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김도현,진희채,정지선 한국정보사회진흥원 2006 정보화정책 Vol.13 No.2
본 논문에서는 u-Korea를 구축하기 위한 유비쿼터스 서비스의 단계별 진화 모델을 개발하고자 한다. u-Korea 서비스의 단계별 모델을 개발하기 위하여 우선 유비쿼터스 소요 기술을 분류하고, 이것은 네트워크, 미들웨어, 단말 및 응용으로 구성된 4 계층 유비쿼터스 기술구조로 구분될 수 있다. 그리고 각 기술의 발전 방향 등을 토대로 각 계층에 대한 로드맵을 작성하고, 소요 기술의 개발 수준과 구성 요소를 기반으로 유비쿼터스 서비스를 위한 진화 모델을 제안한다. 각 서비스의 지능화 수준과 서비스 기술 로드맵에 따라 첫번째 P-to-M 커뮤니케이션, 두번째 상황인지, 세번째 자율반응 단계로 나누고 각 단계별 유비쿼터스 서비스를 위한 진화 모델을 제시한다. 그리고 작성된 진화 방법과 기존 보건∙복지 정책 및 시스템을 고려하여 점진적인 보건∙복지 유비쿼터스 모형을 제안하고, 국내외 유비쿼터스 서비스 사례를 분석하여 제시된 모형을 적용하여 본다.
소수성 촉매를 이용한 수소동위원소 교환 반응 측정을 위한 순환 반응기
최희주,이한수,안도희,강희석,김광락 한국공업화학회 2002 응용화학 Vol.6 No.2
The catalytic rate constants of hydrophobic catalysts developed for the removal of tritium mainly generated in the pressurized heavy water reactors should be measured. A recycle reactor was designed and built for characterzing the long-term behavior of the catalyst performance at the various temperatures and gas velocities.The catalytic rate constants were measured at the apparent gas velocity of 0.5 m/s and the temperature of 60℃. The initial catalytic constant was 8.44×10^-4mol/g.sec. This value is much greater than that considered in the design of Wolsong Tritium Removal Facility.
Hyunsu Kim,Kyung‑Wan Baek,고은지,Nguyen Thanh Luan,Yunjin Lim,Heyong Jin Roh,Nameun Kim,Do‑Hyung Kim,Ahran Kim,Yung Hyun Choi,Suhkmann Kim,Heui‑Soo Kim,Mee Sun Ock,차희재 한국유전학회 2020 Genes & Genomics Vol.42 No.7
Background Viral hemorrhagic septicemia (VHS) is a serious viral disease that infects the olive flounder in South Korea. The Korean aquaculture industry experienced an economic loss caused by the high infectivity and mortality. Objective This study aimed to evaluate the infection density of VHSV in various organs of the olive flounder including spleen, liver, kidney, stomach, esophagus, intestine, gill, muscle, heart, and brain. Olive flounders were collected from a local fish farm and injected subcutaneously with 106 PFU/fish. Methods Each 15 fish were sampled at 0, 3, and 7 days post challenge (dpc), respectively, to perform quantitative analysis of VHSV using SYBR-green based real-time PCR in various tissues including spleen, liver, head-kidney, body-kidney, muscle, esophagus, stomach, intestine, gill, and brain. Results Organs infected with VHSV were obtained after 3 and 7 days. Each organs were examined for viral infection using real-time PCR. The data obtained from this experiment revealed copy numbers higher than 10 copies per 100 ng cDNA in the spleen (15.26 ± 3.11 copies/100 ng of cDNA), muscle (11.24 ± 2.25 copies), and gill (14.23 ± 6.26 copies), but lower in liver, head-kidney, body-kidney, esophagus, brain and stomach. Conclusion The present study, together with previous data, demonstrated that the gill, spleen, and muscle are the major target organs of VHSV in olive flounder. Therefore, central monitoring of spleen, gill and muscle should be considered and might be necessary if anti-VHSV treatment is to be successful in infected olive flounder.
Inhibitory effects of Saururi chinensis extracts on melanin biosynthesis in B16F10 melanoma cells.
Lee, Do Hyun,Kim, Dong Ha,Oh, In Young,Kim, So Young,Lim, Yun Young,Kim, Hyeong Mi,Kim, Young Heui,Choi, Yoo Mi,Kim, Sung Eun,Kim, Beom Joon,Kim, Myeung Nam Pharmaceutical Society of Japan 2013 Biological & pharmaceutical bulletin Vol.36 No.5
<P>Saururus chinensis has been used in folk medicine in Korea for the treatment of edema, jaundice, gonorrhea, and several inflammatory diseases. Saururi chinensis extracts (SCE) have demonstrated anti-inflammatory and anti-oxidant activities, as well as anti-asthmatic, antihypertensive, anti-angiogenic, and therapeutic activities for atopic dermatitis. However, the inhibitory activity of SCE on the melanogenesis signaling pathway is not completely understood. This study examined the effects of SCE on the melanogenesis signaling pathway activated by α-melanocyte-stimulating hormone (α-MSH). We found that SCE inhibited melanin production in a dose-dependent manner without causing cytotoxicity in B16F10 cells. Interestingly, SCE decreased α-MSH-induced tyrosinase activity in B16F10 cells but did not inhibit tyrosinase activity under cell-free conditions. The results of this study indicate that SCE may reduce pigmentation by way of an indirect, nonenzymatic mechanism. We also found that SCE decreased α-MSH-induced microphthalmia-associated transcription factor (MITF) and tyrosinase expression and induced the activation of extracellular signal-regulated kinase (ERK). These results suggest that the depigmenting effect of SCE may result from downregulation of MITF and tyrosinase expression due to increased ERK activity. Thus, our results provide evidence that SCE might be useful as a potential skin-whitening agent.</P>
Copy Number Deletion Has Little Impact on Gene Expression Levels in Racehorses
Park, Kyung-Do,Kim, Hyeongmin,Hwang, Jae Yeon,Lee, Chang-Kyu,Do, Kyoung-Tag,Kim, Heui-Soo,Yang, Young-Mok,Kwon, Young-Jun,Kim, Jaemin,Kim, Hyeon Jeong,Song, Ki-Duk,Oh, Jae-Don,Kim, Heebal,Cho, Byung-W Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.9
Copy number variations (CNVs), important genetic factors for study of human diseases, may have as large of an effect on phenotype as do single nucleotide polymorphisms. Indeed, it is widely accepted that CNVs are associated with differential disease susceptibility. However, the relationships between CNVs and gene expression have not been characterized in the horse. In this study, we investigated the effects of copy number deletion in the blood and muscle transcriptomes of Thoroughbred racing horses. We identified a total of 1,246 CNVs of deletion polymorphisms using DNA re-sequencing data from 18 Thoroughbred racing horses. To discover the tendencies between CNV status and gene expression levels, we extracted CNVs of four Thoroughbred racing horses of which RNA sequencing was available. We found that 252 pairs of CNVs and genes were associated in the four horse samples. We did not observe a clear and consistent relationship between the deletion status of CNVs and gene expression levels before and after exercise in blood and muscle. However, we found some pairs of CNVs and associated genes that indicated relationships with gene expression levels: a positive relationship with genes responsible for membrane structure or cytoskeleton and a negative relationship with genes involved in disease. This study will lead to conceptual advances in understanding the relationship between CNVs and global gene expression in the horse.
Kim, Hyeongmin,Lee, Taeheon,Park, WonCheoul,Lee, Jin Woo,Kim, Jaemin,Lee, Bo-Young,Ahn, Hyeonju,Moon, Sunjin,Cho, Seoae,Do, Kyoung-Tag,Kim, Heui-Soo,Lee, Hak-Kyo,Lee, Chang-Kyu,Kong, Hong-Sik,Yang, Yo Oxford University Press 2013 DNA research Vol.20 No.3
<P>The modern horse (<I>Equus caballus</I>) is the product of over 50 million yrs of evolution. The athletic abilities of the horse have been enhanced during the past 6000 yrs under domestication. Therefore, the horse serves as a valuable model to understand the physiology and molecular mechanisms of adaptive responses to exercise. The structure and function of skeletal muscle show remarkable plasticity to the physical and metabolic challenges following exercise. Here, we reveal an evolutionary layer of responsiveness to exercise-stress in the skeletal muscle of the racing horse. We analysed differentially expressed genes and their co-expression networks in a large-scale RNA-sequence dataset comparing expression before and after exercise. By estimating genome-wide <I>d</I><SUB>N</SUB>/<I>d</I><SUB>S</SUB> ratios using six mammalian genomes, and F<SUB>ST</SUB> and iHS using re-sequencing data derived from 20 horses, we were able to peel back the evolutionary layers of adaptations to exercise-stress in the horse. We found that the oldest and thickest layer (<I>d</I><SUB>N</SUB>/<I>d</I><SUB>S</SUB>) consists of system-wide tissue and organ adaptations. We further find that, during the period of horse domestication, the older layer (F<SUB>ST</SUB>) is mainly responsible for adaptations to inflammation and energy metabolism, and the most recent layer (iHS) for neurological system process, cell adhesion, and proteolysis.</P>
Kim, Do Heui,Mudiyanselage, Kumudu,Szanyi, Já,nos,Hanson, Jonathan C.,Peden, Charles H. F. American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.8
<P>Based on the combined FTIR and XRD studies, we report here that H<SUB>2</SUB>O induces a morphological change of KNO<SUB>3</SUB> species formed on model K<SUB>2</SUB>O/Al<SUB>2</SUB>O<SUB>3</SUB> NOx storage-reduction catalysts. Specifically as evidenced by FTIR, the contact of H<SUB>2</SUB>O with NO<SUB>2</SUB> preadsorbed on K<SUB>2</SUB>O/Al<SUB>2</SUB>O<SUB>3</SUB> promotes the transformation from bidentate (surface-like) KNO<SUB>3</SUB> species to ionic (bulk-like) ones irrespective of K loadings. Once H<SUB>2</SUB>O is removed from the sample, a reversible transformation into bidentate KNO<SUB>3</SUB> is observed, demonstrating a significant dependence of H<SUB>2</SUB>O on such morphological change. TR-XRD results show the formation of two different types of bulk KNO<SUB>3</SUB> phases (orthorhomobic and rhombohedral) in an as-impregnated sample. Once H<SUB>2</SUB>O begins to desorb above 400 K, the former is transformed into the latter, resulting in the existence of rhombohedral KNO<SUB>3</SUB> phase only. On the basis of consistent FTIR and TR-XRD results, we propose a model for the morphological changes of KNO<SUB>3</SUB> species with respect to NO<SUB>2</SUB> adsorption/desorption, H<SUB>2</SUB>O and/or heat treatments. Compared with the BaO/Al<SUB>2</SUB>O<SUB>3</SUB> system, K<SUB>2</SUB>O/Al<SUB>2</SUB>O<SUB>3</SUB> shows some similarities with respect to the formation of bulk nitrates upon H<SUB>2</SUB>O contact. However, there are significant differences that originate from the lower melting temperature of KNO<SUB>3</SUB> relative to Ba(NO<SUB>3</SUB>)<SUB>2</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-8/jp410816r/production/images/medium/jp-2013-10816r_0008.gif'></P>
An Expert Analysis System Based on Research Achievements
Do-Jin Choi,Young-Ho Oh,Do-Woong Pyun,Sang-Ho Song,Christopher Retiti Diop Emane,Jun-Hyeok Jang,Sang-Hyeuk Kim,Sang-Jun Chung,Seo-Heui Lee,Jong-Hun Kim,Jong-Woo Jeon,Hyeon-Byeong Lee,Jong-Tae Lim,Kyou 한국콘텐츠학회 2021 한국콘텐츠학회 ICCC 논문집 Vol.2021 No.12