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RISS 인기검색어
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- 저자 : Mengqi Shi (검색결과 4 건)
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Shi-Ting Feng,Mengqi Huang,Zhi Dong,Ling Xu,Yin Li,Yingmei Jia,Huasong Cai,Bingqi Shen,Zi-Ping Li 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.3
Objective: To explore whether MRI fusion technology (combined T2-weighted imaging [T2WI] and fat-suppressed T2WI [T2WI-FS]) improves signal differences between anal fistulas and surrounding structures. Materials and Methods: A total of 32 patients with confirmed diagnoses of anal fistula were retrospectively studied. All available T2WI and T2WI-FS images for each patient were used to generate fusion image (T2WI-Fusion) based on the addition of gray values obtained from each pixel via an MR post-processing work station. The discriminability of fistula, perianal sphincter, and perianal fat in T2WI, T2WI-FS, and T2WI-Fusion images was quantified with Fisher’s scoring algorithm. For subjective visual image assessment by researchers, five-point scale scores were determined using a modified double-stimulus continuous qualityscale test to evaluate T2WI-FS, T2WI, enhanced axial three-dimensional-volumetric interpolated breath-hold examination (3D-VIBE), and T2WI-Fusion sequence images. The differences were subsequently compared. Results: Mean Fisher scores for fistulas vs. sphincters obtained from T2WI-Fusion (FFusion-fistula = 6.56) were significantly higher than those from T2WI (FT2WI-fistula = 3.35) (p = 0.001). Mean Fisher scores for sphincters vs. fat from T2WI-Fusion (FFusion-sphincter = 10.84) were significantly higher than those from T2WI-FS (FSFS-sphincter = 2.57) (p = 0.001). In human assessment, T2WI-Fusion showed the same fistula discriminability as T2WI-FS, and better sphincter discriminability than T2WI. Overall, T2WI-Fusion showed better discriminability than T2WI, T2WI-FS, and enhanced 3D-VIBE images. Conclusion: T2WI and T2WI-FS fusion technology improves signal differences between anal fistulas and surrounding structures, and may facilitate better evaluation of anal fistulas and sphincters.
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Mengqi Song,Qian Zhao,Xiuting Wang,Chuan Shi,Xiao Hu,Jiwei Li 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9
In this study, an asymmetric wettable composite wound dressing consists of hydrophobic polyvinylidene fluoride(PVDF) outer layer and a hydrophilic polydopamine (PDA) coated Ag nanoparticles (Ag NPs)/PVDF layer (PVDF-Ag-PDA) was successfully prepared through electrospinning and PDA coating. The results show that the contact angle of thePVDF surface is 132.8 °, while the PDA-coated surface is nearly 0 °, indicating an asymmetric wettability. The highlyhydrophilic PVDF-Ag-PDA layer can significantly reduce bacterial growth, while the PVDF layer with a small pore size andhigh hydrophobicity can prevent bacterial adherence. In addition, cytotoxic assays showed that PVDF/PVDF-Ag-PDApresent a high cell viability percentage (above 80 %), which is attributed to that the thin layer of PDA can alleviate thecytotoxicity of Ag NPs. Therefore, the Janus wound dressing noted as PVDF/PVDF-Ag-PDA has the potential for practicalapplications with the advantages mentioned above.
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( Suxia Bao ),( Jianming Zheng ),( Ning Li ),( Chong Huang ),( Mingquan Chen ),( Qi Cheng ),( Kangkang Yu ),( Shengshen Chen ),( Mengqi Zhu ),( Guangfeng Shi ) 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: To investigate the role of selected serum microRNA (miRNA) levels as potential noninvasive biomark ers for differentiating S0-S2 (early fibrosis) from S3-S4 (late fibrosis) in patients with a chronic hepatitis B virus (HBV) infection. Methods: One hundred twenty-three treatment-naive patients with a chronic HBV infection who underwent a liver biopsy were enrolled in this study. The levels of selected miRNAs were measured using a real-time quantitative poly merase chain reaction assay. A logistic regression analysis was performed to assess factors associated with fibrosis progression. Receiver operating characteristic (ROC) curve and discriminant analyses validated these the ability of these predicted variables to discriminate S0-S2 from S3-S4. Re sults: Serum miR-29, miR-143, miR-223, miR-21, and miR-374 levels were significantly downregulated as fibrosis pro gressed from S0-S2 to S3-S4 (p<0.05), but not miR-16. The multivariate logistic regression analysis identified a panel of three miRNAs and platelets that were associated with a high diagnostic accuracy in discriminating S0-S2 from S3-S4, with an area under the curve of 0.936. Conclusions: The levels of the studied miRNAs, with the exception of miR-16, varied with fibrosis progression. A panel was identified that was capable of discriminating S0-S2 from S3-S4, indicating that serum miRNA levels could serve as a potential noninvasive biomarker of fibrosis progression. (Gut Liver 2017;11:860-869)
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Qingxia Huang,Jing Li,Jinjin Chen,Zepeng Zhang,Peng Xu,Hongyu Qi,Zhaoqiang Chen,Jiaqi Liu,Jing Lu,Mengqi Shi,Yibin Zhang,Ying Ma,Daqing Zhao,Xiangyan Li The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3
Background: Ginsenoside compound K (CK), the main active metabolite in Panax ginseng, has shown good safety and bioavailability in clinical trials and exerts neuroprotective effects in cerebral ischemic stroke. However, its potential role in the prevention of cerebral ischemia/reperfusion (I/R) injury remains unclear. Our study aimed to investigate the molecular mechanism of ginsenoside CK against cerebral I/R injury. Methods: We used a combination of in vitro and in vivo models, including oxygen and glucose deprivation/reperfusion induced PC12 cell model and middle cerebral artery occlusion/reperfusion induced rat model, to mimic I/R injury. Intracellular oxygen consumption and extracellular acidification rate were analyzed by Seahorse multifunctional energy metabolism system; ATP production was detected by luciferase method. The number and size of mitochondria were analyzed by transmission electron microscopy and MitoTracker probe combined with confocal laser microscopy. The potential mechanisms of ginsenoside CK on mitochondrial dynamics and bioenergy were evaluated by RNA interference, pharmacological antagonism combined with co-immunoprecipitation analysis and phenotypic analysis. Results: Ginsenoside CK pretreatment could attenuate mitochondrial translocation of DRP1, mitophagy, mitochondrial apoptosis, and neuronal bioenergy imbalance against cerebral I/R injury in both in vitro and in vivo models. Our data also confirmed that ginsenoside CK administration could reduce the binding affinity of Mul1 and Mfn2 to inhibit the ubiquitination and degradation of Mfn2, thereby elevating the protein level of Mfn2 in cerebral I/R injury. Conclusion: These data provide evidence that ginsenoside CK may be a promising therapeutic agent against cerebral I/R injury via Mul1/Mfn2 mediated mitochondrial dynamics and bioenergy.
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