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Hong-Lin Xu,Guang-Hong Chen,Yu-Ting Wu,Ling-Peng Xie,Zhang-Bin Tan,Bin Liu,Hui-Jie Fan,Hong-Mei Chen,Gui-Qiong Huang,Min Liu,Ying-Chun Zhou 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1
Background: Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism and active ingredients remains largely unclear. Herein, we aimed to explore the active ingredients of P. ginseng against inflammation and elucidate underlying mechanisms. Methods: Inflammation model was constructed by lipopolysaccharide (LPS) in C57BL/6 mice and RAW264.7 macrophages. Molecular docking, molecular dynamics, surface plasmon resonance imaging (SPRi) and immunofluorescence were utilized to predict active component. Results: P. ginseng significantly inhibited LPS-induced lung injury and the expression of proinflammatory factors, including TNF-a, IL-6 and IL-1b. Additionally, P. ginseng blocked fluorescence-labeled LPS (LPS488) binding to the membranes of RAW264.7 macrophages, the phosphorylation of nuclear factor-kB (NF-kB) and mitogen-activated protein kinases (MAPKs). Furthermore, molecular docking demonstrated that ginsenoside Ro (GRo) docked into the LPS binding site of toll like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) complex. Molecular dynamic simulations showed that the MD2-GRo binding conformation was stable. SPRi demonstrated an excellent interaction between TLR4/MD2 complex and GRo (KD value of 1.16 × 10<SUP>-9</SUP> M). GRo significantly inhibited LPS488 binding to cell membranes. Further studies showed that GRo markedly suppressed LPS-triggered lung injury, the transcription and secretion levels of TNF-α, IL-6 and IL-1β. Moreover, the phosphorylation of NF-kB and MAPKs as well as the p65 subunit nuclear translocation were inhibited by GRo dose-dependently. Conclusion: Our results suggest that GRo exerts anti-inflammation actions by direct inhibition of TLR4 signaling pathway.
Vitexicarpin Induces Apoptosis in Human Prostate Carcinoma PC-3 Cells through G2/M Phase Arrest
Meng, Fan-Min,Yang, Jing-Bo,Yang, Chun-Hui,Jiang, Yu,Zhou, Yong-Feng,Yu, Bo,Yang, Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Vitexicarpin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone), a polymethoxyflavone isolated from Viticis Fructus (Vitex rotundifolia Linne fil.), has long been used as an anti-inflammatory herb in traditional Chinese medicine. It has also been reported that vitexicarpin can inhibit the growth of various cancer cells. However, there is no report elucidating its effect on human prostate carcinoma cells. The aim of the present study was to examine the apoptotic induction activity of vitexicarpin on PC-3 cells and molecular mechanisms involved. MTT studies showed that vitexicarpin dose-dependently inhibited growth of PC-3 cells with an $IC_{50}{\sim}28.8{\mu}M$. Hoechst 33258 staining further revealed that vitexicarpin induced apoptotic cell death. The effect of vitexicarpin on PC-3 cells apoptosis was tested using prodium iodide (PI)/Annexin V-FITC double staining and flow cytometry. The results indicated that vitexicarpin induction of apoptotic cell death in PC-3 cells was accompanied by cell cycle arrest in the G2/M phase. Furthermore, our study demonstrated that vitexicarpin induction of PC-3 cell apoptosis was associated with upregulation of the proapoptotic protein Bax, and downregulation of antiapoptotic protein Bcl-2, release of Cytochrome c from mitochondria and decrease in mitochondrial membrane potential. Our findings suggested that vitexicarpin may become a potential leading drug in the therapy of prostate carcinoma.
( Yi Fan Hong ),( Hangeun Kim ),( Hye Rim Kim ),( Min Geun Gim ),( Dae Kyun Chung ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.12
It is known that lactic acid bacteria (LAB) have many beneficial health effects, including antioxidative activity and immune regulation. In this study, the immune regulatory effects of Lactobacillus sakei and Lactobacillus plantarum, which are found in different types of kimchi, were evaluated. L. sakei and its lipoteichoic acid (LTA) have greater immune stimulating potential in IL-12, IFN-γ, and TNF-α production as compared with L. plantarum in an in vitro condition. On the other hand, L. plantarum is assumed to repress the Th1 immune response in murine experiments. After being injected with LPS, L. plantarum-fed mice maintained a healthier state, and the level of TNF-α in their blood was lower than in other bacterial strainfed mice and in the LPS-only control mice. Additionally, IL-12 production was significantly decreased and the production of IL-4 was greatly increased in the splenocytes from L. plantarum-fed mice. Further experiments revealed that the pre-injection of purified LTA from L. plantarum (pLTA), L. sakei (sLTA), and S. aureus (aLTA) decreased TNF-α and IL-4 production in LPS-injected mice. Mouse IL-12, however, was significantly increased by aLTA pre-injection. In conclusion, the L. sakei and L. plantarum strains have immune regulation effects, but the effects differ in cytokine production and the regulatory effects of the Th1/Th2 immune response.
The Stabilization and 3D Visual Simulation of the Triple Inverted Pendulum based on CGA-PIDNN
Xiu-Ling Zhang,Hong-Min Fan,Jia-Yin Zang,Liang Zhao,Shuang Hao 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.4
Aiming at the triple inverted pendulum which is a strong coupling, multivariable, high-order and unsteady system, a design method of the controller based on PID neural network (PIDNN) optimized by cloud genetic algorithm (CGA) is proposed, this method is called CGA-PIDNN. CGA can be applied to learn and train the PIDNN connection weights. CGA can overcome the defect of the slow convergence rate and premature convergence for genetic algorithm (GA). PIDNN is a simple and normative network which is easy to be realized and has a good dynamic performance. The CGA-PIDNN control system of triple inverted pendulum is verified with MATLAB simulation test. The comparison results with the control effect of PIDNN control system optimized by standard GA (GA-PIDNN) are presented first. Then in LabVIEW environment, by using the combination of virtual reality technology and MATLAB, the three-dimensional (3D) animation simulation model of the triple inverted pendulum CGA-PIDNN control system is built. The simulation results indicate that CGA-PIDNN control method is effective, whose control effects are superior to those by GA-PIDNN control, it is believed that CGAPIDNN is effective and will become a promising candidate of control methods.
Zhen-Zheng Wang,Hong-Dong Duan,Xia Meng,Yi-Fan Zhang,Hui-Min Qi 한국고분자학회 2016 Macromolecular Research Vol.24 No.9
Two novel types of thiol-based chelating resins were fabricated by modifying poly(2-hydroxyethyl methacrylate- co-glycerol dimethacrylate) (P(HEMA-GDMA)) and poly(2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (P(HEMA-EGDMA)) with (3-mercaptopropyl) trimethoxysilane(MPS), and used to adsorb lead(II) from aqueous solution. The effects of initial lead(II) concentrations, solution pH, coexisting ions on adsorption of lead(II) were investigated. After modifying, the product P(HEMA-GDMA)-SH has excellent adsorption capacity (118.56 mg/g) for lead(II) at initial lead(II) concentration of 200 mg/L. The resins could easily be regenerated and were reused 6 times without significant loss of adsorption capacity. Besides, the presence of coexisting ions did not markedly influence the adsorption capacities of the resins. The results indicate that the functional thiol-based resins are efficient adsorbents for the removal of toxic lead(II) ions in water treatment.
Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.