http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
In Vivo Validation Model of a Novel Anti-Inflammatory Scaffold in Interleukin-10 Knockout Mouse
Kim, Jung Yeon,Chun, So Young,Lee, Sang Hoon,Lih, Eugene,Kim, Jeongshik,Kim, Dae Hwan,Ha, Yun-Sok,Chung, Jae-Wook,Lee, Jun Nyung,Kim, Bum Soo,Kim, Hyun Tae,Yoo, Eun Sang,Han, Dong Keun,Kwon, Tae Gyun Springer-Verlag 2018 조직공학과 재생의학 Vol.15 No.4
Optimal Stem Cell Transporting Conditions to Maintain Cell Viability and Characteristics
Yu, Na-Hee,Chun, So Young,Ha, Yun-Sok,Kim, Hyun Tae,Kim, Dae Hwan,Kim, Jeongshik,Chung, Jae-Wook,Lee, Jun Nyung,Song, Phil Hyun,Yoo, Eun Sang,Kim, Bum Soo,Kwon, Tae Gyun 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.5
Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells
Kwon, Se Yun,Chun, So Young,Ha, Yun-Sok,Kim, Dae Hwan,Kim, Jeongshik,Song, Phil Hyun,Kim, Hyun Tae,Yoo, Eun Sang,Kim, Bum Soo,Kwon, Tae Gyun 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.12 No.3
<P>Atmospheric (in vitro) oxygen pressure is around 150 mm Hg (20% O-2), whereas physiologic (in vivo) oxygen pressure ranges between 5 and 50 mm Hg (0.7-7% O-2). The normoxic environment in cell culture does not refer to a physiological stem cell niche. The aim of this study is to investigate the effect of oxygen concentration on cell properties of human mesenchymal stem cells (MSCs). We analyzed cell proliferation rate, senescence, immunophenotype, stemness gene expression and differentiation potency with human urine stem cells (USCs), dental pulp stem cells (DPSCs), amniotic fluid stem cells (AFSCs), and bone marrow stromal cells (BMSCs). USCs, DPSCs, AFSCs and BMSCs were cultured under either 5% O-2 hypoxic or 20% O-2 normoxic conditions for 5 days. MSCs cultured under hypoxia showed significantly increased proliferation rate and high percentage of S-phase cells, compared to normoxic condition. In real-time PCR assay, the cells cultured under hypoxia expressed higher level of Oct4, C-Myc, Nanog, Nestin and HIF-1 alpha. In immunophenotype analysis, MSCs cultured under hypoxia maintained higher level of the MSC surface markers, and lower hematopoietic markers. Senescence was inhibited under hypoxia. Hypoxia enhances osteogenic differentiation efficiency compared to normoxia. Hypoxia showed enhanced cell proliferation rate, retention of stem cell properties, inhibition of senescence, and increased differentiation ability compared to normoxia.</P>
Wu Pang Hung,Kim Hyeun Sung,An Jin Woo,Kim Myeonghun,Lee Inkyung,Park Jong Seon,Lee Jun Hyoung,Kang Sangsoo,Lee Jeongshik,Yi Yeonjin,Lee Jun Hyung,Park Jun Hwan,Lim Jae Hyeon,Jang Il-Tae 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.2
Study Design: Retrospective cohort study.Purpose: Postoperative evaluation of the cross-sectional area of paraspinal muscle and clinical findings in patients who had interlaminar route uniportal full endoscopic posterolateral transforaminal lumbar interbody fusion (EPTLIF) after 2 years. Overview of Literature: There are limited short-term follow-up studies on efficacy, safety, and physiological changes with a 2-year follow-up. There is no study on paraspinal muscle cross-sectional area change in patients who had undergone uniportal EPTLIF.Methods: We evaluated patients who underwent EPTLIF with a minimum 24-month follow-up. Clinical parameters of the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) were measured at the preoperative, 1-week postoperative mark, postoperative 3-month mark, and final follow-up. Preoperative and 1-year postoperative magnetic resonance imaging measurement of preoperative and postoperative Kjaer grade, right and left psoas muscle mass area, and right and left paraspinal muscle mass area was performed.Results: EPTLIF with a minimum 24-month follow-up of 35 levels was included. The complication rate was 6%, and the mean Bridwell’s fusion grade was 1.37 (1–2). There was statistically significant improvement at 1 week, 3 months, and 2 years in VAS (4.11±1.23, 4.94±1.30, and 5.46±1.29) and in ODI (40.34±10.06, 46.69±9.14, and 49.63±8.68), respectively (p <0.05). Successful operation rate with excellent and good MacNab’s criteria at 2 years was 97%. There was an increment of statistically significant bilateral psoas muscle cross-sectional area, right side (70.03±149.1 mm²) and left side (67.59±113.2 mm²) (p <0.05).Conclusions: Uniportal EPTLIF achieved good fusion and improved clinical outcomes with favorable paraspinal musculature bulk at the 2-year follow-up.
Wu Pang Hung,Kim Hyeun Sung,Grasso Giovanni,An Jin Woo,Kim Myeonghun,Lee Inkyung,Park Jong Seon,Lee Jun Hyoung,Kang Sangsoo,Lee Jeongshik,Yi Yeonjin,Lee Jun Hyung,Park Jun Hwan,Lim Jae Hyeon,Jang Il-T 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.1
tudy Design: Retrospective cohort study. Purpose: To evaluate the clinical and radiological effects of epidural fluid hematoma in the medium term after lumbar endoscopic decompression. Overview of Literature: There is limited literature comparing the effect of postoperative epidural fluid hematoma after uniportal endoscopic decompression. Methods: Magnetic resonance imaging (MRI) and clinical evaluation were performed for patients with single-level uniportal endoscopic lumbar decompression with a minimum follow-up of 2 years. Results: A total of 126 patients were recruited with a minimum follow-up of 26 months. The incidence of epidural fluid hematoma was 27%. Postoperative MRI revealed a significant improvement in the postoperative dura sac area at postoperative day 1 and at the upper endplate at 6 months in the hematoma cohort (39.69±15.72 and 26.89±16.58 mm2) as compared with the nonhematoma cohort (48.92±21.36 and 35.1±20.44 mm2), respectively (p<0.05); and at the lower endplate on postoperative 1 day in the hematoma cohort (51.18±24.69 mm2) compared to the nonhematoma cohort (63.91±27.92 mm2) (p<0.05). No significant difference was observed in the dura sac area at postoperative 1 year in both cohorts. The hematoma cohort had statistically significant higher postoperative 1-week Visual Analog Scale (VAS; 3.32±0.68) pain and Oswestry Disability Index (ODI; 32.65±5.56) scores than the nonhematoma cohort (2.99±0.50 and 30.02±4.84, respectively; p<0.05). No significant difference was found at the final follow-up VAS, ODI, and MRI dura sac area. Conclusions: Epidural fluid hematoma is a common early postoperative MRI finding in lumbar endoscopic unilateral laminotomy with bilateral decompression. Conservative management is the preferred treatment option for patients who do not have a neurological deficit. Symptoms last only a few days and are self-limiting. A common endpoint is a remodeled fluid hematoma and the subsequent expansion of the dura sac area.
Extra-gastrointestinal Stromal Tumor on the Inner Urinary Bladder Wall
Jun Nyung Lee,Se Yun Kwon,Jeongshik Kim,Ghil Suk Yoon,Eun Sang Yoo,Hyun Tae Kim 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.1
A gastrointestinal stromal tumor is the most common mesenchymal tumor of the gastrointestinal tract, and is diagnosed on the basis of the combined expression of CD34 and CD117 (C-kit protein). An extragastrointestinal stromal tumor of the urinary bladder is a very rare neoplasm. In this report, we describe a case of an extragastrointestinal stromal tumor originating from the inner surface of the urinary bladder. A 46-year-old man presented with an incident bladder mass, and he was diagnosed with an extragastrointestinal stromal tumor after transurethral resection of the bladder tumor. A tumor on the inner urinary bladder wall is an unusual presentation of an extragastrointestinal stromal tumor. The patient is doing well with no recurrence at 18 months after surgery.