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Regulation of interleukin-11 expression in ovulatory follicles of the rat ovary
Jang, You-Jee,Park, Jae-Il,Jeong, Seong-Eun,Seo, You-Mi,Dam, Phuong T. M.,Seo, Young-Woo,Choi, Bum-Chae,Song, Sang-Jin,Chun, Sang-Young,Cho, Moon-Kyoung Commonwealth Scientific and Industrial Research Or 2017 Reproduction, fertility, and development Vol. No.
<P> The aim of the present study was to examine the regulation of interleukin (IL)-11 expression, as well as the role of IL-11, during ovulation in gonadotropin-primed immature rats. Injection of equine chorionic gonadotropin (eCG), followed by human CG (hCG) to induce superovulation stimulated expression of the Il11 gene in theca cells within 6 h, as revealed by northern blot and in situ hybridisation analyses. Real-time reverse transcription-polymerase chain reaction analysis showed that the IL-11 receptor, α subunit gene was expressed in granulosa and theca cells and that injection of hCG had no effect on its expression. IL-11 protein expression was stimulated in theca cells by hCG. LH-stimulated increases in Il11 mRNA levels in cultured preovulatory follicles were inhibited by protein kinase A and mitogen-activated protein kinase kinase inhibitors. Toll-like receptor (TLR) 2 and TLR4 were detected in preovulatory follicles, and the TLR4 ligand lipopolysaccharide, but not the TLR2 ligand Pam3Cys, increased Il11 mRNA levels in theca cells, but not in granulosa cells. Treatment of preovulatory follicles with IL-11 stimulated progesterone production and steroidogenic acute regulatory protein (Star) gene expression. Together, these results indicate that IL-11 in theca cells is stimulated by mitogen-activated protein kinase signalling and TLR4 activation, and increases progesterone production during ovulation. </P>
Gain-Scheduling Control of Teleoperation Systems Interacting With Soft Tissues
Jang Ho Cho,Hyoung Il Son,Dong Gun Lee,Bhattacharjee, T.,Doo Yong Lee IEEE 2013 IEEE transactions on industrial electronics Vol.60 No.3
<P>Surgical teleoperation systems are being increasingly deployed recently. There are, however, some unsolved issues such as nonlinear characteristics of the interaction between the slave robot and soft tissues and difficulty in employing force sensors in the surgical end-effectors of the slave. These issues make it difficult to generalize any approach to develop a control for the system. This paper addresses these issues by proposing a <I>H</I><SUB>∞</SUB> suboptimal controller preserving robust stability and performance. The environment, i.e., soft tissues, is characterized with the nonlinear Hunt-Crossley model. This nonlinear characteristics of soft tissues are expressed with an affine combination of linear models within a predefined parameter polytope. For this linear parameter-varying system, a gain-scheduling control scheme is employed to design a suboptimal controller while guaranteeing its stability. To avoid using any force measurement in slave, we used position-position (PP) control architecture. The developed gain-scheduling control is validated with quantitative experimental results. The developed gain-scheduling PP control scheme shows good tracking capacity and high transparency for varied experimental conditions. Error of the transmitted impedance is significantly lower compared with other conventional control schemes for frequencies less than 2 Hz, which is frequently recommended for surgical teleoperation.</P>
Chun, Sang-Hyun,Kim, Jae-Woo,Sohn, Sangmo T.,Park, Jang-Hyun,Han, Wonyong,Kim, Ho-Il,Lee, Young-Wook,Lee, Myung Gyoon,Lee, Sang-Gak,Sohn, Young-Jong American Institute of Physics 2010 The Astronomical journal Vol.139 No.2
<P>Wide-field deep g'r'i' images obtained with the Megacam of the Canada-France-Hawaii Telescope are used to investigate the spatial configuration of stars around five metal-poor globular clusters M15, M30, M53, NGC 5053, and NGC 5466, in a field-of-view ~3°. Applying a mask filtering algorithm to the color-magnitude diagrams of the observed stars, we sorted cluster's member star candidates that are used to examine the characteristics of the spatial stellar distribution surrounding the target clusters. The smoothed surface density maps and the overlaid isodensity contours indicate that all of the five metal-poor globular clusters exhibit strong evidence of extratidal overdensity features over their tidal radii, in the form of extended tidal tails around the clusters. The orientations of the observed extratidal features show signatures of tidal tails tracing the clusters' orbits, inferred from their proper motions, and effects of dynamical interactions with the Galaxy. Our findings include detections of a tidal bridge-like feature and an envelope structure around the pair of globular clusters M53 and NGC 5053. The observed radial surface density profiles of target clusters have a deviation from theoretical King models, for which the profiles show a break at 0.5-0.7r<SUB>t</SUB>, extending the overdensity features out to 1.5-2r<SUB>t</SUB>. Both radial surface density profiles for different angular sections and azimuthal number density profiles confirm the overdensity features of tidal tails around the five metal-poor globular clusters. Our results add further observational evidence that the observed metal-poor halo globular clusters originate from an accreted satellite system, indicative of the merging scenario of the formation of the Galactic halo.</P>
Nam, Ki Min,Shim, Jae Ha,Ki, Hosung,Choi, Sang-Il,Lee, Gaehang,Jang, Jae Kwon,Jo, Younghun,Jung, Myung-Hwa,Song, Hyunjoon,Park, Joon T. WILEY-VCH Verlag 2008 Angewandte Chemie Vol.47 No.49
<B>Graphic Abstract</B> <P>Hollow nan': Hollow face-centered cubic (fcc) Co nanoparallelepipeds were prepared by thermolysis of solid fcc CoO nanoparallelepipeds in oleylamine (see TEM image). The solid fcc CoO nanoparallelepipeds are reduced by the oleylamine surfactant to form hollow fcc Co nanoparallelepipeds. Voids and fcc Co are generated on the surface of the solid fcc CoO nanoparallelepipeds by the removal of oxide as carbon monoxide. <img src='wiley_img/14337851-2008-47-49-ANIE200803048-content.gif' alt='wiley_img/14337851-2008-47-49-ANIE200803048-content'> </P>
Accelerating Palladium Nanowire H<sub>2</sub> Sensors Using Engineered Nanofiltration
Koo, Won-Tae,Qiao, Shaopeng,Ogata, Alana F.,Jha, Gaurav,Jang, Ji-Soo,Chen, Vivian T.,Kim, Il-Doo,Penner, Reginald M. American Chemical Society 2017 ACS NANO Vol.11 No.9
<P>The oxygen, O-2, in air interferes with the detection of H-2 by palladium (Pd)-based 11, sensors, including Pd nanowires (NWs), depressing the sensitivity and retarding the response/recovery speed in air relative to N-2 or Ar. Here, we describe the preparation of H-2 sensors in which a nanofiltration layer consisting of a Zn metal organic framework (MOF) is assembled onto Pd NWs. Polyhedron particles of Zn-based zeolite imidazole framework (ZIF-8) were synthesized on lithographically patterned Pd NWs, leading to the creation of ZIF-8/Pd NW bilayered H-2 sensors. The ZIF8 filter has many micropores (0.34 nm for gas diffusion) which allows for the predominant penetration of hydrogen molecules with a kinetic diameter of 0.289 nm, whereas relatively larger gas molecules including oxygen (0.345 nm) and nitrogen (0.364 nm) in air are effectively screened, resulting in superior hydrogen sensing properties. Very importantly, the Pd NWs filtered by ZIF-8 membrane (Pd NW5@ZIF-8) reduced the H-2 response amplitude slightly (Delta R/R-o = 3.5% to 1% of H-2 versus 5.9% for Pd NWs) and showed 20-fold faster recovery (7 s to 1% of H-2) and response (10 s to 1% of H-2) speed compared to that of pristine Pd NWs (164 s for response and 229 s for recovery to 1% of H-2). These outstanding results, which are mainly attributed to the molecular sieving and acceleration effect of ZIF-8 covered on Pd NWs, rank highest in H-2 sensing speed among room -temperature Pd-based H-2 sensors.</P>
Wu Pang Hung,Kim Hyeun Sung,Grasso Giovanni,An Jin Woo,Kim Myeonghun,Lee Inkyung,Park Jong Seon,Lee Jun Hyoung,Kang Sangsoo,Lee Jeongshik,Yi Yeonjin,Lee Jun Hyung,Park Jun Hwan,Lim Jae Hyeon,Jang Il-T 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.1
tudy Design: Retrospective cohort study. Purpose: To evaluate the clinical and radiological effects of epidural fluid hematoma in the medium term after lumbar endoscopic decompression. Overview of Literature: There is limited literature comparing the effect of postoperative epidural fluid hematoma after uniportal endoscopic decompression. Methods: Magnetic resonance imaging (MRI) and clinical evaluation were performed for patients with single-level uniportal endoscopic lumbar decompression with a minimum follow-up of 2 years. Results: A total of 126 patients were recruited with a minimum follow-up of 26 months. The incidence of epidural fluid hematoma was 27%. Postoperative MRI revealed a significant improvement in the postoperative dura sac area at postoperative day 1 and at the upper endplate at 6 months in the hematoma cohort (39.69±15.72 and 26.89±16.58 mm2) as compared with the nonhematoma cohort (48.92±21.36 and 35.1±20.44 mm2), respectively (p<0.05); and at the lower endplate on postoperative 1 day in the hematoma cohort (51.18±24.69 mm2) compared to the nonhematoma cohort (63.91±27.92 mm2) (p<0.05). No significant difference was observed in the dura sac area at postoperative 1 year in both cohorts. The hematoma cohort had statistically significant higher postoperative 1-week Visual Analog Scale (VAS; 3.32±0.68) pain and Oswestry Disability Index (ODI; 32.65±5.56) scores than the nonhematoma cohort (2.99±0.50 and 30.02±4.84, respectively; p<0.05). No significant difference was found at the final follow-up VAS, ODI, and MRI dura sac area. Conclusions: Epidural fluid hematoma is a common early postoperative MRI finding in lumbar endoscopic unilateral laminotomy with bilateral decompression. Conservative management is the preferred treatment option for patients who do not have a neurological deficit. Symptoms last only a few days and are self-limiting. A common endpoint is a remodeled fluid hematoma and the subsequent expansion of the dura sac area.