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( Sun-uk Bak ),( Suji Kim ),( Hae-jun Hwang ),( Jung-a Yun ),( Wan-sung Kim ),( Moo-ho Won ),( Ji-yoon Kim ),( Kwon-soo Ha ),( Young-guen Kwon ),( Young-myeong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2
Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKLinduced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect. CORM-2 also inhibited RANKLinduced osteoclastogenesis and osteoclastic resorption activity in marrow-derived macrophages. Treatment with hemin, a HO-1 inducer, strongly inhibited RANKL-induced osteoclastogenesis in wild-type macrophages, but was ineffective in HO-1<sup>+/- </sup>cells. CORM-2 reduced RANKL-induced NFATc1 expression by inhibiting IKK-dependent NF-κB activation and reactive oxygen species production. These results suggest that CO potently inhibits RANKL-induced osteoclastogenesis by inhibiting redox-sensitive NF-κB-mediated NFATc1 expression. Our findings indicate that HO-1/CO can act as an antiresorption agent and reduce bone loss by blocking osteoclast differentiation. [BMB Reports 2017; 50(2): 103-108]
Bhang, Suk Ho,Kim, Ju Hee,Yang, Hee Seok,La, Wan-Geun,Lee, Tae-Jin,Kim, Ga Hee,Kim, Hyun Ah,Lee, Minhyung,Kim, Byung-Soo Mary Ann Liebert 2011 Tissue engineering. Part A Vol.17 No.7
<P>Transfection with either hypoxia-inducible factor-1α (HIF-1α) or heme oxygenase-1 (HO-1) gene can induce neovascularization in ischemic tissues. Although expression of transfected HIF-1α gene occurs rapidly, the expressed HIF-1α protein degrades quickly, limiting its therapeutic efficacy. Meanwhile, expressed HO-1 protein does not rapidly undergo degradation, but gene expression occurs a couple of days after transfection, resulting in apoptosis and a delay in angiogenesis in ischemic tissues at the incipient period of HO-1 gene transfection. We hypothesize that combined delivery of HIF-1α and HO-1 gene will enhance antiapoptosis and neovascularization in ischemic tissue compared with HIF-1α or HO-1 single-gene therapy. To test this hypothesis, ischemic mouse hindlimbs were treated with HIF-1α and/or HO-1 gene therapy. The combined gene therapy proved superior to both single-gene therapies, resulting in rapid expression of HIF-1α gene and long-term maintenance of expressed HO-1 protein. The apoptosis in the ischemic region was significantly less, and angiogenic growth factor secretion and angiogenesis were greater in the combined gene therapy than in either of the single-gene therapies. Our results suggest that a combined gene therapy of HIF-1α and HO-1 enhances the transfection of both genes and improves angiogenesis compared with either single-gene therapy.</P>
사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예
배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2
Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.
정호완 우리말글학회 2004 우리말 글 Vol.32 No.-
In this paper we aimed to study on the meaning and distribution of morpheme '-nae(奈)' The conclusions are as follows (1) The original meaning of '-nae' is the stream or water The construction of morpheme '-nae' is composed of dae(大) and su(水) (2) The type of distribution could be categorized into two classes The one is chinese series, the other is originative series Such probability will be found in the relation of correspondence in place name (3) Being influenced morpheme innovation, the chinese series '-cheon(川)' takes the place of '-nae(川)' So the ground name of originative series does not see the usage without Naeseongcheon in the YeongJu area
중학생들의 과학적 사고 수준과 교과서 생물 분야의 탐구활동에서 요구하는 사고수준의 분석
정완호,김영신,권용주 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1
The purpose of this study was to analyze the relationship between junior high school students' reasoning level and thinking pattern of biology inquiry activities in their science textbook. Students' scientific reasoning abilities were investigated by the Lawson's Scientific Reasoning Group Test which was adminstered to 725 junior high school students. Four hundred and sixty-four inquiry activities excerpted from 8 science textbooks were analyzed by the profile of reasoning patterns which were composed of sub-categories of empirical-inductive reasoning and hypothetico-deductive reasoning patterns. The results of this study showed that 38.9 percentiles of all subjects were categorized as empirical-inductive reasoner and 29.1 percentiles were hypothetico-deductive reasoner. Although the percentile of hypothetico-deductive reasoner was increased from the 7th to the 8th grades, the result showed it was decreased from the 8th to the 9th grades which provided another positive evidence for Kwon's theory of the spurt-and-plateau pattern of reasoning development. In addition, the result showed that 86.4 percentiles of all inquiry activities were revealed as empirical-inductive reasoning pattern and 13.6 percentiles were turn in revealed as hypothetico-deductive reasoning pattern. Even the percentile of hypothetical-deductive reasoning pattern of inquiry activities was increased from the 7th to 9th grades, it was lower than the percentiles of students' hypothetico-deductive reasoning level.
정호완 우리말글학회 2001 우리말 글 Vol.21 No.-
This paper take a subject about the meaning and form historically. same time we research distribution type and developement trends. study accent is following: First, Daegu(犬邱) originated from ancient chinese letter dal(達)which means 'high or large'. Second, the form dart(達) symbolizes mountain worship, that is founded at solar worship. physically speaking, 'hai(sai 陽)'signated iron(鐵) in ancient iron age. Third, diferenciation of dal(達) divided into two category, one is meaning class, the other is sound class. front class contains wol(月-) series which is originated from bird totem, other class dae(大-) series.
석민호,김완식,조양자 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1
Upper respiratory colonization and subsequent postoperative pneumonia caused by gram-negative bacilli are increased in patients undergoing surgical procedure. The present study was to investigate the effect of surgical procedure on postoperative respiratory colonization and subsequent infection caused by gram-negative bacilli. Among patients undergoing various major and minor operations at Hanyang university hospital during the months of November and December of 1985, 50 patients were chosen to evaluate the changes in upper respirtory colonization by gram-negative bacilli and receptivity of buccal epithelial cells to Pseudomonas aeruginosa, a common respiratory colonizer and pathogen. Upper respiratory colonization by gram-negative bacilli was significantly increased from preoperative 10% (5/50) to postoperative 29% (13/45). Klebisiella pneumoniae was the most frequent postopertative isolate (4 strains). Viability of buccal epithelial cells was decresed postoperaively (P<0.05). Receptivity of buccal epithelial cell to Pseudomonas aeruginosa was increased postoperatively (P<0.001) in mean numbers of attached bacteria per cell and in numbers of cells with minimal numbers of attached bacteria and these two parameters were extremely correlated (=0.999). Upper respiratory colonization rate of gram-negative bacilli and increase in receptivity of buccal epithelial cells to Pseudomonas aeruginosa was significantly greater in patients whose operation took more than 2 hours than in those whose operation lasted less than 2 hours (P<0.001). Data obtained in the present study suggest that changes in surface binding properties of upper respiratory epithelium may be an important factor in predisposing to postoperative respiratory infection by gram-negative bacilli.