소아 전풍 환자에 대한 임상적 고찰

강효준,왕한영,성호석 ( Hyo Jun Kang,Han Young Wang,Ho Suk Sung ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3

Background: Pityriasis versicolor(PV) is a superficial mycosis, theoretically unusual in children. Epidemiologic and clinical data for children with PV under 14 years were collected. Objective . The purpose of this study was to evaluate the clinical features of PV in the young. Method: We included all cases of PV in patients under 14 years of age observed in our department from 1981 to 1995. All cases were diagnosed on the basis of clinical criteria and were confirmed by microscopic examination. Results : From 1981 to 1995 we encountered 32 cases of PV in children, compared with 637 cases in adults; thus children represented 4.7% of all cases. The ratio of male to female was l. 7:1. Among the age groups, the incidence was the highest in the 10-14 years(43%). The monthly prevalence was the highest in August. Distribution of the lesions were the face(40.9%), neck (25%), chest(13.6%), back(11.3%), extremities(6.8%) and abdomen(2.2%). The incidence of hypopigmented lesions was 70.4% and that of hyperpigmented lesions was 29.6%. Conclusion : This study confirms that the face is a predilectionl site for PV in children and all facial lesions are hypopigmented. Other clinical features are variable and similar to those of adults. (Kor J .Dermatol 1997;35(3): 431-434)

운동성 산화 스트레스와 항산화비타민의 보충이 말초단핵세포의 NF-kB 활성에 미치는 영향

진영수,박건구,박준영,김미정,이왕록,김혜영,이한준,박은경 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Reactive oxygen species(ROS) are implicated in the pathogenesis of a wide variety of human diseases. Numerous studies indicate that ROS may serve as common intracellular molecules that contribute to the process of nuclear factor(NF)κB activation in response to a diverse stimuli. In our laboratory, we have demonstrated tat antioxidants could reverse the decline of immune function caused by exercise-induced ROS. Furthermore, it in necessary to understand a mechanism underlying ROS-dependent disorder in biological system. Recent studies have been shown that several gene expression were regulated by oxidants, antioxidants and other determinants of the intracellular reduction-oxidation(redox) state. In this process, NF-κB have been shown to play a important role. The purpose of the present investigation was to evaluate the effect of exercise-induced oxidative stress and antioxidnt supplementation on NF-κB activation in peripheral mononuclear cells. Forty male SD rats(4 weeks old) were randomly divided into noraml diet group and antioxidants(ATO) supplement group, and then ATO groups were treated with antioxidants(VE: 2001U/kg, VC: 50mg/rat, β-carotene: 300mg/kg, vitamin B6: 250㎍/100g, selenomethionine: 0.1mg/kg) for 16 weeks. After 16 weeks breeding at each condition, each group divided into two groups: Control group(CR) fed generally, Exercise group(CE) fed generally and followed by acute exercise 16 weeks later. Antioxidant Antioxidants and Exercise group(AE) fed with antioxidants and followed by acute exercise. The activation of NF-κB binding activity was increased after exhaustive exercise bout in both group. In addition, pretreatment of ATO group with the antioxidants mixture lead to the inhibition of NF-κB binding activity. This results suggest that NF-κB activation should be further studies in response to a variety of exercise.

뇌사환자의 갑상선 기능, 전신대사 및 중증도에 관한 연구

이영주,정금희,왕희정,문봉기,한연희,이영석 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1

Background and Objectives : Brain death may lead to hormonal depletion, metabolic derangement and multiple organ dysfunction. We have carried out present study to examine the effects of brain death on the thyroid function, metabolic indices, and the severity scoring systems. Methods : 13 adults patients admitted for organ donation or brain death evaluation were examined after brain death was confirmed. Thyroid hormones measured were .thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (FT4). The metabolic indices measured were arterial ketone body ratio (AKBR), lactic acid (LA), and base defiat (BD). as for reference to the severity scoring systems, APACHE Ⅲ and multiple organ failure score (MOFS) were assessed on the day of brain death confirmation. Arterial blood was drawn for all measurements. Results : As for the thyroid function, there were significant decreases in T3 (40.48±20.96 ng/dL) and T4 (3.47±2.15 ㎍/dL), but no significant change in FT4 (0.75±0.31 ng/dL) and TSH (1.12±1.37 uIU/mL) compared to the normal range. Significant decreases in AKBR (0.39±0.31) and BD (-9.46±5.83 m㏖/L), and significant increase in LA (2.57±2.46 m㏖/L) In metabolic indices, were shown, as for severity scoring systems, APACHE Ⅲ score (101.54±19.41) and MOF score (9.11±2.57) indicated a high mortality. There were significant correlation between thyroid hormones (r=0.565 -0.781) but no correlation among other indices. Also, significant inverse correlations were shown between base deficit and lactic acid (r=-0.660), APACHE Ⅲ score (r=-0.726) and MOF score (r=-0.604). The highest correlation was observed between APACHE Ⅲ score and MOF score (r=0.851). Conclusions : As for the thyroid function, significant decrease in T3 and T4, and almost normal range of FT4 and TSH imply the euthyroid sick syndrome. Abnormal finding of the metabolic parameters indicates an inhibition of the aerobic metabolic rate of the body as a whole. And the severity scoring parameters are compatible with high mortality.

정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계

유태열,한진희,채영래,김광수,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

Since the advent of computed tomography(CT). there have been growing evidences of cerebral structural abnormalities in schizophrenics. Among them. reversed hemispheric asymmetry has been regarded as impaired cerebral lateralization of schizophrenics representing another pathology different from brain atrophy. To investigate the pattern and frequency of reversed cerebral asymmetry and their relationship with brain atrophy. we analyzed widths of frontal and occipital region on the brain CT scans of right-handed 56 schizophrenics and 52 normal controls by a manual method. Brain atrophies were assessed using fixed arm planimetry and visual lineat measurements. Compared to normal controls. the schizophrenics show significantly increased frequency of reversed occipital asymmetry. Dividing the schizophrenics into group according to the evidences of atrophy revealed more reversed occipital asymmetry than those with brain atrophy. These findings suggest that reversed cerebral asymmetry might be unrelated to brain process and would be a neuroanatomic evidence of abnormal asymmetry of schizophrenices.

유전 알고리즘을 이용한 전력계통 안정화 장치에 관한 연구

정현환,왕용필,김상효,한영호 東亞大學校 1996 東亞論叢 Vol.33 No.-

In this paper, it is suggested that the method select optimal appropriate parameter using RVGA and RVEGA of power system stabilizer with strength in low frequency oscillation for power system stability. We selected optimal parameter in case of power system stabilizer with both one lead compensator and two lead compensator, in each case, too. Also, we considered the dynamic characteristic and the system eigenvalue in the normal load, proved usefulness of RVEGA to compare of Yu's compensator design theory. The obtained results are summarized as follows. (1) We could know that the optimal parameter selection of power system stabilizer using RVEGA is effective. (2) Proposed RVEGA represented more excellent distribution of fitness and average fitness than RVGA, could remove early convergence in the problem of existing GA. Specially, we could know the good efficiency in the case of multi-variable. (3) In case of normal load, the dynamic characteristic and the eigenvalue represented more excellent in the case of using RVEGA than Yu's method (4) We could know which the optimal parameter selection using RVEGA contribute to power system stability.

어머니의 신경증적 성향과 완벽주의 및 심리적 통제가 유아의 내면화 문제행동에 미치는 영향

왕해경(Hae-kyoung Wang),한세영(Sae-young Han) 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.1

The purpose of this study was to examine the effects of mother's neuroticism, perfectionism and psychological control on children's internalized problem behaviors such as depression, anxiety, and withdrawal. The subjects of this study were 373 mothers of 3, 4, and 5-years-old children who were attending to 7 public kindergartens and 1 private kindergartens located in Cheongju city. The results of this study were as follows: First, it indicated that mother's neuroticism, self-oriented perfectionism, criticism, and unstable emotion had statistically significant effects on young children's depression. That is, the more neuroticism, the less self-oriented perfectionism, and the more psychological control like criticism and unstable emotion mothers showed, the higher young children's depression was. Second, it revealed that mother's neuroticism and criticism and love withdrawal had statistically significant effects on young children's anxiety. That is, children of mothers with more neuroticism and psychological control like criticism and love withdrawal showed higher anxiety. Third, it was found that only mother's neuroticism had a statistically significant effect on young children's withdrawal. That is, the more neuroticism mothers showed, the higher young children's withdrawal was.

Structural and Electrical Properties of PbTio₃ Films on Various Substrates with Metallic Bottom Electrodes

Young-Soo Yoon,Young-Ki Han,Yong-Tae Kim,Chae-Hyun Wang,Do-Jin Choi,Young-Hwa Shin 대한전기학회 1999 Journal of Electical Engineering and information S Vol.4 No.1

Structural and Electrical Properties of PbTio₃Films on Various Substrates with Metallic Bottom Electrodes

Young-Soo Yoon,Young-Ki Han,Yong-Tae Kim,Chae-Hyun Wang,Do-Jin Choi,Young-Hwa Shin 한국정보과학회 1999 Journal of Electrical Engineering and Information Vol.4 No.1

In order to investigate possibility of Pt/RuO₂, on Si as a bottom electrode for deposition of ferroelectric thin film, PbTiO₃, thin films on various substrates were deposited by in-situ metalorganic chemical vapor deposition. X-ray diffraction patterns showed that the PbTiO₃films deposited on Pt/Ti/SiO₂/Si and the Pt/RuO₂/SiO₂/Si had good crystallinity but the film on RuO₂/SiO₂/Si had poor crystallinity. Scanning electron microscopy and atomic force microscopy results suggested that RuO₂, could act as a barrier material. The films on RuO₂/SiO₂/Si and Pt/RuO₂/SiO₂/Si had lower dissipation factor than the film on Pt/Ti/SiO₂/Si. Leak current density - voltage measurement revealed that very low leak current density values and abrupt increase of the leak current density at the high electrical field were obtained in the film on Pt/RuO₂/SiO₂/Si. The as-grown film on Pt/Ti/SiO₂/Si had higher short probability than that on Pt/RuO₂and RuO₂when the top electrode size was increased. The short probability of the film on Pt/Ti/SiO₂/Si was much higher than that on Pt/RuO₂/SiO₂/Si. Furthermore, the film on Pt/Ti/SiO₂/Si deposited at 580℃ showed poor electrical properties than that at 500℃, while the film on Pt/RuO₂deposited at 580℃ has better electrical one than at 500℃.

Virologic Response at 12 Months of Treatment Predicts Sustained Antiviral Efficacy in Patients with Adefovir-Treated Lamivudine-Resistant Chronic Hepatitis B

( Young Kul Jung ),( Jong Eun Yeon ),( Woo Sik Han ),( Ji Hoon Kim ),( Jeong Han Kim ),( Jong Jae Park ),( Jae Seon Kim ),( Young Tae Bak ),( Wang Don Yoo ),( Sun Pyo Hong ),( Soo Ok Kim ),( So Young 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.2

Background/Aims: The aim of our study was to define the potential role of virologic response at 12 months of treatment (VR12) in predicting subsequent virologic and clinical outcomes in adefovir (ADV)-treated lamivudine-resistant chronic hepatitis B. Methods: Two hundred and four patients with lamivudine-resistant chronic hepatitis B virus (HBV) treated with ADV monotherapy were included. Serum HBV DNA was quantified by real-time polymerase chain reactions. VR12 was defined as a HBV DNA level of less than 4 log10 copies/mL after 12 months of ADV treatment. Results: VR12 was observed in 110 of the 204 patients (54%). The mean HBV DNA reductions from baseline after 12 months of ADV treatment were 3.8 and 1.9 log10 copies/mL in patients with and without VR12, respectively (p<0.001). The hepatitis B e antigen (HBeAg) seroconversion rates in patients with and without VR12 were 32% and 14% at 12 months treatment, respectively (p=0.018), and 40% and 27% at 24 months of treatment (p=0.032). The genotypic mutation rates to ADV in patients with and without VR12 were 0% and 6% at 12 months of treatment, respectively (p=0.033), and 21% and 42% at 24 months (p=0.012). The rates of viral breakthrough in patients with and without VR12 were 0% and 7% at 12 months of treatment, respectively (p=0.072), and 9% and 25% at 24 months (p=0.006). Conclusions: Patients without VR12 may need to switch to or add on other potent antiviral drugs in their medical regimens. (Gut Liver 2010;4:212-218)

소아 아토피 피부염에서의 혈청 IgE 및 회상 항원을 이용한 피부 지연 면역 반응 검사 성적과 그 연관성

왕한영(Han Young Wang),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.2

We measured serum 1gE by using IgE 'Eiken' radioirnrnunoassay Kit and delayed cutaneous hypersensitivity responsiveness by the Multitest CMI Kit (Institut Merieux) that simultaneously administrates 7 standardized recall antigens(tetanus, diphtheria, streptococcus, tuberculin, candida, trichophyton, proteus) and 70% W/V glycerin diluent control by multiple prick puncture. We studied 40 cases comprising 20 patients with atopic dermatitis (AD) and 20 healthy children as control. The results were obtained as follows; 1) The mean serum level of IgE in AD(63$ 3-t-395 2 1U/ml) was higher than in control(155.6-67.1IU/ml) (p<0.0l), but the intensity of reaction (IR) & rate of reaction (RR) in AD (l. 34 + 1.06, 0.38+0.23) was not significantly decreased than in control (1.70+0.87,0.44+0.16). 2) 1n both AD & control group, tuberculin showed highest IR R RR. 3) Anergic state was found in only one patient with disseminated cutaneous lesions Sc 4) serum IgE, but rate of hypoergy was significantly increased in AD(65%) than in control (30%) (p<0.05). 4) Serum IgE was not statistically correlated with IR and RR, but IR was statistically correlated with RR (p<0.001, r=0.9504). 5) IgE level in severe AD (generalized skin lesion) was significantly increased than in both mild AD 8c control group (p<0. 001). but IR & RR were not statistically correlated with disease severity.