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Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.
Jing Xiang,Tian-Tian Yang,Lu-Lu Fu,Ya Luo,Jia-Shou Wu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
The reactions of hydrated CdCl2, MnCl2, and NiCl2 with 2,2'-bipyidine-3,3',6,6'-tetracarboxylic acid (H4bptc) afforded the mononuclear [CdII(H2bptc)(H2O)3]·H2O (1), linear {[Cd(H2bptc)(H2O)]·3H2O}n (2), 3-D heterobimetallic [NaCd(Hbptc)(H2O)] (3), layer [Mn(H2bptc)(H2O)]n (4) and a dinuclear compound [Ni2(H2bptc)- (H2O)2]·6H2O (5). These compounds have been characterized by elemental analysis, IR, and their structures have been determined by X-ray crystallography. The thermal stabilities of 1-3 were measured by thermogravimetric analysis (TGA) and their solid state luminescence properties together with the free ligand H4bptc were investigated at room temperature.
Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
Jing Lu Liang,Umair Javed,이승호,박재규,장영동 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Aseries of 6-deoxymollugins were prepared fivesteps from benzaldehyde and its derivatives via phenylboronicacid-catalyzed chromenylation as a key step. Theirinhibitory activities against tyrosinase from mushroom wereevaluated to show that the parent, methyl 2,2-dimethyl-2Hbenzo[h]chromene-5-carboxylate (9a) showed best andpromising inhibitory activity at IC50 = 18.3 lM.
Jing Lu Liang,장영동,Hyo Chang Cha,이승호,손종근,장현욱,Ji-Eun Eom,권영주 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3
A new procedure for the preparation of emodin carbaldehyde and citreorosein was described, in which, ω,ω’-dibromomethylemodin triacetate was prepared as a key intermediate by NBSmediated bromination of 1,3,8-triacetylemodin. Reduction of emodin and citreorosein with SnCl2 in a 1:1 mixture of HOAc and HCl afforded the corresponding anthrones in 90% and 92% yield, respectively, while the corresponding 10-desoxyemodin carbaldehyde was prepared by MnO2 oxidation of 10-desoxycitreorosein. 10-Desoxycitreorosein and emodin carbaldehyde showed feasible μ-calpain inhibitory activities with IC50 values of 20.15 and 25.77 M, respectively.
The Economic and Political System of Hong Kong Special Administrative Region
Lu, Jing-Hua(여정화) 경성대학교 인문과학연구소 2016 인문학논총 Vol.42 No.-
홍콩특별행정구(香港特别行政区)는 홍콩섬(香港島, 향항도)과 주룽반도(九竜半島, 구룡반도), 신제(新界, 신계)와 그 밖의 230개의 부속도서로 구성되어 있는 중국의 특별행정구이다. 1840년 아편 전쟁 이후 영국에 의해 점령 된 홍콩은 중국과 영국의 여러 번의 논의 후 1997년 드디어 중국에 반환과 함께 중국홍콩특별행정구가 수립되었다. 홍콩은 중국의 영토이다. 그러나 1941년에 일본이 홍콩을 점령한 뒤 1945년에 다시 해방되었으며 국공내전으로 인해 영국에 다시 점령되었다. “기본법”, “영국-중국 공동 선언”, “일국양제”에 따라 홍콩은 1997년 7월 1일부터 2047년 6월 30일까지 50년간 외교와 국방을 제외한 고도의 자치권이 인정되는 특별행정구의 지위를 유지하도록 되어있다. 지금까지 중국 국내에서 가장 높은 수준의 자율성을 보유하고 있다. 본 논문은 홍콩특별행정구의 중국 반환 20주년에 맞춰 ‘일국양제’의 특징과 시사점을 분석했으며 학계의 많은 관심을 이끌기 위해, 특히 홍콩의 경제와 정치 구조에 대한 분석을 했다. 이러한 독특한 특성은 매우 시의성이 높으며 한국과 다른 체제제도를 유지하는 중국을 이해하는데 도움을 주는 내용으로 구성되어 있다. Hong Kong is China"s territory since ancient times, which have been occupied by Britain after the Opium War of 1840. Since 1979, China and the United Kingdom have began to discuss the issue about Hong Kong several times. In accordance with the Basic Law, the Sino-British Joitnt Declaration and one country and two systems principle, New Territories, New Kowloon and other areas in Hongkong officially handed over to China in July 1, 1997. Comparing with other provinces, Hong Kong Special Administrative Region has a high degree of autonomy. Since the system of Hongkong Special Administrative Region is an innovative system of national political system, this paper just make a preliminary analysis on the political and economic structure of the Hong Kong Special Administrative Region, in order to arouse many academics" attention that continue to explore this rich system constitute, distinctive characteristics of power relations and structure power. The institutional practice of Hong Kong has unique status on the national governance system and governance modernization.
Jing-Guang Lu,Yingwei Wang,Ming-Rong Yang,Cai-Yun Wang,Jieru Meng,Jiazheng Liu,Zifeng Yang,Kongsong Wu,Li-Ping Bai,Guo-Yuan Zhu,Zhi-Hong Jiang 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9
(±)-Decumicorine A ( 1 ) and (±)- epi -decumicorine A ( 2 ), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purifi ed from the rhizomes of Corydalis decumbens . The separation of (±)- 1 and (±)- 2 was achieved by chiral HPLC to produce four optically pure enantiomers. The structures and absolute confi gurations of compounds (−)- 1 , (+)- 1 , (−)- 2 , and (+)- 2 were elucidated by spectroscopic analysis, ECD calculations, and X-ray crystallographic analyses. The two racemates were generated from a Diels-Alder [4 + 2] cycloaddition between jatrorrhizine and ferulic acid in the proposed biosynthetic pathways, which were fully verifi ed by a biomimetic synthesis. Moreover, compound (+)- 1 exhibited an antiviral entry eff ect on SARS-CoV-2 pseudovirus by blocking spike binding to the ACE2 receptor on HEK-293T-ACE2 h host cells.
A 12-bit Hybrid Digital Pulse Width Modulator
Jing Lu,Ho Joon Lee,Yong-Bin Kim,Kyung Ki Kim 한국산업정보학회 2015 한국산업정보학회논문지 Vol.20 No.1
In this paper, a 12-bit high resolution, power and area efficiency hybrid digital pulse width modulator (DPWM) with process and temperature (PT) calibration has been proposed for digital controlled DC-DC converters. The hybrid structure of DPWM combines a 6-bit differential tapped delay line ring-mux digital-to-time converter (DTC) schema and a 6-bit counter-comparator DTC schema, resulting in a power and area saving solution. Furthermore, since the 6-bit differential delay line ring oscillator serves as the clock to the high 6-bit counter-comparator DTC, a high frequency clock is eliminated, and the power is significantly saved. In order to have a simple delay cell and flexible delay time controllability, a voltage controlled inverter is adopted to build the deferential delay cell, which allows fine-tuning of the delay time. The PT calibration circuit is composed of process and temperature monitors, two 2-bit flash ADCs and a lookup table. The monitor circuits sense the PT (Process and Temperature) variations, and the flash ADC converts the data into a digital code. The complete circuits design has been verified under different corners of CMOS 0.18um process technology node.
Lu, Zhi-Hao,Yang, Li,Yu, Jing-Wei,Lu, Ming,Li, Jian,Zhou, Jun,Wang, Xi-Cheng,Gong, Ji-Fang,Gao, Jing,Zhang, Xiao-Tian,Li, Jie,Li, Yan,Shen, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: Weight loss during chemotherapy has not been exclusively investigated. Macrophage inhibitory cytokine-1 (MIC-1) might play a role in its etiology. Here, we investigated the prognostic value of weight loss before chemotherapy and its relationship with MIC-1 concentration and its occurrence during chemotherapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Materials and Methods: We analyzed 157 inoperable locally advanced or metastatic ESCC patients receiving first-line chemotherapy. Serum MIC-1 concentrations were assessed before chemotherapy. Patients were assigned into two groups according to their weight loss before or during chemotherapy:>5% weight loss group and ${\leq}5%$ weight loss group. Results: Patients with weight loss>5% before chemotherapy had shorter progression-free survival period (5.8 months vs. 8.7 months; p=0.027) and overall survival (10.8 months vs. 20.0 months; p=0.010). Patients with weight loss >5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. Furthermore, serum MIC-1 concentration was closely related to weight loss before chemotherapy (p=0.001) Conclusions: Weight loss both before and during chemotherapy predicted poor outcome in advanced ESCC patients, and MIC-1 might be involved in the development of weight loss in such patients.