狗耕田譚의 民俗學的 硏究

崔仁鶴 관동대학교 1976 關大論文集 Vol.4 No.1

1. Approach to Study in Folklore Study of folktales has been made by many other scholars since Grimm brothers had begun. The study of folktales has been processed in situation of literature, socio-psychology, anthropology, ethnology. It has been processed also in Korea, Japan, and China since early 20th centuries. In China folktales have been classified by W. Eberhard. In Japan folkloristic study of the folktales had been attempted by K.Yanagida and thereafter they were arranged and classified by K.Seki and H.Ikeda. In Korea Jin-Tae Son had attempted to begin its study since 1930's, but it was merely in the stage of enlightenment in view point of history of the study. However since 1950 the study of folktales has been made mainly by scholars of national language and Iiterature. It came to realize that the folktale, as A.Aarne and K. Klohn insisted, has its individual history and channel of transmission. Therefore, it is consented that folktale should be studied its essence by itself than it deals with other fields. Among Korean folktale there is a story which a dog plows a fileld. Similar stories can be found in China and Japan. Then, in what background of folklore and of times did this story originate? And how was it transmitted down? 2. Summary of the Story and its Problems There were two brothers, and younger brother went to visit his mother's grave. He found a dog by the grave and took it home and raised it. The dog plowed a field for him. He became rich because of its help. The elder brother borrowed the dog but the dog did not plow a field and was killed by him. The younger brother buried its body, and then a tree grew up from the grave. It grew up high enough to pierce the storeroom of the heaven. Thus the younger brother became very rich because of the treasure from the storeroom of the heaven. The elder brother moved the tree to his house. Then, the tree pierced the toilet of the heaven so that all of the feculence came down and filled up his house. So he became very poor. Such contents of folktales, although there are a little differences in expression, have been transmitted also in China and Japan. China: No.30 Der Hund pfeugt das Feld. Type chinesischer Volksmarchen. 1937.FFC 120. by W.Eberhard. Japan: No.503 E.F. Kamotori-jiji and Hanasaka-jiji. A Type and Motif Index of Japanese Folk-Literature. 1971. FFC 209. by H. Ikeda. Korea: No.458 Two Brothers and A Dog. A Type Index of Korean folktales. 1975, Tokyo. by In-Hak choi. This folktale is to described an internal conflict of human being. Through the birth of supernatural dog it brings the good good fortune, while the bad punishment. The content of this folktale is very instructive. However, why the dog should appear in the folktale is the most important view of all. In order to solve this problem, first of all, it is necessary to study the nature and folklore of the dog. 3. The Nature and Folklore of the Dog According to the Hasting's dictionary, the dog has a complicated relationship with human being. It is used, for example, for a game, a hunting, a war, an ancestor, a spiritual being, a messenger of god, a beast of burden, a magic etc. Frazer indicated that the dog was used as a spirit of grains. Among the folktales in China and Korea the dog often appears when man becomes a dog after death. The dog is concerned as a spiritual animal in China and Japan, on the other hand they sometimes are apt to consider a dog as an object of enmity or hatred. In Korea it is known as a messenger which leads the soul to the other world whin man dies, and as an animal which brings good fortune. On the other hand, the dog is used for food because if one eat meat of a dog, he can stand well intense heat in summer. In some place of Japan pregnant women worship a dog in order to have a easy childbirth since a dog is usually easy to have a pup. In the old days of Korea and Japan, judging from a dog's barking, they used to tell the rise and fall of a nation or death of a great man. 4. Analyses of the Content and Conclusion In this folktale there are three important motives: an appearance of a dog, a miracle of a dog, and other miracles after its death. There are many variations in the third motif since it can be changed by story-tellers in their own way and even some of them became comic tales. In the part of an appearance of a dog 1) gift of god of king of dragon kingdom (china, Japan), 2) floating down along the stream(Japan), 3) coming out from the grave (China, Korea), 4) raising up (China, Korea, Japan), there are four forms. 1) and 2) belong to the same genre, which has a background of the concept-dog is a messenger of a god. 3)belongs to the concept of Jeonsaeng (轉生) (man is born again to other person or an animal after death). 4) is the latest form of all and a part of the appearance of superrealistic dog seems to be missed. Next, a miracle of a dog 1) plows a field(China, Korea), 2) brings an abundant harvest from hunting(Japan), 3) gets treasure (China, Japan, Korea), 4) transforms into human(China, Korea), can be devided into four forms. 1) It is in doubt that the dog really plowed a field, however, it is clear that a dog was associated with farming. They believe it was a dog that brought man grains at first time in China. 2) Considering a role of a dog in the age of hunting, it is a likely source. 3) belongs to the concept which a dog brings a good fortune. 4) belongs to the concept of Jeonsaeng(轉生). This folktale has not widely been distributed in Korea as much as in China. Korea imported a farming culture from China. with this respect, I believe that this folktale might be originated from China, consequently, it has been transmitted to Korea.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

GG-38 : Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen

( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.

도계부산물인 닭털을 이용한 목재접착제의 내수성 평가

박대학 ( Dae-hak Park ),양인 ( In Yang ),최원실 ( Won-sil Choi ),오세창 ( Sei Chang Oh ),안동욱 ( Dong-uk Ahn ),한규성 ( Gyu-seong Han ) 한국목재공학회 2017 목재공학 Vol.45 No.1

본 연구는 주원료로 도계부산물인 닭털의 NaOH 가수분해물, 경화제로 닭털의 H₂SO₄ 가수분해물 및 폼알데히드계가교제를 반응시켜 접착제를 제조하고, 이에 대한 물성 및 내수성 실험을 통하여 닭털의 목질계 판상재용 접착제의 원료화 가능성을 확인하기 위하여 수행하였다. 닭털은 주로 케라틴계 단백질로 구성되어 있었으며, 중금속의 함유량이 매우 낮거나 검출되지 않았다. 알칼리에 대한 닭털의 가수분해율은 수용액 내의 NaOH 농도가 증가함에 따라 계속 증가하였으나, 과도한 가수분해에 따른 단백질 고유의 접착능 손실을 최소화하고 적정한 가수분해 조건을 찾기 위하여 닭털의 가수분해제 내의 NaOH 농도를 5%, 7.5%, 10%로 결정하였다. 접착제의 조성을 보면, 고형분 함량을 기준으로 70%의 닭털 NaOH 가수분해물 또는/그리고 경화제로 닭털의 H₂SO₄ 가수분해물 및 30%의 가교제로 조제하였는데, 이접착제의 고형분 함량은 가수분해 조건 및 가교제의 종류에 따라 28.3 - 44.8% 범위에 존재하였다. 이 접착제의 점도는 상온에서 전반적으로 높았으나, 50℃에서 측정한 결과 분사형 접착제로서 적용이 가능한 것으로 조사되었다. 접착제의 내수성을 비교하기 위하여 측정된 열수 불용해율은 5% 농도의 NaOH 수용액에서 반응시킨 닭털의 알칼리 가수분해물(CF-AK-5%)에 경화제로 5% 농도의 H₂SO₄ 수용액에서 반응시킨 닭털의 산가수분해물(CF-AC-5%)을 고형분함량 기준 10% 이상 첨가하여 제조하고 경화시킨 접착제에서 높았다. 또한 접착제 제조시 고형분 함량을 기준으로 30%가 첨가된 가교제별 열수 불용해율은 phenol-formaldehyde (PF), melamine-urea-formaldehyde (MUF), formalin 순으로 조사되었다. 닭털 접착제의 열수 불용해율을 섬유판 제조에 사용되고 있는 석유화학계 합성수지와 비교한 결과, CF-AC-5%에 가교제로 PF를 그리고 경화제로 CF-AC-5%를 첨가하여 조제한 접착제는 기존 멜라민-요소수지의 열수불용해율과 통계학적으로 차이가 없었으며, 가교제로 PF를 사용한 모든 접착제와 고형분 함량을 기준으로 55%의 CF-AK-5%, 15%의 CF-AC-5% 그리고 가교제로 30%의 MUF와 함께 제조한 접착제는 기존 요소수지를 대체할 수 있는 것으로 조사되었다. 이 결과를 토대로 적정한 조건에서 가수분해한 닭털은 목질계 판상재용 접착제의 원료로 사용이 가능할 것으로 판단된다. This study was conducted to investigate the potential of chicken feather (CF), which is a by-product in poultry in-dustry, as a raw material of wood adhesives. For the purpose, adhesive resins were formulated with NaOH- and H₂SO₄-hydrolyzed CF as well as crosslinkers, and then the properties and water resistance of the adhesive resins against hot water were measured. CF was made of mainly keratin-type protein, and no or very low content of heavy metals was detected. Hydrolysis rate of CF increased as NaOH concentration in hydrolysis solutions increased. However, in order to minimize the loss of adhesive property of protein itself by the severe hydrolysis of CF and to seek its proper hydrolysis conditions, NaOH concentrations in hydrolysis solution determined to adjust to 5%, 7.5% and 10%. In the NaOH-hydrolyzed CF, H₂SO₄-hydrolyzed CF as a hardener and crosslinker were added to for-mulate CF-based adhesive resins. Solid content of the resins ranged from 28.3% to 44.8% depending on hydrolysis conditions and type of crosslinker. Viscosity of the resins at 25℃ was very high. However, when the temperature of the resins was increased to 50℃, the viscosity decreased greatly and thus the resins could be applied as a sprayable resin. Retention rate measured to evaluate the water resistance of adhesive resins was the highest in the cured resin formulated with 5% NaOH-hydrolyzed CF and 5% H₂SO₄-hydrolyzed CF of 10% based on the solid weight as a hardener. Retention rate depending on crosslinkers added into adhesive resins was the highest phenol-formaldehyde (PF) followed by melamine-urea-formaldehyde (MUF) and formalin. The retention rate of CF-based adhesives formulated with 5% NaOH-hydrolyzed CF, PF and H₂SO₄-hydrolyzed CF of 10% and over did not differ statistically from that of commercial MUF resins. All of CF-based adhesives formulated with PF as a crosslinker and one with 5% NaOH-hydrolyzed CF of 55%, 5% H₂SO₄-hydrolyzed CF of 15%, and MUF of 30% on the basis of solid weight could be substituted for commercial urea-formaldehyde resins, From the results, CF can be used as a raw material of wood adhesives if hydrolyzed in proper conditions.

천연물이 간대사에 미치는 영향에 관한 연구(Ⅲ)

김순선,최기환,김학림,황인창,김동섭,신윤용,류항묵,장영섭 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-

본 연구에서는 만성간염둥 간낄환 01방 및 치료제로서 오래전부터 널러 사용죄고 있으나 그 작용기전이 화실히 밝궈져있지 않은오미자에서 추출한 을hisandrin C의 합성 동족체, biphenf·1 dimethrt carboxylate(ODB)의 간장 보호자용 기전 연구의 일환으로 DDB를 시간(I~T일) 및 용량(25, 50, 100, 200mg/kg)별로 랫드에 투여한 훌 간장내 약물대사효소, CYPtAl과 CYPEBI mRNA 합량을 PolyrEerasff chain reation(PCR)밟법으로 측정하고 CfPIAl에 특이한 ethoxyruesorfin-o-deethylase(EROD)와 CYPaBt에 특이한 benzyloxyresorufin-o- dealkrlase(BROD) 활성을 측정한 결꽈, DDB가 CYPIAI mRNA 힘·량 및 EROD활성에는 영향을 미치지 않았으나 CYPfBl 유전자 발현을 유도시키고 CYPEBI에 특이한 fiROD 될성을 증가시켰다. DD8의 이러한 CYPEBI 유전자 발현유도 효과는 투여시간, 용량에 비례하여 3일, 200rag/kg투여시에 극대치를 나타내었으며 BROD찰상 역시 투여시간, 용량에 비례하여 증가하였다. 또한 DDB의 간보호 효과를 평가하기 위해 DDB를 용량(25, 50, 100,200mgJkg)별로 4일간 연속 길구투여하고 DDB 최종투여 3시간후 CCI,(0.3mJ/kg, i.p)를 처치하여 간독성을 유발 시킨 후, CYPfBl mRNA 함량과 BROD 활성을 조사하고 간조직 검사를 실시하였으며 혈청내 aminotransferase 꽉성 및 간소포체내 lipid perflxidation을 측정하였다. DOB 전투여는 CCI, 처치에 의왜 감소된 CYPBBI mRNA 함량자 BHOD 활성을 용량의콘적으로 증가시켰으며 CCI, 처치에 의해 증가된 혈청내 ALT 활성과 간 소포체 막의 lipid peroxidation을 감소시켰다. 혈청내 ALT 활성같 간 소포체 막치 lipid peroxidation에 근거하면 DDB는 CCI, 처치로 유발된 간독성에 럴호효롸를 나타내며 그 효과는 50mg/kg;투여시에 최대인 것으로 보인다. 반면, CCI, 처치에 의해 유발된 간 표면의 섬유화, 간세포 괴사 및 공포화 변성은 DDB 투여에 의해 통계적으로 유의성있는 개선 효과를보이지 않았다. 이상의 결과는 DDB가 CYP2린1 유전자 발현 및 BROD 활성을 시간 및 용량의존적으로 증가시킴을 나타내며 DDB의 free radical scavenger가능성을 제시한다. 미와 더불어 전년도 시험물질, 대황 및 마황의 환셩성분인 rhein, eptledrine과 황금의 지표성분인 baicalin이 간 대사 및 독성에 미치는 영향을 비교평가 하기 위해 rhein 및 ephedrinr·을 각각 20, 10mg/kg 용량으로 랫드에 4일간 복강주사하고 baicalin은 4mg/kg 용량으로 7일간 경구투여한 후, 간장내 약물대사 효소 CYPIAI과 CYPaBl 유전자 발현정도를 조사하고 애들에 특이한 EROD 와 BROD활성, 혈청내 ALT, AST 활성 및 간소포체내 지질과 산화물(rnslondialdehyde) 함량을 측정한 결과, ephedrine은 만성간염지표인 ALT/AS? ratio을 증가시키고(p (0.03) rhein은 MDA함량을 증가시켰는데,(p(0.01) 이는 대황 투여에 의한 간 소포체 막의 lipid peroxidation증가는 rhein에,마황에 의한 혈청내 ALT/AST ratio증가는 ephedrine에 기인함을 시사해주는 결과이며 금의 지표성분인 baicalin투여에 의해서는 혈청중 ALT 및 AST 활성이 재조군에 비해 유의적으로 감소되어(p(0.05) baiealin의 간보호 가능성을 제시하였다. Biphenyl diinethyl dicarboxylate(DDB) is a synthetic analogue of SchiBandrin C isolated from SchiBandrae Fructus and has been widely used for its hepatic protective effect. This study has beenundertaken to examine the effect of DDB on rat liver drug metaboliEing enzymes and to understand theprotective mechanism of D:DB against carbon tetrachloride(CCl4) -induced hepatic toxicity in rat liver.After DDB was administered into male rats for different periods of time(1 ~7 days) ana with differentdoses(25, 50, 100 and 200mg/kg), mRNA levels of CYPIAI and CYPaHl were measured by polymerasechain reaction (PCR) and also assayed the activities of CYP IAI specific ethoxyresorufin-o-deethylase(EROD) and CYPfBl sf)ecific benzyloxyresorufin-o-dealkylase (BROD) . Furthermore, rats werepretreated with DDB 25, 5() and 100 mg/ltg daily for 4 days, 3-hours after final treatrneBt on the 4thday, CCI, 0.3mf/kg was intraperitonially injected into the rats. Activities of serum aminotransferaseswere assayed and determirled lipid peroxidation(production of ualondialdehyde) in hepatic microsomeand done histopathological examination. DDB treatment resulted in increase in CYPaBl mRMA leveland BROD activity whereas there was no change in CYPIAI niRNA level and EROD activity. This ef-fect of DDB was time and dose dependent reaching maximal level by 3 day and 200mg/kg treatment.Based oi?'studies of serum ALT level and lipid peroxidation, D:DB SOmg/kg pretreatinent appeared themost effective protection against CCI,-induce4 hepatotoxicity. :However, histopathological examinationdid not significantly show any improving effect on balloning degeneration and necrosis caused by CCI,treatment. These results in.dicate that DDB stimulates CYPEBI ruRNA level and BROD activity in timeand dose dependent manner and suggest protective effect of DDB against CCI,-induced hepatotoxicitymight be exerted through free radical scavenging. In addition, we have also investigated the effects ofrhein, ephedrine and baicaBin on hepatic toxicity and metabolism in rat liver in order to compare withtheir natural products f·hick are Rhei Rhizoma, Ephedrae Hel·ba and Scutellariae Radix, respectively.After rhein 20 and ephedrine 10mg/kg were intraperitonially injected into the rats daily for 4 daysrespectively compared as bacaBin was treated orally for 7 days, the expression of CYPIAI and CYPfBlwere examined and tlleir dependent EROD and BROD activities were assayed. The levels of serumaainotransferases and hepatic rnaiondialdehyde(MDA ) were Beasured as well. Ephedrine treatment in-creased in CYPIAI specific EROD activity and the ratio of serum ALT/AST ratio, a marker of chronichepatitis(p <0.01). MDA level was enhanced by rhein treatmentfp < 0.01), but baicalin reduced serumALT and AST levels compared to control group (p < 0.05) .

기혼여성의 스포츠와 여가만족도 규정요인에 관한 연구

김유수,안종학,최인순,안영필 東亞大學校附設스포츠科學硏究所 1998 스포츠科學硏究論文集 Vol.16 No.-

As society has been changing rapidly, so the evaluation of women's position and the value of leisure has been changing. Women's demanding of leisure activities is also increasing today. I studied on the factors which have effected on the satisfaction of leisure time's married women in cities with involvement of leisure and sports activities. The results are as follows ; 1. Married women's leisure and sports activities by ages & educational level. (a) As for married women in cities, the older they are the more they took experiences in sports activities for a year. I think it is desirable but in health care it is concerned that young married women in cities don't take part in sports activities. (b) The higher their ages are, the more time is required for exercise in a time. (c) The old age group at 60s expressed the most active attitudes in joining sports clubs. (d) The young age group of 20s preferred to join clubs in their work and public centers while the old age group of 60s, 88.9%, definitely prefered to join clubs in public centers. (e) In the joining sports clubs, married women in 30s will was highest, while the old age group of 60s and over was lowest. (f) In the last one year, housewife participating in 20s was comparatively lower. (g) In the satisfaction of leisure time, the old age group of 60s and over was highest while the young age group of 20s was lowest. That is, the more ages were highter the more the satisfaction of leisure time was. (h) In the percentage of participating in sports activities in the last one year, the married women who finished only middle school was highest, 95.7%, So the higher educational level is the lower the percentages of that is, (i) In the time required, the higher educational level is, the shorter the time became. (j) In the facilities, many married women who finished university used them in their works or schools, or public centers. (k) In the time of moving to the facilities, there was little difference in educational levels, but the time of married women who finished university was less than others. (l) In the participating in several lectures, the higher educational level was, the higher the percentage was. (m) In the satisfaction of leisure time, the higher educational level was, the lower the percentage was, So I don't think the programs and condition of leisure and sports activities satisfy married women of high educational level. 2. The list of factors which have effected on the satisfaction of leisure time, are as follows ; (a) the attitudes of leisure time or sports activities, (b) the result of leisure time or sports activities(treatment for hypochondria and anxiety) (c) the result of leisure time or sports activities(treatment for shoulder pain and backache, and relief of worries) (d) the time required in a time. (e) confidence of body activities (f) the result of leisure time and sports activities(they got confidence and satisfaction) (g) the frequency of participating in leisure and sports activities in the last one year. (h) the result of leisure time and sports activities(they became to be friendly with and became kind to others) (i) the result of leisure time and sports activities(they became to plan their life-styles actively) (j) health condition. From these lists I could understand the most important factor is the body activity-oriented leisure time activities of married women in cities.

공간정보에 기반한 도로 데이터 자동생성 방법

주인학,최경호,유재준,황태현,이종훈,Joo, In-Hak,Choi, Kyoung-Ho,Yoo, Jae-Jun,Hwang, Tae-Hyun,Lee, Jong-Hun 한국공간정보학회 2002 개방형지리정보시스템학회 논문지 = Journal of the Korea Open Geogr Vol.4 No.2

효율적인 도로정보의 구축은 GIS에서 가장 중요한 주제이다. 본 논문에서는 도로정보를 자동으로 생성, 구축하기 위하여 모바일 매핑 기술과 영상인식 기술을 결합한 방법을 제안하였다. 모바일 매핑 시스템은 CCD 카메라, GPS, INS를 장착한 차량의 형태를 가지며, 취득한 영상에 나타난 공간객체의 좌표를 사진측량기법을 이용하여 계산한다. 모바일 매핑 시스템에 의한 공간객체 좌표추출과 데이터 구축은 자동화되지 않아 시간이 많이 드는 단점이 있다. 도로의 자동 인식은 영상인식 분야에서도 자동주행차량에 대한 연구의 형태로 진행되어 왔다. 그러나 영상인식에 기반한 방법들은 도로 차선에 적용할 경우 차선의 끊김 차량에 의한 가려짐 좋지 않은 날씨와 조명 등 실제의 도로나 도로변의 다양한 예외상황 때문에 원하는 결과를 얻기 힘든 경우가 많다. 이러한 단점을 보완하기 위하여 본 논문에서는 모바일 매핑 시스템으로부터 획득된 GPS/INS 데이터 및 영상인식 기술을 모두 이용한 자동 도로데이터 생성방법을 제안하였다. 영상에 나타난 도로 차선의 3차원좌표로부터 영상에서 객체가 나타날 위치를 추정하기 위한 방법을 고안하였으며, 이러한 방법은 도로 차선을 찾기 위한 복잡한 영상처리 과정을 대폭 줄일 수 있다. 예외상황 때문에 도로차선을 추출하지 못한 경우에는 스플라인 인터폴레이션에 의하여 값을 얻는다. 인터폴레이션은 교차로나 급격한 변화 지점에 따라 구분된 도로 구간 단위로 이루어진다. 본 논문에서는 제안된 객체좌표 추정방법과 인터폴레이션 기법에 대한 실험 및 결과를 제시하였다. VEfficient generation of road data is one of the most important issues in GIS (Geographic Information System). In this paper, we propose a hybrid approach for automatic generation of road data by combining mobile mapping and image processing techniques. Mobile mapping systems have a form of vehicle equipped with CCD camera, GPS, and INS. They can calculate absolute position of objects that appear in acquired image by photogrammetry, but it is labor-intensive and time-consuming. Automatic road detection methods have been studied also by image processing technology. However, the methods are likely to fail because of obstacles and exceptive conditions in the real world. To overcome the problems, we suggest a hybrid method for automatic road generation, by exploiting both GPS/INS data acquired by mobile mapping system and image processing algorithms. We design an estimator to estimate 3-D coordinates of road line and corresponding location in an image. The estimation process reduces complicated image processing operations that find road line. The missing coordinates of road line due to failure of estimation are obtained by cubic spline interpolation. The interpolation is done piecewise, separated by rapid change such as road intersection. We present experimental results of the suggested estimation and interpolation methods with image sequences acquired by mobile mapping system, and show that the methods are effective in generation of road data.

우로수데옥시콜릭산이 치주질환 억제에 미치는 영향

박상현,한승민,최상목,구영,류인철,한수부,이학모,김문무,김상년,정종평,Park, Sang-Hyun,Han, Seoung-Min,Choi, Sang-Mook,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Lee, Hak-Mo,Kim, Moon-Moo,Kim, Sang-Nyun,Chung, Chong-Pyoung 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.1

Ursodeoxycholic acid(UDCA) is a hydrophilic gall bladder acid and has been used as a effective drug for liver disease related to in1munity. This drug inhibits secretions of IL-2, IL-4, and $IFN-{\gamma}$ from T-cells and production of immunoglobulin from B-cells. Also it has been reported that UDCA inhibits production of IL-1 related to the progression of periodontal disease and activation of collagenases. The purpose of the present study was to elucidate the effects of UDCA on inhibition of periodontal disease progression using clinical, microbiological and histometrical parameters. Twelve pure bred, 16 month-old-beagle dogs were used in the study. After ligature-induced periodontal diseases were formed, experimental drugs were applied twice a day and then the results of clinical, microbiological, and histometrical parameters were measured at baselie(initiation of experiment) , 4weeks and 8weeks. The gel with UDCA(concentration 0.5%, 5% 3 dogs in each) was applied to experimental group, chlorhexidine to positive control group(3dogs) and the gel without UDCA(base) to negative control group. After induction of general anesthesia, the maxillary 2nd, 3rd premolars and 1st molar and the mandibular 2nd, 3rd, 4th premolars and 1st molar were ligated in one side selected randomly and were not ligated in the opposite side. The plaque index(PI), gingival index(GI), pocket depth(PD) and gingival crevicular fluid(GCF) volum were measured clinically. The PI and GI were measured at 3 buccal points of all experimental teeth and the GCF was measured only at the 3rd premolar in the maxilla and the 4th premolar in the mandible. In the microbiological study, the samples extracted from the 3rd premolar of the maxilla and the 4th premolar of the mandible at the center of buccal surface were analyzed aerobics, anaerobics and Streptococcus colony forming units, After clinical and microbiological examination at 8weeks, the dogs were sacrificed by carotid artery perfusion. The samples were fixed and sectioned including interproximal area, and the distance from cementoenamel junction(CEJ) to alveolar crest was measured. The results were that PI, GI and PD increased until 4 weeks and decreased at 8 weeks in three groups but the differences between all the groups were not significant. The 0.5% UDCA in non-ligated group showed remarkable decrease of GCF. The experimental group applied 5% UDCA decreased the number of aerobics and anaerobics. The distance from CEJ to alveolar crest was greater in the negative control group on both ligated and non-ligated sides, but the differences were not significant stastically.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Helicobacter pylori cagE 유전자 다형성이 위상피세포주에서 Interleukin-8 유도능에 미치는 영향

이수민,이학성,이인석,조유경,한혜원,오정환,박재명,최명규,정인식,Lee Su-Min,Lee Hak-Sung,Lee In-Suk,Co Yu-Kyung,Han Hae-Won,Oh Jung-Hwan,Park Jae-Myung,Choi Myung-Gyu,Chung In-Sik 한국생명과학회 2004 생명과학회지 Vol.14 No.6

Helicobacter pylori infection is highly prevalent, as high as 2/3 of whole population infected, in Korea. H. pylori infection initiates inflammation by induction of interleukin-8 through type IV secretion of CagA. It was recently suggested that induction failure of IL-8 is not associated with defect in cag PAI but associated with cagE locus diversity. This study was designed to investigate ability of 11-8 in-duction according to sequence variation within the cagE gene, cagA TP motifs and vacA m-types in vitro study using AGS cell-line, and to evaluate its association with different clinical outcome. Seventy-four H. pylori stains were isolated from 23 patients with gastric cancer (Ca), 24 subjects with gastritis (G) and 27 patients with duodenal ulcer (Du) in Kangnam St. Mary's Hospital, Seoul, Korea. cagE gene diversity was confirmed by the PCR-RFLP methods with MboI/NlaIII and tyrosine phosphate motifs (TPMs) of cagA was determined TPM-A and C by using DdeI/Tsp5091 restriction enzyme and TPM-B was determend by Real time PCR the method of Owen et al. and IL-8 was measured by ELISA assay. IL-8 activity was positively detected in 59 among 74 strains $(79.7\%)$. IL-8 secretion was significantly increased in MboI A and MboI B type compared to MboI C type and in MboI/NlaIII A-C and B-C type than C-C type. 1L-8 activity was not associated with either the number or composition of cagA tyrosine phosphorylation motifs and vacA m-type. There was no significant difference in IL-8 activity among patient groups. cagE gene diversity is thought to be mainly associated with the induction of IL-8 in H. pylori infection. 한국에서 분리한 Helicobacter pylori 균주가 위암 세포주에서 IL-8를 유도하는 유도능을 관찰하고자 하였으며, 특히 4형 분비구조의 주요 구성체인 cagE 유전자의 다형성에 따라 IL-8 유도능의 차이 및 각 질환에서 분리한 균주에서의 차이가 있는지 검토하고자 하였다. 강남성모병원 내시경검사를 받은 환자들 중 H. pylori 감염 양성으로 확인된 위암 23명 $(31.0\%)$, 위염 24명$(32.6\%)$, 십이지장궤양27명$(36.4\%)$ 총 74명을 대상으로 하여 H. pylori를 분리한 후 PCR-RFLP방법을 이용하여 cagE 다형성을 확인하였으며, PCR 및 Real-time PCR을 이용하여 ragA TPMs를 결정하였다, 또한 분리된 균주를 위암세포주에 감염시켜 상등액을 취하여 ELISA방법으로 IL-8을 정량화 하였다. 전체 74개의 분리 균주 중 59개의 균주$(79.7\%)$에서 IL-8 유도능이 있는 것으로 확인되었으며, cagE 다형성 중에서 가장 높은 빈도로 관찰되는 형태는 MboI/NlaIII B-C, A-C 및 C-C 타입 이었으며, 이중 A-C와 B-C 형태가 C-C 형태에 비해 유의적으로 높은 IL-8 유도능을 나타냈다. 그러나 cagA TPMs의 분류 및 vacA m-아형 분류와 IL-8 유도능과는 연관성이 없었다. 비록 본 연구에서 cagE 다형성과 IL-8 유도능과 아주 밀접한 연관성이 나타나지는 않았지만 vacA m-아형이나 cagA TPMs 보다는 cagE 다형성이 IL-8 유도능과 연관성이 클 것으로 생각된다.