Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats

Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

교육용 소프트웨어 개발에 적합한 하이퍼미디어 시스템에 관한 연구

박성한,정혜윤,한민규,심진석 한양대학교 공학기술연구소 1993 공학기술논문집 Vol.2 No.1

This paper presents a back-end system of hypermedia authoring system for courseware development. For the design, repersentative hypertext reference models, the Dexter model and the HAM(Hypertext Abstract Machine) which belongs to Campbell & Goodman model were analyzed. Based on those models, data objects, attributes, and operations of back-end system were designed and implemented. Because the application area of this system is on computer based education, the path mechanism is enforced for the various educational strategies. In order to reduce the user disorientation and cognitive overheads in navigating hypernetwork, filtering, backtracking and history mechanism were implemented.

공동사회모임에서 환자와 치료자가 인식한 치료요인

박혜영,배안,신성웅,윤우상 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

본 연구에서 저자들은 공동사회모임에 참여한 환자와 지료자의 공동사회모임에 대한 반응을 알아보고, 일종의 집단정신치료로서 공동사회모임의 치료적 효과를 Yalon의 Q-sort 단축형 척도를 적용하여 평가하므로써 공도사회모임의 문제점을 진단, 보완하고, 집단치료로서의 치료적 기능을 활성화하고자 하였다. 평가대상이 된 10차례의 공동사회모임은 비교적 치료공동체가 부침기에 해당하는 기간에 열렸으며, 매회당 환자군 26.7명(±2.95)과 치료자군 8.5명(±1.43)이 참가했다. 그 결과 환자와 치료자 모두 공동사회모임을 긍정직으로 평가하였으며, 도움이 된 항목에 대하여 환자는 '서로간의 이해와 사랑', '자신에 대하 깨달음'이라고 답하였고, 치료자는 '솔직한 자기표현'과 '대화'가 도움이 되었다고 하였다. 또한 공도사회모임의 집단치료 치료요인의 모든 항목에서 치료자군에 비하여 환자군이 더 치료적이라고 평가하였으며, 특히 '보편성', '지침', '카타르시르'를 제외한 9개의 항목에서 통계적으로 유의한 차이가 있었다. 공동사회모임에서 활성화된 집단치료 치료요인으로서 환자와 치료자는 공통적으로 '실존적 인자'와 '보편성'이라고 압했으며, '외면적 대인간 학습'을 비활성화된 치료요인으로 평가하였다. This research was conducted to investigate the responses of the patients and the therapists who attend the community meeting, to evaluate the therapeutic effects fo community meeting as a group psychotherapy by applying short form scale of Yalom's Q-sort, to diagnose and complement the problems of the community meeting and to aim at activating the therapeutic function as the group psychotherapy. The community meeting was held by 10 times during the stage of oscillation of the community and 26.7 patients group(±2.95) and 8.5 therapists group(±1.43) attended the every meeting. Consequently, both patients group and therapists group evaluate the community meeting as positive, and on the item which is helpful to them, while patient group responds it is 'mutual understanding and love' and 'self-understanding', therapist group does it is 'frank self-expression' and 'conversation'. On all items of group psychotherapy facors in the community meeting, the patients group evaluates it is more therapeutic in comparison with the therapists group, especially there is a significant difference in nine items such as 'altruism', 'group cohesiveness', 'interpersonal input', 'interpersonal output', 'identification', 'instillation of hope', 'family reenactment', 'self-understanding' and 'existential awareness'. In addition, on the therapeutic factor which is activated group psychotherapy factor in the community meeting, both patients and therapists respond that it is 'existential awareness' and 'universality', and they evaluate 'interpersonal output' as an non-activated therapeutic factor.

保護觀察 職員의 業務滿足度에 관한 調査硏究

朴在允,金惠正 國民大學校 法學硏究所 2002 법학논총 Vol.14 No.-

Die vorliegende Arbeit wird sich mit der Untersuchung der Problematik eines Bewa¨hrungssystems durch eine berufliche Zufriedenheit der Bewa¨hrungshelfer in Korea befassen. Fu¨r diese Arbeit wurde eine Umfrage (ein Fragebogen fu¨r gesamte Bewa¨hrungshelfer in Korea) gcstellt. Seit 1989 betrifft die Unterstellung unter dem Bewa¨hrungshelfer gegen jugendliche Krirninalta¨ter vor allem die Riskofa¨lle, bei denen tine giinstige Prognose nur infolge der zur Verfu¨gung gestellten Hilfe and Betreuung gestellt werden kann. Und seit 1997 wird sie gegen Erwachsenenta¨ter erweitert. Seitdem wa¨chst eine Anzahl der Bewa¨hrungshilfe erstaunlich zu. Im Jahr 2000 wurden 90,431 Personen eine Strafaussctzung bzw. Strafrestaussetzung zur Bewa¨hrung beurteilt. Problematisch ist, daB ein Bewa¨hrungshelfer eine Doppelfunktion hat; einerseits soil er dem Verurteilten helfend and betreuend zur Seite stehen, anderseits ist er jedoch verpflichtet, daB er den Verurteilten kontrollicren soli. Aber eine Bezichung zu dem einzelnen Tater kann in der Regel nicht sehr intensiv sein, weft ein Bewa¨hrungshelfer inn Druchschnitt ca. 300 Probanden gleichzeitig zu bewa¨chen and zu betreuen hat. Nach dem Ergebnis der Umfrage sind gegenwa¨rtige Situationen der Bewa¨h ungshilfe Behr niedrig. - Z.B., hauptliche Bewa¨hrungshelfer sind sehr wenig and eine Finanzierung von der Regierung fur die Bewa¨hrungshilfe ist sehr niedrig usw.. - Damit sind die meisten Bewa¨hrungshelfer mit ihrer Arbeit unzufrieden. Sie kritisieren solche schlechten Situationen. Trotz solcher schlechten Situation muJ3 ein Bewa¨hrungssystem weiter entwickelt werden. Dafur kann/soll eine privatliche verfugbare Arbeitskrafte and materielle Quelle entwickelt and breit angewandt werden.

흡입물질의 위생학적 연구 : 본드 흡입이 흰쥐의 폐 및 기타 장기의 효소 활성에 미치는 영향 The Effect of Bond Inhalation on the Enzyme Activity of Lung and Other Organs in Rat

윤수홍,박은주,이주영,서혜령 효성여자대학교 부설 한국환경위생연구소 1991 환경위생연구 Vol.1 No.1

Toluene, alcohol및 vinylester류 등을 함유하고 있는 bond를 이용하여 휘발성 물질이 생체에미치는 영향을 관찰하기 위하여 rat에 일정 농도의 bond를 일정 시간 흡입시킨 뒤 각 조직에대하여 효소의 생화학적 시험과 celluloseacetate electrophoresis를 실시하여 다음과 같은 결과를얻었다. 1. Bond 흡입은 시간이 증가함에 따라 혈청, 심장, 신장, 근육, 뇌의 ChE 활성을 억제하였으며특히 폐와 간장의 ChE활성에 가장 큰 영향을 나타내었다. 2. Bond 흡입에 의해 혈청 및 각 조직 중에서 LDH활성이 증가되었으며 특히 폐와 심장,근육에서 그 영향이 현저히 나타났다. 3. Celluloseacetate electrophoresis를 통한 각 조직의 LDH isozyme pattern에는 차이가 나타났으며 bond 흡입에 의해 band의 소멸과 선명도의 감소가 일어 났는데 특히 폐에 대한 독성이가장 현저했으며 근육에 대한 독성도 큰 것으로 나타났다. Acute poisoning with organic solvents and other volatile compou-nds now usually follows deliberate inhalation(volatile substance abuse) or inges-tion of these compounds. The effect of bond inhalation was analyzed for serum, liver, lung, brain,heart, kidney and muscle. And the observations are revealed on rat cholinesterase activity, lactatedeh-ydrogenase activity and electrophoretic pattern of lactatedehydrogenase isozyme. The results are as follows ; 1. The rat cholinesterase activity on serum, heart, muscle, kidney and brain showthe decrease by increasing of inhalation time of bond, in particular the lungand liver cholinesterase activity was greatly affected. 2. Bond inhalation brough out the lactatedehydrogenase activity increased ofthe serum and the tissues and had an important effect especially in both thelung and muscle lactatedehydrogenase activities. 3. Each tissue was found to have a characteristic distribution of lactatedehydro-genase isozymes on celluloseacetate elelctrophoresis and the development ofinhalation time is shown the disappearence and diffusion of band.

분지형 협착 혈관 모형을 이용한 도플러 파형에 관한 연구

윤혜경,박재형,이동혁,원형진,김성현,서준범,연경모 대한초음파의학회 1998 ULTRASONOGRAPHY Vol.17 No.2

만성 호중구성 백혈병 1예

박기령,조성민,우가은,이기현,손혜영,임정윤,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

Chronic neutrophilic leukemia(CNL) is a very rare myeloproliferative disease, characterized by sustained mature neutrophilic leukocytosis with granulocytic bone marrow infiltration, high NAP(neutrophilic alkaline phosphatase) score and absence of philadelphia chromosome, It is frequently accompanied by hepatosplenomegaly, elevated serum vitamin B_12 and uric acid level. For the diagnosis of CNL, the leukemoid reaction, especially secondary to neoplasia, infection and autoimmune diseases, should be excluded. Since Tuohy's first description in 1920, more than 50 cases fullfilling the above criteria have been reported worldwide, and 4 cases in Korea. Several authors have demonstrated the defect of intracellualr killing in the mature neutrophil and this finding correlates well with the very high incidence of fatal infection, The hemorrhagic diasthesis in CNL is caused by functional abnormality of the platelet. This disease has tendency to transform to blastic crisis and acute leukemia as in other myeloproliferative disease, but characteristically shows frequent coexistence with multiple myeloma. Until now , the therapeutic trials in CNL have been disappointing. Hydroxyrea and busulfan can control hyperleukocytosis. On the basis of functional defect in neutrophil, alpha-2b-interferon has been tried and several reports have demonstrated the clinical and functional effect of interferon on CNL. CNL is very rate hematologic disease and there are few report about general aspect of disorder. We report here a typical CNL case presenting with splenomegaly and leukocytosis with a review of the literature.

근친강간의 유형과 가족 역동성

박혜영,김연옥,홍강의 대한소아ㆍ청소년정신의학회 1996 소아청소년정신의학 Vol.7 No.1

속박감과 자살생각의 관계에서 분노표현양식의 매개효과

윤혜영, 박경 서울여자대학교 특수치료전문대학원 2018 심리치료: 다학제적 접근 Vol.18 No.1

본 연구는 속박감, 자살생각, 분노표현의 관련성을 알아보고, 속박감과 자살생각의 관계에 서 역기능적 분노표현양식의 매개를 살펴보고자 하였다. 연구대상자는 20대 성인 306명이 며, 자살생각 질문지(SIQ), 속박감 척도(ES) 한국판 상태-특성 분노표현 척도(STAXI-K)를 사용하여 설문을 실시하였다. 연구결과는 다음과 같다. 첫째, 자살생각은 속박감의 하위요인 인 내적 속박감과 외적 속박감과 유의한 정적 상관을, 분노표현양식의 하위요인인 분노-표 출과 분노-억제와 유의한 정적 상관을, 분노-조절과는 유의한 부적상관을 나타냈다. 또한 내 적 속박감은 분노-표출과 분노-억제와 유의한 정적 상관을, 분노-조절과는 유의한 부적 상관 을, 외적 속박감은 분노-표출과 분노-억제와 정적 상관을 나타냈다. 둘째, 속박감 및 역기능 적 분노표현양식(분노-표출, 분노-억제)은 각각 자살생각에 유의한 영향력을 미치는 변인으 로 나타났다. 셋째, 내적 속박감과 자살생각의 관계에서 역기능적 분노표현 양식인 분노-표 출과 분노-억제가 부분매개 하였다. 반면, 외적 속박감과 자살생각의 관계에서는 분노-억제 만이 부분매개 하였다. 본 연구 결과는 지속적으로 사회적 문제로 거론되는 자살문제에 대 한 이해를 돕고 효과적인 치료적 방향을 설정하는데 인지적, 정서적 개입이 도움이 될 수 있을 것으로 기대한다.