An ileosigmoid fistula: what is the diagnosis?

( Chun Lan Zhang ),( Ji Li ),( Yan You ),( Yue Hui Ni ),( Yan Zhang ),( Jia Ming Qian ) 대한장연구학회 2017 Intestinal Research Vol.15 No.2

In Vivo Evaluation of 11C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse Brain

Ji-chun Zhang,Jun Toyohara,Jin Wu,Kiichi Ishiwata,갠지하시모토 대한정신약물학회 2012 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.10 No.1

Objective: Glycine transporter 1 (GlyT-1) is one of the most attractive therapeutic targets for schizophrenia. There is great interest in developing radioligands for in vivo imaging of GlyT-1 in the brain using positron emission tomography. Here, we report the properties of three novel non-sarcosine-based radioligands [11C]CHIBA-3007, [11C]CHIBA-3009, and [11C]CHIBA-3011, for GlyT-1imaging in the mouse brain in vivo. Methods: The three radioligands were synthesized by N-[11C] methylation of the corresponding desmethyl precursor. A pharmacological characterization of these radioligands for in vivo imaging of GlyT-1 in the brain was conducted using male ddY mice. Results: [11C]CHIBA-3009 and [11C]CHIBA-3011 were scarcely incorporated into the brain, whereas [11C]CHIBA-3007 showed slight but considerable brain uptake. Regional brain uptake of [11C]CHIBA-3007 (medulla oblongata>cerebellum>cortex) was similar to the distribution of the GlyT-1 protein. However, pretreatment with CHIBA-3007 (1 mg/kg) or the GlyT-1 selective inhibitor ALX5407 (N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine) (30 mg/kg) did not significantly decrease brain uptake of [11C]CHIBA-3007, suggesting low specific binding to GlyT-1. Pretreatment with cyclosporin A significantly increased brain uptake of [11C]CHIBA-3009 and [11C]CHIBA-3011, suggesting a role for P-glycoprotein in the brain uptake of these ligands. All three radioligands were rapidly degraded intact forms were 3-18% in plasma and 15-74% in the brain at 15min after injection. Conclusion: The results suggest that these three radioligands are not suitable for in vivo imaging of GlyT-1 in the brain because of low brain uptake and rapid metabolism. Further structural refinement is necessary to enhance brain uptake.

한,중,일 IoT홈 가전생활재의 지능형 기능성 비교연구

장순순(주저자) ( Chun Chun Zhang ),이연숙(공동저자) ( Yeun Sook Lee ),황지혜(공동저자) ( Ji Hye Hwang ),박재현(공동저자) ( Jae Hyun Park ) 디자인융복합학회 2016 디자인융복합연구 Vol.15 No.2

급속도로 발달한 정보기술은 산업환경 전반에 걸쳐 정보와 기능의 통합화를 이루며 우리 생활에 많은 영향을 미치고 있다. 특히 사물인터넷(IoT), 클라우드 컴퓨팅, 빅 데이터 분석 등 새로운 통신 환경의 출현은 인터넷을 중심으로 한 모든 전자기기들의 연결을 가능하게 함에 따라 이제는 산업환경을 넘어 주거환경까지 변화시키는 중요한 매체로 주목받고 있다. 이에 따라 본 연구의 목적은 고도로 발전하는 기술과 함께 진화하는 주거환경의 스마트 가전의 유형과 그 특성을 파악하고자 하는 것이다. 그리고 이를 위해 한국, 중국, 일본의 대표적인 브랜드 상품((Samsung, Haier, Panasonic)을 선정하여 각 특성을 비교 분석 하였다. 선정된 브랜드는 GHA(General rules of intelligentization technology for intelligent household appliances) 의 스마트 가전 적용 기준을 활용하여 각 유형을 분석하였다. 분류된 유형은 스마트 가전 사용자가 자율적(Self)으로 학습, 활용, 적용, 진단, 추론, 구성, 조절 등이 가능한 7가지의 유목으로 나누어졌으며, 이를 기준으로 나타난 각 국가별 브랜드 상품은 의(Clothing), 식(Food), 주(Housing)의 범주로 체계화 하였다. 브랜드별 나타난 주요 특성으로는 한국의 삼성은 원격제어 기능이, 중국의 하이얼은 전자기술의 적용이, 일본의 파나소닉은 에코나비(ECONAVI)인 에너지 절약 시스템으로 나타났다. Along with rapid development, progress of the network technology and digital information technology, human are stepping into the intelligent society of internet. Thereby the quality of living environment and working environment are keep improving. Under the big background of internet era, the timeliness and convenience of smart home system has been improved greatly. While lots of smart products have gradually penetrated into people``s daily life. The household appliances are among most popular ones. This paper is intended to compare smart features of household living products among most representative brands in China, Japan and South Korea. The smart features include self-learning, self-adapting, self-coordinating, self-diagnosing, self-inferring, self-organizing, and self adjusting. As result, most smart features of these products showed great similarity. While some features were dominated according to countries such as remote control feature in Korea, energy saving feature in Japan, and one button operation feature in China.

Percutaneous Sacroplasty for Sacral Metastatic Tumors Under Fluoroscopic Guidance Only

Ji Zhang,Chun-gen Wu,Yi-feng Gu,Ming-hua Li 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.6

Percutaneous sacroplasty is a safe and effective procedure for sacral insufficient fractures under CT or fluoroscopic guidance; although, few reports exist about sacral metastatic tumors. We designed a pilot study to treat intractable pain caused by a sacral metastatic tumor with sacroplasty. A 62-year-old man and a 38-year-old woman with medically intractable pain due to metastatic tumors of S1 from lymphoma and lung cancer, respectively, underwent percutaneous sacroplasty. Over the course of the follow-up period, the two patients experienced substantial and immediate pain relief that persisted over a 3-month and beyond. The woman had deposition of PMMA (polymethyl methacrylate) in the needle track, but did not experience significant symptoms. No other peri-procedural complications were observed for either patient.

A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer

Ji-Guang Han,Yong-Dong Jiang,Chun-Hui Zhang,Yan-Mei Yang,Da Pang,Yan-Ni Song,Guo-Qiang Zhang 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.2

Purpose: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls. Methods: Serum levels of miRNAs were measured by using quantitative real-time polymerase chain reaction in 99 breast cancer patients and 21 healthy controls. The abundance change of serum miRNAs were also evaluated following surgical resection in 20 breast cancer patients. Receiver operating characteristic (ROC) curve analysis was performed to assess the sensitivity and specificity of miRNAs as diagnostic biomarkers. Results: Serum levels of miR-21 and miR-155 was significantly higher, while miR-365 was significantly lower in breast cancer as compared with healthy controls. The serum levels of miR-21 and miR-155 significantly decreased following surgical resection. Additionally, the serum level of miR-155 at stages I and II was significantly higher compared to stage III. The serum miR-145 level was remarkably higher in progesterone receptor (PR)-positive patients than PR-negative. The positivity of miR-21, miR-155, and miR-365 was high compared to CA 153 and CEA in breast cancer. ROC curve analyses of a combination of miR-21, miR-155, and miR-365 yielded much higher area under curve and enhanced sensitivity and specificity in comparison to each miRNA alone. Conclusion: The combination of serum miR-21/miR-155/miR-365 may potentially serve as a sensitive and specific biomarker that enables differentiation of breast cancer from healthy controls.

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Zhang, Ji-Hong,Wang, Li-Hua,Li, Xiang-Jun,Wang, Ai-Ping,Reng, Li-Qun,Xia, Feng-Guo,Yang, Zhi-Ping,Jiang, Jing,Wang, Xiao-Dan,Wen, Chun-Yang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Purpose: To study the expression of angiogenin-2 (Ang-2) and its receptor Tie-2 in colorectal cancer and discuss the possible mechanisms behind this process. Materials and Methods: Using the streptavidin-peroxidase (SP) immunohistochemical method, paraffin sections from 100 colorectal cancer samples and 10 samples from tumor-adjacent normal tissue (> 2 cm from the edge of the gross tumor) were tested for protein expression of Ang-2, Tie-2, PI3K, and AKT. Reverse transcription-polymerase chain reaction and Western blots were further used to measure expression of the 4 genes and proteins in 20 freshly-resected colorectal cancer samples and tumor-adjacent normal tissues. Results: In colorectal cancer tissues, the expression of the Ang-2, Tie-2, PI3K, and AKT genes and their proteins was significantly higher than in tumor-adjacent normal tissues. Protein expression in poorly-differentiated adenocarcinoma was higher than that in well and moderately differentiated adenocarcinoma. According to Duke's classification, the protein expression in Stages C and D was significantly higher than that in Stages A and B. In the group with lymphatic metastasis, the protein expression was higher than that without lymphatic metastasis. Conclusions: In colorectal cancer, the expression of the Ang-2, Tie-2, PI3K, and AKT genes and their proteins is markedly higher than those in tumor-adjacent normal tissues. No correlation was observed between protein expression and gender, location, or histologic type. Correlations did exist between protein expression and differentiation level, stage of Duke's classification, and lymphatic metastasis; in colorectal cancer tissues with lower differentiation levels, higher stages of Duke's classification, and lymphatic metastasis, the expression of all 4 proteins was higher. The study of their expression patterns and relationships with aggression and metastasis will provide a valuable experimental foundation for assessing prognosis and targeted therapy of colorectal cancer.

Association of FOXJ1 polymorphisms with systemic lupuserythematosus and rheumatoid arthritis in Korean population

Chun-Shi Li,Qinggao Zhang,임미경,신동혁,심승철,Ji-Young Kim,이신석,Ki-Jung Yun,Hyung-Bae Moon,정헌택,채수천 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.6

The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and κBβ that results in re-pression of NF-κB activity. In Foxj1 deficiency mice, systemic autoimune inflamation is quite comon symptom. Therefore, deregulated Foxj1 is suposed to be associated with autoimmune diseases and/or other inflammatory diseases. Previously, we identified that polymorphisms of human FOXJ1 gene (g.460C>T, g.1805G>T and g.3375G>C) are associated with al-lergic rhinitis in a Korean population. In present study, we compared the genotype and allele frequencies of these SNPs between healthy controls and systemic lu-pus erythematosus (SLE) or rheumatoid arthritis (RA) patients. We also investigated the relationships be-twen each genotype and the expression levels of anti- nuclear antibodies in SLE patients, and rheumatoid patients. The frequencies of haplotypes constructed by these FOXJ1 SNPs were compared between con-trols and SLE (or RA) patients. The results of genotype and allele analysis showed that the prevalence of poly-morphism g.3375G>C was associated with the sus-ceptibility of SLE (P = 0.0072 and 0.0042, respectively). But no significant association was found with RA. In the haplotype analysis, however, the main CGG patients (P = 0.048).

Synthesis, Photophysical and Electrochemical Properties of Novel Conjugated Donor-Acceptor Molecules Based on Phenothiazine and Benzimidazole

Zhang, Xiao-Hang,Kim, Seon-Ho,Lee, In-Su,Gao, Chun-Ji,Yang, Sung-Ik,Ahn, Kwang-Hyun Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.8

Two series of new organic fluorophores such as asymmetrical 3-(benzimidazol-2-yl)-10-hexylphenothiazine derivatives 1 and symmetrical 3,7-bis(benzimidazol-2-yl)-10-hexylphenothiazine derivatives 2 have been synthesized. Electronic absorption, fluorescence, and electrochemistry measurements reveal that the electron withdrawing benzimidazole subunit directly connected to the phenothiazine core facilitates the charge transfer characters which were also verified by the theoretical calculations. Various substituents on the benzimidazole moieties can allow a fine-tuning of the LUMO energy levels of the molecules without significantly affecting the HOMO energy levels. The method provides a new route for designing ambipolar molecules whose energy levels are well-matched with the Fermi levels of the electrodes to facilitate the electron or hole injection/transfer in OLED devices.

A Research on User Benefit Analysis of Bathroom Guidelines for Disabled People

Ji-young Park,Yeonsook Lee,Mi-seon Jang,Chun-chun Zhang 한국주거학회 2015 한국주거학회 국제학술대회논문집 Vol.2015 No.4

High Quality Partially Relaxed SiGe Film Grown on Silicon-on-Insulator Substrate by Ultra-High Vacuum Chemical Vapor Deposition

Chang Chun Chen,Wen Tao Huang,Zhi Hong Liu,Ji Lin Wang,Xiao Yi Xiong,Yi Lin Shan,Wei Zhang,Jun Zhu,Pei Hsin Tsien 대한금속학회 2004 METALS AND MATERIALS International Vol.10 No.3