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바이스태틱 레이더에서 Range Walk이 보상된 Squint Cross-Range 도플러 프로세싱
윤재혁(Jae-Hyuk Youn),김관수(Kwan-Soo Kim),양훈기(Hoon-Gee Yang),정용식(Yong-Seek Chung),이원우(Won-Woo Lee),배경빈(Kyung-Bin Bae) 한국전자파학회 2011 한국전자파학회논문지 Vol.22 No.11
고속의 이동 표적을 탐지하는 경우, 특히 송수신부가 독립적으로 이동하는 바이스태틱 레이더의 경우 표적 신호의 레인지 워크(range walk)는 도플러 프로세싱(Doppler processing) 및 표적 탐지를 어렵게 한다. 본 논문에서는 표적 신호에 레인지 워크가 있는 경우 우선 레인지(range) 방향 인터폴레이션(interpolation)을 수행해서 일정한 시간간격으로 샘플링된 표적 성분이 있는 레인지 빈(range bin)을 추출하고, 이어서 도플러 프로세싱을 통한 도플러 정보 추출 알고리즘을 제시한다. 이를 위해 바이스태틱 레이더 환경을 가정하고, 펄스 압축에 의해 레인지 프로세싱 과정을 포함한 도플러 프로세싱 과정을 이론적으로 설명한 후 시뮬레이션을 통하여 제시된 방식의 타당성을 보인다. Range walk has been a major problem in achieving correct Doppler processing. This frequently occurs when range variation is severe just like in a bistatic radar or in high speed target scenario. This paper presents a range walk compensated range-Doppler processing algorithm applicable to the bistatic radar. In order for the compensation, a range-domain interpolation is applied for range compressed signal so that Doppler processing is performed along the evenly time-spaced range bins that contain target returns. Under a bistatic radar scenario, the proposed algorithm including a range domain pulse compression is mathematically described. Finally, the validity of the algorithm is demonstrated by simulation results showing the superiority of a SCDP(Squint Cross-range Doppler Processing) over an uncompensated Doppler processing.
Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
Woo, Yun-Ju,Joo, Young-Bin,Jung, Young-Ok,Ju, Ji-Hyeon,Cho, Mi-La,Oh, Hye-Jwa,Jhun, Joo-Youn,Park, Mi-Kyung,Park, Jin-Sil,Kang, Chang-Min,Sung, Mi-Sook,Park, Sung-Hwan,Kim, Ho-Youn,Min, Jun-Ki Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.10
Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the progression of OA. We investigated the effects of grape seed proanthocyanidin extract (GSPE), which is an antioxidant, on monosodium iodoacetate (MIA)-induced arthritis of the knee joint of rat, which is an animal model of human OA. GSPE (100 mg/kg or 300 mg/kg) or saline was given orally three times per week for 4 weeks after the MIA injection. Pain was measured using the paw withdrawal latency (PWL), the paw withdrawal threshold (PWT) and the hind limb weight bearing ability. Joint damage was assessed using histological and microscopic analysis and microcomputerized tomography. Matrix metalloproteinase-13 (MMP13) and nitrotyrosine were detected using immunohistochemistry. Administration of GSPE to the MIA-treated rats significantly increased the PWL and PWT and this resulted in recovery of hind paw weight distribution ($P$ < 0.05). GSPE reduced the loss of chondrocytes and proteoglycan, the production of MMP13, nitrotyrosine and IL-$1{\beta}$ and the formation of osteophytes, and it reduced the number of subchondral bone fractures in the MIA-treated rats. These results indicate that GSPE is antinociceptive and it is protective against joint damage in the MIA-treated rat model of OA. GSPE could open up novel avenues for the treatment of OA.
( Woo Young Chung ),( Jae Bin Seo ),( Dong Hyun Choi ),( Young Seok Cho ),( Joo Myung Lee ),( Jung Won Suh ),( Tae Jin Youn ),( In Ho Chae ),( Dong Ju Choi ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.3
Background/Aims: The best revascularization strategy for patients with both acute ST-elevation myocardial infarction (STEMI) and multivessel coronary disease (MVD) is still debatable. We aimed to compare the outcomes of multivessel revascularization (MVR) with those of culprit-only revascularization (COR). Methods: A cohort of 215 consecutive patients who had received primary angioplasty for STEMI and MVD were divided into two groups according to whether angioplasty had been also performed for a stenotic nonculprit artery. The primary endpoint was one-year major adverse cardiac events defined as a composite of cardiac death, recurrent myocardial infarction, or any repeat revascularization. Results: One-year major adverse cardiac events were not significantly different between MVR (n = 107) and COR (n = 108) groups. However, the one-year composite hard endpoint of cardiac death or recurrent myocardial infarction was notably increased in the MVR group compared to the COR group (20.0% vs. 8.9%, p = 0.024). In subgroup analysis, the hard endpoint was significantly more frequent in the immediate than in the staged MVR subgroup (26.6% vs. 9.8%, p = 0.036). The propensity score-matched cohorts confirmed these findings. Conclusions: In patients with STEMI and MVD, MVR, especially immediate MVR with primary percutaneous intervention, was not beneficial and led to worse outcomes. Therefore, we conclude that COR or staged MVR would be better strategies for patients with STEMI and MVD.
Woo Bin Yun,Hye Ryeong Kim,Ji Eun Kim,Jun Young Choi,Mi Rim Lee,Jin Ju Park,Bo Ram Song,Young Suk Jung,Hyun Keun Song,Joon Young Cho,Kil Soo Kim,Dae Youn Hwang 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. To compare the fertilization rates of C57BL/6NKorl mice with two commercial C57BL/6N stocks, differences in reproductive organ structures, sperm and egg numbers, fertilization rates, and embryo development rates among C57BL/6NKorl (Korea FDA source), C57BL/6NA (USA source), and C57BL/6NB (Japan source) mice were determined. Among the stocks, no significant differences were detected in organ weight and histological structure of male and female reproductive organs, although body weight was higher in C57BL/6NKorl mice than that in the other groups. The concentration and morphology of sperm and eggs in C57BL/6NKorl mice were similar to those of C57BL/6NA and C57BL/6NB mice. Furthermore, the three stocks had similar in vitro fertilization and embryo development rates, although these rates tended to be higher in C57BL/6NB mice. Pup body weight was higher in C57BL/6NKorl and C57BL/6NB mice than that in C57BL/6NA mice. The results of the present study suggest that C57BL/6NKorl, C57BL/6NA, and C57BL/6NB mice obtained from three different sources have similar fertilization and embryo development rates, although there were slight differences in the magnitude of their responses rates.
Nam, Youn Hee,Le, Hoa Thi,Rodriguez, Isabel,Kim, Eun Young,Kim, Keonwoo,Jeong, Seo Yule,Woo, Sang Ho,Lee, Yeong Ro,Castaneda, Rodrigo,Hong, Jineui,Ji, Min Gun,Kim, Ung-Jin,Hong, Bin Na,Kim, Tae Woo,Ka The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.1
Background: 20(S)-Protopanaxadiol 20-O-D-glucopyranoside, also called compound K (CK), exerts antidiabetic effects that are mediated by insulin secretion through adenosine triphosphate (ATP)-sensitive potassium ($K_{ATP}$) channels in pancreatic ${\beta}$-cells. However, the antidiabetic effects of CK may be limited because of its low bioavailability. Methods: In this study, we aimed to enhance the antidiabetic activity and lower the toxicity of CK by including it with ${\beta}$-cyclodextrin (CD) (CD-CK), and to determine whether the CD-CK compound enhanced pancreatic islet recovery, compared to CK alone, in an alloxan-induced diabetic zebrafish model. Furthermore, we confirmed the toxicity of CD-CK relative to CK alone by morphological changes, mitochondrial damage, and TdT-UTP nick end labeling (TUNEL) assays, and determined the ratio between the toxic and therapeutic dose for both compounds to verify the relative safety of CK and CD-CK. Results: The CD-CK conjugate ($EC_{50}=2.158{\mu}M$) enhanced the recovery of pancreatic islets, compared to CK alone ($EC_{50}=7.221{\mu}M$), as assessed in alloxan-induced diabetic zebrafish larvae. In addition, CD-CK ($LC_{50} =20.68{\mu}M$) was less toxic than CK alone ($LC_{50}=14.24{\mu}M$). The therapeutic index of CK and CD-CK was 1.98 and 9.58, respectively. Conclusion: The CD-CK inclusion complex enhanced the recovery of damaged pancreatic islets in diabetic zebrafish. The CD-CK inclusion complex has potential as an effective antidiabetic efficacy with lower toxicity.