Flurbiprofen 함유 키토산 제제가 치은 섬유아세포에 미치는 영향

정종평,박윤정,이승진,유인철,최상묵 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6

The main goal of periodontal regeneration is to be achieved by epithelial exclusion, periodontal ligament cell activation or alveolar bone regeneration. The purpose of this study was to investigate on the physico-chemical and biological characteristics of biodegradable chitosan beads. Chitosan beads were fabricated by ionic gelation with sodium tripolyphosphate and they had the size in 300㎛ diameter. As therapeutic agent, flurbiprofen was incorporated into the beads by 10, 20% loading contents. The release of drugs from the chitosan beads was measured in vitro. Also, biological activity tests of flurbiprofen loaded chitosan beads including cytotoxicity test, ihhibition of IL-1β production, suppression to PGE_2 production, collagenase inhibition test, the ability of total protein synthesis, and tissue response were evaluated. The amount of flurbiprofen released from chitosan was 33-50% during 7 days. Minimal cytotoxicity was observed in chitosan beads. Flurbiprofen released from chitosan beads significantly suppressed the IL-1β production of monocyte, PGE_2 production and markedly inhibited collagenase activity. Meanwhile, flurbiprofen released from this system showed increased ability for protein synthesis. Throughout 4-week implantation period, no significant inflammatory cell infiltrated around chitosan bead and also fibroblast like cell types at the beads-tissue interface were revealed with gradual degradation of implanted chitosan beads. From these results, it was suggested that flurbiprofen loaded chitosan beads can be effectively useful for biocompatible local delivery system in periodontal regeneration.

고려인삼(Panax ginseng C.A.Meyer)중의 α-amylase에 관한 연구(I) : Separation of crude ginseng α-amylase and its some properties 조(粗)효소의 분리와 그 성질

박성희,김병묵,정동선 서울여자대학교 1979 서울여자대학논문집 Vol.- No.8

In order to study α-amylase from Korean ginseng (Panax ginseng C.A. Meyer), the crude ginseng α-amylase preparation was separated by fractionation of ginseng extracts with ammonium sulfate, and its properties were examined. The results were as follow: (1) Ginseng extracts contained α-amylase, β-amylase and invertase, but not lipase, protease and catalase. (2) α-amylase of ginseng was extracted most effectively with water. (3) α-amylase of ginseng was fractionated with ammonium sulfate between 0.4 and 0.8 saturation. (4) Crude α-amylase of ginseng was stable at pH ranges between 5 and 10, and at temperature below 50℃. (5) Crude α-amylase of ginseng showed optimum pH between 5 and 6, and optimum temperature between 35 and 40℃. (6) The activities of ginseng α-amylase had proportional relations with enzyme concentrations below OD 2.5 at 500nm and substate concentrations below 12㎎%. (7) Crude α-amylase of ginseng was inhibited by some metal ions such as Hg?? and Cu??.

호텔레스토랑 부서간 갈등지각 수준에 관한 연구

강상묵,정연홍 한국문화관광학회 2004 문화관광연구 Vol.6 No.1

The objective of this research is to determine the issues related to the internal hotel restaurant management conflicts especially between front line employees and back stage employees. In addition, it is the purpose of this research to measure the level of inter-departmental disputes within different hotel divisions and to offer an effective solution to managing these inter-departmental conflicts. In order to accomplish this research objective, authors, have established non-managerial level employees of food & beverage department and food preparation department of top-class hotels in Seoul. Furthermore, authors propose to study this subject base in order to determine cause and effect of inter-departmental conflicts as presented in this research.

S.D. Rats를 이용 1, 1-Dichloro-1-fluoroethane의 아민성 흡입독성 연구

김현영,이성배,임철홍,김철우,점용현,한정희,전윤석,최수영,강대봉,이용묵 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1

There were no specific effects for test materials on Sprague-Dawley (S.D.) rats in clinical symptoms, amounts of food intakes, weight changes, laboratory findings, and pathology after whole body l, l-Dichloro-1 -fluoroethane (used as coolant, metal cleaner and solvents) exposure(0, 1,500, 3,000, and 6,000 ppm) for 13 weeks (6 hour/day, 5 days/week). However, the loss of capillary vessels in eyeball (pupil) was observed in a female rat among 6,000 ppm group. Though there was a tendency for MCHC (Mean Corpuscular Hemoglobin Concentration) in rat to be decreased (p<0.05), it was not regarded as abnormal because the values were within normal limits. In asthma-stimulation related evaluations, there was also a tendency for inflammatory cell counts in bronchoalveolar lavages to be increased. But it had no statistical significance, and also no dependency on sex and the exposed concentration. Based on this result, the non observed effect level (NOEL) induced by 1, 1-Dichloro-l -fluoroethene inhalation was evaluated in groups with 3,000 ppm below (S .D. Rats, 13 weeks). Finally, it was concluded that the short term exposal of 1, 1-Dichloro-l-fluoroethane is not considered as a asthma stimulant by inhalation despite of some study limitations such as test animals use and short-term exposure .

SD Rats를 이용 1-hexene의 흡입독성 연구

김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

소아 재발성 호흡기 감염증에서 Broncho-Vaxom�의 임상효과

배종우,차성호,조병수,정사준,최용묵,안창일 한국의학사 1990 診斷과治療 Vol.10 No.9

기관지천식 환아에서 Ketotifen(Zaditen^(�))의 임상적 효과에 관한 연구

배종우,차성호,조병수,정사준,최용묵,안창일 한국의학사 1988 診斷과治療 Vol.8 No.4

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

Growth and Properties of Sb-doped ZnMgO Thin Films Deposited Using rf Magnetron Sputtering

Sung Mook Chung,Jae Heon Shin,Min Ki Ryu,Chi-Sun Hwang,Hye Yong Chu,Kyoung Ik Cho 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3

We report on the growth and the properties of Sb-doped ZnMgO thin films deposited using radiofrequency (rf) magnetron sputtering for applications as transparent thin film transistors (TFTs) with p-type channels. The target was prepared with high-purity MgO mixed with ZnO and Sb2O5 as doping agents. Thin films were heat-treated in vacuum, oxygen, and nitrogen atmospheres. The effects of the working gas (Ar/O2) ratios and the annealing conditions on the structural and the electrical properties were investigated. The atomic ratio of Zn/Mg in the films, and accordingly the films properties, depended on the post-annealing conditions and on the oxygen partial pressure in the working gas during sputtering. We report on the growth and the properties of Sb-doped ZnMgO thin films deposited using radiofrequency (rf) magnetron sputtering for applications as transparent thin film transistors (TFTs) with p-type channels. The target was prepared with high-purity MgO mixed with ZnO and Sb2O5 as doping agents. Thin films were heat-treated in vacuum, oxygen, and nitrogen atmospheres. The effects of the working gas (Ar/O2) ratios and the annealing conditions on the structural and the electrical properties were investigated. The atomic ratio of Zn/Mg in the films, and accordingly the films properties, depended on the post-annealing conditions and on the oxygen partial pressure in the working gas during sputtering.

아동의 얼굴표정에 대한 예비교사의 정서인식 : 인종에 따른 차이를 중심으로

정정희(Chung, Chung-hee),배정옥(Bae, Jung-ok),최성묵(Choi, Sung-mook),정효진(Jeong, Hyo-jin),이지연(Lee, Ji-yeon),이효림(Lee, Hyo-rim) 한국어린이문학교육학회 2022 어린이문학교육연구 Vol.23 No.1

본 연구는 아동의 얼굴표정에 대한 예비교사의 정서인식을 인종에 따른 차이를 중심으로 살펴보았다. 연구목적 수행을 위해 유아 · 초 · 중등 예비교사 405명을 대상으로 하였으며, 연구도구로는 Schultz, Izard, & Bear(2004)가 개발한 ACES(Assessment of Children"s Emotion Skills)와 한국판 ACES 의 얼굴표정 섹션에 제시된 아동얼굴표정을 사용하였다. 연구결과, 예비교사들의 한국아동과 외국아동에 대한 얼굴표정 인식의 정확성과 정서강도 인식은 인종에 따라 차이가 있었으며 정서유형별로도 차이가 있는 것으로 나타났다. 예비교사들의 한국아동의 정서인식 정확도가 외국 아동에 비해 높은 것으로 나타났으며 정서강도의 경우, 한국아동에서는 기쁨과 슬픔이, 외국아동의 경우 분노와 공포가 강하게 표출되는 것으로 인식하였다. 정서유형별로는 기쁨을 가장 정확히 인식하고 공포 정서에 대한 인식 정확도가 가장 낮은 것으로 나타났다. 이러한 결과를 통해 교사교육에서 아동들의 얼굴표정을 통한 정서인식의 중요성을 강조하고, 인종에 따른 교사의 정서인식에 대한 내용을 포함시키는 것이 필요하다는 시사점을 얻을 수 있다. The present study investigated the emotion recognition of preservice teachers for children’s facial expressions, focusing on differences according to race. For this purpose, data were collected and analyzed from 405 preservice teachers of early childhood, elementary, and secondary schools using the initial version of ACES developed by Schultz, Izard., & Bear(2004), and the Korean version of ACES. The results showed that preservice teachers’ recognition of children’s emotional facial expressions differed according to race. The recognition accuracy scores for Korean children were significantly higher than those of foreign counterparts. In terms of emotional type, the participants showed the highest accuracy scores for ‘joy’ and the lowest for ‘fear.’ Given the centrality of emotional facial expressions in educating young learners, the current findings have important bearing on preservice teacher education.