직업적 디메틸아세트아미드(Dimethylacetamide) 노출에 의해 집단적으로 발생한 독성간염

최태성,우극현,김진석,박완섭,함정오,정상재,유재영 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

목적 : DMAC에 노출된 후 집단적으로 발생한 독성 간염 7례보고. 방법 : 2000년 2월 신설된 스판덱스 섬유제조 공장에 근무하는 생산직 근로자 178명중 2000년 2월 부터 8월까지 7명이 간장질환이 발생하였다. 환례들의 나이는 23∼47세였고, 남자 5명, 여자 2명이었다. 이들에 대해 혈액검사, 간 초음파 검사 등의 임상검사와 작업장 조사를 실시하였다. 결과 : 근무 부서는 중합 1명, 방사 1명, 권취 4명, 그리고 포장 1명이며 평균근무기간은 10주였다. 주 호소 증상은 심한 피로감, 어지럼증 및 황달이었고, 검사실 소견상 독성간염의 소견을 보였다. A, B 및 C형 간염 표지자 검사는 모두 음성이었고, 간초음파 소견상 특이 소견이 없었다. 문진 상 알코올 성 간염을 일으킬 정도의 음주력이나 최근 약물 복용력을 가지고 있는 환례는 없었다. 입원 후 보존적인 치료로 모두 급속히 호전되었다. 초기에 발생했던 환례에서 퇴원후 DMAC에 재 노출되어 독성 간염이 재발되었다. 이후 모든 환례들은 퇴원 후 DMAC 비노출 부서로 전환하였고, 퇴원후 지속적인 추적검사에서 간 효소 수치가 완전히 정상화되었고, 정상화되는 기간은 1∼2개월 정도 소요되었다. 결론 : 환례들의 임상증상, 검사결파, 노출력 및 과거력상 DMAC에 의한 독성간염으로 추정된다. Dimethylacetamide is widely used in the production of plasics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide (DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubln, alanlne aminotransferase (ALT), and aspartate aminotransferase (AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.

간질에 대한 임상적 고찰

최진영,유병연 건국대학교 1995 學術誌 Vol.39 No.2

Epilepsy occurs in all age groups with a variety of diseases that alter neuronal function in a specific way. In spite of the development in diagnosis and treatment of epilepsy, epileptic patients were treated inappropriately and are often handicapped by the psychosocial consequence of their conditions, The purpose of this study is to provide reference and education to patients and their families. Clinical study via chart review was carried out on 110 patients with seizure who visited outpatient department of neurology and were consulted from other departments, Kon Kuk University Hospital from July, 1990 to August, 1993. The results were as follows : Males were more affected than females in the ratio of 1.89 :1. In their distribution of age, teens were most frequent(38.18%). seizure occured most frequently in the first decade(35.45%). The seizure types were : generalized seizure 86.36%(tonic-clonic 74.54%, tonic 8.18%, clonic 1.82%, atonic0.19%, atypical absence 0.91%) : Partial seizure 13.63%(complex partial 7.27%, secondary generalized6.37%). Causes of seizure were idiopathic(58.18%), trauma(13.63%), developmental(8.18%), cerebrovascular disease(7.27%), etc. The major part of all idiopathic cases had their attack of seizure before 30 years of age and those of symptomatic cases were rather late over age of 30. On EEG, abnormal findings were noted in 66.99%. Abnormal EEG findings were found more commonly in complex partial seizure(71.43%) than generalized seizure(66.67%) and secondary generalized seizure(66.67%). On brain CT scan, abnormal findings were noted 52.94%, and the abnormal findings were found more commonly in complex partial seizure(66.77%) than generalized seizure(54.54%) and secondary generalized seizure(25%). Abnormal brain CT scan findings were noted in 46.67% of normal EEG patients and in 51.52% of abnormal EEG patients. Most frequently used antiepileptic drug was carbamazepine. The serum level of antiepileptic drugs was in therapeutic ranges and clinical effect was good. Epileptic patients can perform daily activities without any handicap if they are properly treated. We should educate the community against the miss-belief about epilepsy.

일부 인쇄회로기판 납땜근로자들의 눈, 호흡기, 피부의 증상에 대한 조사연구

유재영,우극현,김진석,함정오,최태성,하봉구,정상재,박신구,김일룡 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 이 연구는 납점작업자를 대상으로 납점작업으로 유발될 가능성이 높은 눈, 호흡기, 피부 등의 증상호소율 및 노출강도에 따른 관련성을 파악하기위해 수행되었다. 방법 : 연구참가자 146명중 연구목적에 적합한 20명을 제외한 126명을 대상으로 '눈이 가렵고 충혈됨', '코가 가렵거나 파가움', '재채기', '콧물'. '코막힘' , '목이 따끔거림' , '목에 무언가가 걸려있는것 같음' , '갑자기 연속적인 기침을 함' , '운동 시에 다른 사람에 비해 숨이 가쁨', '숨을 쉴 때 쌕쌕하는 소리가 남', '가래가 끓음', '손이나 안면에 가려움을 느낌' , '안면에 여드름이 날' '손이나 안면에 붉은 반점이 남' 등 14가지 증상에 대한 경험유무와 혈중연농도, 납점작업의 건강위험요인에 대한 지식상태 등을 조사하였다. 결과 : 조사된 14가지의 증상 중, '갑자기 연속적인 기침을 함'이 하루 납점시간 4시간 이상인 군아서 4시간 미만인 군보다 유의하게 증상호소율이 높았으며, 다른 증상의 경우 하루 납땜시간에 따라 유의한 결과를 보이지 않았다. 납땜작업의 건강위험요인에 대한 질문에 12.8 %가 플럭스에 의한 건강위험을 지적하였다. 전체 대상자의 평균 혈중연농도는6.05 rg/dL였으며, 히고치는 15.50 rg/dL이었다.결론 : 납땜작업자에게 호흡기 증상의 위험이 높을 가능성이 있으며, 납땜작업의 건강위험에 대한추가적인 연구와 납점작업자들을 대상으로 납점작업에 의해 유발될 수 있는 건강장해에 대한 적극적인교육 및 홍보활동을 필요로 한다. Objectives : This study was conducted to evaluate the prevalence of ocular, respiratory and skin symptoms among solderers and to investigate the relationship between symptom prevalence and exposure intensity. Methods : We analyzed 126 eligible participants out of a population of 146 male solder-ers who completed the symptom questionnaires. Fourteen symptoms including 'itchy and red eyes', 'itchy or prickly nose', 'sneezing', 'rhinorrhea', 'blocked nose', 'prickly throat', 'foreign body sensation in throat', 'sudden bouts of coughing', 'exertional breathlessness', 'wheezing', 'sputum production', 'itchy face or hands', 'acneiform erup-tions on the face' and 'red spots on the face or hands' were contained. Blood lead levels of all the 126 participants were tested and the participants' own assessments of the health risk of soldering were collected. Results : Of the 14 investigated symptoms, 'sudden bouts of coughing' was significantly more prevalent in solderers who worked 4 hours or more a day than those who worked less than 4 hours a day, as for the other symptoms, there were no significant differences in the prevalences related to daily soldering hours. 2.8% of the solderers considered the risk of flux exposure to be serious. The mean blood lead bevel was 6.05 μg/dL (maximum 15.50 μg/dL). Conclusions : Soldering may increase the risk of respiratory symptoms. Further invert tigations on the hazards of soldering processes are warranted and solderers should be educarted on these hazards.

지역학으로서의 독일학 육성을 위한 정보자료의 디지털화와 활용방안에 관한 연구

최병진,정동규,천미애,남유선 한국독어독문학회 2003 獨逸文學 Vol.88 No.-

In dieser Arbeit wurde vor allem versucht, den Blick auf zwei Punkte zu richten: Erstens sollte das Forschungsvorhaben, das im Rahmen eines zweija¨hrigen Projekts unter finanzieller Unterstu¨tzung des Koreanischen Research Foundation (KRF) durchgefu¨hrt wurde, in grobem Abriss vorgestellt werden. Zweitens werden die Probleme skizziert, die wa¨hrend der Durchfu¨hrung des Projekts auftauchten, und aus denen sich schließlich unmittelbar einige Verbesserungs- vorschla¨ge ergeben. Das Projekt hatte die Aufgabe, ein auf digitalisierten Daten basierendes Informationssystem u¨ber Deutschland zu erstellen. Das System der Wissenschaftsinformationen, das in der vorliegenden Arbeit vorgestellt wurde, wird beispielsweise aufgrund seiner umfangreichen Informationsdaten dem Fach Germanistik zur weiteren und vertiefenden deutschlandeskundlichen Forschung von großem Nutzen sein. Daru¨ber hinaus aber kommt es auch den Lehrenden zugute, da ihnen dann ein vielseitiges und reichhaltiges Lehrveranstaltungsmaterial als Veranstaltungsthemen zur Verfu¨gung steht. Um ein solches Wissenschaftssystem der Deutschlandforschung zu erstellen und weiter zu entwickeln, wird jedoch nicht nur vie1 Zeit, sondern eine sta¨ndige Aktualisierung der Datenbank no¨tig werden. Um diese Aufgaben zu bewa¨ltigen, sollten mo¨glichst viele Germanisten fu¨r das Projekt zur Verfu¨gung stehen. Zurzeit findet das Internet im privaten und o¨ffentlichen Bereich breite Anwendung wie noch nie zu vor, und diese Tendenz wird sich noch versta¨rken. Forscher suchen und sammeln Informationen anhand des Internets. So nimmt es im Forschungsleben als Forschungswerkzeug einen wichtigen Platz ein. In Zukunft wird sich der Service im Bereich des Netzwerks weiter entwickeln/verbessern. Dies bedeutet fu¨r die Forscher eine Chance im Hinblick auf die Zukunft der Forschung, wenn sie gemeinsam ein wissenschaftliches Kooperationssystem entwickeln, um Wissen unter einander auszutauschen.

CGI 프로그램에서 클라이언트와 서버의 자동화된 상태정보 전달

최준용,유진호,장종표,방만원 木浦大學校 情報産業硏究所 1997 情報産業硏究誌 Vol.5 No.-

The HTTP Protocol composed of WWW's client/server model is unconnected and not keep state, so, there is one connection for one request. In this condition, it has no guarantee to memory which is needed in sequential processing, and HTTP Protocol has no choices to transfer the information from client to server's CGI or the information exchange. This paper uses the word 'key' instead of this 'state information'. We studied the key which creates automatically the HTML document for data search hierarchically in WWW environment and to confirm applied this to multimedia order and sale system of agricultural and marine products.

주의력결핍 과잉행동장애 아동에서 틱 장애 동반 여부에 따른 확산 텐서 영상 비교 연구

최지욱,임명호,이창화,박진균,손정우,심세훈,유인규,강현수,정범석 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : Diffuse tensor imaging (DTI) was applied to explore the difference in regional distribution and extent of white matter (WM) abnormalities in boys with Attention-deficit/hyperactivity disorder (ADHD) versus boys with comorbid ADHD and tic disorders. Methods : Fifteen boys with ADHD (mean age 9.3 +1.8), 24 ADHD boys with chronic tic disorder or Tourette's disorder(9.9 =b 1.2) and 9 age-, gender-matched controls (9.2 d= 1.8) received DTI assessments. Fractional Anisotropy (FA) maps of WM were compared between groups with a voxel-wise analysis after intersubject registration to MNI space. Results : Bo groups, ADHD group and ADHD with tic disorder group, commonly showed decreased FA than healthy control group in left cerebellar middle peduncle and right frontal lobe, increased FA in right middle occipital WM. In the common areas of left cerebellar middle peduncle and right middle occipital WM, comorbid group showed broader areas of significant FA. The comorbid group also showed increased FA in right cerebellar peduncle, additionally. Conclusion : The findings in ADHD group support previous ADHD hypothesis of the functional abnormalities in corticocerebellar circuit, and suggest that ADHD might have more complicated pathology of neuronal circuit including occipital visual system. The comorbid group showed common areas of overlapping but more extensive abnormalities and also had additional WM abnormalities. ADHD with chronic tic disorders may represent a severe form of ADHD with additional regions of abnormal connectivity.

관상동맥 누공에 의한 급성 심근 경색 1예

서유승,최재웅,송창섭,조용범,양진수,박준섭,정인수 대한내과학회 2003 대한내과학회지 Vol.65 No.2

관상동맥 동정맥루 기형은 매우 드문 질환으로 치료가 불필요한 경우가 대부분이나 coronary steal 현상으로 인해 증상이 발생하거나 합병증이 발생한 환자에 대해선 치료를 요한다. 최근에는 시술에 적합한 누공을 가진 선택된 환자군을 대상으로 카테터를 이용한 중재적 시술이 시행되어 수술적 치료와 유사한 결과를 얻고 있다. 저자들은 젊은 남자에서 관상동맥 동정맥루 기형과 동반된 급성 심근 경색증을 진단하여 비 수술적 방법인 카테타 코일 색전술로 성공적 치료 후 증상 및 심근 재관류에 호전을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of coronary fistula between the left anterior descending and main pulmonary artery complicating acute non-Q wave myocardial infarction. A 27-year-old man visited emergency department because of severe chest pain lasting two hours. The electrocardiogram showed ST segment elevation in precordial leads V3~6. Cardiac enzymes were as follows;CK-MB:36.44 IU/L T-T:0.489 ng/mL, CPK:542 IU/L, and LDH:475 IU/L. The thallium-201 dipyridamole stress perfusion scan showed perfusion defect and reversed redistribution in the anteroseptal wall. The coronary angiogram revealed coronary artery fistula between the proximal left anterior descending artery and main pulmonary artery without significant stenoses of coronary arteries. The result of ergonovine test was negative. After micro-coil embolization to the coronary fistula, symptoms were improved. Follow-up thallium-201 scan showed normalized blood flow in the left anteroseptal wall.

남성 건강검진 수진자에서 간기능 장애 및 비알코올성 지방간과 대사 증후군과의 관련성

최태성,유재영,김진석,장은철,박주언,김병익 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

실과·기술교과교육 연구의 동향과 교과 교육학 강좌의 교재 개발 전략

김진순,최유현 충남대학교 공업교육연구소 1997 論文集 Vol.20 No.1

The purposes of this study were to review the international trends on the reform of technology education, to synthesize the research trends for structuring the research model of technology education, and to discuss the contents of pedagogical course for developing the texts. This study was conducted through reviewing an extensive of literature related to journals of practical arts & technology education since 1990, and to thesis, action research etc. The major findings of this study were as follows: 1. Countries such as UK(National Curriculum), USA(National Standards), New Zealand(National Curriculum) were introducing nationalwide common curriculum, and emphasizing some subjects as the 'core'. The philosophy and methodology of Technology Education in these countries based on problem solving-oriented approaches. 2. Articles on elementary practical arts education were published in the Journal of Korean Practical Arts Education(1985-1997), The Journal of Practical Arts Education Research(1995-1997). Articles on technology education were published in the Journal of the Korean Institute of Industrial Educators(1972-1997), The Journal of Vocational Education Research (1984-1997). Also, some action-research, thesis, dissertation on technology education were had studied. 3. Four variables of Research Model of Technology Education developed this study were Input, Process, Output, and Support Variable based on the generality of education and speciality of technology education. This model will be contributed the structuring of the paper on the study of technology education. 4. The subjects of pedagogical course of elementary practical arts education suggested in this study were Introduction of Practical Arts Education and Research on the Text Contents of Practical Arts Education. Also, the subjects of pedagogical course of technology education suggested in this study were Introduction of Technology Education, Teaching of Technology Education, Curriculum and Assessment of Technology Education, and Research on the Text of Technology Education. Therefore texts for this course should be developed and published through cooperative writing.