복지근피판 거상후 공여부의 재건술

윤정섭,이상헌,신극선,이훈범 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

Post radical mastectomy reconstruction using a transverse rectus abdominis myocutaneous flap involves certain problems at the donor site as the difficulty in closure secondary to excessive tension and the development of a postsurgical abdominal hernia. The usage of alloplastic materials such as Marlex may also cause eventual weakness as well as a foreign body reaction. While autogenous tissues may be used for a remote myocutaneous flap transposition or a free-tissue transfer, the problems such as a donor site defect, atrophy secondary to denervation, etc. exist. To avert these problems, we propose to use the autogenous tissue in a manner that provides a dynamic support in addition to the functional reconstruction. The components separation method decribed here separates the muscle groups of the abdominal wall, and allows several advantages over treating the abdominal wall as a single unit. One of the advantages is the increased mobility of individual muscles. The allows transferance of the flap over a greater distance which in turn reduces excessive tension and makes closure of the donor site defect easier. Thus, this procedure provides a dynamic support and reduces the incidence of hernia. We experienced 3 cases of abdominal wall reconstruction after TRAM flap transfer(one case after bilateral TRAM flap, two cases after contralateral unilateral TRAM flap) using external oblique muscle sharing or rectus sharing. So we present clinical cases of the abdominal wall reconstruction after TRAM flap transfer with a review of the literature.

Trinitrophenyl Cellulose의 조제

맹정섭,남윤규,박승희,최우영 충남대학교 농업과학연구소 1995 농업과학연구 Vol.22 No.2

Two types of modified celluloses which contain trinitrophenyl groups as chromophore were synthesized from carboxymethyl cellulose Whatman CM 70 and CM 32. Diaminoethyl groups were added to the CM 70 and CM 32 to make DAE-CM celluloses and then the DAE-CM groups were substituted by 2,4,6-trinitrophenyl groups to produce TNP-celluloses. Average particle size of the TNP-cellulose from CM 32 was 44.6 ±9.6 μm in diameter and 127.9±22.5 μm in length, which was much smaller than those from CM 70, however its TNP-moiety per gram determined by using the molar extinction coefficient 1.33×10^4 of ε-TNP-lysine at 345 nm, was 0.68 millimoles, which was 5.6-fold greater than those from CM 70. The absorption spectrum of TNP-oligosaccharides which were the soluble products of TNP-celluloses by a cellulase preparation Onozuka R-10, showed a maximal peak at 344 nm. Increases in the absorbance during hydrolysis were linear with the enzyme concentration, and the differences of slope values between two types of TNP-celluloses that the more semsitive assay could be achieved by using those from CM 32 as substrate at the low range of the enzyme concentration.

TNP-cellulose의 섬유소 분해효소 활성도 측정을 위한 기질로서의 특성

맹정섭,남윤규,최우영 충남대학교 농업과학연구소 1994 농업과학연구 Vol.21 No.2

Characteristics of TNP-cellulose which prepared from carboxymethyl cellulose powder, CM32, as substrate for cellulase activity assay were investigated. Enzymatic hydrolysis of TNP-cellulose occured on the cellulose moiety but not on amide bonds, following Michaelis-Menten kinetics. Tree cellulase preparations from Trichoderma viride, Aspergillus niger. and Cellulomonas sp. were tested for their pH and temperature dependences and compared with the method determining the increase in reducing power. The enzyme activity was found to have the same temperature range in both methods, however the pH range was broadened in the case of using TNP-cellulose as substrate. The colorimetric method for cellulase assay using TNP-cellulose as substrate was compared with the other methods: one based on determination of the increase in reducing power; and the other based on determining the decrease in viscosity of Na-CM-cellulose solution. The activities measured by the colorimetric method showed a linear correlation with the enzyme concentration of certain range in all three enzymes tested, and the activity values were proportional to those obtained from the other methods. Depending on the enzyme. however, the activity values from this method were not always in proportion to those from the viscometric method, suggesting that this method was not specific for determination of the endo-type cellulase.

유리피판 이식술 83예의 분석

신극선,탁관철,윤정섭 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

Eighty-three consesutive free-flap transfers were reviewed to analyze distribution of type of reconsturctions, kinds of donor flaps as well incidence of complications. The role of emergent exploration and the effect of preoperative wound conditions in flap survival were evaluate. Free flap transfer for head and neck reconstruciton was most common as 46 cases, followed by for upper extremity of 22cases, for lower extremity 12 cases and for trunk & breast 3 cases. Two patients exhibited within 7 days after the operation because of respiratory complications. Eight flaps exhibited signs of circulatory insufficiency between 5 hours and 7 days. three were managed conservatively with ultimate partial necrosis of the flaps. Five flaps required return to the operating room. On exploration, early arterial occlusion was revealed in 1 flap, late arterial occlusion in 2 flaps, late venous occlusion in 1 flap and hematoma in 1 flap. The average time from the first abnormal examination to exploration was 2.4 hours. There were no false-positive explorations. Two free flaps in which abonormal findings were first noticed 4 days and 7 days after microsurgical transfer respectively failed in spite of the correction of the cause of circulatory compromise. The remaining 3 flaps were salvaged following the correction of the cause. Recipient vessel problems such as irradiation and infection were the most common cause of circulatory crisis. Among the five flaps requiring return to the operating room. single vein was anastomosed in four flaps and two veins in the remaining one. In the totally failed two flaps only songle vein was anastomosed. The results of this study demonstrate the efficacy of clinical monitoring and the role of early exploration. Precautious selection of recipient vessels and two vein anastomosis are recommended for safe and better prognosis.

사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구

박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

16,17세기 해남윤씨(海南尹氏)의 화산(花山) 竹島 해언전(海堰田) 개간 -윤이후(尹爾厚)의 『지암일기(支菴日記)』를 중심으로-

정윤섭 ( Yoon Seob Jeong ) 호남사학회(구-전남사학회) 2012 역사학연구 Vol.46 No.-

이 논문은 16·17세기 무렵 해남윤씨에 의해 진행된 도서지역의 海堰田 개발을 살펴보고자 한 것이다. 해남윤씨는 우리나라 서남해 지역의 가장 끝인 해남에 기반을 두고 세거해온 집안으로 서남해 연안지역은 潮水간만의 차가 크고 갯벌이 잘 발달되어 있어 간척을 하기에 매우 유리한 조건을 지니고 있었다. 연해지역의 海堰田 간척은 經濟力과 勞動力 그리고 간척이 용이한 지리적 조건을 요구하고 있었다. 이 때문에 海堰田 간척은 주로 왕실과 특권신분층을 비롯하여 양반 재지사족들이 참여하고 있었지만 이들 모두가 海堰田 개발에 참여할 수는 없었다. 해남윤씨는 16세기 무렵부터 중앙의 관직 진출과 妻邊의 재산상속을 통한 부의 획득, 양자입양으로 양부와 친부로부터 물려받은 재산의 배가 등에 의해 튼튼한 경제적 기반을 마련하고 풍부한 노비노동력을 동원해 民間에서는 매우 이른 시기에 海堰田 간척을 시작한다. 해남윤씨의 海堰田 간척은 주로 내륙의 연해 지역을 중심으로 이루어졌지만 도서지역에서도 이루어지고 있었다. 진도 굴포와 완도 노화도 등은 도서지역에 간척한 대표적인 곳이며 17세기 무렵 화산 죽도에서 진행되었던 간척은 해남의 대표적인 도서지역 海堰田 간척지이다. 화산 죽도의 海堰田 개발은 이시기 재지 양반가의 도서경영이 어떻게 이루어지고 있었는지를 구체적으로 살펴볼 수 있으리라 본다. 화산 죽도의 海堰田 개발을 살펴보기 위해서 특히 해남윤씨의 문헌자료로 전해져 온 尹爾厚의 『支菴日記』를 살펴보았다. 『支菴日記』는 17세기 당시 재지양반가의 생활과 토지경영의 모습을 살펴볼 수 있는 일기로 海堰田 개발과 관련된 사항을 기록하고 있다. 고산 尹善道의 손자인 지암 尹爾厚가 기록한 『支菴日記』는 17세기 당시 해남윤씨의 海堰田 개발에 관한 기록을 여러 곳에서 찾아볼 수 있으며, 이를 통해 海堰田 개발에 동원된 노동력과 海堰田 개발과정 등을 살펴볼 수 있다. 본 연구에서는 이처럼 사림정치기를 통해 재지양반가문으로 성장한 해남윤씨의 海堰田 개발이 16세기와 17세기 무렵 花山 竹島를 중심으로 어떻게 진행되고 관리되었는가를 고찰해 본 것이다. This study is 16 and 17th century, preceded by Haenam Yoon Family islands for the reclamation of the sea are discussed. Haenam Yoon Family`s the end of the country in Southwestern region`s most live been based on the Southwestern Coastal areas in the house tides are large and well developed tidal land reclamation was to have a very favorable conditions. Reclamation of the sea, the coastal area of ??labor and the economic and geographical conditions requiring reclamation was easy. Because of this, the reclamation of the sea floor, including mainly noble status and privileges of the royal redirected to participate, but all of them could not participate in land reclamation. Haenam Yoon Family office in the center of the 16th century from the time advance and the wife of the wealth acquired through inheritance, adoption and paternity adoption adoptive father to the wealth inherited from a ship by a strong economic foundation, etc, and mobilizing private sector wealth in the very early labor Novi Reclamation will start when the sea. Haenam Yoon Family inland sea of land reclamation mainly focused on the coastal area was performed, but also were observed as islands. Aging also islands, etc. Progress in Jindo gulpo, wando nohawdo typical 17th century the hwasan jukdo is where has been progress in the Haenam Reclamation Reclaimed islands is typical. Reclamation of the sea, the hwasan jukdo of this period yangban family how redirected specifically look at whether you know that it may have been. In particular, the reclamation of hwasan jukdo in order to examine the Haenam Yoon Family was passed on to the literature of the Yoon ihoo`s 『jiamilgi』 examined. 『Jiamilgi』 during the 17th century yangban family redirect the appearance of life and land management to look at matters relating to land reclamation in the diary is written. Grandson of yunseondo jiam Yoon ihoo`s(1636-1699) recorded 『jiamilgi』 Haenam Yoon Family during the 17th century on the development of the reclamation of history can be found in many places, and through this process of reclamation and development in the labor force mobilized and can look at. In this study, such a public sphere through political groups grown Moon country Haenam Yoon Family redirect the reclamation of the 16th century and 17th century development of around the hwasan jukdo were being managed study What`s happening is this.

Service Delivery Agent System for Mobile Devices

Jeong Seob Yoon,Ki Hyun Lee,Geun Sik Jo 한국지능정보시스템학회 2001 한국지능정보시스템학회 기타 간행물 Vol.- No.-

Validation of Herpes Zoster Diagnosis Code in the Electronic Medical Record: A Retrospective, Multicenter Study

( Yoon Seob Kim ),( Hyun-min Seo ),( Chul Hwan Bang ),( Ji Hyun Lee ),( Yong-gyu Park ),( You Jeong Kim ),( Gyong Moon Kim ),( Chul Jong Park ),( Hyun Jeong Park ),( Dong Soo Yu ),( Jun Young Lee ),( 대한피부과학회 2018 Annals of Dermatology Vol.30 No.2