In vitro and in vivo anti-inflammatory activities of ethanolic extract of Sargassum confusum

우가은,김민지,안동현 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.1

This study was to investigate the anti-inflammatory activity of ethanolic extract of Sargassum confusum (SCEE). LPS is recognized by TLR4 on the macrophage surface, which activates the NF-κB and MAPK signaling pathways, increasing the expression of inflammatory cytokine like interleukin-6 (IL-6), IL-1β, and tumor necrosis factor (TNF)-α and inflammatory mediators such as nitric oxide (NO) and cyclooxygenase-2 (COX-2). The anti-inflammatory effect of SCEE (0, 1, 10, 50 μg/mL) was identified using LPS stimulated RAW 264.7 macrophages. As a result, it was confirmed that inflammatory factors were suppressed by inhibiting expression of COX-2 and iNOS without any cytotoxicity. In addition, phosphorylation of ERK, JNK and NF-κB p65, transcription factors, were inhibited by SCEE does-dependent manner. These results suggest that SCEE has an anti-inflammatory effect and can be used as a material for health functional foods to prevent inflammatory diseases.

Ticlopidine(Ticlid^�)으로 유발된 담즙울혈성 황달 1예

우가은,조홍근,신길자 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

담즙울혈성 황달은 ticlopidine 투여후 발생할 수 있는 부작용중 매우 드문 질환으로, 저자들은 1996년 11월 이화여자대학교 부속병원에 입원한 42세 남자 환자에서 ticlopidine 투여후 발생한 담즙울혈성 황당1예를 경험하였기에 문헌고찰과 더불어 보고하는 바이다. Ticlopidine, a platelet aggregation inhibitor, is widely used in the secondary prevention of stroke and previous manifestation of peripheral arterial occlusive disease, Ticlopidine is also used to prevent myocardial infarction and post-stenting occlusion after intracoronary stent implantation. The exact mechanism of action of ticlopidine is unclear, but likely involves the inhibition of platelet activity by the suppression of adenosine diphosphate-induced patelet aggregation. The most common adverse effects are gastrointestinal problems, skin reactions, and hematologist changes. The adverse hepatic effects are not frequent(4% in different series). We experienced a case of ticlopidine-induced cholastatic jaundice, and report with review of literatures

급성 설사 환자에서 대장내시경의 유용성과 대장내시경 시 얻은 생검 조직 및 장액을 이용한 살모넬라-시겔라균의 배양

우가은,정성애,강인숙,오희정,김수현,이미애,유권,문일환 대한소화기내시경학회 2002 Clinical Endoscopy Vol.24 No.5

Background/Aims: The aim of this study was to investigate the value of colonoscopy for Salmonella-Shigella culture of biopsy specimen and intraluminal fluid during colonoscopy in patients with acute diarrhea. Methods: From March 2001 to August 2001, sixty-six patients with watery or bloody diarrhea lasting less than 15 days were participated after exclusion of the patients with previous history or presumption of inflammatory bowel disease, radiation colitis, ischemic colitis, or pseudomembranous colitis. The biopsy specimen was taken and colonic luminal fluid was aspirated during colonoscopy for Salmonella-Shigella cultures. Results: Male and female ratio was 1:1.3 and mean age was 45 17 years. The normal colonoscopic finding was showed in twelve cases (18.2%). The severity of acute colitis was mild in 25 cases (25/54, 46.3%), moderate in 9 cases (9/54, 16.7%), and severe in 20 cases (20/54, 37.0%). The extent of acute colitis was as followed: involvement of one segment in 9 cases (16.7%), involvement of two or more segments in 26 cases (48.1%), pancolitis in 7 cases (13.0%), and pancolitis with involved terminal ileum in 12 cases (22.2%). In culture study, identification of Salmonella species was in 11 cases (16.7%). Salmonella species were identified in 6.0% (3/50) with stool specimen, 18.0% (9/50) with biopsy specimen, and 4.0% (2/50) with intraluminal fluid, but without statistical significance. Conclusion: The culture using biopsy specimens and intraluminal fluid obtained during colonoscopy may be helpful in diagnosis of cases of suggesting Salmonella-Shigella infection. (Korean J Gastrointest Endosc 2002;24:278-284) 목적: 본 연구는 2주 이내의 급성 설사로 내원하는 환자들에게 대장내시경을 시행하여 점막 병변의 양상과 그 정도를 관찰하고 이때 얻은 생검 조직과 장액으로 살모넬라-시겔라 배양 검사를 실시하여 그 유용성을 확인하고자 하였다. 대상 및 방법: 2001년 3월부터 8월까지 14일 이내의 수성 또는 혈성 설사를 주소로 내원한 환자 중 만성 또는 재발성 장질환의 악화 및 약물에 의해 유발된 위막성 대장염을 배재한 66명을 대상으로 전향적 연구를 시행하였다. 대장내시경 검사를 시행하여 병변의 범위와 중증도를 관찰하고, 생검 조직을 얻고 장액을 흡입하여 살모넬라-시겔라 배양 검사를 시행하였다. 결과: 환자의 남녀비는 1:1.3이었으며 평균 연령은 45±17세였다. 정상 소견을 보인 12예(18.2%)를 제외한 54예에서 병변의 중증도는 경증이 25예(46.3%), 중등증이 9예(16.7%), 중증이 20예(37.0%)이었다. 대장내시경상 장염의 중증도는 장염의 범위와 유의한 상관관계를 보였다(r=0.687, p<0.01). 대장내시경 결과 병변의 범위는 상행, 횡행, 하행, S상 결장 및 직장으로 나누어 표시하였을 때 한 부위만 침범한 경우가 9예(16.7%), 두 부위 이상을 침범한 경우가 26예(48.1%), 전 대장을 침범한 경우가 7예(13.0%), 전 대장을 침범하면서 회장 말단까지 침범한 경우가 12예(22.2%)이었다. 66명 중 11명(16.7%)에서 살모넬라균이 배양되었으며, 세 가지 검체의 배양이 모두 시행된 50명을 대상으로 비교하였을 때 대변이 6.0% (3/50), 생검 조직이 18.0% (9/50), 장액이 4.0% (2/50)로 생검 조직에서 살모넬라균의 동정률이 높은 경향을 보였으나 서로 간에 통계적 유의성은 없었다. 결론: 급성 설사 환자에서 대장내시경을 시행하였을 때 검사와 연관된 합병증은 없었고, 대장내시경을 통한 생검 조직과 장액의 배양에서 통계적으로 유의하지는 않았으나 대변 배양에 비해 균동정률이 높아 균을 동정하는 보조적인 검체로 사용할 수 있는 가능성을 보였다.

국내에서 보고된 만성 호산구성 폐렴 11예에 대한 임상적 고찰

우가은 ( Ka Eun Woo ),장중현 ( Jung Hyun Chang ),최영아 ( Young Ah Choi ),주미순 ( Mi Soon Joo ),서기열 ( Ki Youl Seo ),신태림 ( Tae Rim Shin ),천선희 ( Seon Hee Cheon ),조영주 ( Young Joo Cho ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

급성 설사 환자에서 대장내시경 과정 중에 얻은 생검 조직 및 장액을 이용한 원인균의 분석

우가은 ( Ka Eun Woo ),정성애 ( Sung Ae Jung ),조지윤 ( Ji Yoon Cho ),조유경 ( You Kyoung Cho ),송지현 ( Ji Hyun Song ),김도영 ( Doe Young Kim ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ) 대한내과학회 2002 대한내과학회지 Vol.63 No.6

목적: 본 연구의 목적은 급성 설사로 내원하는 환자들을 대상으로 대장내시경을 시행하여 대장 점막 병변을 관찰하고,대장내시경 과정 중에 얻은 생검 조직과 장액으로 배양 검사를 실시하여, 대장내시경의 유용성을 알아보고자 하였다. 대상 및 방법: 2000년 3월부터 8월까지 14일 이내의 수성 또는 혈성 설사를 주소로 내원한 환자 중 염증성 장질환, 방사선성 대장염, 허혈성 대장염 및 위막성 대장염의 과거력이 있거나 현재 임상적으로 의심된 환자를 제외한 41 Background: The aim of this study was to investigate the value of colonoscopy for assessment of colonic mucosal lesions and for microbial identification in patients with acute diarrhea. Methods: From March 2000 to August 2000,forty-one patients with water

카라기난 첨가 수리미 혼합물의 냉장 저장 중 특성 변화

한현수,우가은,김수형,박예린,강유석,박정철,서훈서,최예희,정행순,황혜지,이가혜,안동현 한국수산과학회 2022 한국수산과학회지 Vol.55 No.5

Iota carrageenan-containing surimi was refrigerated for 7 days to investigate the change in its properties. Physical properties, color differences, and sensory evaluation were tested for analysis after addition of 0–3 Wt% iota carrageenan. In unheated surimi, the 2% carrageenan- containing surimi had higher chromaticity and color difference compared to the surimi without added carrageenan. However, the surimi with 3% iota carrageenan showed enhanced yellowness, resulting in a modified color difference. Surimi containing iota carrageenan showed the same trend in color difference in heated surimi after storage for 7 days, particularly when carrageenan content was 2% or greater. The hardness, gumminess, and chewiness of the heated Iota carrageenan-containing surimi also increased after 7 days of storage. Compared to surimi without added carrageenan, the heated Iota carrageenan-containing surimi had higher hardness, gumminess, chewiness, and lower adhesiveness after storage. The overall preference for surimi decreased, while the hardness increased, when carrageenan was added. Therefore, the addition of the iota carrageenan to stored surimi can significantly enhance its hardness.

만성 호중구성 백혈병 1예

박기령,조성민,우가은,이기현,손혜영,임정윤,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

Chronic neutrophilic leukemia(CNL) is a very rare myeloproliferative disease, characterized by sustained mature neutrophilic leukocytosis with granulocytic bone marrow infiltration, high NAP(neutrophilic alkaline phosphatase) score and absence of philadelphia chromosome, It is frequently accompanied by hepatosplenomegaly, elevated serum vitamin B_12 and uric acid level. For the diagnosis of CNL, the leukemoid reaction, especially secondary to neoplasia, infection and autoimmune diseases, should be excluded. Since Tuohy's first description in 1920, more than 50 cases fullfilling the above criteria have been reported worldwide, and 4 cases in Korea. Several authors have demonstrated the defect of intracellualr killing in the mature neutrophil and this finding correlates well with the very high incidence of fatal infection, The hemorrhagic diasthesis in CNL is caused by functional abnormality of the platelet. This disease has tendency to transform to blastic crisis and acute leukemia as in other myeloproliferative disease, but characteristically shows frequent coexistence with multiple myeloma. Until now , the therapeutic trials in CNL have been disappointing. Hydroxyrea and busulfan can control hyperleukocytosis. On the basis of functional defect in neutrophil, alpha-2b-interferon has been tried and several reports have demonstrated the clinical and functional effect of interferon on CNL. CNL is very rate hematologic disease and there are few report about general aspect of disorder. We report here a typical CNL case presenting with splenomegaly and leukocytosis with a review of the literature.

포스타 전시 발표 : 소화기 ; CLO 검사와 유사한 HP 검사의 유용성 비교

임정윤,안영미,이진화,황민규,우가은,김도영,문일환 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

경구유발시험으로 확진된 메밀알레르기 1례

홍은순,박진아,신태림,서기열,우가은,이나영,김미선,맹선희,조영주 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.1

Buckwheat belongs to the Polygonacea or buckwheat family and is not a true cereral since it does not belong to the Graminiae, or grain family. Its products have long been considered excellent foods for both human and animal consumption. The earlist reference to case of buckwheat sensitivity was a report by Smith in 1909. He accurately described a case of angionerotic edema and urticaria in a young man upon ingestion accurately described a case of angionerotic edema and urticaria in a young man upon ingestion of small amounts of buckwheat, and violent asthma on the ingestion of moderate quantities of buckwheat. The authors have experienced one case of buckwheat allergy. The chief complaints were wheezing and dyspnea for several years. The skin tests showed positive reaction to the extracts of buckwheat flour and buckwheat husk. The buckwheat allergy is considered to be the model of the typeⅠallergy(that is lgE dependent type) proposed by Cooms and Gell. The antigenicity of buckwheat is extremely string, so oral provocation test must not easily be applied for fear of severe and dangerous reaction.

Ticlopidine 복용으로 유발된 담즙정체성 간염 3예

김지현,권영주,김정은,우가은,김용재 대한신경과학회 2002 대한신경과학회지 Vol.20 No.4