四七湯이 拘束스트레스 흰쥐의 血淸 catecholamine 含量 變化에 미치는 影響

崔銀洙,李仁仙 동의대학교 한의학연구소 1999 동의한의연구 Vol.3 No.-

Background and Objective : Sachiltang(SCT) was known as anti-stress medicine. The aim of this study is to investigate of plasma catecholamine and the effect of SCT on rats in immobilization stress. Material and Method : Sprague-Dawley female rats were divided into 3 groups. The normal group(NG) was healthy 8 rats. The control(CG) and experimental group(EG) were subdivided 3 groups(CG1, CG2, CG3, EG1, EG2, EG3), were conditioned 12 hours a day immobilization stress for 5, 10, 11 days. And then, the plasma were obtained. Results : Plasma epinephrine(EP), norepinephrine(NE) and dopamine of EG were decreased as compared with CG (EP & NE ; p<0.005, dopamine ; p<0.05) Conclusion : SCT was useful in anti-stress effect.

일개 대학병원 직원에서 인플루엔자 백신접종 후 이상반응

최새로운,김수미,이진수,김은실,정문현 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

Influenza vaccination on health care workers in a university hospital was conducted using inactivated split vaccines from two pharmaceutical companies (A, B), December 2003. Among 1,880 health care workers, 1,404 (74.7%) were vaccinated and 714 (50.8%) responded to the questionnaires about adverse reactions. Pain and redness at the injection site, febrile sensation, and restricted occupational activities were reported by 316 (44.3%), 141 (19.7%), 169 (23.6%), and 62 (8.7%) participants, respectively. There was no serious adverse events. The incidence of adverse reactions was similar to the previous reports. No statistical difference was detected according to the vaccines company.

주개 이온을 첨가한 강유전체 Bi₄Ti₃O_12(BIT) 박막의 특성

최은경,박문흠,김두회,구영건,김상수 昌原大學校 基礎科學硏究所 2001 基礎科學硏究所論文集 Vol.13 No.-

Bismuth layered structure ferroelectric thin films, BIT and donor (V, Nb and W) doped BIT, were prepared on the Pt/Ti/SiO2/Si substrates by sol-gel method. BIT film was characterized by strong c-axis prepared orientation. In the case of donor doped BIT thin films, the degree of c-axis prepared orientation decreased systematically V-BIT→W-BIT→Nb-BIT and Nb-BIT film was shown random orientation. Surface morphologies of BIT and V-BIT films had a plate-like and Nb-BIT and W-BIT had a mixture of plate-like and rod-like. In the results of ferroelectric hysteresis loops, the remanent polarization (2Pr) of random-oriented Nb-BIT capacitor was 26 μC/cm2, and this value was over two times higher than that of 12 μC/cm2 for BIT capacitor. The polarization fatigue up to 4.5×1010 read/write switching cycles of W-BIT capacitor was shown superior to the other capacitors. The polarization of the W-BIT capacitor decreased only 10% of the initial value after 4.5×1010 switching cycles.

p-형 Si(100) 기판 위에 성장시킨 Bi_(3.25)La_(0.75)Ti₃O_(12) (BLT) 박막의 전기적 특성

최은경,박문흠,김현주,하태곤,강민주,김상수 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-

Bi₃zsLa(0.75)Ti₃0_(12) (BLT) thin film have been grown on p-type Si(l00) substrates by a sol-gel spin coating process. The structure and surface morphology of the film were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEMI. Furthermore, the electrical properties were examined by capacitance-voltage ( C-V) characteristics by using a LF Impedance Analyzer(HP 4192A). XRD measurement show layered perovskite structure with a single phase in BLT thin film annealed at 700C for 30 min in oxygen. The measured grain size of BLT on Si is about 0.04 - 0.1 pn. From the cross-sectional SEM image, BLT film thickness is measured to be 0.4 pm. The C-V characteristic hysteresis curves show that the NIFS (metal-fexroelectric-semiconductor) structure has memory effect. The memory window decreases, with increasing frequency at MFS structure. And it is found that the memory window increases as the applied voltage to the ferroelectric capacitor is increased. These phenomena may be due to polarization reversals of the BLT ferroelectric film and because of the charge injection from Si substrate into the ferroelectric thin film. The results obtained indicate that the present BLT films are suitable for making ferroelectric field effect transistor(FeFET) memory.

세균성 뇌막염과 병발된 다엽성이면서 다발성인 화농성 뇌농양 1예

최용석,김정미,한영수,차경만,한정호,조은경,김두응 최신의학사 2004 最新醫學 Vol.47 No.1

方向분산성이 고려된 海浜流 流動特性에 관한 연구

최은주,유수진,권정곤 부산대학교 환경문제연구소 1994 環境硏究報 Vol.12 No.-

This study was managed to develope the existing numerical calculation model of near shore current and wave fields where wave and current coexist around shallow water region, and analyse their problems. Until now, nearshore current model that include longshore current and on-off shore current had shown wave characteristic based on regular wave theory. In this study, however, nearshore current characteristic was changed by directional dispersion. So the effect of directional dispersion of multidirectional irregular wave was examined numerically by the basic study of nearshore current calculation due to multidirectional wave that was driving force of pollutant material at shallow water region.

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

휴전선 인접 마을의 새마을운동 사례를 통해 본 1970년대 한국 농촌사회 정치·경제적 변화 : 강원도 철원군 사곡2리와 군탄1리를 중심으로

김수경,최은봉 이화여자대학교 2005 사회과학연구논총 Vol.14 No.-

이 논문은 1970년대 권위주의 유신체제 하에서 농촌근대화를 목적으로 추진되었던 새마을운동이 한국 농촌사회에 어떠한 정치적·경제적 변화를 초래하였는지 살펴보는 것을 목적으로 한다. 실증적인연구제시를 위해 강원도 철원군 근남면 사곡2리와 갈말면 군탄1리 두 마을의 새마을운동을 사례로 분석하였다. 이 사례연구는 한수이남에 집중되어 있던 기존 새마을운동 연구의 공간적 범위를 휴전선인접지역까지 확장시켰다. 1970년대 당시 두 마을 새마을지도자들과의 인터뷰 자료와 현재 마을회관에 남아 있는 새마을운동사업 기록을 토대로 마을간 사업추진 방식과 두 마을 주민들의 참여태도, 사업성과 둥을 분석하였다. 철원군 근남면 사곡2리와 갈말면 군탄1리의 새마을운동 전개양상은 마을의 입지조건 및 마을 구성원의 차이에 따라 상이한 결과로 나타났다. 사례연구의 케이스가 협소하긴 하지만, 이 연구를 통해서 새마을운동이 직 ·간접적으로 농촌사회에 가져온 변화를 찾을 수 있었다. 새마을운동은 마을 단위로 진행되었기 때문에 동일 지역에서도 마을구성의 상이한 조건적 차이로 인해 새마을운동의 결과도 다르게 나타났다. The objective of this thesis is to see political and economic changes in Korean rural society in 1970s when Saemaul Undong(Movement) was launched by authoritarian government for the modernization in an agricultural district. This paper focuses on Saemaul Undong in two villages of Cheorwon, Kangwon Province or Sagok2-ri and Cuntanl-ri in order to provide actual evidence. Based on the interviews of two towns' then Saemaul Leaders and the information on Saemaul Undong of those areas during the 1970s, this research analyzes people's attitudes, the way of the Movement and the achievement of the Movement. In addition, this paper emphasizes on some changes in political and economic areas of the two villages for about 8 years, comparing to before and after the movement being implemented. They have similarities as well as differences in the stages of Saemaul Undong. firstly, it led the dwellers to actvely participate in the process. Secondly, the residents could express their opinion to the government through the town meefngs. Thirdly, newly-elected leaders, called Saemaul Undong leaders were main actors who are at the center of the course. Although they took the helm just within the Saemaul Undong project, their capacities resulted in various consequences of the Movement under the autonomy of the town unit. Apart from other changes, it altered the appearances of the rural communities. It came to build new roads, convert old houses to modernized ones. It is difficult to say that Saemaul Undong has drawn the actual increase in the economic incomes. However, development in the repairing facilities in it played a key role in going up in the crop productivity, Therefore, it is fair to say that Saemaul Undong had a positive effect on the agricultural economy to some extent.

몇 가지 항진균제가 Aspergillus fumigatus에 의한 대식세포의 Cytokine 생산에 미치는 영향

권은영,박철민,박선희,최수미,이동건,유진홍,신완식,최정현 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

배경 : 현재 임상에서 사용되는 서로 다른 계열의 항진균제가 면역세포인 폐 대식세포(alveolar macrophage)에서의 cytokine 생산과 nuclear factor- κB (NF- κB)활성에 미치는 영향을 시험관내에서 파악하고 그 의미를 추론해 보고자 하였다. 재료 및 방법 : AmB, MF, ITZ 등 세 가지 항진균제가 쥐의 폐 대식세포인 RAW264.7 세포의 생존에 미치는 영향과, 이들 항진균제의 전처치가 Aspergillus fumigatus conidia 자극에 의한 RAW264.7 세포에서의 TNF-α, IL-10 생산, NF-κB 활성에 미치는 영향, 그리고 GMCSF와의 상승 작용 등을 WST-1, ELISA, western blot assay를 이용해 통해 측정하였다. 결과 : AmB, MF, ITZ 모두 농도 의존적으로 RAW264.7 세포의 생존을 감소시켰다. A. fumigatus conidia 자극으로 RAW264.7 세포에서 TNF-α 생산이 증가하였으며, 세포 생존에 영향을 미치지 않는 농도의 AmB를 전처치하고 conidia로 자극한 경우 TNP-α 생산에는 차이를 보이지 않았으나, MF와 ITZ을 전처치한 경우에는 TNF-α 생산이 감소하였다. GM-CSF는 AmB 전처치 및 A. fumigatus conidia 자극에 의한 TNF-α 생산에 상승 효과를 보였으나, MF, ITZ은 GM-CSF에 의한 상승 효과를 보이지 않았다. IL-10은 AmB에 의해 생산량이 증가하였으며 GM-CSF와 동시 투여시 IL-10 생산이 유의하게 상승하였다. MF와 ITZ 역시 RAW264.7 세포에서 IL-10 생산을 유도하였으나 AmB에 비해 상승폭이 적었으며 GM-CSF와의 상승 효과는 관찰되지 않았다. A. fumigatus conidia는 NF- κB를 활성화하였으며 항진균제와 GM-CSF 등 약제 처치에 따른 NF-κB의 활성 정도는 분비된TNF-α와 IL-10의 생산 정도와 상관관계를 보였다. 결론 : AmB, MF, ITZ 등 본 연구에 사용된 항진균제는 시험관내에서 A. fumigatus conida로 자극하는 RAW264.7 세포에 전처치함으로써 염증성 cytokine인 TNF-α의 생산을 감소시키고 항염증성 cytokine인 IL-10의 생산을 증가시키는 면역 조절 효과를 나타낼 수 있음이 관찰되었다. 추후 약제간의 면역조절 기능 차이가 항진균효과에 미치는 영향 및 약제에 따른 면역 조절 경로 등에 대한 연구가 필요할 것으로 사료된다. Background : We wanted to evaluate the immunomodulatory effect of three antifungal agents, amphotericin B (AmB), micafungin (MF), itraconazole (ITZ), in the aspect of cytokine production and expression of nuclear factor-κB (NF-κB) in the Aspergillus fumigatus conidia treated-RAW264.7 cells, a murine alveolar macrophage cell line. Materials and Methods : We evaluated cytotoxic effect of antifungal agents using commercial cell proliferation assay. Tumor necrosis factor (TNF)-α and interleukin (IL)-10 production according to stimulation (control, A. fumigatus conidia only, conidia + antifungal drug, conidia + antifungal drug + GM-CSF) was evaluated and compared each using commercial ELISA method. NF-κB activation was evaluated by western blot analysis. Results : AmB, MF, ITZ showed dose-dependent cytotoxic effect on the tested cells. Stimulation of cells by A. fumigatus conidia induced TNF-α production. Pretreatment of AmB at concentration not affecting cellular survival did not change the production of TNF-α compared to conidia treated cells, but pretreament of MF or ITZ showed reduced amount of TNF-α production compared to conidia treated cells. AmB also showed synergistic effect on TNF-α production when simultaneously treated with GM-CSF. IL-10 production was markedly increased when the cells were treated with AmB with conidia. MF and ITZ induced less increase of IL-10 production than AmB. AmB also showed synergistic effect on the production of IL-10 when treated with GM-CSF simultaneously. A. fumigatus conidia enhanced expression of NF-κB. The degree of NF-κB expression was associated with the amount of TNF-α and IL-10 produced. Conclusion : The antifungal agents we used in this experiment showed that decreased TNF-α production and increased IL-10 production from the RAW264.7 cells stimulated by A. fumigatus conidia after pretreatment of antifungal agents. But more studies, such as the association between immunomodulatory effect, antifungal activity and difference of signal pathway of cellular activation according to drugs should be performed.

임신과 동반된 난소섬유난포막종 1례

류은석,김윤숙,전섭,김종수,최승도,선우재근,배동한,양승화 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Fibrothecoma are mesenchymal tumors deriving from the ovarian stroma and consisting of theca-like elements and fibrous tissues. The reported incidence is between 0.4 and 8.0% of all ovarian tumors and this side variability can be attributed to the difficulty in differentiation fibrothecoma from ovarian fibroma or hyperplastic stroma nodules. We experienced a rare case of ovarian fibrothecoma in woman at 38 weeks gestation with previous repeat cesarean section diagnosed after tertiary cesarean delivery and bilateral tubal ligation with a brief review of literature.