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십이지장 궤양 환자와 만성 위염 환자의 염증 분포의 차이 및 H. pylori 집락도와 염증도의 상관관계
유광하,진춘조,박형석,이재동,김예리,윤성욱,이수인,윤호상 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
An inflammatory difference between the gastric antrum, body and fundus was studied in 39 H.pylroi positive duodenal ulcer and 29 H. pylori chronic gastritis patients. Also we studied correlation of H. pylori colony count and inflammatory severity. Patients with newly diagnosed duodenal ulcer and chronic gastritis were endoscoped and two biopsy secimens each taken from the antrum, body and fundus. Although intestinal metaplasia in antrum and inflammatory activity in fundus were more severe in chronic gastritis patients. another inflammatory difference was equally likely to be found between two groups. There was no definite histological inflammatory difference between duodenal ulcer and chronic gastritis patients. A positive correlation was found between the number of H. pylori and the severity of inflammation.
Youn, Dong-Ye,Lee, Dong-Hyoung,Lim, Mi-Hyun,Yoon, Jung-Sook,Lim, Ji Hee,Jung, Seung Eun,Yeum, Chung Eun,Park, Cheol Whee,Youn, Ho-Joong,Lee, Jae-Seon,Lee, Seong-Beom,Ikawa, Masahito,Okabe, Masaru,Tsuj American Physiological Society 2008 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND M Vol.295 No.6
<P>Bcl-2 interacting cell death suppressor (Bis), also known as Bag3 or CAIR-1, is involved in antistress and antiapoptotic pathways. In addition to Bcl-2, Bis binds to several proteins, suggesting it has diverse functions in normal and pathological conditions. To better define the physiological function of Bis in vivo, we developed bis-deficient mice with a cre-loxP system. Targeted disruption of exon 4 of the bis gene was demonstrated by Southern blotting and PCR, and Western blotting showed that no intact or truncated Bis protein was synthesized in bis(-/-) mice. While heterozygotes were fertile and appeared normal, Bis-deficient mice showed growth retardation and died by 3 wk after birth. The relative weight of the thymus and spleen was reduced and the total numbers of white blood cells, splenocytes, and thymocytes were significantly reduced compared with wild-type littermates. Serum profiles indicated significant hypoglycemia as well as decrease in triglyceride and cholesterol levels. Expression profiles of metabolic genes indicated that gluconeogenesis and beta-oxidation are activated in the liver of bis(-/-) mice. This activation, as well as a decrease in peripheral fat and an induction of fatty liver, appears to be an adaptive response to hypoglycemia. Our study reveals that the absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment.</P>
클라우드 자원 브로커에서 확장성 있는 가상 머신 할당 기법을 이용한 비용 적응형 작업 스케쥴링 알고리즘
( Ye Ren ),김성환 ( Seong Hwan Kim ),강동기 ( Dong Ki Kang ),김병상 ( Byung Sang Kim ),윤찬현 ( Chan Hyun Youn ) 한국정보처리학회 2012 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.1 No.3
사용자들은 자신의 작업을 처리하기 위해 자신에게만 한정된 가상 컴퓨팅 자원을 클라우드 서비스 제공자로부터 할당 받아 타 사용자로부터 독립된 환경에서 작업을 처리하게 된다. 이를 자동화된 방법으로 최적화를 대신 수행해주기 위한 모델로 브로커 미들웨어가 제시되었고 마감시간을 만족하는 이내에서 자원 이용률을 높이는 접근법으로 필요 가상 머신의 숫자를 줄여 비용을 절약한다. 이를 다루는 많은 논문들에서 작업 스케줄링은 기존 사용자들간의 독립을 보장하여 하나의 가상 머신이 하나의 작업에 한정된 가상 머신에서 처리하는 방식으로 다루어지고 있다. 하지만 기존의 SRSV 방식에서는 높은 정도의 다중 프로그래밍 작업이 아닐 경우 시스템을 효율적으로 사용하지 못한다. 이에 본 논문에서는 해당 자원을 마감시간과 스래싱(thrashing), 문맥 전환(context switching)에 따른 성능 저하를 고려한 상태에서 다중 프로그래밍 정도를 높여 낭비되는 자원을 최소화하여 비용을 절약하려고 한다. 실험 결과를 통해 제안하는 방법이 제약조건 이내에서 기존의 방식에 비해 좀 더좋은 가격 대비 성능을 가지는 것을 보인다. Cloud service users request dedicated virtual computing resource from the cloud service provider to process jobs in independent environment from other users. To optimize this process with automated method, in this paper we proposed a framework for workflow scheduling in the cloud environment, in which the core component is the middleware called broker mediating the interaction between users and cloud service providers. To process jobs in on-demand and virtualized resources from cloud service providers, many papers propose scheduling algorithms that allocate jobs to virtual machines which are dedicated to one machine one job. With this method, the isolation of being processed jobs is guaranteed, but we can’t use each resource to its fullest computing capacity with high efficiency in resource utilization. This paper therefore proposed a cost-efficient job scheduling algorithm which maximizes the utilization of managed resources with increasing the degree of multiprogramming to reduce the number of needed virtual machines; consequently we can save the cost for processing requests. We also consider the performance degradation in proposed scheme with thrashing and context switching. By evaluating the experimental results, we have shown that the proposed scheme has better cost-performance feature compared to an existing scheme.
Dong-Wook Kim,Sang Il Youn,Ye Seob Jee 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.4
Purpose: This study aimed to compare treatment options and outcomes based on peritoneal cancer index (PCI) among patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC). Methods: Between January 2016 and July 2019, clinicopathological data of patients with AGC diagnosed with PM were reviewed. Different treatment methods were performed according to the PCI score: (1) group A (PCI ≤ 13) received cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with postoperative intraperitoneal (IP) and systemic chemotherapy (n = 29), while (2) group B (PCI > 13) received IP chemotherapy with systemic chemotherapy (n = 22). Results: Clinical outcomes of 51 patients at the Dankook University Hospital were reviewed. Group A had a significantly lower mean PCI score (9.8 ± 6.9 vs. 32.6 ± 7.1, P < 0.01) than group B, with 25 patients (86.2%) achieving complete cytoreduction. Complications occurred in 16 patients (31.4%), none of who suffered mortality (group A: 11 patients, 37.9% vs. group B: 5 patients, 22.7%; P = 0.25). Among the morbidity, 5 cases (17.2%) and 2 cases (9.1%) exhibited a Clavien-Dindo grade greater than III in groups A and B, respectively (P = 0.04). Groups A and B had an overall median survival time of 34.0 and 16.0 months, respectively (P = 0.03). Conclusion: Patients with PM of AGC received different treatments according to their PCI score. When accompanied with careful patient selection, our approach may be considered an acceptable option for the treatment of PM of AGC.
Study on the Environmental Risk Assessment of Transgenic Chinese Cabbage
Ye Sun Chung,Young Doo Park,Eun Taek Woo,Kuen Woo Park,Kyu Hwan Chung,Sang Yong Lee,Mun Il Ryoo,Jong Ok Ka,Min Jea Kim,Dong Ho Lee,Youn Hyung Lee,Dong Jin Lee,Chan Lee,Dae Yeul Son,Tae Sung Park,Hong 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-
Sufficient Calorie Intake Ameliorates Cognitive Impairment in Alcoholic Liver Disease
( Ye Rin Choi ),( Min Jea Shin ),( Gi Soo Youn ),( Sang Jun Yoon ),( Haripriya Gupta ),( Na Young Lee ),( Hyeong Seop Kim ),( Dong Joon Kim ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Alcoholic liver disease (ALD) is the most common cause of chronic liver disease. And cognitive dysfunction is one of the complications and associated with calorie intake in ALD. However, relation between nutrition and cognitive function has not been fully evaluated. The aim of this study is to explore the effect of diet on cognitive function in ALD. Methods: A total of 43 patients were enrolled and neuropsychological tests assessed according to the nutritional state (BMI<21.7 and BMI≥21.7). In animal study, mice were sub-divided into 4 groups (n=9/group; control (5% EtOH liquid diet), low fat (5% EtOH+low fat diet), high fat (5% EtOH+high fat diet), and high protein (5% EtOH+high protein diet)) for 8 weeks. For the cognitive function, we performed T-maze study weekly before and after alcohol binge. Results: In the comparison of cognitive function (BMI<21.7 and BMI≥21.7), language score of Korea mini-mental state (7.37 ± 1.4 and 7.85 ± 0.4 P=0.04), rey-complex figure (72.0±25.9 and 58.4±33.6, P=0.05), boston naming (11.7±2.7 and 13.0±1.8, P=0.02), forward digit span (6.7±1 .8 and 7.5±1.6, P=0.04), Korean-color word stroop (24.2±26.5 and 43.6±32.4, P=0.006), interference score (33.9±31.9 and 52.3±33.9, P=0.02) showed high scores in BMI≥21.7 group. In the animal study on day 40, all groups shortened the time to find feed (low fat: P=0.004, high fat: P=0.02) compared to the control group. Interestingly, binge drinking mice reduced the time than before trained mice. Conclusions: ALD patients with BMI<21.7 enhance their cognitive dysfunction. Although it needs more studies which correlation of calorie intake and cognitive function, this study indicates that sufficient intake of calories provides major benefits for preventing cognitive dysfunction.