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RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
중환자실에 입원한 급성 신부전 환자에서 지속적 신대체요법
황은아 ( Eun Ah Hwang ),윤정수 ( Jeong Soo Yoon ),장미현 ( Mi Hyun Jang ),김정은 ( Jung Eun Kim ),강성식 ( Seong Sik Kang ),최고 ( Go Choi ),한승엽 ( Seung Yeup Han ),박성배 ( Sung Bae Park ),김현철 ( Hyun Chul Kim ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Purpose: The mortality rate in critically ill patients with acute renal failure (ARF) remains unacceptably high, despite numerous advances in dialysis techniques and intensive care medicine. We evaluated clinical characteristics and prognostic factors in ICU patients with ARF requiring continuous renal replacement therapy (CRRT). Methods: We retrospectively reviewed the medical records of all ICU patients who received CRRT at the Keimyung University Dongsan Hospital from September 2002 to October 2007. Results: Total number of patients who required CRRT in ICU was 58. The mean age was 58.3±14.8 years. The treatment duration of CRRT was 63.5±40.7 hours. The mechanical ventilation rate was 82.8%, vasoactive drug 79.3%, sepsis 39.7%. APACHE II score was 25.2±7.9, SAPS II score 48.1±15.1, CCF score 9.3±3.6, the number of organ dysfunction 2.1±1.3. Overall mortality rate was 48%. When we compared sepsis group with non-sepsis group, the number of organ dysfunction and severity of illness were significantly higher in sepsis group than that of non-sepsis group. A mortality rate of sepsis group was significantly higher than non-sepsis group (82.6% vs 31.3%, p<0.001). In univariate analysis, significant risk factors for mortality were the number of organ dysfunction, severity of illness, MAP, platelet count, serum albumin level, and a type of hemofilter. Significances of all these factors were lost in multiple linear regression analysis. Conclusion: A large scaled, prospective randomized multi-center trials are needed to confirm the beneficial effect of CRRT in patient with ARF in ICU.
무선망에서 데이터 전송 향상을 위한 SCTP SNOOP 적용 연구
황은아(Hwang Eun-Ah),송복섭(Seong Bok-Sob),김정호(Kim Jeong-Ho) 한국콘텐츠학회 2007 한국콘텐츠학회 종합학술대회 논문집 Vol.5 No.2_1
최근 유무선 혼합망의 사용이 증가됨에 따라 무선망의 핸드오프, 경로 손실, 페이딩, 등과 같은 전송 오류의 원인을 개선하기 위한 연구가 전개되고 있다. 유선의 신뢰성을 보장하는 표준 TCP, SCTP를 무선망에 적용하는 것은 혼잡제어, 흐름제어의 메커니즘을 적용함으로써 데이터 전송의 효율을 저하시킨다. 본 연구는 무선망에서 SCTP를 적용하기 위해서 SCTP와 SNOOP을 혼합하는 것으로, 무선망에서 전송오류가 발생했을 때 BS의 동작과정을 개선한 것이다. BS (Basic Station : 기지국)는 전송오류 시 ZWP(Zero Window Probe)를 MN(Mobile N여:e이동노드)에게 보내어 경로와 상태를 확인하고 RWND를 갱신하여 에러상태를 확인한다. 그리고 새로운 경로를 선택하고, FH(Fixed Host : 고정호스트)에게는 ZWA(Zero Window Advertisement)를 보내어 혼잡제어나, 흐름제어 메커니즘을 호출하는 것을 방지하고 대기상태로 기다리게 한다. 무선망의 연결이 안정된 후에 데이터 전송을 함으로써 데이터의 전송 효율을 약 10% 향상한다. Recently the use of wireless network increases according to it solves the hand-off and with path loss, pading, noise etc of wireless network the research for transmission error improvement is developed. TCP and SCTP of standard where it guarantees the reliability of wire network apply in wireless network the congestion control, flow control mechanism used it decreases the efficiency of data transfer throughputs. In this paper, It mixes SCTP and SNOOP for SCTP apply on wireless network, to improve BS(Basic Station) operation processes when the transmission error occurs in wireless network. BS send ZWP(Zero Window Probe) to MN(Mobile Node) when the transmission error occurs so, check path and status and update RWND and error status checked. It selects the new path, send ZWA(Zero Window Advertisement) to FH(Fixed Host) and the prevents call to congestion control or flow control and it does to make wait status standing. Continuously of data transfer after the connection of wireless network is stabilized, it make increase about 10% the transmission throughput of data.
Choi, Eun-Ok,Park, Cheol,Shin, Soon Shik,Cho, Eun-Ju,Kim, Byung Woo,Hwang, Jin Ah,Hwang, Hye-Jin,Choi, Yung Hyun D. A. Spandidos 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.1
<P>Zanthoxylum schinifolium is widely used as a food flavoring in east Asia. Although this plant has also been used in traditional oriental medicine for the treatment of the common cold, toothache, stomach ache, diarrhea and jaundice, its anti-obesity activity remains to be elucidated. The present study investigated the effects of ethanol extract from the leaves of Z. schinifolium (EEZS) on adipocyte differentiation, and its underlying mechanism, in 3T3-L1 pre-adipocytes. The results demonstrated that EEZS effectively suppressed intracellular lipid accumulation at non-toxic concentrations, and was associated with the downregulation of several adipocyte-specific transcription factors, including peroxisome proliferation-activity receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBP)α and C/EBPβ, in a concentration-dependent manner. Furthermore, it was observed that EEZS markedly inactivated the extracellular signal-regulated protein kinase (ERK) and phosphatidylinositide 3-kinase (PI3K)/Akt pathways, which act upstream of PPARγ and C/EBPs in adipogenesis. These results suggested that EEZS inhibited lipid accumulation by downregulating the major transcription factors involved in the pathway of adipogenesis, including PPARγ, C/EBPα and C/EBPβ, via regulation of the ERK and PI3K/Akt signaling pathways in 3T3-L1 adipocyte differentiation. This indicated the potential use of EEZS as an anti-obesity agent.</P>