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Kim, Suji,Lee, Kyu-Sun,Choi, Seunghwan,Kim, Joohwan,Lee, Dong-Keon,Park, Minsik,Park, Wonjin,Kim, Tae-Hoon,Hwang, Jong Yun,Won, Moo-Ho,Lee, Hansoo,Ryoo, Sungwoo,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Youn American Society for Biochemistry and Molecular Bi 2018 The Journal of biological chemistry Vol.293 No.49
<P>Inflammatory cytokines, including tumor necrosis factor-α (TNFα), were elevated in patients with cardiovascular diseases and are also considered as crucial factors in the pathogenesis of preeclampsia; however, the underlying pathogenic mechanism has not been clearly elucidated. This study provides novel evidence that TNFα leads to endothelial dysfunction associated with hypertension and vascular remodeling in preeclampsia through down-regulation of endothelial nitric-oxide synthase (eNOS) by NF-κB–dependent biogenesis of microRNA (miR)-31-5p, which targets eNOS mRNA. In this study, we found that miR-31-5p was up-regulated in sera from patients with preeclampsia and in human endothelial cells treated with TNFα. TNFα-mediated induction of miR-31-5p was blocked by an NF-κB inhibitor and NF-κB p65 knockdown but not by mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase inhibitors, indicating that NF-κB is essential for biogenesis of miR-31-5p. The treatment of human endothelial cells with TNFα or miR-31-5p mimics decreased endothelial nitric-oxide synthase (eNOS) mRNA stability without affecting <I>eNOS</I> promoter activity, resulting in inhibition of eNOS expression and NO/cGMP production through blocking of the functional activity of the eNOS mRNA 3′-UTR. Moreover, TNFα and miR-31-5p mimic evoked endothelial dysfunction associated with defects in angiogenesis, trophoblastic invasion, and vasorelaxation in an <I>ex vivo</I> cultured model of human placental arterial vessels, which are typical features of preeclampsia. These results suggest that NF-κB–responsive miR-31-5p elicits endothelial dysfunction, hypertension, and vascular remodeling via post-transcriptional down-regulation of eNOS and is a molecular risk factor in the pathogenesis and development of preeclampsia.</P>
Son, Suji,Lee, Jang Mee,Kim, Se-Jun,Kim, Hyejin,Jin, Xiaoyan,Wang, Kang Kyun,Kim, Minho,Hwang, Jeong Wook,Choi, Wonyong,Kim, Yong-Rok,Kim, Hyungjun,Hwang, Seong-Ju Elsevier BV 2019 Applied Catalysis B Vol.257 No.-
<P><B>Abstract</B></P> <P>Hybridization with conductive 2D nanosheets (NSs) attracts plenty of research activities because of its effectiveness for improving the photocatalyst performance of diverse semiconductors. Here, versatile roles of conductive NSs in hybrid-type photocatalysts are systematically investigated with three representative conductive 2D NSs to synthesize highly efficient visible light-active photocatalysts. Among several conductive NS-based nanohybrids, the RuO<SUB>2</SUB> NS-based nanohybrid exhibits the highest photocatalytic activities. Based on systematic spectroscopic analyses, polar RuO<SUB>2</SUB> NS appears to be more effective as electron reservoir, photosensitizer, cocatalyst and charge carrier pathway in hybrid-type photocatalyst than MoS<SUB>2</SUB> and graphene NSs. The high efficiency of RuO<SUB>2</SUB> NS as hybridization matrix is attributable to the high surface hydrophilicity, high surface bond polarity, and enhanced interfacial electronic coupling of this hydrophilic NS with semiconductor. The present study underscores that hydrophilic conductive metal oxide NS can act as the most efficient hybridization matrix for exploring high-performance photocatalysts with strong interfacial electronic coupling.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2D conductive nanosheets play versatile roles in hybrid-type photocatalysts. </LI> <LI> Hybridization with conductive nanosheet remarkably enhances photocatalyst activity. </LI> <LI> Interfacial electronic coupling is the most crucial factor for hybrid-type photocatalyst. </LI> <LI> Hydrophilic metal oxide nanosheet is the most efficient hybridization matrix. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
당귀(Angelica gigas N.)와 토사자(Cuscuta chinensis Lam.)를 포함하는 생약 복합 추출물의 폐경 동물모델에서의 갱년기 증상 완화 효과
김수지(Suji Kim ),장병현(Byung-Hyun Jang),장서혁(Seo-Hyuk Chang),강희(Hee Kang),박기문(Ki-Moon Park),안덕균(Duk Kyun Ahn),김수현(Soohyun Kim),김선미(Sunmi Kim),서대방(Daebang Seo),신송석(Song Seok Shin),박계원(Kye Won Park) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.8
대부분의 여성은 폐경 이후 신체적 변화를 겪게 된다. 폐경의 증상으로는 홍조, 발한, 몸무게의 증가와 질 건조증 등이 있다. 본 연구에서는 여성의 폐경기 증상 완화에 효능이 있는 열 가지 종류의 생약을 조합하여 만든 혼합 추출물이 동물의 폐경 모델인 난소절제(ovariectomized, OVX) 레트에 어떠한 영향을 미치는지 알아보고자 하였다. 경구투여를 통해 각각 500 mg/kg/d, 1,000 mg/kg/d 농도의 열수 추출물(자음미단)을 8주간 섭취시켰으며, 양성대조군으로 에스트라디올(50 μg/mL)을 사용하였다. 실험을 통해 자음미단이 난소절제 레트에서 몸무게를 유의적으로 감소시켰으며, 간에서의 지방 함량 증가를 억제함을 확인하였다. 자음미단의 섭취는 페경 후 증가하는 혈액의 중성지방과 콜레스테롤 수치도 감소시켰다. 또한, 자음미단은 질의 무게를 증가시켰으며, 특히 질 내벽의 상피세포의 두께에 영향을 주었다. 자음미단의 1,000 mg/kg/d의 농도에서는 에스트로디올과 유사한 정도의 내벽 두께를 관찰할 수 있었다. 따라서 본 실험을 통해 자음미단이 폐경기 여성의 증상인 비만, 대사질환 및 질 건조증의 증상을 완화해줄 수 있으며, 이를 활용한 기능성 식품의 개발이 기대된다. During menopause, elderly woman experience physical and emotional symptoms, including hot flashes, night sweats, weight gain, vaginal dryness, and mood swings. In this study, we investigated the effects of mixed herbal extracts containing Angelica gigas Nakai and Cuscuta chinensis Lam. on menopause symptoms in ovariectomized (OVX) rats. Daily oral treatments of 500 mg/kg and 1,000 mg/kg in OVX rats for 8 weeks significantly reduced weight gain, inhibited hepatic lipid accumulation, and lowered serum lipid levels comparable to the effects induced by estradiol treatments. Mixed herbal extracts (named Jaeummidan) also prevented vaginal dryness as measured by increased vaginal weight. Increased vaginal weight was associated with enlarged epithelium thickness. These data show the preventive actions of Jaeummidan against menopause symptoms and further suggest the possibility of developing functional ingredients in elderly human populations experiencing menopause symptoms.
서간체 소설의 문학교육적 의미 ― <제야>, <순례자들은 왜 돌아오지 않는가>를 중심으로
김수지 ( Kim Suji ),김서율 ( Kim Seoyul ) 국어교육학회 2021 國語敎育學硏究 Vol.56 No.1
이 연구는 현대사회에서 ‘편지’와 ‘서간체 소설’이 지니는 문화적 가치를 바탕으로 서간체 소설의 문학교육적 의미를 탐색하는 연구이다. 서간체 소설은 편지글의 형식적·내용적 자질을 취하는 문학 장르이다. 이 연구는 서간체 소설이 특정 시대의 장르가 아니라 1920년대부터 현대에 이르기까지 생산, 향유되고 있는 장르라는 점에 주목하였다. 염상섭의 <제야>, 김초엽의 <순례자들은 왜 돌아오지 않는가>를 예시로 분석하여 서간체 소설의 장르적 특성을 탐색하였다. 편지가 문학적으로 형상화되는 과정에서 나타난 서간체 소설의 형식적 자질은 액자식 구성, 편지에 대한 직접 명시, 편지 형식의 차용으로 나누어 살펴보았다. 그리고 서간체 소설의 내용적 자질은 고백서사와 개인의 내밀성, 자아 개념과 자아정체성의 성립으로 나누어 살펴보았다. 이와 같은 장르적 특성을 바탕으로 서간체 소설의 문학교육적 가치를 고찰하고 문학교육에서의 활용 방안을 탐색하고자 하였다. 서간체 소설을 활용한 문학교육의 가능성을 문학 지식 습득과 문학 능력 증진을 위한 문학교육, 자기 성찰·계발 역량과 의사소통 역량 신장을 위한 문학교육, 작문교육·매체교육과 연계한 문학교육의 측면에서 제시하였다. 이 연구는 즉시성과 유동성으로 대표되는 현대사회에 서간체 소설이 지니는 문화적 의미와 교육적 효용을 새롭게 밝히고 문학교육적 활용 방안을 모색하였다는 데에 의의가 있다. 향후 교육적 시사점을 도출하는 것에서 나아가 실제적인 교육 내용과 방안을 마련하여 구체적인 실천태를 마련하기 위한 후속 연구가 이루어져야 할 것이다. This study explores the literary educational meanings of the epistolary novel genre based on the cultural values of “letter” and “epistolary novel” in modern society. Epistolary novel is a literary genre that takes on the formal and other content qualities of a letter. This study noted that the genre is not limited to a particular era, but one that has been produced and enjoyed since the 1920s to the present day. The genre characteristics of the epistolary novel were explored by analyzing “New Year’s Eve” by Yum Sang-seop and “Why Don’t the Pilgrims Come Back” by Kim Cho-yup as examples. The formal qualities of an epistolary novel in the process of literary embodiment were divided into frame composition, direct representation of a letter, and borrowing the default format of the letter. The content qualities of the epistolary novels were divided into confessional narratives, the individual intimacy, the formation of self-concepts and self-identification. Based on these genre characteristics, it was intended to consider the literary value of the epistolary novel and explore the use of it in literary education. The possibilities for literary education using epistolary novels was presented in literary education to acquire literary knowledge, literary education to increase self-observation and development and communication competence and improve literary ability, and literary education in conjunction with writing education and media education. This study is meaningful in that it newly revealed the cultural meaning and educational utility of epistolary novels in a modern society represented by immediacy and liquidity and sought ways to utilize literary education. To derive future educational implications, further research will be carried out to develop practical educational content and concrete practices.
Choi, Suji,Park, Jinkyung,Hyun, Wonji,Kim, Jangwon,Kim, Jaemin,Lee, Young Bum,Song, Changyeong,Hwang, Hye Jin,Kim, Ji Hoon,Hyeon, Taeghwan,Kim, Dae-Hyeong American Chemical Society 2015 ACS NANO Vol.9 No.6
<P>Thermal therapy is one of the most popular physiotherapies and it is particularly useful for treating joint injuries. Conventional devices adapted for thermal therapy including heat packs and wraps have often caused discomfort to their wearers because of their rigidity and heavy weight. In our study, we developed a soft, thin, and stretchable heater by using a nanocomposite of silver nanowires and a thermoplastic elastomer. A ligand exchange reaction enabled the formation of a highly conductive and homogeneous nanocomposite. By patterning the nanocomposite with serpentine-mesh structures, conformal lamination of devices on curvilinear joints and effective heat transfer even during motion were achieved. The combination of homogeneous conductive elastomer, stretchable design, and a custom-designed electronic band created a novel wearable system for long-term, continuous articular thermotherapy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-6/acsnano.5b02790/production/images/medium/nn-2015-02790x_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02790'>ACS Electronic Supporting Info</A></P>
작약 및 포제작약의 최종당화산물 억제를 통한 피부 주름 개선 효과
김수지 ( Suji Kim ),이아름 ( Ahreum Lee ),김수현 ( Soohyun Kim ),김경조 ( Kyeongjo Kim ),권오준 ( Ojun Kwon ),최준영 ( Joonyoung Choi ),구진숙 ( Jinsuk Koo ),노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.4
Objectives:Collagen decrease of Skin appears through various path ways. One of causes may be the Advanced glycation endproducts (AGEs) that combine formation of glucose and protein. The aim of this study was to explore the prevent wrinkle formation of Paeoniae radix (PR) and heated Paeoniae radix (HPR) via AGEs path way. Methods:AGEs formation inhibitory activities of PR and HPR measured using bovine serum albumin, glucose, and fructose. To evaluate the protective effects of PR and HPR in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rat were distributed into four groups. Normal rats (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 ㎎/㎏ PR(PR), AGEs-induced rats treated with 100 ㎎/㎏ HPR (HPR). To induce AGEs, streptozotocin (50 ㎎/㎏) was administered intraperitoneally and after 3 days administrated 100mM methyl glyoxal for 3 weeks. Results:The oral administration of HPR inhibited AGEs in skin tissues compared with PR. The increased reactive oxygen species (ROS) levels in the serum were diminished by HPR treatment. The analyses of kidney and skin tissues proteins indicated that HPR treatment effectively reduced AGEs related protein levels as compared to that by PR treatment. Also, HPR decreased anti-oxidant related protein levels in skin tissues such as catalase, glutathione peroxidase. Moreover, it inhibited the reduction of COL1A2 by decreasing MMP-1. Conclusion:Based on these results, it was suggested that PR and HPR could have Improving effects on wrinkle formation. These evidences provide useful information for the development wrinkle formation treated agent.