Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

中國文學과 日錄學에서의 類書의 자리

安正燻 韓國中國語文學會 2003 中國文學 Vol.40 No.-

이 글은 세계화와 신자유주의의 물결이 밀려드는 오늘의 상황에서 우리가 나아가야 할 새로운 시민 주체의 길을 모색하는 것을 목적으로 하고 있다. 그래서 우선 이 글은 오늘날 전개되는 세계화와 전체주의의 관계를 분석하고, 다음으로는 세계화의 기형적 현상 속에 자리하고 있는 신자유주의의 등장과 그 영향에 대해서 고찰하고 있다. 그리고 마지막으로 이런 신자유주의 물결이 우리 내부 상황에 미치는 연관 관계를 DJ노믹스와 관련하여 다루고 있다. 이 글은 이와 같은 연구 과정을 통하여 세계화가 안고 있는 전체주의적인 면을 지적하고, 나아가 우리 내부에 민중의 길과 시민적 길의 갈등을 제시하였다. 마지막으로 이 글은 이와 같은 문제점을 극복하기 위하여 아렌트의 '행위의 정치학'을 수용하여 관찰하고 판단하는 새로운 시민 주체를 모색해 보고자 했으며, 이런 시민 주체를 통하여 권력을 소유하는 주체가 아니라 권력을 감시하고 관찰하는 새로운 주체를 확립해 보려고 하였다.

則天武后의 문자숭배 관념에 대한 고찰

安正燻 韓國中國語文學會 2004 中國文學 Vol.41 No.-

則天武后是唐朝唯一的女皇帝, 也是中國歷史上一位著名的女皇帝. 中國封建社會連續了兩千多年, 男尊女卑的封建觀念始終統治着人們的思想, 但則天武后作爲一個皇后, 却能突破封建傳統的束縛, 建立瞭强有力的專制統治, 倂推動瞭社會和經濟的發展. 通過考察則天武后的統治行蹟, 我們能發現저就是一個具有强烈自卑感的人物. 저的自卑感表現出爲缺乏自信和盲信民間迷信的傾向. 저崇佛, 重道, 篤信神영, 迷信祥瑞, 又看重文字的力量, 且動輒將政敵改姓. 缺乏自信的령一충表現是年號的頻繁變更. 在저之前的唐太宗統治23年只用了1개年號; 在저之后的唐玄宗, 統治44年用了3개年號, 平均每개年호用14.7年; 而武則天涉政, 執政的50年中, 竟用了32개年號, 平均每개年號僅用1.5年. 如比頻繁的更換年號, 在中國封建社會的歷史中非常우見. 年號也是帝王意志的 現, 是某충象征與祈求的表示. 年號的頻繁變動, 表面上看, 是則天武后迷信的表現, 實質上是저內心겁度空虛雜亂, 缺乏自信的反映, 希望通過變換年호使心理上得到某충寄托和安慰. 古代中國人都認爲自己的姓名就是自己存在的表現符호. 所以則天武后用不吉的文字將自己的政敵改姓改名的行爲, 是一충非常恐怖的詛呪方式. 他這마盲信文字的神秘力量, 說明他的內心缺乏自信, 所以需要 迷信爲自己壯단, 鼓起自己的勇氣. 但要注意的是, 雖然則天武后的這충崇拜文字現象尤爲突出, 古代中國的兩千年歷史來講, 這충崇拜文字, 盲信祥瑞現象就是一直被發現的一개明顯的標志.

정신분열병 환자에서 존속살인의 임상적 특성

안병훈,최상섭,안성호,하태현,김선범,권경희,김정현 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : This study aimed to describe the demographic, clinical and offense characteristics of the patients with Schizophrenia who committed parricide. This study also investigated the risk factors of parricide by comparing with characteristics of stranger killers to prevent the tragic offense. Methods : The sample consisted of 88 schizophrenic patients who committed homicide, 59 of them committed parricide and 29 of them killed strangers. Medical chart review regarding demographic and clinical characteristics as well as offense Characteristics was conducted. The information that was difficult to be obtained through chart review was acquired by direct interview. Results : Parricide group had earlier age of onset, more conflicts with the victims, more violence history toward victims and more offense provoking events than stranger killing group. Parricide group showed higher rate of past treatment than that of stranger killing group. However drug compliance at the time of offense was low in both groups. Offense provoking events in the parricide group included blaming, threatening a forced hospitalization or medication toward patients. The most common Psychiatric symptoms associated with homicide were threat/control override (TCO) symptoms, delusional perception, commanding auditory hallucination and especially with parricide, Capgras syndrome (CS). Conclusion : Interaction between psychotic symptoms such as TCO, CS and underlying emotion toward victims are likely to be associated with parricide. Mental health professionals are expected to play an important role in preventing this tragic offense by active history taking of the violence and effective management with active caregiver education/intervention of intrafamilial conflicts.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

압입하중-변위곡선의 정량적 해석을 통한 가공경화지수의 평가

全銀埰,安政勳,權東一 대한금속재료학회 2001 대한금속·재료학회지 Vol.39 No.12

Continuous indentation test with ball indenter has been studied for years because of its convenience and simpleness. Especially, the test is expected to supersede tensile test. Among tensile properties work-hardening exponents of various steels were evaluated by the test. We newly defined true stress and true strain with contact depth and indentation load. Finite element analysis shows that the contact depth is affected by elastic deflection and pile-up/sink-in. Therefore, the contact depth was calculated with taken both elastic deflection and pile-up/sink-in into account. The work-hardening exponents derived in this study show good agreement to those from tensile test.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

소화성궤양의 임상적 고찰

박승국,허정욱,강영우,안성훈,이상곤 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

저자들은 1981년부터 1990년사이에 64,207명을 대상으로 내시경검사를 시행하여 8,814명에서 소화성궤양을 진단하여 다음과 같은 결론을 얻었다. 소화성궤양의 발생률은 13.7%였다. 위궤양과 십이지장궤양의 발생비는 1981년에는 1:0.9였으나 그후로는 1:1.1-1:1.5로 십이지장궤양의 발생비율이 높았다. 발생비율을 남녀별로 보면 위궤양의 경우에는 약 4:1 십이지장궤양은 3:1로 남자에서 많았다. 연령별로는 위궤양은 40대, 50대, 60대의 순서였고, 십이지장궤양은 30대, 40대, 20대 순으로 호발하였다. 위궤양은 위체부에서 대부분 발생하였다. In this century, very striking changes in incidence and prevalence of peptic ulcers, as well as in sexual proportion, in the age of the affected population and in the proportion of duodenal to gastric ulcers had occured and these epidemiological changes are ongoing. Therefore, we reviewed 8,814 cases with endoscopically proven peptic ulcers from 1981 to 1990. The results obtained are as follows; The prevalence of peptic ulcers among patients received endoscopy was 13.7%. The ratio of peptic ulcers among patients received endoscopy was 13.7%. The ratio of gastric ulcer to duodenal ulcer was 1: 0.9 in 1981, but after then the propotion of duodenal ulcer was higher in 1: 1.1-1:1.5. The ratio of male to female was about 4:1 in gastric ulcer and 3:1 in duodenal ulcer. The prevalence of gastric ulcer was highest in foruth decade and then fifth and sixth in order and the prevalence of duodenal ulcer was highest in thrid decade and then fourth and second decade in order. Most of the gastric ulcers were found at the gastric body.

관상동맥조영술중 비이온성 조영제 Iodixanol (Visipaque®)에 의해 발생한 아나필락시양 반응 1예

최원욱,조정수,김성철,김상훈,안영수,최재웅 대한내과학회 2004 대한내과학회지 Vol.66 No.1

흉통을 주소로 내원한 45세 남자에서 관상동맥조영술 중 비이온성 조영제에 의하여 아나필락시양 반응이 발생한 증례를 경험하였기에 보고하는 바이다. Radiocontrast agent infusion is the most common cause of non-IgE mediated anaphylactoid reaction in the modern medical procedures. The newer lower-osmolar nonionic contrast agents cause significantly lower adverse reactions than the high-osmolar ones. However, anaphylactoid reaction to nonionic contrast agent can cause life-threatening events and even death has been rarely reported. Iodixanol (Visipaque®) is a nonionic, dimeric contrast agent, which is currently used in cardiac catheterization. Here we report a case of anaphylactoid reaction to Iodixanol, a nonionic radiocontrast agent, during cardiac catheterization. A 45-year-old male patient underwent cardiac catheterization for evaluation of substernal pain during exercise. Five minutes after this contrast injection to the left coronary artery, he complained itching and dizziness. Subsequently, generalized urticaria, cyanosis and hypotension were developed. His coronary angiogram showed normal findings. He was treated with intravenous fluids, intravenous diphenhydramine, sucutaneous epinephrine and sympathomimetics and one hour later he recovered. This case suggests that anaphylactoid reaction to a radiocontrast media, iodixanol, should be considered in the list of differential diagnoses for cardiopulmonary arrest during cardiac catheterization.

재래종 콩 유전자원의 주요 형태적 특성과 변이

윤문섭,백형진,이정란,김행훈,조양희,안종웅,김창영 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

본 실험은 한국, 중국 및 일본 재래종 콩 유전자 자원의 주요형질 변이를 조사하고 이들 자원간의 지리적 유연관계를 비교하고자 수행하였으며, 그 결과를 요약하면 다음과 같다. 1. 경장은 한국(66㎝)이나 일본자원(54.9㎝)보다 중국자원(71㎝)에서 더 컸으며, 또한 변이도 중국자원에서 가장 큰 것으로 나타났다. 2. 개화일수 및 생육일수는 한국자원(65.5일, 151.4일)이 가장 길었으며 중국(57일, 120일)과 일본자원(59.9일, 122.4일)은 같은 경향을 나타냈다. 또한 한국과 중국자원은 지역에 따른 차이를 나타냈으나 일본자원에서는 확인할 수 없었다. 3. 백립중은 한국(18.8g), 일본(17.2g) 및 중국(14.7g) 순으로 무거웠다. 특히 한국자원은 9~11g과 23~25g에서 정점을 나타냈고, 변이폭도 가장 컸다. 반면 일본과 중국자원은 13~17g사이에서 정점을 나타냈다. 4. 협수는 중국(46.9개)이나 일본자원(36.5개)보다 한국자원(75.5개)에서 가장 많았으며, 변이폭도 한국자원에서 가장 컸다. 내도복성은 일본자원에서 가장 강하였다. 5. 정준판별분석결과 can 1을 경계로 하여 오른쪽 상하에 한국재래종이 주로 분포하였고 왼쪽에는 중국과 일본 재래종이 주로 분포하여 각 나라별로 고유한 영역을 가지고 분리되었다. 전체적 경향이 중국과 일본자원이 한국자원보다 가까운 경향을 나타냈다. This experiment was carried out to compare the characters of 944 Korean soybean landraces, 716 Chinese, and 170 Japanese soybean landraces introduced from USDA soybean germplasm collection. Cannonical discriminant and cluster analyses were conducted by their origins. The population from China was taller in plant height than those from Korea and Japan, also its variation was largest in Chinese population. The population from Korea was langer than those from China and Japan in terms of days to flowering and maturity. Also, Korean and Chinese accessions appeared the difference of those traits according to latitude. One hundred seeds weight was in the order of Korean(18.8g), Japanese(17.2g) and Chinese populations(14.7g), especially Korean population was distinguished into two groups; the group including accessions between 10 and 15g, and the other group including accessions between 20 and 25g. However, others showed the peak in range of 13~17g. The number of pod per plant was more in Korean accession(75.5) with the largest variation than Chinese(46.9) and Japanese accession(36.5). The distribution of Korean, Chinese and Japanese accessions reflected the origin of accessions analyzed by cannonical discriminant analysis. The relationship between their geographical origins showed the population of China and Japan are losely related.