Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

교잡종 찰옥수수에 대한 연구 III : Ⅲ. 국내 옥수수 유전자원 수집종에 대한 주요 특성 분포

서정은,주현민,최윤표,홍범용,조양희,주정일,지희정,이희봉 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

2006년 국내 각 지역으로부터 수집된 재래종옥수수 유전자원을 관행방법에 의해 파종하고 주요특성별로 분포도를 살펴본 결과는 다음과 같다. 1. 수집된 유전자원에 대한 발아율은 대부분 80∼100%이상의 분포를 보였으나, 일부 수집계통에는 30% 미만의 극히 저조한 발아율을 보였다. 2. 수집자원에 대한 초기생육을 살펴보면 극히 생육이 저조한 것이 40% 정도를 보였고, 극히 우수한 자원은 3%미만으로 나타났다. 3. 간장은 대부분이 150∼199cm범위에 55%가 분포하고 있었으나, l00cm이하가 5%, 250cm이상이 8%로 나타나 수집종간에 큰 차이를 보였다. 4. 주당 분얼수는 1개 미만이 40%의 분포를 보였으나, 일부 수집종에서 2 내지 3개의 분얼수를 보이는 계통이 확인되었다. 5. 개화소요일수는 61∼64일의 범위에서 40%, 57∼60일의 범위에서 30%의 분포를 보였으며, 특히 일부 수집종의 경우 55일 이하의 극조생종도 10% 정도의 분포를 보였다. 6. 이삭길이는 대부분 11∼15cm범위에 60%가 포함되어 있으나, 일부계통에서 5cm미만이 2%, 16∼20cm의 이삭길이도 10%가 분포하였다. Germination ratio on the 300 collected genetic resources showed 80 to 100 percentage, but those of some accessions were very low as below 30 percentage. Early growth phase of most of these lines were very poor while some collected lines were very vigor. Range of stem height showed from 150 to 199cm, but that of some accessions showed below 100cm as five percentage and some of them was over 250cm as eight percentage. Number of tillers per plant appeared less one but some collected lines have two to three tillers per plant. In days to tasseling, some accessions showed more four per plant. Ear length of these accession showed above 60 percentage as 11 to 15cm, while that of some collected lines showed over 10 percentage as 16 to 20cm.

프로토콜 분석을 통한 창의적 디자인 전략으로서의 은유와 유추

최한희(Choi, Han_Hee),주서령(Ju, Seo Ryeung),김미정(Kim, Mi Jeong) 한국실내디자인학회 2013 한국실내디자인학회논문집 Vol.22 No.1

The aim of this research is to explore the potential of analogy and metaphor as design strategies for supporting the creative design thinking. For the empirical research on analogical and metaphoric process in designing, we conducted design experiments that consist of three different conditions of given items as stimulation for design inspiration: baseline, surrealist paintings, and housing design collections. The results were analyzed using a protocol analysis in order to obtain more systmatic interpretation of the design processes and strategies. As a result, it was noted that students are more apt to read visual information rather than semantic information in the given items. Instead of the representation of their senses or feelings from the paintings, they visualized the analogical images of the paintings for the design representation. However, analogical and metaphoric thinking derived from the given items seem change a designer’s perspective, thus bring a novel interpretation on design problems, and eventually more creative and meaningful design ideas. An extended research using one-semester training and observation of the design studio process is introduced as a follow-up study for this paper. This research will investigate the long-term effect of the analogy and metaphor on the design thinking.

경연 대회를 통한 초ㆍ중고생의 창의력 신장 효과에 관한 연구

이희복,육근철,류해일,김현섭,김희수,박달원,유병환,김선효,김여상,서광수,변두원,서명석,배성효,박종석,심규철,이성희 공주대학교 과학교육연구소 2001 과학교육연구 Vol.32 No.1

미래 사회를 대비하기 위한 개인의 개성을 존중과 창의적인 능력을 지닌 인간을 양성을 목적으로 충청남도 지역의 초 ㆍ 중고등학생들을 대상으로 한 창의력 경연대회가 공주대학교 과학교육연구소에서 개최되었다. 충청남도 초 ㆍ중 ㆍ 고등학생들을 대상으로 실시한 창의력 경연대회는 창조적 아이디어를 내어 스스로 문제를 해결해 나갈 수 있는 교육 프로그램을 제공하는 좋은 기회였음이 확인되었으나, 일부의 팀에서만 참신하고 재미있는 아이디어들이 제안되었다. 여학생의 참가자 수가 상당히 증가하였으며, 대체적으로 입상권의 학생들의 상당 부분이 여학생이라는 것이 특이할만하다. 학년이 올라감에 따라서 창의적인 아이디어를 내는 양이나 질에 있어서 뒤떨어지는 것으로 분석되었으며, 토론 학습의 적응력이 미흡하고 발표력 및 청취력에 있어서도 떨어지는 것으로 나타났다. 따라서 중 ㆍ고등학교의 학교교육에서도 학생들에게 프로젝트형 탐구학습 프로그램의 적용은 물론 토론식 수습을 통한 학생들의 사고의 전환의 기회를 제공해야 할 것으로 사료된다. The creativity competition was held to foster the creativity of elementary and secondary school students in the Institute of Science Education, Kongju national University. It was found that the creativity competition effected on the improvement of inventing creative ideas and problem solving activities. But, only some competitors participated in semifinal and final contests, presented original and interesting ideas. More female students participated in competition than last year. More female participants were awarded a prize than males. Totally, participants were defective in discussion and communication, and presentation and listening ideas. Increasing grades correlated inversely with creativity and originality. There is need of inquiry project teaming programs and presenting opportunities of conversion of thinking by discussing instructions in school

문화의 차원에 비추어 본 다문화사회로서의 한국의 특수성

서덕희(Seo, Deok-Hee) 고려대학교 아세아문제연구소 2013 亞細亞硏究 Vol.56 No.1

This paper aims to identify the characteristics of South Korea as a multicultural society in terms of cultural dimensions, which are supposed to reveal systematically the relation between universalism and particularism. In particular, it aims to explore how particularities of South Korea such as nationalism based upon bloodlineage and Confucianism operate in three dimensions of culture: law, tradition, and disposition (habitus). In result, it reals that paternal-lineagism is still dominant in the dimension of law, Confucianism is residual in the dimension of tradition, and ethnocentric instrumentalism pervades in the dimension of disposition( habitus). Based upon the results, it can be interpreted that the late modern historic experiences of South Korean people such as tragic colonization, division, and war have caused the formation of an absolute trust on family, the failure of internalizing democracy, and the inclination toward ethnocentric instrumentalism. From this interpretation, it is maintained that normative multiculturalism against the backdrop of universal globalization can be realized only with the full understanding and overcoming of cultural particularities based upon South Korean history.

A corpus-based study of green discourse in the South Korean press in comparison with the US press

Bang Min-hee,Shin Seo-in 한국사회언어학회 2012 사회언어학 Vol.20 No.1

Bang, Min-hee·Shin, Seo-in. 2012. A corpus-based study of green discourse in the South Korean press in comparison with the US press. The sociolinguistic Journal of Korea 20(1). pp. 79-110. This paper analyses corpora of South Korean and US newspapers to investigate the representation of environmental issues. The analysis focuses on the frequency and collocation of 녹색(noksaek: green) denoting environmental- friendliness. As a corpus-based study, the analysis aims to show how environmental issues are construed in the use of noksaek through collocational patterns and the context in which it occurs. The English word green is analysed for comparison as the English translation equivalent of noksaek. 그린(grin: green), a phonetic translation of green is also included in the analysis. The most characteristic of the green discourse in the South Korean press is expressed in 성장(seongjang: growth), the top collocate of noksaek. The construal of environmental issues as a matter of economic growth is a distinctively Korean approach, contrasting with the ways the issues are talked about in the US press. The use of grin(green) in the South Korean press shows that grin(green) is mainly used in the commercial sector and often to mask an un-green aspect of an entity modified by the word. (172 words)

학부모의 유아교육기관 재이용선택에 영향을 미치는 요인

임선희 ( Sun Hee Lim ),서부일 ( Bu Il Seo ) 대구한의대학교 제한동의학술원 2011 제한동의학술원논문집 Vol.9 No.1

Once theories about the quality of service were introduced to Korea, many studies in the hospitals, hotels, finance and retails have been conducted. However, studies on education fields have been conducted mostly in the quality of higher education service of University and customer satisfactions. Since qarents and early childhood education centers are very important to the child growth and developmentand share the responsibility in development and education of early childhood, participation of parents can make the curriculum of early childhood education centers more effective. The most important role of early childhood education center is to give information to parents in order to recognize, judge and make a decision correctly about early childhood education and earlychildhood education centers. Earlychildhood education centers need to provide more detailed information in order to form the trust through positive relationships with parents by their direct experiencing and understanding the development of children, and let them understand better development of early childhood and improvements on education, educational direction and operating policies of early childhood education centers. Therefore, this studyis to conduct the survey in order to supply the bassic materials to improve the quality of service of current early childhood education centers for parents. The subjects were 236 parents who live in Seo-Gu in Daegu from August 2010 to September 2010 and results of the survey are as follows. 1. The operating system and trustaccording to the general characteristics of subjects There was no significant difference in the operating system and the trust according to the general characteristics. 2. The physical environmentaccording to the general characteristics of subjects There was significant difference in the physical environment in terms of gender, age and monthly average income according to the general characteristics. Overall, more than 3.37 out of 5 was shown and it`s above the average. 3. The teachers` trust according to the general characteristics of subjects There was significant difference in the teachers`trust in terms of gender, age and monthly average income according to the general characteristics. Overall, more than 3.46 out of 5 was shown and it`s above the average. 4. The way of coming according to the general characteristics of subjects There was significant difference in the way of coming in terms of age according to the general characteristics. Overall, more than 4.27 out of 5 was shown and it`s very high level. 5. The value of service according to the general characteristics of subjects There was significant difference in the value of service in terms of gender, occupation and educational level according to the general characteristics. Overall, more than 3.24 out of 5 was shown and it`s above the average. 6. The intention of reuse according to the general characteristics of subjects There was no significant difference in the intention of reuse according to the general characteristics.

청소년 생활역량 진단검사의 표준화 연구

윤명희(Myung hee Yun),서희정(Hee jung Seo),김경희(Keung hee Kim),조정은(Jeong eun Jo) 한국교육평가학회 2015 교육평가연구 Vol.28 No.2

본 연구의 목적은 청소년이 독립된 생활인으로서 필수적으로 갖추어나가야 할 일상생활 속에서의 역량을 구체적으로 진단할 수 있는 '표준화 청소년 생활역량 진단검사'를 개발하는데 있다. 연구의 목적을 달성하기 위해 실험적으로 개발된 228개의 문항에서 내용적ㆍ통계적으로 양호한 114개의 문항을 추출하였고, 1,908명의 중ㆍ고등학생을 대상으로 자료를 수집하여 개별 문항 및 검사도구의 양호도, 검사를 구성하고 있는 요인구조의 적합도 등을 통해 타당성을 확인하고 규준을 개발하였다. 이러한 과정을 통해 개발된 표준화 검사는 자기조절역량, 자기개발역량, 학습역량, 대인관계역량, 민주시민역량, 문제상황대처역량의 6개 하위 생활역량과 이를 실제적으로 함양할 수 있는 19개의 생활기술, 각 생활기술별 6개 문항, 총 114개의 문항으로 구성되어 있다. 규준집단의 생활역량은 대인관계역량이 가장 높았으며, 감정조절기술을 제외한 대부분의 생활기술 및 하위 생활역량에서 남학생보다 여학생의 평균이 유의하게 높았다. 또한, 중학생과 고등학생 간에는 일부 하위 생활역량에 유의한 차이가 있을 뿐 전반적인 생활역량에는 차이가 없는 것으로 나타났다. The purpose of this study is to develop the standardized life competency test for adolescences. For this, 114 items were selected from 228 items previously developed by Yun and Seo's study through the indexes of item goodness and statistical criteria. 1,908 middle and high school students were sampled nationwidely. The coefficients of Cronbach α and construct validity were high, and suitability indexes of item factor structure were high. The concurrent validity with youth activity competency scale was verified. As a result of standardization process, the Life Competency Scale with 6 life competencies, 19 life skills and 114 items was developed. The norm table was made in terms of total group, gender, and school level. The norm groups marked the highest scores in interpersonal relationship area among competencies and life skills. The scores of girls recorded significantly higher than those of boys in most life competencies and life skills except in emotional regulation skill. There were no differences in school level over life competency and life skill between middle and high school students. Students can get informations about their life competencies easily through this standardized test, furthermore, teachers or parents can provide educational programs to enhance student 's deficient competencies or life skills. Also, the collected data from 'The Standardized Life Competency Scale' tests can be used as basic data for youths to develop programs and to make policy in schools or fields of youth.

중원의 지각 변동에 대한 1630년 조선의 현실 대응: 선약해의 <심양사행일기>와 권칙의 <강로전>을 중심으로

이서희(Lee, Seo-Hee) 동남어문학회 2017 동남어문논집 Vol.1 No.44

17세기 초반은 중원의 중심이었던 명나라가 후금의 잇따른 침공으로 위기를 겪게 됨에 따라 커다란 지각 변동이 발생하는 시기였다. 본 논문에 서는 격변하는 시대적 분위기 가운데 조선이 어떻게 대응하는지 살펴보기 위해 1630년에 저작된 선약해의 <심양사행일기>와 권칙의 <강로전>을 주목하 였다. 두 작품은 공통적으로 중원의 지배권을 둘러싸고 후금과 명이 대치하는 상황을 사실적으로 형상화하고 있다. 선약해는 위문사로 파견되어 사행을 다녀 왔던 자신의 체험을 바탕으로 보고 전해 들은 것을 상세하게 기록하였고, 권칙 또한 심하전투에 파견되었던 실제 경험을 토대로 작품을 창작하였다. 하지만 현실 대응의 모습은 대비되는 것으로 나타났다. 1630년은 서인 세력이 ‘숭명배호론’을 표방했던 시기였던 지라, 권칙은 후금에 투항한 강홍립을 부정적인 인물로 왜곡하여 그 이념에 충실하고자 했다. 반면 선약해는 조선을 대표하는 사신으로서 후금에 당당하게 맞서는 듯하지만, 급속도로 변화하는 중원의 질서를 목도한 후 내적인 혼란과 두려움을 시를 통해 완곡하게 표현 하였다. 결국 <강로전>은 숭명배호론의 이상을 구현하고자 했고 <심양사행일기>는 후금에 대한 위기의식 제고와 함께 현실에 중점을 두고자 했다. 이러한 현실 대응은 17세기 초반 중원의 지각 변동으로 인해 조선이 겪어야 했던 문제적 상황을 잘 보여준다고 할 수 있다. The early 17th century was a time of cataclysm as Ming Dynasty, which held the supremacy in China for a long time, underwent a crisis due to the subsequent invasions of Later Jin. In this study, Seon Yakhae s Shimyang-sahaeng-ilgo and Gwon Chik s Gangnojeon written in 1630 were examined and compared to understand how Joseon responded to the convulsing situations at the time. Both works commonly include realistic representations of the confrontation between Ming and Later Jin over the supremacy in China. Seon Yakhae made a detailed record of what he saw and heard of the situation based on his own experiences of traveling to China as a messenger of condolence dispatched by the Joseon Dynasty. Gwon Chik, on the other hand, wrote Gangnojeon based on his actual experience of being dispatched to the Battle of Sarhu. However, it was found that the representation of Joseon s response to the reality at the time differed in these two literatures. The year of 1630 was a time when the Seo-in faction in the royal court of Joseon advocated Sungmyeongbaehoron, the idea of respecting Ming and excluding the Manchurian force. Accordingly, Gwon Chik distorted the image of Gang Hongrib, who surrendered to Later Jin, and presented him as a negative figure to stand faithful to Sungmyeongbaehoron. On the other hand, Seon Yakhae, as a representative of Joseon Dynasty, appeared to have gallantly stood against Later Jin, but, in fact,expressed through a poem his internal confusion and fear after witnessing the rapid change of order in the supremacy in China. In conclusion, Gangnojeon embodied the vision of Sungmyeongbaehoron, whereas Shimyang-sahaeng-ilgi focused on the situations at the time with due consideration of the crisis awareness for Later Jin. These responses to the cataclysm of China s supremacy in the early 17th century clearly demonstrate the problematic situation Joseon had to go through due to the power struggle in China.

울릉도 소의 전염성 병원체 감염률 조사

서민구 ( Min Goo Seo ),도재철 ( Jae Cheul Do ),우인옥 ( In Ohk Ouh ),조민희 ( Min Hee Cho ),김중규 ( Joong Kew Kim ),김영환 ( Young Hoan Kim ),박노찬 ( No Chan Park ),곽동미 ( Dong Mi Kwak ) 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.4

Prevalence of infectious agents, including Brucella abortus (BA), Mycobacterium bovis (MB), bovine leukemia virus (BLV), M. avium subsp. paratuberculosis (MP), Neospora caninum (NC) and Toxoplasma gondii (TG), was investigated in all the cattle raised in Ulleung island during 2007∼ 2010. For BA, the prevalences in head and farm were 8.1% (44/545) and 5.5% (4/73) in 2007, all negative in 2008∼2009, and 0.5% (4/774) and 1.7% (1/58) in 2010, respectively. For MB, no sample was positive by PPD or ELISA in 2007∼2010. For BLV and MP, no sample was positive by ELISA in 2007∼2009. For NC, seroprevalences in head and farm were 0.2% (1/545) and 1.4% (1/73), respectively, in 2007 and all negative in 2008∼2009. For TG, seroprevalences in head and farm were 17.6% (97/552) and 54.8% (34/62) by ELISA in 2009. By regions, the seroprevalences of TG in Ulleung-eup, Seo-myeon and Buk-myeon were 26.0%, 9.8% and 16.7%, respectively, which had significant differences (P<0.0001). Tiger cattle were more resistant to TG infection than Hanwoo. The seroprevalence of TG in summer was higher than in autumn. The seroprevalence of TG in cows was higher than in oxen. The seroprevalence of TG in cattle was increased with age. In conclusion, this study indicates that the prevalences of six infectious diseases, except for TG which are widely spread, are relatively low in cattle reared in Ulleung island.