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Xing-Chun Wu,Chang-Xun Fang,Jin-Yang Chen,Qing-Shui Wang,Ting Chen,Wen-Xiong Lin,Zhong-Liang Huang 한국식물학회 2011 Journal of Plant Biology Vol.54 No.4
To determine the proteomic response to UV irradiation, two cultivars, i.e., Lemont (UV tolerant) and Dular (UV sensitive), were exposed to natural and enhanced ultraviolet-B (UV-B) irradiation for 1, 7, and 14 days, and two-dimensional gel electrophoresis in combination with mass spectrometry (MS) and bioinformatics were used to compare the different proteomic responses in the leaves of the two cultivars. Thirty-nine proteins were up- or downregulated following the UV-B treatments. Among them, 30 increased or decreased more than 1.5-fold in abundance. They were further tested by using matrix-assisted laser desorption/ionization time of flight MS and performed a database search. Twentyfour proteins were thus identified. These identified proteins were mostly upregulated in Lemont, whereas only 14 of them upregulated in Dular. Nine proteins involved in glycometabolism and fatty acid metabolisms, signal transduction, and protein synthesis and folding in Dular were not changed. These results suggest that there was a complex regulative mechanism on the proteomes in rice leaves upon UV-B exposure.
Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.
Effect of the Circle-Grid Electrodes on Concentrated GaAs Solar Cell Efficiency
Chen-Chen Chung,Binh Tinh Tran,Ming-Hung Han,Kung-Liang Lin,Hung-Wei Yu,Yen-Teng Ho,Chun-Yen Chang,Edward Yi Chang 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.5
In this study, we investigate the effect of the shading factor of the front grid pattern on concentrated solar cell efficiency, taking the trade-off between the series resistance of the electrodes and the amount of incident light into consideration. We examine the thermal effect with regard to five different circle-grid electrode patterns of the front contact. The front contacts with different grid patterns affect the characteristics of light-concentratedtype GaAs single-junction solar cells. The device parameters analyzed include the open-circuit voltage (Voc), short-circuit current (Isc), fill factor (FF) and conversion efficiency (η). The results of our study show that for a concentration ratio greater than 60x with AM1.5G, the device with a shading factor of 7.1% has the best cell efficiency of 27.05%, due to the smaller current crowding at the center spot. The results indicate that the conversion efficiency of solar cells can be improved by establishing a compromise between the shading effect and the series resistance effect.
( Chen-hua Liu ),( Chi-yi Chen ),( Wei-wen Su ),( Chun-jen Liu ),( Ching-chu Lo ),( Ke-jhang Huang ),( Jyh-jou Chen ),( Kuo-chih Tseng ),( Chi-yang Chang ),( Cheng-yuan Peng ),( Yu-lueng Shih ),( Chia 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4
Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR<sub>12</sub>) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR<sub>12</sub> rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5-94.2%), 94.1% (95% CI, 87.8-97.3%), and 100% (95% CI, 96.2-100%). Number of patients who failed to achieve SVR<sub>12</sub> were attributed to virologic failures. The SVR<sub>12</sub> rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR<sub>12</sub>, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16-14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 ㎡/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 ㎡/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis. (Clin Mol Hepatol 2021;27:575-588)
Chen, Ying-Chen,Lin, Chih-Yang,Huang, Hui-Chun,Kim, Sungjun,Fowler, Burt,Chang, Yao-Feng,Wu, Xiaohan,Xu, Gaobo,Chang, Ting-Chang,Lee, Jack C IOP 2018 Journal of Physics. D, Applied Physics Vol.51 No.5
<P>Sneak path current is a severe hindrance for the application of high-density resistive random-access memory (RRAM) array designs. In this work, we demonstrate nonlinear (NL) resistive switching characteristics of a HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB>-based stacking structure as a realization for selector-less RRAM devices. The NL characteristic was obtained and designed by optimizing the internal filament location with a low effective dielectric constant in the HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB> structure. The stacking HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB>-based RRAM device as the one-resistor-only memory cell is applicable without needing an additional selector device to solve the sneak path issue with a switching voltage of ~1 V, which is desirable for low-power operating in built-in nonlinearity crossbar array configurations.</P>
Chang, Chih-Chun,Sun, Jen-Tang,Chen, Jing-Yuan,Chen, Yi-Ting,Li, Pei-Yu,Lee, Tai-Chen,Su, Ming-Jang,Wu, Jiann-Ming,Yen, Tzung-Hai,Chu, Fang-Yeh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Potential disadvantages of blood transfusion during curative gastrectomy for gastric cancer have been reported, and the role of peri-operative transfusions remains to be ascertained. Thus, the aim of our study was to survey its impact in patients with gastric cancer undergoinging gastrectomy. Materials and Methods: Clinical data of patients receiving curative gastrectomy at Far Eastern Memorial Hospital were obtained. Findings for pre-operative anemia states, pre-, peri- and post-operative transfusion of red blood cell (RBC) products as well as post-operative complication events were collected for univariate analysis. Results: A total of 116 patients with gastric cancer received gastrectomy at Far Eastern Memorial Hospital from 2011 to 2014. Both pre-operative and intra- and post-operative transfusion of RBC products were markedly associated with post-operative infectious events (OR: 3.70, 95% CI: 1.43-9.58, P=0.002; OR: 8.20, 95% CI: 3.11-22.62, P<0.001, respectively). In addition, peri- and post-operative RBC transfusion was significantly associated with prolonged hospital stay from admission to discharge (OR: 8.66, 95% CI: 1.73-83.00, P=0.002) and post-operative acute renal failure (OR: 19.69, 95% CI: 2.66-854.56, P<0.001). Also, the overall survival was seemingly decreased by peri-operative RBC transfusion in our gastric cancer cases (P=0.078). Conclusions: Our survey indicated that peri-operative RBC transfusion could increase the risk of infectious events and acute renal failure post curative gastrectomy as well as worsen the overall survival in gastric cancer cases. Hence, unnecessary blood transfusion before, during and after curative gastrectomy should be avoided in patients with gastric cancer.
Chang Chun Chen 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.6
Mn-modified BiFe1-xMnxO3 (x = 0, 0.05, 0.1, and 0.15) ceramics were fabricated by a Sol-gel method together with calcination at an elevated temperature. The crystal structures of samples were analyzed by X-ray diffraction (XRD). The dependences of the ferroelectric, dielectric, and magnetic properties of samples on Mn contents were thoroughly investigated. The XRD patterns indicated that as increasing Mn content in samples, the unwanted impurity phases such as Bi2Fe4O9 and Bi36Fe24O57 are markedly decreased. Polarization-electric field (P-E) hysteresis loops observed for all the samples indicated that the permanent polarization (Pr) and the coercive field (Ec) were significantly improved due to Mn substitution. With an increase of Mn content, the value of dielectric constant of samples also increased. In addition, symmetric magnetic hysteresis (M-H) loops in samples indicated that they were magnetic ordered materials, and the saturated magnetization (Ms) of the BiFe1-xMnxO3 ceramics increased with an increase of Mn content.
Chang Chun Chen,Zhonghai Tang,Gui Wang,Chunhua Lu,Zhongzi Xu 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2
Nd-modified Bi1 − xNdxFeO3 (x = 0, 0.05, 0.1, and 0.15) ceramics were fabricated by a sol-gel method. The crystal structures of Nd-modified Bi1 − xNdxFeO3 (x = 0, 0.05, 0.1, and 0.15) ceramics were analyzed by X-ray diffraction (XRD). The effects of the Nd content on the ferroelectric, dielectric, and magnetic properties of these Bi1 − xNdxFeO3 ceramics were thoroughly investigated. The XRD patterns indicated that with an increase of the Nd doped content in Bi1 − xNdxFeO3 ceramics, the unwanted impurity phases such as Bi2Fe4O9 and Bi36Fe24O57 are markedly decreased. Clear polarization-electric field (P-E)hysteresis loops were observed for all the Nd-modified Bi1 − xNdxFeO3 ceramics and the shape of the P-E loop of the Bi1 − xNdxFeO3 ceramics was significantly improved due to the Nd substitution. In addition, slim magnetic hysteresis (M-H)loops in the Bi1 − xNdxFeO3 ceramics were also observed, and the saturated magnetization (Ms) of the Bi1 − xNdxFeO3 ceramics also increased with an increase of the Nd content.
Chang Chun Chen,Nan Ye,ChuanFu YU,Ting FAN 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.2
ZnO nanorods were grown on glass substrates coated by an Al-doped ZnO seed layer via a simple solvothermal method using zinc acetate dihydrate (Zn(CH3COO)2 • 2H2O) and Hexamethylenetetramine (C6H12N4) reagent. The structure, morphology and optical properties of these ZnO nanorods dependence on the molar ratio of Zn(CH3COO)2 • 2H2O to C6H12N4 were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Ultraviolet and Visible Spectrophotometry (UV-vis) and photoluminescence (PL) spectrometry, respectively. The XRD patterns indicated that all the ZnO nanorods were well-faceted hexagonal structures and preferentially grown along the c-axis. As the molar ratio of Zn(CH3COO)2 • 2H2O to C6H12N4 decreasing from 2.5 to 0.25, the crystallinity of ZnO nanorods synthesized gradually became inferior and the width of ZnO nanorods also decreased. The blue-shifts of UV emission excited from ZnO nanorods probably arised from the decreased size of ZnO nanorods.