수출입 컨테이너 장치장 배정을 위한 소프트웨어의 개발

김갑환,김홍배,홍봉희,김기영,배종욱,최진오,김두열,이영기,박영만,박강태,손행대 한국경영과학회 1995 經營 科學 Vol.12 No.3

The Pusan Container Terminal faces a rapid increase in berthing time of container ships as well as in waiting time of external trucks, which is due to an absolute lack of yard space. This research is focused on the development of a decision support system for the planning of the container terminal yard assignment so that the yard space would be utilized most effectively. Efforts should be given to the reasonable assignment of the yard storage and the dynamic adaptation to the ever changing environment. The software introduced here is based o the know-how of the field exports and its framework takes the approach of the hierarchical decision making.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

고지방식이가 백서 골격근 및 지방조직의 지방분해에 미치는 영향

김철희,정윤이,이성진,박중열,홍성관,김홍규,서교일,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:지방산화의 증가가 골격근에서 인슐린 저항성을 유발한다는 주장이 꾸준히 제기되어 나왔으나, 최근 제2형 당뇨병 환자나 인슐린저항성 상태에서 골격근의 지방산화능이 저하되어 있다는 보고도 있어 논란이 있는 상태이다. 본 연구에서는 고지방식이를 투여하여 인슐린저항성을 유발한 백서에서 microdialysis 기법을 이용하여 조직내의 지방분해 결과로 간질액내로 방출되는 글리세롤 농도를 골격근 및 지방조직에서 직접 측정하여 지방분해의 변화를 알아보고자 하였다. 방법:정상 Sprague­Dawley 백서를 두 군으로 나누어 4주간 고지방식이 및 저지방식이를 투여하였다. 4주간 기저상태 및 고인슐린 정상혈당 클램프 중의 골격근 및 지방조직에 microdialysis probe를 삽입하고 일정한 농도의 글리세롤을 포함하는 dialysate를 통과시켜 주입액과 유출액의 글리세롤 농도 차이로부터 조직 간질의 글리세롤 농도를 산출하엿다. 결과:기저상태에서 골격근 및 지방조직 간질의 글리세롤 농도는 저지방식이군에 비하여 고지방식이군에서 유의하게 낮았다. 고인슐린 정상혈당 클램프 중에는 골격근 및 지방조직 간질의 글리세롤 농도가 양군에서 모두 억제되었는데, 기저 상태와 마찬가지로 골격근 및 지방조직 모두에서 저지방식이군보다 고지방식이 군에서 더 낮았다. 기저 상태에 대한 고인슐린 클램프중의 글리세롤 방출 억제 정도는 저지방식이군에 비하여 고지방식이군에서 덜 억제되는 경향을 보였는데, 골격근조직에서만 통계적으로 유의하였다. 결론:본 연구 결과는 고지방식이에 의한 인슐린저항성 모델에서 골격근 및 지방조직내 지방분해가 억제되어 있음을 보여주며, 기존의 포도당­지방산 cycle 이론과는 달리 조직내 지방산화의 증가보다는 지방산화능의 감소에 따른 세포내 지방축척이 인슐린저항성과 관련될 가능성을 시사하였다. Background : It has been hypothesized that increased fat oxidation reduces glucose utilization in skeletal muscle, and is responsible for the insulin resistance associated with obesity or high-fat feeding. In contrast, there have been reports that fat oxidation capacity was decreased in skeletal muscles from insulin resistant subjects. This study was undertaken to examine whether insulin resistance in high-fat fed rats is associated with increased lipolysis in skeletal muscle and adipose tissue. Methods : Two groups of Sprague-Dawley rats were fed either high-fat or low-fat diets for 4 weeks. Lipolysis in skeletal muscle and adipose tissue was determined by measurement of interstitial 1 glycerol concentrations by a microdialysis method in basal and hyperinsuline mic-euglycemic clamp conditions. Results : In basal state, plasma glycerol levels and interstitial glycerol concentrations of skeletal muscle, and adipose tissue were lower in high-fat fed than in low-fat fed rats. The degree of suppression of glycerol release by the hyperinsuline mia was smaller in the high-fat diet than in the low-fat diet group. However, plasma and interstitial glycerol concentrations during the hyperinsuline mic euglycemic clamps were also lower in the high-fat diet group. Conclusion : Lipolysis was decreased in skeletal muscle and adipose tissue of insulin resistant, high-fat fed rats. These results support the idea that limited fat oxidation capacity resulting in lipid accumulation in tissues, rather than increased fat oxidation perse, is responsible for the insulin resistance associated with high-fat feeding (J Kor Diabetes Asso 24:641~651, 2000).

국제기준에 의한 국내 비자동저울의 품질 평가에 관한 연구

김홍원,남궁재관,김창열,공재향 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

This study is to improve the quality of electronic weighing machine by providing a reformation plan on currently problems of domestic manufactured nonautomatic weighing instruments, and by test items and criteria considering internal situation, on base of identification of quality level of domestic manufactures electronic weighing machine according to the international standards.

산업근로자의 식생활 의식행태 조사

김무룡,황연자,차경미,이순자,위광복,남철현,김기열,김홍길 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

This study was carried out to grasp the awareness and habits of food intake and use the information for health education program in order to help healthy dietary life. The survey was done in cooperation with health manager in industries on 1,200 workers who was selected randomly from 5 types of industries from Sep. 2 to Oct. 31, 1995. The results are summarized as follows: 1) The percentage of subjects who assess themselves "Healthy" was more higher in female, in 20∼29 age group, in single, in daytime workers, in college graduate than other groups respectively. 2) As for the degree of health education satisfaction, 35.5% of the subjects answered "dissatisfaction" 3) As for the exercise, 52.7% exercised for their health and the rate of exercise was more higher in male, in 30 years age group, in single than other groups respectively. 4) The rate of smoking was 57.6% and the rate of drinking alcohol was 47.3%. 5) 92.8% of the subjects got stress everyday and the rate is more higher in female, in less than 19 years old, in single, in longer working duration, in lower income, in high school graduates, in workers of product field line than other groups respectively. 6) As for drinking times of coffee or soft drink, two times per day was 29.5%, more three times per day was 28.0%. As for the eating speed of meal, 46.0% of the subjects answered "fast" and the rate was more higher in male, in 30 years age group, in married group, than other groups respectively. 7) With regard to the level of preference to instant food, 23.1% preferred to take instant food. As for the level of preference to hot and salty food, 28.1% preferred to have hot and salty food. 8) The score of eating behavior was 3.38±32 point to 6 point full marks. 9) With regard to the correlation among related variables, the variables of gender, marital status and working duration had positive relation with the variables of regular meal intake, the preference to food intake between regular meals.

폐경기 자궁 액체 축척 여성에서 자궁두께에 따른 조직학적 소견

김흥열,김흥배,어완규 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Objectives : The aim of the study was to assess the hitologic appearance according to endometrial thickness in postmenopausa endometrial fluid accumulation women. Methods : A group of 20 postmenopausal women with an endometrial fluid accumulation confirmed by ultrasonography and underwent Dilatation & Curettage. The patients were divided into two groups according to the endometrial thickness(ET). Sixteen women had thin endometrium (<4mm) and four women had the thick endometrium (≥4mm). Results : When ET was ≥ 4mm, proliferative endometrium was found in 2 patients (50%), atrophic endometrium was in I patient (25%) and endometritis was in I patient (25%). When ET was < 4mm, atrophic endometrium was found in 14 patients (87%), A majority of patients with ET of less than 4mm in ultrasound had atrophic endometrium. The incidence of intrauterine pathology increased with the increasing thickness of endometrium as abserved by ultrasound. Conclusion : The presence of endometrial fluid accumulation in postmenopausal patients without any symptoms seems to be a benign condition. Normal endometrium of less than 4mm observed by ultrasound in postmenopausal women without vaginal bleeding dose not necessarily need further surgical investigation.

신경회로망 기반 패턴인식 성능향상 기법

김재열,윤성운,홍성훈,유홍연,김창현 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

Availability of defect test algorithm that recognizes exact and standardized defect information in order to fundamentally resolve generated defects in industrial sites by giving artificial intelligence to SAT(Scanning Acoustic Tomograph), which previously depended on operator’s decision, to find various defect information in a semiconductor package, to decide defect pattern, to reduce personal errors and then to standardize the test process was verified. In order to apply the algorithm to the lately emerging Neural Network theory, various weights were used to derive results for performance advancement plans of the defect test algorithm that promises excellent field applicability.

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

벼 雜種品種의 開發硏究 現況과 展望

許文會,金弘烈,高熙宗 서울大學校農科大學 農業開發硏究所 1991 서울대농학연구지 Vol.16 No.1

벼에서 雜種强勢 이용 育種法은 中國에서의 성공적인 實用化와 더불어 現在의 收量 水準을 한 段階 올릴 수 있는 획기적인 育種法으로 평가되고 있다. 이에 本 稿에서는 雜種品種 硏究의 進行狀況과 今後의 展望 等을 벼에서의 雜種强勢 정도, 雄性不稔 및 稔性回復 體系, 雜種種子 生産 및 經濟性 等으로 구분하여 考察하였다. 그 結果를 要約하면 다음과 같다. 1. 지금까지 보고된 바로 벼에서의 收量 雜種强勢는 40% 정도를 기대할 수 있을 것으로 보이며, 收量構成要素 中에는 粒數의 增加가 收量 雜種强勢에 가장 크게 寄與하는 것으로 나타났다. 장차 Indica와 Japonica의 hybrid는 雜種强勢 水準을 크게 높일 것으로 보인다. 2. 細胞質 雄性不稔의 種類와 稔性回復因子 等을 검토하였고, 雜種品種 育成 體系를 單純化시킬 수 있는 方案들을 論議하였다. 3. 雜種品種 實用化의 관건이 되는 雜種種子 生産 現況과 自然交雜率 提高方案 等을 고찰하였고, 經濟性은 中國의 例를 검토하였다. Utilization of hybrid vigor in rice has been evaluated as an innovative breeding method to elevate the current yield-level, with the success in China. In this study, Current achievements and future outlook on hybrid rice were reviewed and discussed with the topics of extent of heterosis-level, the system of male sterility and fertility restoration, hybrid seed production, and the economical aspects. The results are summarized as follows; 1. The practical yield advantage over the best commercial cultivars might be 40%, and number of grains out of yield components was mainly responsible for the yield heterosis from the reports. It was expected that hybrids between Indica and Japonica might level up the heterosis extensively. 2. The system and genetics of cytoplasmic male sterility and fertility restoration reported in rice were reviewed. The feasible methods to simplify the system of breeding hybrid rice were estimated. 3. The status of hybrid seed production and the strategy for the improvement of natural outcrossing were summarized, and the economics of hybrid rice in China was discussed.

자궁경부 소세포암 4예의 임상적 특징과 예후에 관한 연구

오영림,김흥열,어완규,김홍배 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : To investigate clinicopathologic finding of patients with small cell carcinoma of uterine cervix, and to evaluate the recurrence pattern and survival time of small cell carcinoma of uterine cervix Methods : The medical records of four patients who were diagnosed with small cell carcinoma of the uterine cervix and whose initial treatment was between January 1990 and December 2006 were studied retrospectively Results : Patient ages ranged between 43 and 50 years. The clinical stages at diagnosis were Ib, IIa, IIb, IIIa. All patients presented with abnormal vaginal bleeding. Tumor size at diagnosis was under 2cm in 1 patient and over 2cm in 3 patients. Disease recurred in 3 patients at 5~26 months and all of them died. Through analyzing overall survival time, FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterus Conclusion : Small cell carcinoma of uterine cervix revealed poor prognosis. Our study found FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix. Because of limitation of number of patients, further large scaled multicenter studies are needed.