양성 및 음성 정신분열증 환자에서의 양이경청의 비대칭성

노왕구,채정호,한진회,김광수,유태열,정진복 대한신경정신의학회 1990 신경정신의학 Vol.29 No.3

A dichotic listening test was administered to assess attentional impairment and evaluate possible altered cerebral laterality in 30 right-handed schizophrenic patients compared with 10 control sujects. With the purpose to delineate the assumed differential pattern in cognitive dysfunction, schizophrenics were subdivided into three groups according to dominant clinical features of ‘positive, negative, and mixed symptoms. Schizophrenics showed decreased performance trend in comparison with normal control. Between the subgroups, positive symptom schizophrenics revealed more notable changes in overall hits, laterality index, and absolute ear advantage among which left ear performance was significantly lower than the control (p〈0.05). There was no significant statistical changes in negative symptom schizophrenics comparable to that of positive schizophrenics. It suggests that ^attentional impairments associated with schizophrenic symptoms are more evident in positive group. Furthermore, it is assumed that these findings are compatible with interhemispheric or left hemispheric dysfunctions.

악성증후군

노왕구,한진희,유태열 한국의학사 1990 診斷과治療 Vol.10 No.2

전격(電撃)요법에 의하여 유발된 조증 1례

노왕구,한진희,유태열 대한신경정신의학회 1989 신경정신의학 Vol.28 No.3

We have experienced a case of depression which switched to mania during the course of electroconvulsive therapy(ECT). The depressive symptoms responded well to ECT but by the third treatment in this course, the patient rapidly lapsed into manic state, showing typical psychomotor excitement, combativeness, and so on. There was no evidence of significant organic impairment. ECT was stopped and then combined trial of lithium and haloperidol was started. By this regimen, the patient’s manic symptoms were gradually subsided and eventually he was discharged 1 month later. The direct causal relationship between ECT and the ‘switch process’ has not yet been fully elucidated. However, clinicians should be alert for the fact that depressed patients recieving electroconvulsive treatment could develop manic states. Further research is needed to establish the strategies for management and prevention of this troublesome iatrogenic complication.

오래된 생각을 읽는 이유: Phyllis Tyson과 Robert Tyson의 책 정신분석 발달이론에 대한 에세이

노왕구 한국정신분석학회 2011 精神分析 (Psychoanalysis) Vol.22 No.1

미국정신분석학회 2011년 뉴욕 참석기

노왕구 한국정신분석학회 2011 精神分析 (Psychoanalysis) Vol.22 No.1

정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계

유태열,한진희,채영래,김광수,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

Since the advent of computed tomography(CT). there have been growing evidences of cerebral structural abnormalities in schizophrenics. Among them. reversed hemispheric asymmetry has been regarded as impaired cerebral lateralization of schizophrenics representing another pathology different from brain atrophy. To investigate the pattern and frequency of reversed cerebral asymmetry and their relationship with brain atrophy. we analyzed widths of frontal and occipital region on the brain CT scans of right-handed 56 schizophrenics and 52 normal controls by a manual method. Brain atrophies were assessed using fixed arm planimetry and visual lineat measurements. Compared to normal controls. the schizophrenics show significantly increased frequency of reversed occipital asymmetry. Dividing the schizophrenics into group according to the evidences of atrophy revealed more reversed occipital asymmetry than those with brain atrophy. These findings suggest that reversed cerebral asymmetry might be unrelated to brain process and would be a neuroanatomic evidence of abnormal asymmetry of schizophrenices.

고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1례

홍현상,박흥수,정염성,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient's symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.

양성 및 음성 정신분열증 환장에서의 양이경청의 비대칭성

유태열,정진복,채정호,김광수,한진희,노왕구 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.3

A dichotic listening test was administered to assess attentional impairment and evaluate possible altered cerebral laterality in 30 right-handed schizophrenic patients compared with 10 control sujects. With the purpose to delineate the assumed differential pattern in cogni-tive dysfunction, schizophrenics were subdivded into three groups according to dominant clinical features of positive, negative, and mixed symptoms. Schizophrenics showed decrea-sed performance trend in comparison with normal control. Between the subgroups, positive symptom schizophrenics revealed more notable changes in overall hits, laterality index, and absolute ear advantage among which left ear performance was significantly lower than the control(p<0.05). There was no significant statistical changes in negative symptom schizo-phrenics comparable to that of positive schizophrenics. It suggests that attentional impair-ments associated with schizophrenic symptoms are more evident in positive group. Furthe-rmore, it is assumed that these findings are compatible with interhemispheric or left hemi-spheric dysfunctions.

주요우울증 환자에서의 청각 사건관련 전위 P300

노왕구,유태열,채정호 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.4

Event-related potential(ERP) had been demonstrated to be sensitive to both sensory and cognitive processes. P300 component of the EPR is regarded as an endogenous evoked potential which can be altered by psychological or cognitive differences. In this study, we investigated the characteristics of amplitude and latency of P300 using two tone discrimination task in 22 patients with major depression compared to those of 14 control subjects. We obtained the following results. 1) The latencies of P300 were prolonged in depressed group than control subjects with statistical significance(p<0.05). 2) Although thee is no statistical significance, the latencies of P300 showed more prolonged trend according to the severity of the depressive symptoms(r=0.393). 3) The latencies of P300 were markedly prolonged in the group that showed more severe depressive symptoms than those with less severe symptoms(p<0.005). This findings suggests that the latencies and amplitudes of P300 may be useful clinical measures which can reflect cognitive dysfunction in patients with major depression.

아산화 질소(Nitrous Oxide) 남용으로 유발된 기질성 기분장애 1례

박원명,노왕구,유태열 대한신경정신의학회 1990 신경정신의학 Vol.29 No.3

We experienced a case of dentist who developed organic mood disorder following abuse of nitrous oxide for about two years. He showed manic symptoms of elated mood, flight of ideas, grandiosity, insomnia, persecutory delusions. There was no evidence of significant confusion or cognitive dysfunction . Past history revealed no previous major psychiatric disorders and no family history of psychiatric disorders. After discontinuation of nitrous oxide, he responded well to combined regimen including lithium and chrolpromazine and was discharged with improved condition. Nitrous oxide is one of anesthetic inhalants which is widely used in the operating room and dental practice. It is known as laughing gas which has an potential risk of abuse due to its psychedelic effects. Although lacking in the comprehensive study explaining the pattern of abuse, incidence of mental symptoms and mechanism of psychotomimetic effects, this case brings up the need for alertness for the potential diverse psychotic symtoms among the population who are exposed to possible misuse, especially the health professionals