다발성 말초신경병증의 조기진단 : 적외선 체열촬영검사와 전류지각역치검사의 조합진단 Combination Diagnosis Using by Digital Infrared Thermogram and Current Perception Threshold

이삼규,김재형,최인성,이소영,한재영,조성렬,김재휴,노성만,정민영,정동진,김현성 全南大醫大 2001 전남의대학술지 Vol.37 No.3

CD34+ 조혈 모세포 이식 2례

김정아,정현식,김원석,윤성수,이홍기,박찬형,박성규,김동욱,이종욱,한치화,민우성,김춘추,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1

Background: In most solid tumors, the CD34 antigen has not been detected, so positive selection of CD34+ cells may reduce tumor cell contamination and the CD34+ cells are capable of reconstituting hematopoiesis. We tried CD34+ cell transplantation in two patients. Method: CD34+ cells from chemotherapy + G-CSF mobilized PBPCs or bone marrow were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). Case 1. One course of chemotherapy using cyclophosphamide(200㎎/㎡) and etoposide (4.2g/㎡), combined with G-CSF(5㎍/㎏) S.C. was used in a relapsed lymphoma patient. This patient responded to the induction chemotherapy. CD34+ cells from harvested bone marrow were selected by the CellPro immunoadsorption column. The total number of mononuclear cells loaded onto the CellPro was 2.4×10^(8)/㎏, with 1.1% CD34+ cells. After column separation, the total number of positively selected cells was 5.16×10^(6)/㎏. The number of CFU-GM was 76.8×10⁴/㎏. This patient was treated with melphalan (140㎎/㎡) and TBI (1200cGy) and the positively selected CD34+ cells were infused. The time to neutrophil recovery greater than 0.5×10^(9)/L was 19 days and the time to platelet recovery greater than 50×10^(9)/L was 21 days. Case 2. Two courses of mobilizing chemotherapy were given 4 weeks apart using taxol(210㎎/m2) and adriamycin(60㎎/m2), combined with G-CSF(5㎍/㎏) S.C. in a breast cancer patients with 7 axillary node metastasis. CD34+ cells from each single leukapheresis product were selected by the CellPro immunoadsorption column. In the first collection, the total number of nucleated cells was 4.4×10^(8)/kg, with 0.42% CD34+ cells. In the second collection, the total number of nucleated cell was 2.8× 10^(8)/㎏ with 0.43% CD34+ cells. After colum separation, the total numbers of collected cells were 4.0×106/kg and 4.8×10^(6)/kg, the total number of CD34+ cells were 1.2×10^(6)/㎏ and 0.82×10^(6)/㎏. Colonogenic assays of positively selected CD34+ cells gave rise to myeloid erythroid, and multilineage colonies, with a median of 190 CFU-GM, 190 BFU-E, and 164 CFU-GEMM per 1×10³ adsorbed cells, respectively. High-dose chemotherapy with cumulative doses of 40mg/㎡ mitoxantrone, 750mg/㎡ thioptepa, and 1000mg/㎡ carboplatin was administered. Positively selected CD34+ cells were rapidly infused 24 hours after the end of high-dose chemotherapy. The time to neutrophil recovery greater than 0.5×10^(9)/L was 16 days and the time to platelet recovery greater than 50×10^(9)/L was 20 days.

탄소섬유보강판의 홈삽입에 따른 철근콘크리트 보의 보강효과

한상훈,최만용,조홍동,박중열,황선일 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.1

This paper presents a feasibility study of an alternative strengthening method by slot-bonded CFRP plates for reinforced concrete beam. A total 14 reinforced concrete beam were constructed, tested and the response of the beams in terms of deflection, strains, failure load and failure mode were examined. Each specimen was initially loaded for 75% of ultimate load, cracked specimen were strengthened with CFRP plate and then tested until complete failure. Test variables included the strengthening method, steel ratio and strengthening length, and the effects according to each test variables are analysed. The experimental results show that proposed methods can increase the flexural strength and stiffness of the beam significantly. Also, the failure of the specimens strengthened by the proposed method are more ductile than externally bonded specimen.

Immobilized metal ion affinity chromatography(IMAC)를 이용한 His-tagged B^30-homoserine 인슐린 전구체의 rapid one-step 분리 정제

한성욱,김동일,조정우 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

To purify His tagged B^30-homoserine insulin precursor from recombinant E. coli using a rapid single-step purification method, immobilized Ni^2+ -affinity chromatography which has been widely used to purify genetically fused to the interest protein was used. His tagged B^30-homoserine insulin precursor, molecular weight 9KDa, expression was accomplished by IPTG induction on pellet centrifuged of flask and batch broth and confirmed by SDS-PAGE either. It showed that recombinant protein is expressed as inclusion body. His-tagged B^30-homoserine insulin precursor which chelated with Ni^2+ metal ion was eluted lX Elution buffer, pH7.9 including 6M Urea with 1000mM imidazole. His tagged B^30-homoserine insulin precursor band was ascertained by SDS-PAGE with freeze dried powder obtained from lX Elution buffer extract.

비모형화 동특성을 고려한 로보트 매니플레이터의 실시간 적응제어

한성현,김휘동,이진,이현철,이희섭 경남대학교 신소재연구소 1994 論文集 Vol.4 No.-

기존의 로봇 매니퓰레이터의 제어방법들을 간단한 고전적 제어방법들의 응용은 가능하지만, 고속운전이나 빈번한 부하변동에 의해 역학적으로 나타나는 각 관절사이의 연성(coupling), 관성파라미터의 불확실성, 모델링오차 등으로 인하여 로봇 제어기의 성능과 응용범위등은 큰 제약을 받게 된다. 본 연구에서는 제어기의 예측불허의 외란 및 파라미터의 불확실성 등에 대한 적응성의 향상을 위하여 적응 모델추종제어기법을 적용하여 로봇 매니퓰레이터 동적모델에서의 매개변수의 불확실성 및 미지의 외란, 존재, 갑자스런 부하변동에서도 좋은 제어성능이 유지 될 수 있는 견실한 로봇 관정 제어방식에 대한 연구를 중점으로 다룬다. 적응제어알고리즘은 초안정도(hyperstability)이론과 적응 모델 추종 제어의 원리를 바탕으로 유도되었고, 적응 제어기의 기온구조를 비선형성의 보상을 위한 내부루프의 MRAC구조와 고정된 게안을 갖는 외부루프와 PID제어기의 조합으로 구성되는 혼성구조의 제어기를 제언한다. In this paper, robust adaptive control approach is presented to inplement of the real time control of the industrial robot manipulator. The purpose of proposed adaptive control scheme is to achieve good tracking performance of desired trajectory tracking of joint position and veloeity under the existence of the payload variation and uncertinity of inertia parameter. The feedback gains of the controller are updated and adaptied in each sampling time to achieve the desired control performance. The proposed adaptive control algorithm is developed within the framework of adaptive model following control scheme using the Lyapunov direct method. To illustrate the performance of the proposed adaptive controller, simulation test is performed in the presence of the parameter uncertainties and payload variations.

Apple Ⅱ 마이크로 컴퓨터와 HP 3000과의 interface를 위한 Hardware 및 Software 開發에 關한 硏究

韓秉誠,申東佑 전북대학교 공업기술연구소 1983 工學硏究 Vol.14 No.-

Frequently, Rs-232c method is in use to computer terminal interface. For interface between Apple Ⅱ microcomputer and HP 3000 minicomputer, we designed Rs-232c interface card for Apple Ⅱ with USART(universal Synchronous/Asynchronous Receiver/Transmitter)IC Intel 8251 etc., For data communication, we developed software and memorized in EPROM(erasible and electrically programmable read-only memory) IC Intel 2716. As this software apply, Apple Ⅱ microcomputer is used the terminal of HP 3000 minicomputer and can be applied other application. As dip switch select, User can change the band rate for the data communication with HP 3000 minicomputer.

순천향대학교 학생들의 거주형태별 환경, 보건 및 복지실태

한성현,송라윤,한동우 순천향대학교 사회과학연구소 1998 순천향 사회과학연구 Vol.3 No.2

Three major factors influencing students' general well-being of school life were investigated: environmental, health, and welfare. A Survey was conveyed among all attending students of Soonchunhyang University by a structured questionnaire method to which was follwed by a complementary survey to explore and identify the housing situation of school area residents by the trained interviewers. Respondents tended to show relatively low degree of satisfaction regarding almost items regarding environmental and welfare conditions adressed. Residence types were significantly related to three factors. Research results suggest that more programs to meet the students' needs of environmental, health, and welfare services and facilities be provided.

민어(Miichthys miiuy)의 卵發生過程 및 仔稚魚 발육단계에 따른 형태발달

한경호,오성현,황동식,조영현,서대철 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.2

본 연구는 2000년 8월 19일 전라남도 신안군 임자도 연안에서 2각망으로 어획된 민어 어미를 인위적인 방법으로 수정하여 부화 사육하면서 관찰한 卵發生 過程 및 仔稚魚 형태변화는 다음과 같다. 1. 민어의 受精卵은 구형의 분리 부성난으로 알의 크기는 0.96~1.08㎜(평균 1.01㎜, n=50)였고, 크고 작은 油球가 1~5개(0.06~0.34㎜) 존재하였다. 2. 사육수온 25.2~28.4℃에서 受精 후 17시간 10분에는 배체가 卵膜을 뚫고 머리부터 孵化하기 시작하였다. 3. 孵化 직후 仔魚의 전장은 2.36~2.63㎜(평균 2.48㎜, n=10)로 전장의 45.0~47.0%에 달하는 큰 卵黃(장경 1.11~1.20㎜, 단경 0.92~0.96㎜)을 가지고 있으며 筋節은 7~8+ 17~19=24~27개였다. 4. 孵化 후 3일째 仔魚는 전장 3.98~4.32㎜(평균 4.16㎜, n=10)로 입은 열려있었고, 이 시기에 섭이활동이 활발하게 관찰되면서 卵黃이 완전히 흡수되어 後期仔魚期로 이행되었다. 5. 孵化 후 10일째 後期仔魚는 전장이 5.88~6.74㎜(평균 6.30㎜, n=10)로 꼬리의 말단이 굽어지기 시작하는 시기로 黑色素胞가 기저후두골 뒷부분의 체측에서 점모양 및 나뭇가지모양 으로 출현하였다. 6. 孵化 후 31일째 개체의 전장은 9.62~12.76㎜(평균 11.12㎜, n=10)로 모든 지느러미가 정수에 달하였고, 체형이나 반문이 成魚와 닮아 種魚期로 이행하였다. Egg development and morphological change of larvae of the brown croaker, Miichthys miiuy, were investigated after obtaining samples by artificial insemination. The spawning season extends from the middle to the end of August in the seas off Lim-ja Island, Cheollanam-do. The fertilized eggs were transparent, spherical, separate and they floated. Egg diameter ranged 0.96~1.08㎜ with several oil globules of 0.06~0.34㎜. Hatching occurred 17 hours 10 minutes after fertilization in 25.2~28.4℃ water temperature. The newly-hatched larvae were 2.36~2.63㎜(mean:2.48㎜, n=10) in total length(TL), had a large yolk, and 7~8+17~19=24~27 myotomes. Melanophores were distributed on the eye lens. Three days after hatching the larvae had attained 3.98~4.32㎜ in TL(mean:4.16㎜, n=10), the yolk sac was completely absorbed, and they had transformed into the postlarva stage. The larva reached the juvenile stage with all fins formed and with a complete set of fin rays(D.Ⅹ-28~31;A.Ⅱ-7~8;P. 21~23;C. 19~21;V. 25~26) on the 31st day after hatching. The juveniles were 9.62~12.76㎜(mean:11.12㎜, n=10) in total length. At this point the juvenile was similar to the adult in body form and pigmentation pattern.

경북 지역의 지하수 수질에 관한 연구 4 : 암반 종류에 따른 지하수 수질 특성 The Characterisrics of Groundwater by Rock Types

한성욱,이동섭,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by rock types. From the view point of rock types, the obtained results were as follows; The mean depth of rock types were decreased as follows sedimentary > gneiss > granite > granodiorite. In case of pH, the difference of value was small. While, the concentration of COD showed that it's concentration was increased as the mean depth was increased. In the region of granite, sedimentary and gneiss, the value of nitrate nitrogen was 3.5mg/l, 3.3mg/l and 1.7mg/l, respectively. In case of chloride ion, the concentration was highest for granite as 30.5mg/l and was medium for sedimentary and gneiss as 29.8mg/l and 26.9mg/l, respectively. while granodiorite was lowest as 8.97mg/l. The EC values were as follows; In the region of granite, sedimentary, gneiss and granodiorite, the value of EC was 444mg/l, 430mg/l, 390mg/l and 242mg/l, respectively.

2-methoxy-1, 2-diphenyl diazoethane의 광화학분해에 관한 연구

韓性彬,金奎喆,成大東 濟州大學校 基礎科學硏究所 1990 基礎科學硏究 Vol.3 No.1

Photochemical decomposition of 2-meothoxy-1, 2-diphenyl diazoethane in methanol-acetonitrile binary solvent mixtures gave the O-H insertion, hydrogen-migration and phenyl-migration products to carbene. Kinetic data showes the maximun rate phenomenon at 70% (v/v) methanol content in methanol-acetonitrile binary solvent mixture. From Linear Solvation Energy Relationship by Taft's equation, the decomposition reaction of 2-meothoxy-1, 2-diphenyl diazoethane was affected not only by hydrogen bond acceptor basicity of the solvent, but also the polarity-polarizability ability of solvent a little bit.