Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

급성 포름알데히드 가스 흡입에 의한 흰쥐 후각상피의 형태학적 변화

백선용,전재기,문용석,황승영,노환중,고의경,왕수건 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

공압을 이용한 수중운동체의 수압시뮬레이터 설계 연구

전우선,정원지,김원제,남경원 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-

HILS(Hardware In Loop Simulation) is an effective means of testing unmanned underwater vehicle under extreme operational conditions and a variety of operational environments. In order to verify the vehicle performance under time-varying pressure conditions, a reliable pressure simulator is vital to an integrated system for the HILS. This paper presents the results of design research for the pressure simulator using pneumatic pressure (nitrogen), a high speed solenoid valve and a PWM control method. The test and evaluation results of the pressure simulator show that the simulator can generate an appropriate level of desired pressure with an average error below 1m depth for time-varying pressure change conditions corresponding to vehicle dynamics. In addition, the levels of overshoot and vibration have been shown to be under the requirements of design specifications.

간담도질환에 있어서 혈청 GGT 활성치의 의의

전동석,김경선,김재식,김중명 대한병리학회 1982 Journal of Pathology and Translational Medicine Vol.16 No.4

사염화탄소의 간독성에 대한 파두 다당류분획의 예방효과

이은경,길이룡,소동수,창동신,전선덕,정명규,문창규 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

In present study, we fractionated polysaccharides from Croton tiglium and investigated their hepatoprotective effects on CCI₄ intoxication. Polysaccharide fraction of which molecular weight is over 300,000(HP) showed the most potent hepatoprotective effects on CC1₄ intoxication. Lipid peroxidation, BAST and sALT were used as parameters to evaluate the liver damage. Glucose, xylose and arabinose were found to be monosaccharides composing sugar moiety of HP.

체중감량이 유도선수의 Renin, 면역기능 및 유·무산소 운동능력에 미치는 영향

권영우,전승훈,김진해,민경선,민진아 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this study was to investigate the effect of short terms weight reduction period on body composition and body fluid. Seven Judo athletes (21±1.21 yrs) were matched and randomly placed. Body weight reduction period consists of 7 day. Each groups reduced body weight by 3%(2th day from pre weight reduction), 5%(4th day from pre weight reduction, 7%(7th day) and investigated the recovery period on 3 hour after breakfast, lunch, and 1day, 2day after 7% body reduction. Weight reduction reduced weight during weight reduction period then returned to baseline during recovery(p<.05) and decreased LBM, electrolyte, and immune function and then increased in recovery period to baseline. In conclusion, weight reduction of Judo athletes caused the change biological variable and performance and STWR may detrimental effects body' homeostasis.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

정신분열증 환자의 신체증상과 인구통계학적, 임상인자들과의 관련성

윤정흠,김선경,전현태,이귀행 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

배경 : 이 연구의 목적은 정신분열병 환자의 신체증상과 인구통계학적, 임상인자들과의 관련성을 알아보기 위함이다. 방법 : 연구 대상군은 입원중인 63명의 정신분열병 환자를 대상으로 하였다. 신체 증상의 정도는 한국어판 신체증상목록을 사용하여 측정하였다. SPSS 11.5를 이용하여 신체증상의 정도와 우울, 불안, 교육정도, 적응상태와의 관계를 피어슨 상관분석을 통하여 평가하였다. 결과 : 1) 신체증상의 정도는 교육기간과 입원 당시의 적응 상태와는 부적 상관을 보였다(p<0.05). 2) 신체증상의 정도는 우울, 불안과는 정적 상관을 보였다(p<0.05). 3) 정신분열병 환자의 신체 증상의 빈도는 다음 순이었다: 두통, 피로, 수면장애, 건강염려, 현기증, 오심, 위장장애, 근력 약화, 허리나 등의 통증, 복부의 가스. 결론 : 정신분열병의 신체증상의 정도는 교육기간이 길고 입원 당시의 적응상태가 좋을수록 감소하였다. 그리고 신체 증상은 우울, 불안의 증상이 심할수록 증가하였고, 이는 특히 신체증상이 우울, 불안과 관련이 있다는 것을 알 수 있었다. Background : The purpose of this study was to examine the correlation between somatic symptoms and demographic and clinical variables in schizophrenia patients. Methods : The subject were 63 schizophrenia patients ; male(n=35, mean age =39), female(n=28, mean=age 40). The degree of somatic symptoms was measured using the Korean versions of Wahler Physical Symptom Inventory(WPSI). The relationship among somatic symptoms, anxiety, depression, education period and adjustment was evaluated by Pearson correlation with SPSS 11.5. Results : 1) The degree of somatic symptoms showed negative correlation with education period and current adjustment at admission(p<0.05). 2) The degree of somatic symptoms was significantly correlated with degree of the depression and the anxiety(p<0.05). 3) The frequent somatic symptoms were as follows in order : headaches, feeling tired, difficulty sleeping, poor health in general, dizzy spells, nausea, intestinal or stomach trouble, muscular weakness, backaches and excessive gas. Conclusion : The somatic symptoms of schizophrenia were decreased in the group of the long education period and the good current adjustment at admission. The more depression and anxiety were increased, the more somatic symptoms were revealed. It suggests that somatic symptoms of schizophrenia may be related to depression and anxiety.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

난치성 만성정신분열증 환자의 생활의 질에 미치는 정신사회치료 프로그램의 효과에 대한 예비연구

송동호,배민진,이종호,이홍식,김선경,서호석,김찬형,전지용 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : Recent studies of psychosocial adjustment after hospitalization have found that the combination of maintenance antipsychotic drug treatment and psychosocial treatment including psychoeducational program are highly predictive of social rehabilitation and reduction of subsequent relapse. Two groups of patients with refractory chronic schizophrenia were preliminarily compared to determine the effect of a psychosocial treatment program on the quality of life in refractory chronic schizophrenics in an open comparative trial. Methods : One group(N=11) was assigned to approximately six months of the psychosocial treatment program(including psychoeducation program and activity program such as interpersonal relationship program, social skill training, self management program, outings, etc), in a group format, twice a week and a fixed maintenance dosage of clozapine ; while scale(QLS) was used to provide an objective measure of changes in patient's psychosocial functioning and a general assessment of psychopathology was made using the Brief Psychiatric Rating Scale(BPRS). Results : Both BPRS total positive score and the QLS total score, especially in the intrapsychic foundation factor of the scale showed a statistically significant improvement in the psychosocial treatment group. But there was no significant change in both BPRS and QLS scores over a 6-month period in the non-psychosocial treatment group. A significant negative correlation was found between the negative symptom and changes of QLS total, instrumental role and common object and activities scores respectively after receiving a 6-month of the psychosocial treatment program. Conclusion : These results suggest that a psychosocial treatment program including the integration of psychoeducation and a skill training oriented activity program serve as an outpatient treatment modality to improve the quality of the life in refractory chronic schizophrenia. To further clarify the effect of psychosocial treatment in chronic schizophrenia, a randomized trial should be done.