부신피질 호산성 과립세포종 1예

이성진,이호권,박철영,정인경,홍은경,오기원,김현규,김두만,유재명,임성희,최문기,유형준,박성우 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

저자들은 건강검진에서 시행한 복부 초음파검사상 우연히 좌측 부신 종괴가 발견되어 복부 전산화 단층 촬영검사와 호르몬검사를 시행한 후 부신피질 악성종양과의 감별 진단을 위해 부신절제술과 전자현미경검사를 포함한 병리조직학적 검사를 시행하여 부신피질호산성 과립세포종으로 진단한 증례를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. Oncocytomas are neoplasms, histologically are composed of epithelial cells, with abundant, acidophilic and granular cytoplasm. Electron microscopic studies of oncocytomas have shown that the cytoplasm of oncocytes is packed with mitochondria. The adrenal gland is a very rare anatomical site for oncocytomas, and to the best of our knowledge, only thirty-six cases of adrenal oncocytomas have been described. Herein, a case of a large adrenal mass in a forty-year-old man, which was incidentally detected by abdominal ultrasonography, is presented. This patient demonstrated no clinical manifestation associated with adrenal hyperfunction. Hormonal studies showed no abnormal findings, except for a mild elevation of the 24-hour urinary VMA level. Abdominal computed tomography with enhancement revealed a large, well-defined left adrenal mass, measuring 5.0×4.2 ×3.0 cm. The patient underwent a left adrenalectomy, and a light microscopic examination confirmed an adrenocortical oncocytoma, with characteristic oncocytes and polygonal, abundant, eosinophilic and granular cytoplasm. The tumor cells were positive for cytokeratin and vimentin as well as S-100, but negative for chromogranin on immunohistochemical staining. An electron microscopic examination demonstrated closely packed mitochondria, containing intramitochondrial inclusions. After surgery, there was no evidence of a recurrent or distant metastatic disease at the 5 month follow-up. In summary, an extremely rare case of a man with an adrenocortical oncocytoma is reported, which was confirmed by histological examinations, including electron microscopy (J Kor Soc Endocrinol 19:82∼89, 2004).

불안정 고혈압 환자에서 후두경하 기관내 삽관시 Propofol 혹은 Thiopental Sodium-Esmolol이 혈역학 및 혈중 Catecholamine치에 미치는 영향

오인영,최영석,정우영,이일옥,공명훈,이미경,김난숙,임상호 대한정맥마취학회 2000 정맥마취 Vol.4 No.2

서론: 마취 유도 중 후두경하 기관내 삽관은 환자의혈압과 맥박을 상승시키고 경우에 따라 부정맥, 심근 허혈 또는 심근경색 등과 같은 치명적인 합병증을 유발시킬 수 있다. 본 연구는 불안정 고혈압을 보이는 환자의 마취유도시 propofol 단독 사용 또는 thiopental과 esmolol의 혼합사용이 후두경하 기관내 삽관시 심혈관계와 혈중 catecholamine 치의 변화에 미치는 영향을 조사하고자 시행되었다. 방법: 불안정 고혈압을 보이는 미국마취과학회 전신상태 분류상 1 또는 2 등급에 속하는 36명의 계획수술 환자를 대상으로 연구목적과 방법을 설명하고 동의를 얻은 뒤 두 군(n = 18)으로 분류하여 1군은 propofol 3 ㎎/㎏을 2군은 thiopental sodium 5 ㎎/㎏과 semolol 0.5 ㎎/㎏을 투여하고 두 군 모두 succinylcholine 1㎎/㎏을 투여하여 전신마취를 유도하였다. 일반적인 후두경하 기관내 삽관을 시행하고 마취유지를 위해 50% 산소, 50% 아산화질소, 2% enflurane와 vecuronium 0.08-0.1 ㎎/㎏을 투여하였으며 호기말 이산화탄소 분압을 35-40 ㎜Hg로 유지하도록 조절호흡을 시행하였다. 수술실 도착 후부터 기관내삽관 후까지 총 7차례 환자 감시장치(CRITICON DINAMAO^TM 1846SX, USA)를 사용하여 비침습적 혈압(수축기, 이완기, 평균동맥압)과 심박수를 측정하고 혈중 카테콜아민 측정을 위한 혈액채취를 하였다. 측성지간은 각각 ① 수술실 도착 후, ② 기관내삽관 직전, ③ 기관내삽관 직후, ④ 삽관 후 1분, ⑤ 삽관 후 2분, ⑥ 삽관 후 5분, ⑦ 삽관 후 10분이었다. 두 군의 각 측정치를 통계적으로 비교 분석하였다. 결과: 1군에서 2군에 비하여 삽관 후의 수축기와 이완기 혈압변동이 유의하게 적었으며, 2군에서 1군에 비하여 삽관 후의 심박수 변동이 유의하게 적었다. 혈중 카테콜아민 치는 두 군 모두에서 전 측정기간 중 정상이었다. 결론: 불안정 고혈압을 가진 환자의 전신마취 유도시 기관내 삽관에 따른 혈역학적 변동을 줄이는데 propofol 3 ㎎/㎏의 사용은 적절한 방법 중의 하나로 사료된다. Background: Endotracheal intubation under the laryngoscopy is one of the most potent stimuli that increase in heart rate and blood pressure and following cardiac complication such as arrhythmia, myocardial ischemia and infarction can lead to fatal situation. This study was designed to evaluate the effects of propofol and esmolol-thiopental sodium on cardiovascular system and catecholamine change to tracheal intubation in labile hypertensive patients. Methods: Thirty six hypertensive patients, ASA class 1 or 2, scheduled for elective surgery were selected randomly. They were divided into two groups. (Group 1: propofol 3.0 ㎎/㎏, Group 2: esmolol 0.5 ㎎/㎏ + thiopental sodium 5 ㎎/㎏, n = 18 in each group). Induction of anesthesia was started with propofol 3.0 ㎎/㎏ (Group 1), esmolol 0.5 ㎎/㎏ + thiopental sodium 5 ㎎/㎏ (Group 2), and succinylcholine (1 ㎎/㎏). After tracheal intubation under the routine laryngoscopic technique, vecuronium 0.08-0.1 ㎎/㎏ was injected, 50% nitrous oxide in oxygen and 2% enflurane were inhaled. Using noninvasive automatic blood pressure monitor (CRITICON DINAMAP^TM 1846SX, USA), blood pressure (systolic, diastolic and mean arterial pressure) and heart rate were measured at 7 points; ① on arrival to operating room, ② just before intubation, ③ just after intubation, ④ 1 minute after intubation, ⑤ 2 minutes after intubation, ⑥ 5 minutes after intubation, ⑦ 10 minutes after intubation. Results: There was a significant attenuation in systolic and diastolic arterial pressure after tracheal intubation in Group 1 compared to Group 2. Heart rate was significantly blunted in Group 2 than Group 1. The catecholamine level was normal range all the time in bath group. Conclusions: We suggest that 3.0 ㎎/㎏ of propofol as a induction dose of anesthesia could be a good choice for blunting hemodynamic changes caused by laryngoscopy and endotracheal intubation in labile hypertensive patients.

Identification of Single Nucleotide Polymorphisms in the TNFRSF17 Gene and Their Association with Gastrointestinal Disorders

Chae, Soo-Cheon,Yu, Ji-In,Oh, Gyung-Jae,Choi, Chang-Soo,Choi, Suck-Chei,Yang, Yun-Sik,Yun, Ki-Jung Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.1

TNFRSF17 is preferentially expressed in mature B lymphocytes, and may be important for the development of B cells. TNFRSF17 is selected as a candidate susceptibility gene to IBD pathogenesis by our cDNA microarray analysis, and we showed the specific expression of TNFRSF17 in resting and activated $CD19^+$ cells obtained from human blood. We identified four SNPs (g-1729G>A, g.2295T>C, g.2445G>A and g.2493G>A) and one variation site (g.-894delT) in the TNFRSF17 gene using direct sequencing analysis. In addition, the association of the genotype and allelic frequencies of these SNPs was studied in healthy controls and in patients with ulcerative colitis (UC) or irritable bowel syndrome (IBS). Although, the genotype and allelic frequencies of these SNPs, in the UC and IBS patients, were not significantly different from those in the healthy controls, the distribution of the AAG, GGA, AGG and AAA haplotypes, of the SNPs (g.-1729G>A, g.2445G>A and g.2493G>A) associated with the TNFRSF17 gene, in the UC patients, were notably different from those of the healthy controls (P = 0.002, 0.002, 4.7E-4 and 3.3E-6, respectively). Moreover, the frequencies of the AAG, AGG, GAG and GAA haplotypes were significantly different in the IBS patients compared to the healthy controls (P = 4.2E-5, 4.4E-17, 1.8E-22 and 1.6E-10, respectively). These results suggest that the haplotypes of the TNFRSF17 polymorphisms might be associated with UC and IBS susceptibility.

그레이브스병에서 치료에 따른 폐동맥압의 변화

남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).

한국인 내당능장애 환자의 인슐린 분비능과 인슐린 감수성

정재훈,이명식,최윤호,김광원,정인경,양태영,오은영,김동준,이문규,민용기,함종렬 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.3

Background: Although insulin resistance has been known to be a primary defect causing type 2 diabetes in Pima Indians and Caucasians. However, insulin secretory defect rather than insulin resistance has been speculated and demonstrated to be a more important factor in the development of type 2 diabetes in other ethnic groups. Thus, we undertook this study to investigate the initial abnormality of glucose intolerance in Korean subjects. Methods: 374 Korean subjects were stratified according to the World Health Organization criteria (normal glucose tolerance (NGT), n=128; impaired glucose tolerance (IGT), n=128; diabetes, n=118) and subdivided further into the two groups; non-obese (BMI $lt; 25 kg/㎡) and obese group (BMI 25 kg/㎡). Insulinogenic index (the ratio of the increment of insulin to that of plasma glucose 30 min after glucose load) was used as an index of early-phase insulin secretion. AUC insulin (area under the insulin curve during OGTT) was used as an index of total insulin secretion. Insulin resistance was assessed by HOMA (R), the R value of the Homeostasis model. Results: Insulinogenic index decreased significantly in IGT compared with that in NGT in both non-obese and obese groups, respectively. There was no significant difference in AUC insulin and HOMA (R) between NGT and IGT group. Whereas AUC insulin showed its peak level in the range of IGT (7.7∼9.9 mmol/t.), insulinogenic index showed the peak level in the range of NGT (5.6∼7.7 mmol/IL and decreased progressively with increase of plasma glucose 120 min value. Conclusion: Early-phase insulin secretory defect might be the initial abnormality in the development of IGT from NGT in both non-obese and obese Korean subjects.

P089 : Toll-like receptor 2 mediates a cutaneous reaction induced by repetitive ultraviolet b irradiation in c57/bl6 mice in vivo

( Jin Yong Kim ),( Jung Yoon Ohn ),( Hyun Sun Park ),( Seon Pil Jin ),( Youn Gae Lee ),( In Gyung Oh ),( Serah Lee ),( Jung Ho Kim ),( Kwang Hyun Cho ),( Jin Ho Chung ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Toll like receptors (TLR) are a family of pattern recognition receptors that play an essential role in the induction of the immune response. Objectives: Previous studies suggested that single ultraviolet (UV) exposure may initiate a TLR-mediated sterile inflammation in vitro. This study was conducted to verify whether TLR2 mediates sterile inflammation, which is induced by repetitive to UVB exposure in vivo. Methods: Inflammatory responses to repetitive UVB irradiation were compared between wild-type (WT) and TLR2 knock-out (KO) mice. Results: After 6 weeks of repetitive UVB irradiation, inflammatory response of the TLR2 KO group was less severe than that of the TLR2 WT group. Compared to the group of TLR2 WT mice, the group of TLR2 KO mice displayed less prominent erythema and scaling; and histopathologically fewer inflammatory cells and significantly thinner skin. UVB-induced expression of the heat shock protein 70, an endogenous ligand of TLR2, was lower in the TLR2 KO group. Quantitative RT-PCR was used to measure the gene expression levels of interleukin (IL)-1β, IL-6, and matrix metalloproteinase (MMP)-13, all of which were lower in the TLR2 KO group, compared to the WT group. This finding was further corroborated with ELISA and western blot, each of which showed lower protein expression level of IL-1β, and MMP-13, respectively. Conclusion: This study demonstrated that TLR2 is involved in cutaneous inflammatory reaction to repetitive UV irradiation in C57/B16 mice.

공증발과 열산화로 제조한 Ag-CuO-SnO₂ 박막에서 미세조직과 CO 가스 감지특성

지인걸,한규석,오재희,고태경,Ji, In-Geol,Han, Kyu-Suk,Oh, Jae-Hee,Ko, Tae-Gyung 한국세라믹학회 2009 한국세라믹학회지 Vol.46 No.4

In this study, we investigated microstructure and the CO gas sensing properties of Ag-CuO-$SnO_2$ thin films prepared by co-evaporation and subsequently thermal oxidation at air atmosphere. The sensitivity of a Cu-Sn films, thermally oxidized at $600^{\circ}C$, is strongly affected by the amount of Cu. At Cu:7 wt%-Sn:93 wt%, the film exhibited a maximum sensitivity of ${\sim}2.3$ to CO gas of 1000 ppm at $300^{\circ}C$. In contrast, the sensitivity of a Sn-Ag film did not change significantly with the amount of Ag. An enhanced sensitivity of ${\sim}3.7$ was observed in the film with a composition of Ag:3 wt%-Cu:4 wt%-Sn:93 wt%, when thermally oxidized at $600^{\circ}C$. In addition, this thin film shows a response time of ${\sim}80$ sec and a recovery time of ${\sim}450$ sec to 1000 ppm CO gas. The results demonstrate that the CO sensitivity of the Ag-CuO-$SnO_2$ thin films may be closely associated with coexistence of $SnO_2$ and SnO phase, decrease in average particle size, and a porous microstructure. We also suggest that co-evaporation and followed by thermal oxidation is a very simple and effective method to prepare oxide gas sensor thin films.

키토산 가공품의 규제와 규격 비교

오인재 ( In Jae Oh ),고성애 ( Xing Ai Gao ),조경현 ( Gyung Hyun Jo ),김영주 ( Young Ju Kim ),박노동 ( Ro Dong Park ) 한국키틴키토산학회 2009 한국키틴키토산학회지 Vol.14 No.2

In order to input chitin and chitosan into pharmaceutical, biotech, cosmetic, and dietary supplementation, the product consistency and safety will become important for consideration by regulatory authorities. To compare internationally the specification and regulation of chitosan-related products, data has been collected and analyzed in definition, application and function, physicochemical and biological quality criteria, analysis method, and regulatory authority.

Comparison of the Seroprevalence of Measles Antibodies among Healthcare Workers in Two Korean Hospitals in 2019

Kwak Yee Gyung,Song Je Eun,Oh Gang-Bok,Jeong In Hye,Cho Chong Rae,Kim Namhee,Yoo Hyeon Mi,Yoo Gyeong Min,Lee Myung Jin,김백남 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.1

We performed a point seroprevalence survey of measles among healthcare workers (HCWs) at two Korean teaching hospitals in 2019. A total of 2,830 HCWs underwent an antibody test. The overall seropositivity of measles was 93.1%. The seroprevalence of measles was lowest in HCWs aged 20 - 24 years (81.2%), followed by those aged 25 - 29 years (90.1%). The rates of anti-measles IgG positivity were significantly different between the two hospitals (97.0% vs. 89.4%, P <0.001). These results suggest that the seropositivity of measles in HCWs may differ depending on the hospital's vaccination policy.

가정내 학대피해경험이 청소년 자살생각에 미치는 영향

심혜인(Hye-In, Sim),오세윤(Se-Yoon, Oh),곽대경(Dae-Gyung, Kwack) 한국범죄심리학회 2020 한국범죄심리연구 Vol.16 No.2

COVID-19로 인해 펜데믹이 아동과 청소년의 중요한 활동이었던 등교가 원활하게 진행되지 않는 상황에서 가정내 갈등이 증가하고 있는 것으로 나타났다. 특히 자녀에 대한 신체적, 정서적 학대와 방임 등이 양육자로부터 발생하고 있으며, 이러한 부정적인 요인들이 청소년에게 부정적인 행동을 초래할 가능성을 증가시키고 있다. 따라서 이 연구에서는 청소년의 가정내 학대피해경험이 자살생각에 미치는 영향을 살펴보고 구체적인 정책방안을 제안하기 위하여 우울감을 매개로 한 관계에서 사회적 지지가 조절효과를 나타내는지를 검증하고자 하였다. 이를 위해 ‘2017 청소년실태조사’ 자료 중 중학교 1학년부터 고등학교 3학년까지의 청소년을 연구대상으로 선정하여 분석관련 변수에서 무응답 또는 결측률이 높은 사례를 제외하고 총 6,333개를 분석자료로 활용하였다. 조절된 매개효과를 검증하기 위하여 SPSS PROCESS macro의 모델 59번을 사용하여 가설을 검증하였다. 가정내 신체적 학대, 정서적 학대 그리고 방임의 세가지 유형별 피해경험이 우울을 매개로 한 자살생각에 미치는 영향관계에서 사회적 지지는 조건부의 직접적, 간접적 효과가 유효한 것으로 나타났다. 실증연구결과를 바탕으로 청소년 자살생각을 중단할 수 있도록 사회적 지지를 활용한 선제적 정책방안을 제시해 보고자 하였다. During the pandemic situation due to Covid-19, it appears that domestic conflicts have increased while the school life, one of the important activities of children and teenagers, has not progressed smoothly. The media reports on the situations that caregivers abuse and neglect children and teenagers physically, emotionally, etc. An increase in the number of negative factors including domestic abuse can increase the likelihood of teenagers’ negative behaviors. Thus, for the purpose of suggesting specific policy plans by studying how experiences of domestic abuse can affect teenagers’ suicidal ideation, this research aims to verify whether social support moderates the relationship between experiences of domestic abuse and suicidal ideation mediated by depression. The data of the first year of middle school and the third year of high school students were selected from ‘2017 General Research on Youth’, and 6,333 data with relevant variables were used for analysis. To verify the mediating effect, SPSS PROCESS macro was used to examine the hypothesis. It turned out that the social support has valid direct and indirect effects on the relationship between the three types of experiences - physical abuse, emotional abuse, and neglect - in the family and the suicidal ideation due to depression. Based on the results of the empirical study, this research attempts to discuss the preemptive policy plans that actively utilize social supports to prevent the teenagers’ suicidal ideation mediated by depression due to experiences of domestic violence.