고혈압성 안저변화와 생리적 제인자간의 상관관계에 관한 연구

원인건,심운택 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

The author investigated the correlation among physiological factors that could affect the hyperten-sive retinopathy as a line in the chain of basic investigation to prevent and manage the hypertensive disorders. The study group composed of 130 people with arteriosclerotic or hypertensive retinopathy and 260 healthy people. The results obtained were as follows: 1. Grade I was the most common in hypertensive retinopathy as 65.4%, and the distribution by age and sex showed that grade I in 50-59 year old group was the most common in male and female as 20.0% and 15.4%, respectively. 2. Grade I was the most common in arteriosclerotic retinopathy as 66.1%, and the distribution by age and sex showed that grade I in 50-59 year old group was the most common in male and female as 35.0% and 40.0%, respectively. 3. In the realtionship between hypertensive retinopathy and blood pressure, Grade I was the most common n the grade of 150-159㎜Hg, systolic blood pressure and 100-109㎜Hg, diastolic blood pressure as 22.3% and 33.8%, respectively. 4. In the case group, the level of serum cholesterol(211.26±47.53㎜g/㎗), serum triglyceride (184.05±93.3㎜Hg/㎗), low density lipoprotein(125.22±48.98㎜Hg/㎗), atherogenic index 1(3.67±1.85), and atherogenic index 2(2.86±1.64), were higher than those in the control group, however, only the level of high density lipoprotein(51.88±11.95㎜Hg/㎗) was lower. 5. The significant correlation to the grade of hypertensive and arteriosclerotic retinopathy were found in systolic and diastolic blood pressure. 6. The odds ratio between the case group and control group in serum lipid showed the significant difference in more than 200㎎/㎗ of total serum cholestrol and more than 190㎎/㎗ of serum triglyceride as 3.59 and 2.48, respectively. 7. The odds ratio between the case group and control group in atherogenic and obesity index showed the significant difference in more than 3.0 of atherogenic index 1 and more than 30% of obesity index as 2.40 and 3.67, respectively.

공군사관생도의 심폐능력에 따른 심리 · 생리요인 비교

김인기(In-ki Kim),김건희(Gun-hee Kim),송성우(Sung-woo Song),최가람(Ga-ram Choi),엄장원(Jang-won Eom),곽재준(Jae-jun Kwak),유영남(Young-nam You),정덕화(Deok-hwa Jeong),강지훈(Ji-hun Kang) 육군사관학교 화랑대연구소 2019 한국군사학논집 Vol.75 No.2

The purpose of this study was to analyze the differences in psychological and physiological factors between groups by classifying groups based on the 3km running record of fourth grade Air Force Academy cadets. Among the top 46 Air Force Academy cadets who wanted to participate in the study, the study conducted an open survey of the top 13 and the bottom 15 who wanted to provide the data prior to the study. The subjects of the experiment and in-depth interview were studied by a total of 18 people, 9 of each upper and lower members who wished to participate in the study. Psychological factors were structured through inductive content analysis of data extracted from in-depth interviews, and physiological factors were conducted to verify differences between groups of body composition and cardiopulmonary function. The psychological factors of the upper and lower groups were found to be general areas of performance strategy, achievement motivation, emotional response, military spirit, situation perception, and basic physical strength. In the detailed areas, the subjects were also examined in 15 areas including physical fitness indicators, confidence, condition control, task orientation, and positive self-perception. As a result of comparison between upper and lower groups, the upper group was 2.2 times higher than the lower group and the lower group was 1.7 times higher than the upper group in the military spirit and performance strategy of the general area response rate. In general area response, the ratio of mental strength and confidence was different in the general area of military spirit. In addition, the upper group in the achievement motivation showed a high percentage of task tendency at 47%, while the lower group showed a high rate of zero motivation at 50%. In the emotional response, the upper group showed an equal ratio, while the lower group showed an 81% ratio of negative emotions. In the overall response by sub-region, the negative emotions of the subgroup were high at 28%. In the body composition, BFM showed a statistically significant difference between upper and lower groups, and Weight, FFM, and SMM did not show any significant difference between groups. In cardiopulmonary capacity, VO2max showed a statistically significant difference between upper and lower groups, and VE and LT did not show significant differences between groups.

ERK1/2-Mediated Schwann Cell Proliferation in the Regenerating Sciatic Nerve by Treadmill Training

Seo, Tae Beom,Oh, Myung-Jin,You, Byoung-Gun,Kwon, Ku-Birm,Chang, In-Ae,Yoon, Jin-Hwan,Lee, Chan-Yong,Namgung, Uk Mary Ann Liebert 2009 JOURNAL OF NEUROTRAUMA - Vol.26 No.10

<P>Proliferation of Schwann cells in the injured peripheral nerve supports axonal regeneration, and physical training in experimental animals has been shown to promote nerve regeneration. Extracellular signal-regulated kinase 1/2 (ERK1/2) activity can mediate neuronal responses to lesion signals, but its role in non-neuronal cells in the injured area is largely unknown. Here we report that treadmill training (TMT) facilitates axonal regeneration via the upregulation of phospho-ERK1/2 protein levels in Schwann cells in the injured sciatic nerve. Low-intensity, but not high-intensity, TMT increased neurite outgrowth of dorsal root ganglion (DRG) sensory neurons and potentiated Schwann cell proliferation. TMT elevated levels of GAP-43 mRNA and protein, and phospho-ERK1/2 protein in the injured sciatic nerves. TMT also enhanced phospho-c-Jun protein levels in the injured nerve. In-vivo administration of the ERK1/2 inhibitor PD98059 eliminated phospho-c-Jun, suggesting ERK1/2 phosphorylation of the c-Jun protein. PD98059 treatment decreased levels of BrdU-labeled proliferating Schwann cells in the distal portion of the injured nerve, and delayed the axonal regrowth that was promoted by TMT. The present data suggest that increased ERK1/2 activity in Schwann cells may play an important role in TMT-mediated enhancement of axonal regeneration in the injured peripheral nerve.</P>

‘청춘’ 밖의 청춘, 그들의 성인기 이행과 자아정체성

정수남(Joung, Sunam),권영인(Kwon, Young In),박건(Park, Gun),은기수(Eun, Ki-Soo) 한국문화사회학회 2012 문화와 사회 Vol.12 No.-

본 연구는 빈곤청년들의 성인기 이행과 자아정체성의 특징을 살펴보는 데 목적을 두고 있다. 오늘날 한국사회 청년들의 성인기 이행이 지체되고, 사회경제적 독립이 점차 어려워지면서 자아정체성 형성에도 커다란 변화가 일어나고 있다. 그리고 이는 오늘날 커다란 사회적 이슈이자 문제로까지 확산되고 있다. 그러나 이러한 변화가 모든 계층의 청년들에게 공통적으로 나타난다고 볼 수 없다. 본 연구가 초점을 맞추고 있는 빈곤 청년들은 ‘정상적인’ 가정생활, 학교생활, 노동생활을 경험하지 못했다. 이들은 빈곤한 경제상황 때문에 일찍부터 생계를 부담하고 가족관계를 재구성해야 했으며, 학업보다는 아르바이트에 시간을 더 쏟고, 노동현장에서는 저임금과 착취를 당하면서 청(소)년기를 보내고 있다. 그 결과 이들은 가정에서 ‘자녀’, 학교에서 ‘학생’, 일터에서 ‘노동자’라는 통상적인 의미에서의 정체성을 확립하지 못했다. 그럼에도 이들은 각기 나름의 전략을 통해 정체성을 형성함으로써 성인기 이행에 들어서고 있다. 이러한 논의를 바탕으로 본 연구는 빈곤계층 청년들의 성인기 이행은 상당히 압축적이지만 그에 따르는 사회적 인정이 뒷받침되지 못함으로써 자아정체성 형성에서 다양한 훼절이 나타나고 있음을 주장하고자 했다. 본 연구를 위해 총 25명의 20대 청년들이 인터뷰에 응해주었으며, 이들의 경험을 심층적으로 이해하기 위해 질적 방법론을 활용하였다. This study aims at exploring the transition to adulthood and self-identity of the disadvantaged youths or youths in poverty. It is well known that transition to adulthood for all youths is postponed in Korean society as well as in other societies. Growing hardship in achieving socioeconomic independence also makes Korean youths develop self-identity. This has become a big social issue and futhermore one of social problems. However, we cannot say that these changes are found common to youths across all social classes. Disadvantaged youths in Korean society have not experienced so-called “normal” life in family, school and the labor market. Earlier hardship in their life forced them to work to support family life, to reconstruct family relationship, and to spend more time in par-time work rather than in studying at school. They were spending their youthful years suffering from low wage and sometimes exploitation in the labor market unlike ordinary youths who manage “normal” family and school life in their 10s and 20s. As a result, they have failed to establish their identity as a child in family, a student in school and a worker in the labor market. However, they have utilized their own strategy for their identity construction, which eventually leads to a transition to adulthood later. For this research, we interviewed 25 youths in their 20s. We also collected their life history using semi-structured questionnaire and in-depth interview with them. We find that their transition to adulthood is very compressive, but frequently disrupted in various ways because of the lack of social recognition. This is one of the big differences in transition to adulthood between ordinary and disadvantaged youths in Korean society.

위 장관 상피암에서 에스트로젠 수용체 표출에 대한 면역 조직학적 연구

김인건,김창진,강상균 순천향대학교 1992 논문집 Vol.14 No.4

The presence of Estrogen Receptor(ER) has been reported in various tumors, as orain tumor, lung cancer, gastrointestinal carcinomas and others, which have been believed to be non targer organs for the estrogen. The gastrointestinal carcinoma is one of the most frequent malignancy in Korea and several therapeutic modalities such as surgery, chemotherapy, radiotherapy and immunotherapy. are tried Hormone therapy had been applied selected cases with ER positive cancers and the results were good. To observe the presence of ER in gastrointestinal carcinomas We studied 20 cases of gastric carcinoma and 20 cases of colorectal carcinomas by immunohistochemical method. The results were as follows: 1. The ER was present in 35% (n=7) of 20 cases of gastric adenocarcinoma. Carcinomas in male showed ER positivity in 20% while in 40% in female. 2. Histologically, expanding type(n=4) showed 75% positivity of ER while infiltrative type)n=16) showed 13% of positivity. 3. The ER was present in 45%(n=9) of 20 cases of colorectal carcinomas. The male to female ratio of ER positivity was 57%(n=7) to 38%(n=5). 4. All the mucinous carcinomas(n=4) showed ER negativity, but poorly differentiated adenocarcinoma(n=1) and squamous cell carcinoma((n=1) showed ER positivity. 5. Well differentiated adenocarcinoma of the colorectum showed 50%(n=7) positivity of ER. Above results suggest that carcinomas in gastrointestinal tract, which was not considered as estrogen target organ, can express estrogen recetor and the trial of hormone therapy might be highly encouraged.

Synergistic effects of codecoration of oxide nanoparticles on the gas sensing performance of In₂O₃ nanorods

Park, Sunghoon,Sun, Gun-Joo,Kheel, Hyejoon,Lee, Wan In,Lee, Sangmin,Choi, Seung-Bok,Lee, Chongmu Elsevier 2016 Sensors and actuators. B Chemical Vol.227 No.-

<P><B>Abstract</B></P> <P>n-In<SUB>2</SUB>O<SUB>3</SUB> nanorods codecorated with n-Fe<SUB>2</SUB>O<SUB>3</SUB> and p-Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles were synthesized by the thermal evaporation of In<SUB>2</SUB>S<SUB>3</SUB> powders in an oxidizing atmosphere followed by the solvothermal deposition of Fe<SUB>2</SUB>O<SUB>3</SUB> and Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles, and their ethanol gas sensing properties were examined. The p-Co<SUB>3</SUB>O<SUB>4</SUB>-decorated n-In<SUB>2</SUB>O<SUB>3</SUB> nanorods exhibited stronger and faster response to ethanol gas than the n-Fe<SUB>2</SUB>O<SUB>3</SUB>-decorated n-In<SUB>2</SUB>O<SUB>3</SUB> nanorods due to the larger modulation of the conduction channel width and interfacial potential barrier height, and stronger catalytic activity of p-Co<SUB>3</SUB>O<SUB>4</SUB> than n-Fe<SUB>2</SUB>O<SUB>3</SUB>. Furthermore, the codecorated In<SUB>2</SUB>O<SUB>3</SUB> nanorod sensor exhibited significantly stronger and faster response to ethanol gas than its mono-oxide nanoparticle-decorated counterparts under the condition of the same total amount of the decorating nanoparticles. The origin of the synergistic effects of codecoration on the ethanol sensing properties of the In<SUB>2</SUB>O<SUB>3</SUB> nanorod sensor is not the formation of compounds or nanoalloys between the oxides but the formation of a large number of the p–n junctions between the two different types of decorating oxides, i.e., Fe<SUB>2</SUB>O<SUB>3</SUB>–Co<SUB>3</SUB>O<SUB>4</SUB> p–n junctions in addition to the Co<SUB>3</SUB>O<SUB>4</SUB>–In<SUB>2</SUB>O<SUB>3</SUB> p–n junctions.</P>

제1형 당뇨병 환자에서 췌도세포 동종이식의 반복시행

양태영,정인경,서인아,오은영,조건영,오승훈,김성주,정재훈,민용기,이명식,이문규,김광원,도영수,주성욱 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

연구배경:췌도세포 이식은 시술이 간편하고 안전하기 때문에 반복이식이 가능하여 그 동안 여러 센터에서 반복이식의 성공을 보고한 바 있다. 국내에서도 본 병원을 비롯하여 몇몇 센터에서 췌도세포 이식이 활발히 시도되고 있으나 사람에서의 동종이식 및 동종 이식의 반복시행은 보고된 바 없는 실정이다. 저자 등은 국내 최초로 췌도세포 동종이식을 시행하여, 혈청 C­펩타이드가 증가하고 인슐린 요구량이 감소하였으며, 혈당농도와 당화혈색소의 안정을 보였다. 그러나 이식 70일 후 다시 인슐린 요구량이 증가하고 C­펩타이드가 감소하여 췌도세포 이식을 다시 시행한 바 있다. 2차 이식 후 70여일이 지난 현재 다시 혈청 C­펩타이드가 증가하고, 인슐린 요구량이 더 감소되어 췌도세포 이식에서 반복 시행의 유용성을 보고하는 바이다. 방법:환자는 32세 남자로 17년전 당뇨병 진단 후 인슐린 치료 중이었으며, 3년전 부터는 만성신부전증으로 혈액툭석을 하고있었다. 1999년 12월 25일 신장이식을 하였고 3일 후 췌도이식을 하였으며, 두번째 이식은 70일 후 시행하였다. 췌도분리는 변형된 Recordi방법과 비연속성 자당 농도차(discontinuous density gradient)를 이용하였으며 분리한 췌도는 배양 후 환자의 신장기능이 정상화되고 미생물학 검사에서 음성을 확인한 후 경피경간으로 간문맥을 접근하여 16G 폴리 에틸렌 카테터를 이용하여 간실질에 이식하였다. 결과:1차 췌도이식시 순수분리전 췌도수는 210,000개, 순수분리후 획득한 췌도수는 90,000개, 순도 95%, 세포양 1.0mL 이었고, 2차 췌도이식시 순수분리전 췌도수는 420,000개, 순수분리후 획득한 췌도수는 370,000개, 순도 95%, 세포양 1.5mL 이었다. 1,2차 모두 간문맥을 통해 약 20분에 걸쳐 간실질에 주입하였다. 췌도이식전 인슐린요구량은 75∼75U/일, HbA1e 8∼10%, C­펩타이드 0.6ng/mL 였으며, 1차 췌도이식수 7일째 인슐린 요구량은 40U/일, C­펩타이드 1.5ng/mL, FPS 109mg/mL 였고, 40일 추적관찰 후 인슐린 요구량이 36U/일, C­펩타이드 1.8ng/mL, HbA1e 6.5∼7.0%로 안정되었다. 그러나 이식 50일째부터 인슐린 요구량이 50∼56U/일, C­펩타이드 0.6ng/mL, FPS 130∼200mg/dL로 혈당 조절이 불안정하여 다시 췌도이식을 시행하였다. 2차 이식후 50일이 경과한 현재, 인슐린 요구량은 26U/일, C­펩타이드 1.8ng/mL, FPS 90∼120mg/dL로 다시 안정되었다. 결론:췌도이식은 반복이식이 가능하며, 본 환자의 경우 인슐린요구량 감소, 혈당의 안정화 및 C­펩타이드가 상승하여 이식한 췌도의 기능을 확인할 수 있었고, 향후 스테로이드 등 면역억제가 유지 용량으로 감량되면 인슐린 요구량은 더 감소될 것으로 기대된다. Over the past 20 years, significant advances have been made in human islet transplantation. However, cases of prolonged insulin independence after islet allotransplantation have rarely been reported and over time, a slight, gradual decrease in insulin secretion appears to occur, as suggested by the lower C-peptide. Although preliminary clinical success achieved over the past few years has been considerably higher with whole pancreatic transplant than with isolated islet grafts, both approaches remain experimental. Islet grafts might gain, over time, increasing credibility and might eventually provide an easier alternative in terms of grafting procedures and patient management, as compared with the more "traumatizing" whole-pancreas transplantation. Also, using islet, re-transplantation is possible. But it is not known whether re-transplantation of islet could be suitable for those patients who lost grafted islet function. The aim of the present study was to investigate the benefits of re-transplantation of islet in previously simultaneous islets-kidney transplant (SIK) patient who have lost graft function. Methods : The recipient was a 32 year old male. First islet transplantation was underwent at December 25, 1999. However, the grafted islets lost function after 70 days. So we performed re-transplantation of islets. The isolation of islet was conducted sterilely on a laminarflow hood and isolated by a modified Recordimethod. The islet was injected slowly into the liver via a cannular placed in the potalvein for 20 minutes. Results : Transplanted islets were 90,000 IEq at first islet transplantation, 370,000 IEq at second islet transplantation. The insulin requirement was reduced from 75-85 to 35-40 U/day, the basal C-peptide level was 1.5 ng/mL at 7 days posttransplant Unfortunately, the grafted islets lost function after 70 days. After second transplantation, the insulin requirement was reduced to 26 U/day. Conclusions : Despite the continuous need for exogenous insulin therapy, islet transplantation can prevent wide glucose fluctuations, thus resulting in normalization of glycemic control and improvement in HbAlc, and also, show that islets can be successfully and safely re-transplanted intraportally in patients who have lost previously grafted islet function (J Kor Diabetes Asso 457~466, 2000).

국내 대학병원에서 정주용 Ciprofloxacin 사용의 적정성 평가

김신우,박효정,오원섭,김연숙,장현하,정숙인,정두련,이혁,염준섭,기현균,손준성,백경란,우건조,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내 병원에서의 정주 ciprofloxacin 사용의 적정성을 평가하고자 하였다. 재료 및 방법 : 2003년 9월 25일부터 8개의 대학병원에서 정주 ciprofloxacin을 받았던 290명의 연속적으로 모집한 성인환자를 대상으로 약제사용 평가(DUE)를 전향적으로 수행하였다. 이 연구에 사용된 DUE 기준은 미국병원약사회의 기준을 국내 실정에 맡게 수정하여 사용하였으며 1) 사용의 정당성에 관한 항목, 2) 사용 시 준수되거나 시행되어야 할 사항에 대한 항목, 3) 부작용에 대한 항목, 4) 치료 효과에 대한 항목으로 나누어 조사하였다. 결과 : 환자의 평균 나이는 54세였다. 33예(26.9%)에서만 약제 사용의 적정성 측면에서 기준을 만족하였고 91예(73.1%)에서는 사용이 적절하지 않았다. 정주 cipro-floxacin의 부적절한 사용의 흔한 원인은 수술 전후의 예방약 사용, 비뇨기계 처치 전의 예방적 사용, 열성 질환에 대한 경험적 사용 등의 순이었다. 사용 시 준수사항 의 측면에서는 사용 전 배양검사(73.8%)와 사용 중 배양검사(68.6%)가 낮은 수행 정도를 보였으나 그 외는 비교적 높은 적정성(82.4-100%)을 보여주었다. 정주 ciprofloxacin사용의 합병증은 드물었다. 치료 효과의 면에서 치료반응은 93.3%였다. 결론 : 약제 사용의 정당성 기준에 따른 정주 cipro-floxacin의 부적절한 사용은 연구에 포함된 대학병원에서 매우 흔하였다(73.1%). 그러므로 적절한 항생제 사용에 대한 교육과 제도적 장치가 매우 필요한 것으로 판단되었다. Background : To evaluate the appropriateness of intravenous (IV) ciprofloxacin usage in university hospitals in Korea. Materials and Methods : We prospectively evaluated the appropriateness of drug usage in 290 consecutive adult patients who received IV ciprofloxacin in eight teaching hospitals during the period from September 25, 2003 to November 15, 2003. Drug use evaluation (DUE) in this study was based on the modified standard by the American Society of Hospital Pharmacy with regard to the justification of drug use, critical and process indications, complications, and outcome measures. Results : Average age of the patients was 54 years. The use of IV ciprofloxacin was appropriate only in 33 cases (26.9%). Common reasons for inappropriate use of IV ciprofloxacin include perioperative uses or prophylactic injection before urologic procedures, and empirical therapy for febrile episodes. Most of the "critical indications" and "process indications" showed high rate of appropriateness (82.4-100%). However, the rate of taking culture and sensitivity test before (73.8%) and during ciprofloxacin use (68.6%) were low. Complications with ciprofloxacin use were rare. In 93.3% of cases, ciprofloxacin treatment was clinically effective. Conclusion : Use of intravenous ciprofloxacin is frequently inappropriate in tertiary care hospitals in Korea. Implementation of education program and antibiotic control system is critical in improving the appropriateness of antimicrobial use.

Comparison of clinical characteristics and prognosis of pneumocystis jirovecii pneumonia in patients with immunocompromised and non-immunocompromised conditions

( Hong-joon Shin ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young- Chul Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Pneumocystis jirovecii pneumonia (PCP) is a fatal respiratory infection frequently associated with immunocompromised (IC) conditions. Although PCP has been reported in non-immunocompromised (non-IC) patients, however, few studies have been conducted. This study was aimed to compare the clinical characteristics and prognosis of PCP in IC and non-IC patients. Methods: We retrospectively analyzed patients who were suspected of having PCP with polymerase chain reaction (PCR) test positive for Pneumocystis jirovecii from January 2013 to May 2019. IC group was classified into human immunodeficiency virus (HIV), hematologic, solid organ tumor, rheumatologic and immunosuppressive agent group. Results: A total 192 PCP cases including 176 IC cases and 16 non-IC cases were analyzed. Patients were older in the non-IC group compared with the IC group (72.5 vs. 62.0, P=0.002). Hematologic malignancy was the most common (47.2%), followed by HIV (14.8%) in the IC group. The interval between test for PCP-PCR and PCP treatment was shorter in the IC group compared with non-IC group (0 [0-3] vs. 4.0 [2.2-7.7] days, P=0.001). In-hospital mortality was not significantly different between IC and non-IC groups (43.2% vs. 62.5%, P=0.189). Age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02-1.09; P=0.002) and PaO₂/FiO₂ (OR 0.99; 95% CI 0.98-1.00; P=0.039) were the prognostic factors for in-hospital mortality in the multivariate logistic regression analysis. There was no significant difference between IC and non-IC group in 6-month survival. However, HIV group had better 6-month survival compared with non- IC group in the subgroup analysis (Hazard ratio 0.16; 95% CI 0.05-0.53; P=0.003]. Conclusion: Patients with PCP in non-IC group were older than IC group, and had similar prognosis as other IC group except HIV group.

생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구

김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.