Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells

( Ji Hyun Shin ),( Dong Jun Bae ),( Eun Sung Kim ),( Han Byeol Kim ),( So Jung Park ),( Yoon Kyung Jo ),( Doo Sin Jo ),( Dong Gyu Jo ),( Sang Yeob Kim ),( Dong Hyung Cho ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4

Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and identified mefl oquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefloquine-treated RPE cells. Treatment with mefloquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefloquine-treated cells by enhancing autophagic fl ux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefloquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefloquine positively regulates the elongation of primary cilia in RPE cells.