Metabolic Risk Factors Are Associated with the Disease Severity and Prognosis of Hepatitis B Virus-Related Acute on Chronic Liver Failure

Chen Lu,Dai Jinjin,Xie Qing,Wang Xiaolin,Cai Wei 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.3

Background/Aims: Metabolic risk factors could accelerate hepatitis B virus (HBV)-related mortality; however, their impacts on disease severity in HBV-related acute on chronic liver failure (HBV-ACLF) patients remain unexplored. In this study, we assessed the effects of metabolic risk factors on the outcome of HBV-ACLF patients. Methods: This study retrospectively enrolled antiviral therapy naïve HBV-ACLF patients from a single center in China. Patients were evaluated according to Child-Turcotte-Pugh score, Model for End-Stage Liver Disease (MELD) score, 30-day, 90-day mortality and survival rate to estimate the prognosis of HBV-ACLF. The impacts of different metabolic risk factors were further analyzed. Results: A total of 233 patients, including 158 (67.8%) with metabolic risk factors and 75 (32.2%) without metabolic risk factors, were finally analyzed. Patients with metabolic risk factors had significantly higher MELD score (22.6±6.1 vs 19.8±3.8, p<0.001), 90-day mortality rate (56.3% vs 38.7%, p=0.017), and shorter median survival time (58 days vs 75 days: hazard ratio, 1.553; 95% confidence interval, 1.061 to 2.274; p=0.036) than patients without them. Moreover, metabolic risk factors were independently associated with patients’ 90-day mortality (hazard ratio, 1.621; 95% confidence interval, 1.016 to 2.585; p=0.043). Prediabetes/diabetes and hypertension were related to higher rates of infection and worse renal function in HBV-ACLF patients. Conclusions: HBV-ACLF patients with metabolic risk factors, especially prediabetes/diabetes or hypertension, could have more severe disease and lower survival rates. In addition, the existence of metabolic disorder is an independent risk factor for HBV-ACLF patients’ 90-day mortality.

Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus

Guo, Jinjin,Zhu, Tongbo,Collins, LeaAnn,Xiao, Zhi-Xiong J.,Kim, Sung-Hoon,Chen, Chang-Yan Alan R. Liss, Inc 2007 Molecular carcinogenesis Vol.46 No.2

<P>The Phellinus Linteus (PL) mushroom has been shown to possess anti-tumor properties. Through influencing lymphocytes, PL indirectly augments the host's immune system against cancer cells. PL has also been demonstrated to reduce tumor proliferation. However, the mechanisms of PL against malignant growth have not yet been fully explored. In this study, we report that PL mediates the following two activities in mouse and human lung cancer cells: cell-cycle arrest at a low concentration of PL and apoptosis in response to a high dose of PL. After exposure to a low dose of PL, G<SUB>1</SUB> growth arrest occurred in the lung cancer cells. The negative growth control mediated by PL is evidenced by the decrease of the activities of cyclin-dependent kinases CDK2, 4, and 6. In contrast, at high doses, PL-induced lung cancer cells to undergo apoptosis in a dose-dependent fashion. This was evidenced by DNA fragmentation, caspase activation, and loss of clonogenecity in the lung cancer cells, all of which were lacking in the lung cancer cells treated with low concentrations of PL as well as the normal mouse lung epithelial cells exposed to either low or high concentrations of PL. The addition of the caspase inhibitor Z-VADfmk completely suppressed PL-induced apoptosis. Furthermore, the low dose of PL was able to synergize with doxorubicin to induce apoptosis in the lung cancer cells. Thus, our findings suggest that PL regulates two responses in the lung cancer cells: cell-cycle arrest and apoptosis. © 2006 Wiley-Liss, Inc.</P>

Dual Targeting-Integrated Nanogel with On-Demand Drug Delivery Inhibits Progression of Highly Metastatic Malignancy

Jianxun Ding,Jinjin Chen,Weiguo Xu,Xiuli Zhuang,Xuesi Chen 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Genomic Characteristics and the Potential Clinical Implications in Oligometastatic Non–Small Cell Lung Cancer

Rongxin Liao,Kehong Chen,Jinjin Li,Hengqiu He,Guangming Yi,Mingfeng Huang,Rongrong Chen,Lu Shen,Xiaoyue Zhang,Zaicheng Xu,Zhenzhou Yang,Yuan Peng 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose Oligometastatic non–small cell lung cancer (NSCLC) patients have been increasingly regarded as a distinct group that could benefit from local treatment to achieve a better clinical outcome. However, current definitions of oligometastasis are solely numerical, which are imprecise because of ignoring the biological heterogeneity caused by genomic characteristics. Our study aimed to profile the molecular alterations of oligometastatic NSCLC and elucidate its potential difference from polymetastasis. Materials and Methods We performed next-generation sequencing to analyze tumors and paired peripheral blood from 77 oligometastatic and 21 polymetastatic NSCLC patients to reveal their genomic characteristics and assess the genetic heterogeneity. Results We found ERBB2, ALK, MLL4, PIK3CB, and TOP2A were mutated at a significantly lower frequency in oligometastasis compared with polymetastasis. EGFR and KEAP1 alterations were mutually exclusive in oligometastatic group. More importantly, oligometastasis has a unique significant enrichment of apoptosis signaling pathway. In contrast to polymetastasis, a highly enriched COSMIC signature 4 and a special mutational process, COSMIC signature 14, were observed in the oligometastatic cohort. According to OncoKB database, 74.03% of oligometastatic NSCLC patients harbored at least one actionable alteration. The median tumor mutation burden of oligometastasis was 5.00 mutations/Mb, which was significantly associated with smoking, DNA damage repair genes, TP53 mutation, SMARCA4 mutation, LRP1B mutation, ABL1 mutation. Conclusion Our results shall help redefine oligometastasis beyond simple lesion enumeration that will ultimately improve the selection of patients with real oligometastatic state and optimize personalized cancer therapy for oligometastatic NSCLC.

Prediction of black tea fermentation quality indices using NIRS and nonlinear tools

Chunwang Dong,Hongkai Zhu,Jinjin Wang,Haibo Yuan,Jiewen Zhao,Quansheng Chen 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4

Catechin content, the ratio of tea polyphenols and free amino acids (TP/FAA), as well as the ratio of theaflavins and thearubigins (TFs/TRs) are important biochemical indicators to evaluate fermentation quality. To achieve rapid determination of such biochemical indicators, synergy interval partial least square and extreme learning machine combined with an adaptive boosting algorithm, Si-ELM-AdaBoost algorithm, were used to establish quantitative analysis models between near infrared spectroscopy (NIRS) and catechin content and between TFs/TRs and TP/FAA, respectively. The results showed that prediction performance of the Si-ELM-AdaBoost mixed algorithm is superior than that of other models. The prediction results with root-mean-square error of prediction ranged from 0.006 to 0.563, the ratio performance deviation values exceeded 2.5, and predictive correlation coefficient values exceeded 0.9 in the prediction model of each biochemical indicator. NIRS combined with Si-ELMAdaBoost mixed algorithm could be utilized for online monitoring of black tea fermentation. Meanwhile, the AdaBoost algorithm effectively improved the accuracy of the ELM model and could better approach the nonlinear continuous function.

Ginsenoside compound K protects against cerebral ischemia/ reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy

Qingxia Huang,Jing Li,Jinjin Chen,Zepeng Zhang,Peng Xu,Hongyu Qi,Zhaoqiang Chen,Jiaqi Liu,Jing Lu,Mengqi Shi,Yibin Zhang,Ying Ma,Daqing Zhao,Xiangyan Li The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3

Background: Ginsenoside compound K (CK), the main active metabolite in Panax ginseng, has shown good safety and bioavailability in clinical trials and exerts neuroprotective effects in cerebral ischemic stroke. However, its potential role in the prevention of cerebral ischemia/reperfusion (I/R) injury remains unclear. Our study aimed to investigate the molecular mechanism of ginsenoside CK against cerebral I/R injury. Methods: We used a combination of in vitro and in vivo models, including oxygen and glucose deprivation/reperfusion induced PC12 cell model and middle cerebral artery occlusion/reperfusion induced rat model, to mimic I/R injury. Intracellular oxygen consumption and extracellular acidification rate were analyzed by Seahorse multifunctional energy metabolism system; ATP production was detected by luciferase method. The number and size of mitochondria were analyzed by transmission electron microscopy and MitoTracker probe combined with confocal laser microscopy. The potential mechanisms of ginsenoside CK on mitochondrial dynamics and bioenergy were evaluated by RNA interference, pharmacological antagonism combined with co-immunoprecipitation analysis and phenotypic analysis. Results: Ginsenoside CK pretreatment could attenuate mitochondrial translocation of DRP1, mitophagy, mitochondrial apoptosis, and neuronal bioenergy imbalance against cerebral I/R injury in both in vitro and in vivo models. Our data also confirmed that ginsenoside CK administration could reduce the binding affinity of Mul1 and Mfn2 to inhibit the ubiquitination and degradation of Mfn2, thereby elevating the protein level of Mfn2 in cerebral I/R injury. Conclusion: These data provide evidence that ginsenoside CK may be a promising therapeutic agent against cerebral I/R injury via Mul1/Mfn2 mediated mitochondrial dynamics and bioenergy.

Piezoelectric Shunt Damping by Synchronized Switching on Negative Capacitance and Adaptive Voltage Sources

Ehtesham Mustafa Qureshi,Xing Shen,JinJin Chen 한국항공우주학회 2014 International Journal of Aeronautical and Space Sc Vol.15 No.4

Synchronized switch damping (SSD) techniques have recently been developed for structural vibration control using piezoelectric materials. In these techniques, piezoelectric materials are bonded on the vibrating structure and shunted by a network of electrical elements. These piezoelectric materials are switched according to the amplitude of the excitation force to damp vibration. This paper presents a new SSD technique called ‘synchronized switch damping on negative capacitance and adaptive voltage sources’ (SSDNCAV). The technique combines the phenomenon of capacitance transient charging and electrical resonance to effectively dampen the structural vibration. Also, the problem of stability observed in the previous SSD techniques is effectively addressed by adapting the voltage on the piezoelectric patch according to the vibration amplitude of the structure. Analytical expressions of vibration attenuation at the resonance frequency are derived, and the effectiveness of this new technique is demonstrated, for the control of a resonant cantilever beam with bonded piezoelectric patches, by comparing with SSDI, SSDVenh, and SSDNC techniques. Theoretical predictions and experimental results show the remarkable vibration damping capability of SSDNCAV technique, which was better than the previous SSD techniques. The broadband vibration control capabilities of SSDNCAV technique are also demonstrated, which exceed those of previous SSD techniques.

Piezoelectric shunt damping by synchronized switching on negative capacitance and adaptive voltage sources

Qureshi, Ehtesham Mustafa,Shen, Xing,Chen, JinJin The Korean Society for Aeronautical and Space Scie 2014 International Journal of Aeronautical and Space Sc Vol.15 No.4

Synchronized switch damping (SSD) techniques have recently been developed for structural vibration control using piezoelectric materials. In these techniques, piezoelectric materials are bonded on the vibrating structure and shunted by a network of electrical elements. These piezoelectric materials are switched according to the amplitude of the excitation force to damp vibration. This paper presents a new SSD technique called 'synchronized switch damping on negative capacitance and adaptive voltage sources' (SSDNCAV). The technique combines the phenomenon of capacitance transient charging and electrical resonance to effectively dampen the structural vibration. Also, the problem of stability observed in the previous SSD techniques is effectively addressed by adapting the voltage on the piezoelectric patch according to the vibration amplitude of the structure. Analytical expressions of vibration attenuation at the resonance frequency are derived, and the effectiveness of this new technique is demonstrated, for the control of a resonant cantilever beam with bonded piezoelectric patches, by comparing with SSDI, SSDVenh, and SSDNC techniques. Theoretical predictions and experimental results show the remarkable vibration damping capability of SSDNCAV technique, which was better than the previous SSD techniques. The broadband vibration control capabilities of SSDNCAV technique are also demonstrated, which exceed those of previous SSD techniques.

Vibration control laws via shunted piezoelectric transducers: A review

Ehtesham Mustafa Qureshi,Xing Shen,JinJin Chen 한국항공우주학회 2014 International Journal of Aeronautical and Space Sc Vol.15 No.1

Attaching a piezoelectric transducer to a vibrating structure, and shunting it with an electric circuit, gives rise to different passive, semi-passive, and semi-active control techniques. This paper attempts to review the research related to structural vibration control, via passive, semi-passive, and semi-active control methods. First, the existing electromechanical modeling is reviewed, along with the modeling methods. These range from lumped parameters, to distributed parameters modeling of piezostructural systems shunted by electrical networks. Vibration control laws are then discussed, covering passive, semi-passive, and semi-active control techniques, which are classified according to whether external power is supplied to the piezoelectric transducers, or not. Emphasis is placed on recent articles covering semi-passive and semi-active control techniques, based upon switched shunt circuits. This review provides the necessary background material for researchers interested in the growing field of vibration damping and control, via shunted piezostructural systems.

Vibration control laws via shunted piezoelectric transducers: A review

Qureshi, Ehtesham Mustafa,Shen, Xing,Chen, JinJin The Korean Society for Aeronautical and Space Scie 2014 International Journal of Aeronautical and Space Sc Vol.15 No.1

Attaching a piezoelectric transducer to a vibrating structure, and shunting it with an electric circuit, gives rise to different passive, semi-passive, and semi-active control techniques. This paper attempts to review the research related to structural vibration control, via passive, semi-passive, and semi-active control methods. First, the existing electromechanical modeling is reviewed, along with the modeling methods. These range from lumped parameters, to distributed parameters modeling of piezostructural systems shunted by electrical networks. Vibration control laws are then discussed, covering passive, semi-passive, and semi-active control techniques, which are classified according to whether external power is supplied to the piezoelectric transducers, or not. Emphasis is placed on recent articles covering semi-passive and semi-active control techniques, based upon switched shunt circuits. This review provides the necessary background material for researchers interested in the growing field of vibration damping and control, via shunted piezostructural systems.